SlideShare a Scribd company logo
Dr Ardra Thorat
MS Shaltatantra
Wound healing
 Replacement of destroyed tissue by living tissue
1. Regeneration- replacement of lost tissue by similar
type of tissue
2. Repair- replacement of lost tissue by granulation
tissue, followed by fibrosis & scar formation,
8/1/2020 Dr Ardra Thorat
Definition of wound healing :-
 Wound healing is process by which skin or other
body tissue repairs itself after trauma
 In undamaged skin, the epidermis and dermis
form a protective barrier against the external
environment.
8/1/2020 Dr Ardra Thorat
General principle of
wound healing
8/1/2020 Dr Ardra Thorat
Healing by 1st intention
 When wound sutured primarily
 Minimal scar
8/1/2020 Dr Ardra Thorat
Healing by 2nd intention
1. When there is irreparable skin loss
2. when the wound becomes infected and breaks
open
3. primary suturing is not possible, so the wound
heals with more scar tissue and takes longer time
to heal.
8/1/2020 Dr Ardra Thorat
Wound healing processes
 Rapid hemostasis
This refers to the mechanism that stops the actual
bleeding. Most of the time, body will accomplish this
through a process called vasoconstriction.
 Following processes take place
a) Inflammation
b) Wound contraction
c) Epithelization
d) Granulation tissue formation
e) Scar remodeling
8/1/2020 Dr Ardra Thorat
1. Inflammation
trauma
Platelet become adherent
Vasoconstriction
Vasodilatation( Histamin)
Prostaglandin PEG1, PEG2
Local inflammatory vascular response
8/1/2020 Dr Ardra Thorat
2. Wound contraction
 Open wounds, after 3-5 days
 Amount of contraction depends upon amount of skin
available
 Causes – removal of fluid, contraction of collagen,
contraction of granulation tissue
 Inhibiting factors-
a) Corticosteroid
b) burns
c) immediate skin grafting
d) X ray irradiation
e) cytotoxic agents
8/1/2020 Dr Ardra Thorat
3 Epithelization
 Epidermis grows
 It forms edges of wound by process of cell migration and
cell multiplication.
 This is mainly brought about marginal basal cells
proliferation
 Thus within 48 hours entire wound is re- epithelialised.
 When there is wound with skin loss, skin appendages, also
help in epithelisation , surface cells get keratinised.
8/1/2020 Dr Ardra Thorat
4.Grannulation tissue formation
1) Mainly formed by proliferation & migration of surrounding
connective tissue element.
2) Stage of vascularization
3) Stage of devascularization- Fibroplasia along with capillary
budding gives rise to granulation tissue.
4) Between third and fifth day, polymorphoneuclear leukocytes
diminish in number but monocytes increases. They are
specialised scavengers.
5) By fifth or sixth day, fibroblasts appers, proliferate and
eventually gives rise to protocollagen which is converted into
collagen in presence of enzyme, protocollagen hydroxylase,
oxygen, ferrous ions and as corbic acid are neccessory for
this step.
8/1/2020 Dr Ardra Thorat
5. Scar remodeling
Following changes take place during scar formation
–
1) Fibroplasia and laying of collagen is incresed.
2) Vascularity becomes less.
3) Epithelialisation continues.
4) Remodeling of collagen take place with
cicatrisation resulting in scar.
8/1/2020 Dr Ardra Thorat

More Related Content

Similar to Wound healing

Karya ilmiah ummu fix
Karya ilmiah ummu fixKarya ilmiah ummu fix
Karya ilmiah ummu fix
Dzatun Nithaqain
 
Wound healing and care presentation
Wound healing and care presentationWound healing and care presentation
Wound healing and care presentation
payneje
 
