WHO estimates that 235 million people currently suffer from asthma. Asthma is the most common noncommunicable disease among children and occurs in all countries regardless of development level, though most asthma-related deaths occur in low- and lower-middle income countries. Asthma is under-diagnosed and under-treated, creating a substantial burden for individuals and families by often restricting activities for life. The causes of asthma are not fully understood but include a combination of genetic and environmental factors such as indoor and outdoor allergens, air pollution, tobacco smoke, and certain medications. While asthma has no cure, appropriate management can control the disease and enable a good quality of life through short-term medications to relieve symptoms and long-term medications
Since 1972, Restoration Specialists has helped homeowners to recover from all forms of property damage. Serving the areas around Lake City, Lecanto, Leesburg, Ocala, Gainesville, and Brooksville, Restoration Specialists draws on a detailed working knowledge of mold and the importance of removing it.
There is an important distinction among the 3 terms, prevention, control, and eradication. Prevention is of most immediate concern to the individual veterinarian in private practice. Prevention can be defined as inhibiting the introduction of disease into an area, herd, or individual.
Control is a more appropriate term when disease is already present. Control efforts consist of the steps taken to reduce the problem to a tolerable level.
Eradication is the final step in disease control efforts; it consists of complete elimination of the disease-producing agent from a defined geographic region.
- http://www.onemedicine.tuskegee.edu/
Since 1972, Restoration Specialists has helped homeowners to recover from all forms of property damage. Serving the areas around Lake City, Lecanto, Leesburg, Ocala, Gainesville, and Brooksville, Restoration Specialists draws on a detailed working knowledge of mold and the importance of removing it.
There is an important distinction among the 3 terms, prevention, control, and eradication. Prevention is of most immediate concern to the individual veterinarian in private practice. Prevention can be defined as inhibiting the introduction of disease into an area, herd, or individual.
Control is a more appropriate term when disease is already present. Control efforts consist of the steps taken to reduce the problem to a tolerable level.
Eradication is the final step in disease control efforts; it consists of complete elimination of the disease-producing agent from a defined geographic region.
- http://www.onemedicine.tuskegee.edu/
In this presentation, I look at The Hygiene Hypothesis, or the idea that preventing children from coming into contact with germs will make them more prone to certain illnesses.
this ppt is made by shrikrishna kesharwani , student of urban planning,4th year, Manit , Bhopal,
in this ppt, I have discussed how to do pandemic or epidemic management in detail.,
Food Borne Diseases are also called foodborne illness. any illness brought on by eating or drinking things that have been contaminated with certain infectious or noninfectious substances. Agents like bacteria, viruses, or parasites are to blame for the majority of cases of foodborne disease. Other harmful substances include mycotoxins (fungal toxins), marine biotoxins, and the toxins found in poisonous mushrooms. They also include metals like lead, mercury, and cadmium that can contaminate food through soil, water, or air pollution, organic pollutants like dioxin and polychlorinated biphenyls (PCBs), which are byproducts of some industrial processes, and prions (abnormal protein forms). Foodborne illness agents can result in a wide range of ailments, including gastroenteritis, reproductive or developmental problems, and neurological illnesses like bovine spongiform encephalopathy (mad cow disease). Since many cases of foodborne illness go unreported, it is challenging to determine how common they are, but the burden of illness is believed to be significant. For instance, tens of millions of individuals get diarrheal disorders each year, a frequent indicator of a foodborne illness. Outbreaks of foodborne infections frequently happen, and they have the potential to harm a lot of people. For instance, a hepatitis A epidemic in 1988 in China that was brought on by eating infected clams impacted more than 300,000 people, while a salmonellosis outbreak in 1994 in the United States that was brought on by eating contaminated ice cream affected 224,000 individuals. Food-borne infections are often fatal. Consuming tainted foods or drinks results in foodborne disease. Foods can be contaminated by a wide range of pathogens or disease-causing bacteria, leading to a wide range of foodborne diseases. Eating food tainted with germs, viruses, parasites, or chemicals like heavy metals can result in over 200 ailments. Through pressure on healthcare systems, lost productivity, and detrimental effects on trade and tourism, this growing public health issue has a significant socioeconomic impact. The worldwide burden of disease and mortality is considerably increased by these illnesses.
