The FDA is amending its pregnancy labeling rules to remove the A, B, C, D, X pregnancy categories and replace them with a new structure. The new rule reorganizes existing subsections into "Pregnancy" and "Lactation" and adds a new section called "Females and Males of Reproductive Potential." This aims to provide more individualized risk assessments and access to safety information for prescribing drugs to pregnant and lactating women. However, transitioning to the new categories may be difficult for commonly used drugs approved before 2001 due to limited information.