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Why steroids can cross the cell membrane?
Why steroids can cross the cell membrane?
Solution
Steroids are organic molecules, found in our body in the form of cholesterol, steroid hormones,
vitamin D and also in the form of medicinal drugs. The steroids are non-polar and are similar to
lipids. These molecules play a very important role in cell membrane stability and also in signal
transduction in the body.
To carry out the different functions in the body, the steroid molecules must enter the cell and
bind to its target receptor and initiate the cascade of cellular response. The cell membrane is
made of phospholipids with polar head groups of lipids on the exterior of cell surface and
towards the cytosol, and the non-polar chains in the middle.
This architecture of the cell membrane allows steroids to cross the cell membrane being
lipophilic. The entry of steroids in the cell might take place with the help of receptors or carrier
proteins.

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