Major DiseasesCHAPTER 10Chapter 10Maj.docxcarliotwaycave
Major Diseases
CHAPTER 10
*
Chapter 10
Major Diseases
Learning Outcomes:Identify agents and vectors involved in the spread of infectious diseasesDescribe the process of infection, and the role of the body’s immune systemDiscuss prevention and treatments for colds and influenzaName and describe common infectious diseasesEvaluate your personal infectious disease risk factors, and strategies to decrease risk
Infectious Diseases
Infection is triggered by a pathogen (disease-causing organism) that is transmitted to the host (person or population) by a vector (biological or physical vehicle)
Types of microbes that can cause infection are:
Viruses Fungi
Bacteria Protozoa
Helminths (Parasitic Worms)
Agents of Infection: VirusesThe most common viruses are as follows:Rhinoviruses and Adenoviruses: which get into the mucous membranes and cause upper respiratory tract infections and coldsInfluenza viruses: can change their outer protein coats so dramatically that individuals resistant to one strain cannot fight off a new oneHerpes viruses: take up permanent residence in the cells and periodically flare upPapillomaviruses: may be responsible for a rise in the incidence of cervical cancer among younger womenHepatitis viruses: cause several forms of liver infection, ranging from mild to life threateningSlow viruses: give no early indication of their presence but can produce fatal illnesses within a few years
Agents of Infection: Viruses cont’dRetroviruses: named for their backward (retro) sequence of genetic replication compared to other viruses. One retrovirus, human immunodeficiency virus (HIV), causes acquired immune deficiency syndrome (AIDS)
Filoviruses: resemble threads and extremely lethal
Coronavirus 2019-COVID-19CDC is responding to a pandemic of respiratory disease spreading from person-to-person caused by a novel (new) coronavirus. The disease has been named “coronavirus disease 2019” (abbreviated “COVID-19”)
COVID-19 is caused by a coronavirus. Coronaviruses are a large family of viruses that are common in people and many different species of animals, including camels, cattle, cats, and bats. Reported illnesses have ranged from very mild (including some with no reported symptoms) to severe, including illness resulting in death. Older people and people of all ages with severe chronic medical conditions — like heart disease, lung disease and diabetes, for example — seem to be at higher risk of developing serious COVID-19 illness
Agents of InfectionBacteria: are the most plentiful microorganisms as well as the most pathogenic. Bacteria harm the body by releasing either enzymes that digest body cells or toxins that produce the specific effects of diseases such as diphtheria or toxic shock syndromeFungi: consist of threadlike fibers and reproductive spores. Fungi lack chlorophyll and must obtain their food from organic material, which may include human tissueProtozoa: single-celled, microscopic animals release enzymes.