WOUND HEALING AND CARE. THIS IS WOUND HEALING NOTES.tx
WOUND HEALING AND CARE. THIS IS WOUND HEALING NOTES.txWOUND HEALING AND CARE. THIS IS WOUND HEALING NOTES.tx
WOUND HEALING AND CARE. THIS IS WOUND HEALING NOTES.tx
SamoeiJK
 
Tissue repair
Tissue repairTissue repair
Tissue repair
melebest
 
8031735.ppt
8031735.ppt8031735.ppt
8031735.ppt
HassaanShah5
 
Biomaterial science presentation
Biomaterial science presentationBiomaterial science presentation
Biomaterial science presentation
Huzaifa Ummar
 
Wounds And wound dressing (Advanced Nursing I) .pptx
Wounds And wound dressing (Advanced Nursing I) .pptxWounds And wound dressing (Advanced Nursing I) .pptx
Wounds And wound dressing (Advanced Nursing I) .pptx
bilwiaabdulrahim99
 
scar.ppt
scar.pptscar.ppt
artificial skin technique
artificial skin  techniqueartificial skin  technique
artificial skin technique
siddharth singh
 
graft &flap physical therapy interventions.pptx
graft &flap physical therapy interventions.pptxgraft &flap physical therapy interventions.pptx
graft &flap physical therapy interventions.pptx
MostafaAhmed891986
 
wound healing.pptx
wound healing.pptxwound healing.pptx
wound healing.pptx
Ankitmandal29
 
Wounds and Wound healing..pptx
Wounds and Wound healing..pptxWounds and Wound healing..pptx
Wounds and Wound healing..pptx
HarunMohamed7
 
Presentation1
Presentation1Presentation1
Presentation1
chiragvets
 
Skin grafting full
Skin grafting fullSkin grafting full
Skin grafting full
Sara Jalil
 
Nexcare tm wound care module 2020
Nexcare tm wound care module 2020Nexcare tm wound care module 2020
Nexcare tm wound care module 2020
Clinicians
 
Wound healing
Wound healingWound healing
Wound healing
Sakkar Chowdhury
 
woundhealing-190112152216 (1).pdf
woundhealing-190112152216 (1).pdfwoundhealing-190112152216 (1).pdf
woundhealing-190112152216 (1).pdf
DeviSneha1
 
4.Wound Healing.pptx
4.Wound Healing.pptx4.Wound Healing.pptx
4.Wound Healing.pptx
PradipChauhan27
 
Tissue repair.pptx
Tissue repair.pptxTissue repair.pptx
Tissue repair.pptx
SaketKumar946153
 
Chapter 6 woundhealing
Chapter 6 woundhealingChapter 6 woundhealing
Chapter 6 woundhealing
FebrinaSugianto
 

Similar to Wound healing (20)

Karya ilmiah ummu fix
Karya ilmiah ummu fixKarya ilmiah ummu fix
Karya ilmiah ummu fix
 
Wound healing and care presentation
Wound healing and care presentationWound healing and care presentation
Wound healing and care presentation
 
WOUND HEALING AND CARE. THIS IS WOUND HEALING NOTES.tx
WOUND HEALING AND CARE. THIS IS WOUND HEALING NOTES.txWOUND HEALING AND CARE. THIS IS WOUND HEALING NOTES.tx
WOUND HEALING AND CARE. THIS IS WOUND HEALING NOTES.tx
 
Tissue repair
Tissue repairTissue repair
Tissue repair
 
8031735.ppt
8031735.ppt8031735.ppt
8031735.ppt
 
Biomaterial science presentation
Biomaterial science presentationBiomaterial science presentation
Biomaterial science presentation
 
