The book "Spreading Poison, a book about racism and prejudice" by John Langone documents examples of racism and prejudice against African Americans, Asian Americans, Hispanics, Irish, Italians, Jews, Native Americans, women, and homosexuals in America and elsewhere. It describes how these groups faced discrimination in jobs, rights, and treatment due to physical differences, religious beliefs, disease associations, and gender or sexuality. The book aims to educate readers about past impacts of racism and prejudice in order to reduce stereotypical thinking and promote a more just world.