Major DiseasesCHAPTER 10Chapter 10Maj.docxendawalling
Major Diseases
CHAPTER 10
*
Chapter 10
Major Diseases
Learning Outcomes:Identify agents and vectors involved in the spread of infectious diseasesDescribe the process of infection, and the role of the body’s immune systemDiscuss prevention and treatments for colds and influenzaName and describe common infectious diseasesEvaluate your personal infectious disease risk factors, and strategies to decrease risk
Infectious Diseases
Infection is triggered by a pathogen (disease-causing organism) that is transmitted to the host (person or population) by a vector (biological or physical vehicle)
Types of microbes that can cause infection are:
Viruses Fungi
Bacteria Protozoa
Helminths (Parasitic Worms)
Agents of Infection: VirusesThe most common viruses are as follows:Rhinoviruses and Adenoviruses: which get into the mucous membranes and cause upper respiratory tract infections and coldsInfluenza viruses: can change their outer protein coats so dramatically that individuals resistant to one strain cannot fight off a new oneHerpes viruses: take up permanent residence in the cells and periodically flare upPapillomaviruses: may be responsible for a rise in the incidence of cervical cancer among younger womenHepatitis viruses: cause several forms of liver infection, ranging from mild to life threateningSlow viruses: give no early indication of their presence but can produce fatal illnesses within a few years
Agents of Infection: Viruses cont’dRetroviruses: named for their backward (retro) sequence of genetic replication compared to other viruses. One retrovirus, human immunodeficiency virus (HIV), causes acquired immune deficiency syndrome (AIDS)
Filoviruses: resemble threads and extremely lethal
Coronavirus 2019-COVID-19CDC is responding to a pandemic of respiratory disease spreading from person-to-person caused by a novel (new) coronavirus. The disease has been named “coronavirus disease 2019” (abbreviated “COVID-19”)
COVID-19 is caused by a coronavirus. Coronaviruses are a large family of viruses that are common in people and many different species of animals, including camels, cattle, cats, and bats. Reported illnesses have ranged from very mild (including some with no reported symptoms) to severe, including illness resulting in death. Older people and people of all ages with severe chronic medical conditions — like heart disease, lung disease and diabetes, for example — seem to be at higher risk of developing serious COVID-19 illness
Agents of InfectionBacteria: are the most plentiful microorganisms as well as the most pathogenic. Bacteria harm the body by releasing either enzymes that digest body cells or toxins that produce the specific effects of diseases such as diphtheria or toxic shock syndromeFungi: consist of threadlike fibers and reproductive spores. Fungi lack chlorophyll and must obtain their food from organic material, which may include human tissueProtozoa: single-celled, microscopic animals release enzymes.
In this presentation, I look at The Hygiene Hypothesis, or the idea that preventing children from coming into contact with germs will make them more prone to certain illnesses.
this ppt is made by shrikrishna kesharwani , student of urban planning,4th year, Manit , Bhopal,
in this ppt, I have discussed how to do pandemic or epidemic management in detail.,
Food Borne Diseases are also called foodborne illness. any illness brought on by eating or drinking things that have been contaminated with certain infectious or noninfectious substances. Agents like bacteria, viruses, or parasites are to blame for the majority of cases of foodborne disease. Other harmful substances include mycotoxins (fungal toxins), marine biotoxins, and the toxins found in poisonous mushrooms. They also include metals like lead, mercury, and cadmium that can contaminate food through soil, water, or air pollution, organic pollutants like dioxin and polychlorinated biphenyls (PCBs), which are byproducts of some industrial processes, and prions (abnormal protein forms). Foodborne illness agents can result in a wide range of ailments, including gastroenteritis, reproductive or developmental problems, and neurological illnesses like bovine spongiform encephalopathy (mad cow disease). Since many cases of foodborne illness go unreported, it is challenging to determine how common they are, but the burden of illness is believed to be significant. For instance, tens of millions of individuals get diarrheal disorders each year, a frequent indicator of a foodborne illness. Outbreaks of foodborne infections frequently happen, and they have the potential to harm a lot of people. For instance, a hepatitis A epidemic in 1988 in China that was brought on by eating infected clams impacted more than 300,000 people, while a salmonellosis outbreak in 1994 in the United States that was brought on by eating contaminated ice cream affected 224,000 individuals. Food-borne infections are often fatal. Consuming tainted foods or drinks results in foodborne disease. Foods can be contaminated by a wide range of pathogens or disease-causing bacteria, leading to a wide range of foodborne diseases. Eating food tainted with germs, viruses, parasites, or chemicals like heavy metals can result in over 200 ailments. Through pressure on healthcare systems, lost productivity, and detrimental effects on trade and tourism, this growing public health issue has a significant socioeconomic impact. The worldwide burden of disease and mortality is considerably increased by these illnesses.