Wounds And wound dressing (Advanced Nursing I) .pptx
Wounds And wound dressing (Advanced Nursing I) .pptxWounds And wound dressing (Advanced Nursing I) .pptx
Wounds And wound dressing (Advanced Nursing I) .pptx
 
scar.ppt
scar.pptscar.ppt
scar.ppt
 
artificial skin technique
artificial skin  techniqueartificial skin  technique
artificial skin technique
 
graft &flap physical therapy interventions.pptx
graft &flap physical therapy interventions.pptxgraft &flap physical therapy interventions.pptx
graft &flap physical therapy interventions.pptx
 
wound healing.pptx
wound healing.pptxwound healing.pptx
wound healing.pptx
 
Wounds and Wound healing..pptx
Wounds and Wound healing..pptxWounds and Wound healing..pptx
Wounds and Wound healing..pptx
 
Presentation1
Presentation1Presentation1
Presentation1
 
Skin grafting full
Skin grafting fullSkin grafting full
Skin grafting full
 
Nexcare tm wound care module 2020
Nexcare tm wound care module 2020Nexcare tm wound care module 2020
Nexcare tm wound care module 2020
 
Wound healing
Wound healingWound healing
Wound healing
 
woundhealing-190112152216 (1).pdf
woundhealing-190112152216 (1).pdfwoundhealing-190112152216 (1).pdf
woundhealing-190112152216 (1).pdf
 
4.Wound Healing.pptx
4.Wound Healing.pptx4.Wound Healing.pptx
4.Wound Healing.pptx
 
Tissue repair.pptx
Tissue repair.pptxTissue repair.pptx
Tissue repair.pptx
 
Chapter 6 woundhealing
Chapter 6 woundhealingChapter 6 woundhealing
Chapter 6 woundhealing
 

Recently uploaded

Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...
Oleg Kshivets
 
Top-Vitamin-Supplement-Brands-in-India List
Top-Vitamin-Supplement-Brands-in-India ListTop-Vitamin-Supplement-Brands-in-India List
Top-Vitamin-Supplement-Brands-in-India List
SwisschemDerma
 
TEST BANK For Basic and Clinical Pharmacology, 14th Edition by Bertram G. Kat...
TEST BANK For Basic and Clinical Pharmacology, 14th Edition by Bertram G. Kat...TEST BANK For Basic and Clinical Pharmacology, 14th Edition by Bertram G. Kat...
TEST BANK For Basic and Clinical Pharmacology, 14th Edition by Bertram G. Kat...
rightmanforbloodline
 
Clinic ^%[+27633867063*Abortion Pills For Sale In Tembisa Central
Clinic ^%[+27633867063*Abortion Pills For Sale In Tembisa CentralClinic ^%[+27633867063*Abortion Pills For Sale In Tembisa Central
Clinic ^%[+27633867063*Abortion Pills For Sale In Tembisa Central
19various
 
Aortic Association CBL Pilot April 19 – 20 Bern
Aortic Association CBL Pilot April 19 – 20 BernAortic Association CBL Pilot April 19 – 20 Bern
Aortic Association CBL Pilot April 19 – 20 Bern
suvadeepdas911
 
Top Effective Soaps for Fungal Skin Infections in India
Top Effective Soaps for Fungal Skin Infections in IndiaTop Effective Soaps for Fungal Skin Infections in India
Top Effective Soaps for Fungal Skin Infections in India
SwisschemDerma
 
Histololgy of Female Reproductive System.pptx
Histololgy of Female Reproductive System.pptxHistololgy of Female Reproductive System.pptx
Histololgy of Female Reproductive System.pptx
AyeshaZaid1
 
Journal Article Review on Rasamanikya
Journal Article Review on RasamanikyaJournal Article Review on Rasamanikya
Journal Article Review on Rasamanikya
Dr. Jyothirmai Paindla
 
Muscles of Mastication by Dr. Rabia Inam Gandapore.pptx
Muscles of Mastication by Dr. Rabia Inam Gandapore.pptxMuscles of Mastication by Dr. Rabia Inam Gandapore.pptx
Muscles of Mastication by Dr. Rabia Inam Gandapore.pptx
Dr. Rabia Inam Gandapore
 
