6. Personality
• I am an honest and reliable person, and I do
my best to accomplish the project I undertake.
• I am energized by challenging a problem and a
quick learner. I am willing to help others and
take advice.
• I am people person that I am good at insight
into what people absolutely need.
6
7. Experimental Techniques
• HPLC (high performance liquid chromatography)
• AFM（atomic force microscopy）
• ABI-433 and PS3peptide synthesizer
• Flow Cytometer
Material simulated softwares:
• Accelrys Materials Studio
• Cascade polymer properties
Bioinformatic softwares:
• Accelrys Discovery Studio
• MOE(molecular operation experiment)
• AutoDock Vina
7
13. Education and working Experience
13
2007~2011 B.S., Department of Life Science, Tzu Chi
University
Atomic Force Microscopic studies on antimicrobial
action of C10C4C10 on Escherichia coli.
2011~2012年 M.S., Department of Biochemistry, School
of Medicine, Tzu Chi University
Investigate topic [in silico selections for design of
anti-inflammatory
therapeitic molecules].
2012 Sep.~2013 Sep. Associate Researcher in ITRI, Taiwan, R.O.C ; Material and
Chemical Research Laboratories, Dept. of multi-scale simulation.
•Development of low dielectric material－ cross linked PPO polymer
resin for high frequency substrate application.
Oct. 2013- Dec. 2014 RA in Shiow-Ju Lee’s lab at Institute of Biotechnology and
Pharmaceutical Research, National Health Research Institutes, Taiwan.
•Development of novel anticancer drug.
•Docking for design and modify inhibitors for the target protein.
15. 15
The picture obviously shown that the outer membrane (OM) of E coli destroyed by the
Sushi1 with the concentration changed.
The middle of the bacterial body were already hollow (refer to the height diagram ) at
the 1μM indicated by arrow; and the hollow displayed clearly to see at 5μM.
The E coli treated
by Sushi 1 for an
hour observed
from Atomic
force Microscope
in different
concentrations.
(A)Empty S1
(B) 0.25μM S1
(C) 0.5μM S1
(D) 1μM S1
(E)5μM S1
(F) 10μM S1
The anti-bacterial mechanism analyzed by Bioimage Data
16. In silico selections for design of
anti-inflammatory therapeutic molecules
16
Wen Yi Chen 1 , Meng Jiun Lai2, Hao Jen Hsu3 and Je Wen Liou2,4
1 Master program in Microbiology, Immunology and Biochemistry, 2Institute
of Medical Biotechnology, 3College of Life Science, 4 Department of
Biochemistry, Tzu Chi University, Hualien, Taiwan
Correspondence e-mail address: jwliou@mail.tcu.edu.tw
22. 1. Development of novel anticancer drugs: designed and
modified compound inhibitors for the targeting
Glutaminase.
2. Modification of inhibitors for improving their
selectivity against KGA and GAB.
The aims of the project
Glutaminase
KGA
GAB
22
23. O. Trott, A. J. Olson, AutoDock Vina: improving the speed and accuracy of docking with a new
scoring function, efficient optimization and multithreading, Journal of Computational Chemistry
31 (2010) 455-461
23
27. Thank you very much for your
attention
2727
https://www.researchgate.net/profile/Wen_Yi_Chen
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