Major DiseasesCHAPTER 10Chapter 10Maj.docxcarliotwaycave
Major Diseases
CHAPTER 10
*
Chapter 10
Major Diseases
Learning Outcomes:Identify agents and vectors involved in the spread of infectious diseasesDescribe the process of infection, and the role of the body’s immune systemDiscuss prevention and treatments for colds and influenzaName and describe common infectious diseasesEvaluate your personal infectious disease risk factors, and strategies to decrease risk
Infectious Diseases
Infection is triggered by a pathogen (disease-causing organism) that is transmitted to the host (person or population) by a vector (biological or physical vehicle)
Types of microbes that can cause infection are:
Viruses Fungi
Bacteria Protozoa
Helminths (Parasitic Worms)
Agents of Infection: VirusesThe most common viruses are as follows:Rhinoviruses and Adenoviruses: which get into the mucous membranes and cause upper respiratory tract infections and coldsInfluenza viruses: can change their outer protein coats so dramatically that individuals resistant to one strain cannot fight off a new oneHerpes viruses: take up permanent residence in the cells and periodically flare upPapillomaviruses: may be responsible for a rise in the incidence of cervical cancer among younger womenHepatitis viruses: cause several forms of liver infection, ranging from mild to life threateningSlow viruses: give no early indication of their presence but can produce fatal illnesses within a few years
Agents of Infection: Viruses cont’dRetroviruses: named for their backward (retro) sequence of genetic replication compared to other viruses. One retrovirus, human immunodeficiency virus (HIV), causes acquired immune deficiency syndrome (AIDS)
Filoviruses: resemble threads and extremely lethal
Coronavirus 2019-COVID-19CDC is responding to a pandemic of respiratory disease spreading from person-to-person caused by a novel (new) coronavirus. The disease has been named “coronavirus disease 2019” (abbreviated “COVID-19”)
COVID-19 is caused by a coronavirus. Coronaviruses are a large family of viruses that are common in people and many different species of animals, including camels, cattle, cats, and bats. Reported illnesses have ranged from very mild (including some with no reported symptoms) to severe, including illness resulting in death. Older people and people of all ages with severe chronic medical conditions — like heart disease, lung disease and diabetes, for example — seem to be at higher risk of developing serious COVID-19 illness
Agents of InfectionBacteria: are the most plentiful microorganisms as well as the most pathogenic. Bacteria harm the body by releasing either enzymes that digest body cells or toxins that produce the specific effects of diseases such as diphtheria or toxic shock syndromeFungi: consist of threadlike fibers and reproductive spores. Fungi lack chlorophyll and must obtain their food from organic material, which may include human tissueProtozoa: single-celled, microscopic animals release enzymes.