Top 10 Best Ayurvedic Kidney Stone Syrups in India
Top 10 Best Ayurvedic Kidney Stone Syrups in IndiaTop 10 Best Ayurvedic Kidney Stone Syrups in India
Top 10 Best Ayurvedic Kidney Stone Syrups in India
Swastik Ayurveda
 
Efficacy of Avartana Sneha in Ayurveda
Efficacy of Avartana Sneha in AyurvedaEfficacy of Avartana Sneha in Ayurveda
Efficacy of Avartana Sneha in Ayurveda
Dr. Jyothirmai Paindla
 
CHEMOTHERAPY_RDP_CHAPTER 6_Anti Malarial Drugs.pdf
CHEMOTHERAPY_RDP_CHAPTER 6_Anti Malarial Drugs.pdfCHEMOTHERAPY_RDP_CHAPTER 6_Anti Malarial Drugs.pdf
CHEMOTHERAPY_RDP_CHAPTER 6_Anti Malarial Drugs.pdf
rishi2789
 
Integrating Ayurveda into Parkinson’s Management: A Holistic Approach
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachIntegrating Ayurveda into Parkinson’s Management: A Holistic Approach
Integrating Ayurveda into Parkinson’s Management: A Holistic Approach
Ayurveda ForAll
 
Tests for analysis of different pharmaceutical.pptx
Tests for analysis of different pharmaceutical.pptxTests for analysis of different pharmaceutical.pptx
Tests for analysis of different pharmaceutical.pptx
taiba qazi
 
Ear and its clinical correlations By Dr. Rabia Inam Gandapore.pptx
Ear and its clinical correlations By Dr. Rabia Inam Gandapore.pptxEar and its clinical correlations By Dr. Rabia Inam Gandapore.pptx
Ear and its clinical correlations By Dr. Rabia Inam Gandapore.pptx
Dr. Rabia Inam Gandapore
 
A Classical Text Review on Basavarajeeyam
A Classical Text Review on BasavarajeeyamA Classical Text Review on Basavarajeeyam
A Classical Text Review on Basavarajeeyam
Dr. Jyothirmai Paindla
 
K CỔ TỬ CUNG.pdf tự ghi chép, chữ hơi xấu
K CỔ TỬ CUNG.pdf tự ghi chép, chữ hơi xấuK CỔ TỬ CUNG.pdf tự ghi chép, chữ hơi xấu
K CỔ TỬ CUNG.pdf tự ghi chép, chữ hơi xấu
HongBiThi1
 
Role of Mukta Pishti in the Management of Hyperthyroidism
Role of Mukta Pishti in the Management of HyperthyroidismRole of Mukta Pishti in the Management of Hyperthyroidism
Role of Mukta Pishti in the Management of Hyperthyroidism
Dr. Jyothirmai Paindla
 
Hemodialysis: Chapter 4, Dialysate Circuit - Dr.Gawad
Hemodialysis: Chapter 4, Dialysate Circuit - Dr.GawadHemodialysis: Chapter 4, Dialysate Circuit - Dr.Gawad
Hemodialysis: Chapter 4, Dialysate Circuit - Dr.Gawad
NephroTube - Dr.Gawad
 
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptx
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptx8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptx
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptx
Holistified Wellness
 

Recently uploaded (20)

Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...
 
Top-Vitamin-Supplement-Brands-in-India List
Top-Vitamin-Supplement-Brands-in-India ListTop-Vitamin-Supplement-Brands-in-India List
Top-Vitamin-Supplement-Brands-in-India List
 
TEST BANK For Basic and Clinical Pharmacology, 14th Edition by Bertram G. Kat...
TEST BANK For Basic and Clinical Pharmacology, 14th Edition by Bertram G. Kat...TEST BANK For Basic and Clinical Pharmacology, 14th Edition by Bertram G. Kat...
TEST BANK For Basic and Clinical Pharmacology, 14th Edition by Bertram G. Kat...
 
Clinic ^%[+27633867063*Abortion Pills For Sale In Tembisa Central
Clinic ^%[+27633867063*Abortion Pills For Sale In Tembisa CentralClinic ^%[+27633867063*Abortion Pills For Sale In Tembisa Central
Clinic ^%[+27633867063*Abortion Pills For Sale In Tembisa Central
 
Aortic Association CBL Pilot April 19 – 20 Bern
Aortic Association CBL Pilot April 19 – 20 BernAortic Association CBL Pilot April 19 – 20 Bern
Aortic Association CBL Pilot April 19 – 20 Bern
 
Top Effective Soaps for Fungal Skin Infections in India
Top Effective Soaps for Fungal Skin Infections in IndiaTop Effective Soaps for Fungal Skin Infections in India
Top Effective Soaps for Fungal Skin Infections in India
 
Histololgy of Female Reproductive System.pptx
Histololgy of Female Reproductive System.pptxHistololgy of Female Reproductive System.pptx
Histololgy of Female Reproductive System.pptx
 
Journal Article Review on Rasamanikya
Journal Article Review on RasamanikyaJournal Article Review on Rasamanikya
Journal Article Review on Rasamanikya
 
Muscles of Mastication by Dr. Rabia Inam Gandapore.pptx
Muscles of Mastication by Dr. Rabia Inam Gandapore.pptxMuscles of Mastication by Dr. Rabia Inam Gandapore.pptx
Muscles of Mastication by Dr. Rabia Inam Gandapore.pptx
 
Top 10 Best Ayurvedic Kidney Stone Syrups in India
Top 10 Best Ayurvedic Kidney Stone Syrups in IndiaTop 10 Best Ayurvedic Kidney Stone Syrups in India
Top 10 Best Ayurvedic Kidney Stone Syrups in India
 
Efficacy of Avartana Sneha in Ayurveda
Efficacy of Avartana Sneha in AyurvedaEfficacy of Avartana Sneha in Ayurveda
Efficacy of Avartana Sneha in Ayurveda
 
CHEMOTHERAPY_RDP_CHAPTER 6_Anti Malarial Drugs.pdf
CHEMOTHERAPY_RDP_CHAPTER 6_Anti Malarial Drugs.pdfCHEMOTHERAPY_RDP_CHAPTER 6_Anti Malarial Drugs.pdf
CHEMOTHERAPY_RDP_CHAPTER 6_Anti Malarial Drugs.pdf
 
Integrating Ayurveda into Parkinson’s Management: A Holistic Approach
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachIntegrating Ayurveda into Parkinson’s Management: A Holistic Approach
Integrating Ayurveda into Parkinson’s Management: A Holistic Approach
 
Tests for analysis of different pharmaceutical.pptx
Tests for analysis of different pharmaceutical.pptxTests for analysis of different pharmaceutical.pptx
Tests for analysis of different pharmaceutical.pptx
 
Ear and its clinical correlations By Dr. Rabia Inam Gandapore.pptx
Ear and its clinical correlations By Dr. Rabia Inam Gandapore.pptxEar and its clinical correlations By Dr. Rabia Inam Gandapore.pptx
Ear and its clinical correlations By Dr. Rabia Inam Gandapore.pptx
 
A Classical Text Review on Basavarajeeyam
A Classical Text Review on BasavarajeeyamA Classical Text Review on Basavarajeeyam
A Classical Text Review on Basavarajeeyam
 
K CỔ TỬ CUNG.pdf tự ghi chép, chữ hơi xấu
K CỔ TỬ CUNG.pdf tự ghi chép, chữ hơi xấuK CỔ TỬ CUNG.pdf tự ghi chép, chữ hơi xấu
K CỔ TỬ CUNG.pdf tự ghi chép, chữ hơi xấu
 