Major DiseasesCHAPTER 10Chapter 10Maj.docxendawalling
Major Diseases
CHAPTER 10
*
Chapter 10
Major Diseases
Learning Outcomes:Identify agents and vectors involved in the spread of infectious diseasesDescribe the process of infection, and the role of the body’s immune systemDiscuss prevention and treatments for colds and influenzaName and describe common infectious diseasesEvaluate your personal infectious disease risk factors, and strategies to decrease risk
Infectious Diseases
Infection is triggered by a pathogen (disease-causing organism) that is transmitted to the host (person or population) by a vector (biological or physical vehicle)
Types of microbes that can cause infection are:
Viruses Fungi
Bacteria Protozoa
Helminths (Parasitic Worms)
Agents of Infection: VirusesThe most common viruses are as follows:Rhinoviruses and Adenoviruses: which get into the mucous membranes and cause upper respiratory tract infections and coldsInfluenza viruses: can change their outer protein coats so dramatically that individuals resistant to one strain cannot fight off a new oneHerpes viruses: take up permanent residence in the cells and periodically flare upPapillomaviruses: may be responsible for a rise in the incidence of cervical cancer among younger womenHepatitis viruses: cause several forms of liver infection, ranging from mild to life threateningSlow viruses: give no early indication of their presence but can produce fatal illnesses within a few years
Agents of Infection: Viruses cont’dRetroviruses: named for their backward (retro) sequence of genetic replication compared to other viruses. One retrovirus, human immunodeficiency virus (HIV), causes acquired immune deficiency syndrome (AIDS)
Filoviruses: resemble threads and extremely lethal
Coronavirus 2019-COVID-19CDC is responding to a pandemic of respiratory disease spreading from person-to-person caused by a novel (new) coronavirus. The disease has been named “coronavirus disease 2019” (abbreviated “COVID-19”)
COVID-19 is caused by a coronavirus. Coronaviruses are a large family of viruses that are common in people and many different species of animals, including camels, cattle, cats, and bats. Reported illnesses have ranged from very mild (including some with no reported symptoms) to severe, including illness resulting in death. Older people and people of all ages with severe chronic medical conditions — like heart disease, lung disease and diabetes, for example — seem to be at higher risk of developing serious COVID-19 illness
Agents of InfectionBacteria: are the most plentiful microorganisms as well as the most pathogenic. Bacteria harm the body by releasing either enzymes that digest body cells or toxins that produce the specific effects of diseases such as diphtheria or toxic shock syndromeFungi: consist of threadlike fibers and reproductive spores. Fungi lack chlorophyll and must obtain their food from organic material, which may include human tissueProtozoa: single-celled, microscopic animals release enzymes.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
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Who asthma
1. Facts aboutasthma
WHO estimatesthat235 millionpeoplecurrentlysufferfromasthma.Asthmaisthe mostcommon
noncommunicabledisease amongchildren.
Asthmaisa publichealthproblemnotjustforhigh-incomecountries;itoccursin all countries
regardlessof the level of development.Mostasthma-relateddeathsoccurinlow- andlower-
middle income countries.
Asthmaisunder-diagnosedandunder-treated.Itcreatessubstantialburdentoindividualsand
familiesandoftenrestrictsindividuals’activitiesforalifetime.
The causes
The fundamental causesof asthmaare not completelyunderstood.The strongestriskfactorsfor
developingasthmaare a combinationof geneticpredispositionwithenvironmental exposureto
inhaledsubstancesandparticles thatmayprovoke allergicreactionsor irritate the airways,such
as:
indoorallergens(forexample,housedustmitesinbedding,carpetsandstuffedfurniture,
pollutionandpetdander),outdoorallergens(suchaspollensandmoulds), tobaccosmoke
chemical irritantsinthe workplace,airpollution.
Othertriggerscan include coldair,extreme emotional arousal suchasangeror fear,and physical
exercise.Evencertainmedicationscantriggerasthma:aspirinandothernon-steroidanti-
inflammatorydrugs,andbeta-blockers(whichare usedtotreathighbloodpressure,heart
conditionsandmigraine).
Urbanizationhasbeenassociatedwithanincrease inasthma.Butthe exactnature of this
relationshipisunclear.
Reducingthe asthmaburden
Althoughasthmacannotbe cured,appropriate managementcancontrol the disease andenable
people toenjoyagoodqualityof life.Short-termmedicationsare usedtorelieve symptoms.
Medicationssuchas long-terminhaledsteroidsare neededtocontrol the progressionof severe
asthma.
People withpersistentsymptomsmusttake long-termmedicationdailytocontrol the underlying
inflammationandpreventsymptomsandexacerbations.Inadequateaccesstomedicinesisone of
the importantreasonsforthe poor control of asthma inmany settings.
Medicationisnotthe onlywayto control asthma.It isalso importanttoavoidasthmatriggers -
stimuli thatirritate andinflame the airways.Withmedical support,eachasthmapatientmust
learnwhattriggershe or she shouldavoid.