Role of Mukta Pishti in the Management of Hyperthyroidism
Role of Mukta Pishti in the Management of HyperthyroidismRole of Mukta Pishti in the Management of Hyperthyroidism
Role of Mukta Pishti in the Management of Hyperthyroidism
 
Hemodialysis: Chapter 4, Dialysate Circuit - Dr.Gawad
Hemodialysis: Chapter 4, Dialysate Circuit - Dr.GawadHemodialysis: Chapter 4, Dialysate Circuit - Dr.Gawad
Hemodialysis: Chapter 4, Dialysate Circuit - Dr.Gawad
 
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptx
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptx8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptx
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptx
 

Wound healing

  • 1. Dr Ardra Thorat MS Shaltatantra
  • 2. Wound healing  Replacement of destroyed tissue by living tissue 1. Regeneration- replacement of lost tissue by similar type of tissue 2. Repair- replacement of lost tissue by granulation tissue, followed by fibrosis & scar formation, 8/1/2020 Dr Ardra Thorat
  • 3. Definition of wound healing :-  Wound healing is process by which skin or other body tissue repairs itself after trauma  In undamaged skin, the epidermis and dermis form a protective barrier against the external environment. 8/1/2020 Dr Ardra Thorat
  • 4. General principle of wound healing 8/1/2020 Dr Ardra Thorat
  • 5. Healing by 1st intention  When wound sutured primarily  Minimal scar 8/1/2020 Dr Ardra Thorat
  • 6. Healing by 2nd intention 1. When there is irreparable skin loss 2. when the wound becomes infected and breaks open 3. primary suturing is not possible, so the wound heals with more scar tissue and takes longer time to heal. 8/1/2020 Dr Ardra Thorat
  • 7. Wound healing processes  Rapid hemostasis This refers to the mechanism that stops the actual bleeding. Most of the time, body will accomplish this through a process called vasoconstriction.  Following processes take place a) Inflammation b) Wound contraction c) Epithelization d) Granulation tissue formation e) Scar remodeling 8/1/2020 Dr Ardra Thorat
  • 8. 1. Inflammation trauma Platelet become adherent Vasoconstriction Vasodilatation( Histamin) Prostaglandin PEG1, PEG2 Local inflammatory vascular response 8/1/2020 Dr Ardra Thorat
  • 9. 2. Wound contraction  Open wounds, after 3-5 days  Amount of contraction depends upon amount of skin available  Causes – removal of fluid, contraction of collagen, contraction of granulation tissue  Inhibiting factors- a) Corticosteroid b) burns c) immediate skin grafting d) X ray irradiation e) cytotoxic agents 8/1/2020 Dr Ardra Thorat
  • 10. 3 Epithelization  Epidermis grows  It forms edges of wound by process of cell migration and cell multiplication.  This is mainly brought about marginal basal cells proliferation  Thus within 48 hours entire wound is re- epithelialised.  When there is wound with skin loss, skin appendages, also help in epithelisation , surface cells get keratinised. 8/1/2020 Dr Ardra Thorat
  • 11. 4.Grannulation tissue formation 1) Mainly formed by proliferation & migration of surrounding connective tissue element. 2) Stage of vascularization 3) Stage of devascularization- Fibroplasia along with capillary budding gives rise to granulation tissue. 4) Between third and fifth day, polymorphoneuclear leukocytes diminish in number but monocytes increases. They are specialised scavengers. 5) By fifth or sixth day, fibroblasts appers, proliferate and eventually gives rise to protocollagen which is converted into collagen in presence of enzyme, protocollagen hydroxylase, oxygen, ferrous ions and as corbic acid are neccessory for this step. 8/1/2020 Dr Ardra Thorat
  • 12. 5. Scar remodeling Following changes take place during scar formation – 1) Fibroplasia and laying of collagen is incresed. 2) Vascularity becomes less. 3) Epithelialisation continues. 4) Remodeling of collagen take place with cicatrisation resulting in scar. 8/1/2020 Dr Ardra Thorat