My fortnightly column, A Dose of IT that discusses the Bangalore India Bio and its outcomes
Kapil Khandelwal
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Disruptive Healthcare Business Models and UID : Kapil Khandelwal, www.kapilkh...Kapil Khandelwal (KK)
My fortnightly column, A Dose of It that discusses Disruptive Healthcare Business Models and UID and Aadhar
Kapil Khandelwal
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Keep looking for your 'Grameen' : Kapil Khandelwal, www.kapilkhandelwal.com Kapil Khandelwal (KK)
My fortnightly column, A dose of IT that discusses the issues and solutions on Social Healthcare Enterprises in India
Kapil Khandelwal
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The Genomic Opportunity: Kapil Khandelwal, www.kapilkhandelwal.com Kapil Khandelwal (KK)
My Fortnightly column, A Dose of IT that discusses the genomic opportunity for creating a Bio Health Network
Kapil Khandelwal
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You saved my life, Dr. Robot : Kapil Khandelwal, www.kapilkhandelwal.com Kapil Khandelwal (KK)
My fortnightly column, A Dose of IT that discusses on the opportunity for Robotic Surgery in India
Kapil Khandelwal
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The bridge to education: Kapil Khandelwal, www.kapilkhandelwal.com Kapil Khandelwal (KK)
My fortnightly column, A Dose of IT that is discussing issues around ICT in health education
Kapil Khandelwal
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CIS: Surgeons on steroids: Kapil Khandelwal, www.kapilkhandelwal.com Kapil Khandelwal (KK)
My fortnightly column A Dose of IT discussing on the Computer-aided image-guided surgery (CIS) technology
Kapil Khandelwal
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www.kapilkhandelwal.com
My fortnightly column, A Dose of IT that discusses on various issues to manage chronic diseases in India
Kapil Khandelwal
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Disruptive Healthcare Business Models and UID : Kapil Khandelwal, www.kapilkh...Kapil Khandelwal (KK)
My fortnightly column, A Dose of It that discusses Disruptive Healthcare Business Models and UID and Aadhar
Kapil Khandelwal
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www.kapilkhandelwal.com
Keep looking for your 'Grameen' : Kapil Khandelwal, www.kapilkhandelwal.com Kapil Khandelwal (KK)
My fortnightly column, A dose of IT that discusses the issues and solutions on Social Healthcare Enterprises in India
Kapil Khandelwal
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www.kapilkhandelwal.com
The Genomic Opportunity: Kapil Khandelwal, www.kapilkhandelwal.com Kapil Khandelwal (KK)
My Fortnightly column, A Dose of IT that discusses the genomic opportunity for creating a Bio Health Network
Kapil Khandelwal
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www.kapilkhandelwal.com
You saved my life, Dr. Robot : Kapil Khandelwal, www.kapilkhandelwal.com Kapil Khandelwal (KK)
My fortnightly column, A Dose of IT that discusses on the opportunity for Robotic Surgery in India
Kapil Khandelwal
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The bridge to education: Kapil Khandelwal, www.kapilkhandelwal.com Kapil Khandelwal (KK)
My fortnightly column, A Dose of IT that is discussing issues around ICT in health education
Kapil Khandelwal
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www.kapilkhandelwal.com
CIS: Surgeons on steroids: Kapil Khandelwal, www.kapilkhandelwal.com Kapil Khandelwal (KK)
My fortnightly column A Dose of IT discussing on the Computer-aided image-guided surgery (CIS) technology
Kapil Khandelwal
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www.kapilkhandelwal.com
My fortnightly column, A Dose of IT that discusses on various issues to manage chronic diseases in India
Kapil Khandelwal
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www.kapilkhandelwal.com
Agenda for a Healthy City: Kapil Khandelwal, www.kapilkhandelwal.com Kapil Khandelwal (KK)
My Fortnightly Column, A Dose of IT that discusses Six point agenda for health and well being of Bangalore citizens
Kapil Khandelwal
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Integrative medicine becons ICT vendors: Kapil Khandelwal, www.kapilkhandelwa...Kapil Khandelwal (KK)
My fortnightly column, A Dose of IT that discusses the digital opportunity in integrative medicine in India
Kapil Khandelwal
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Its time for BDA to wake up to reality : Kapil Khandelwal, www.kapilkhandelwa...Kapil Khandelwal (KK)
My fortnightly column, A Dose of IT discusses on Urban census and public health and well being
Kapil Khandelwal
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Integration is a modern necessity : Kapil Khandelwal, www.kapilkhandelwal.com Kapil Khandelwal (KK)
My fortnightly column, A Dose of IT that discusses the The 5 Ps Of Universal Healthcare Access
Kapil Khandelwal
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Medical study needs reform : Kapil Khandelwal, www.kapilkhandelwal.comKapil Khandelwal (KK)
My fortnightly column A Dose of IT that discusses about Medical education reform in India
Kapil Khandelwal
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Speculation about the Apple Car has kicked into high gear. The amount of news chatter, hiring trends, and investments would take someone years to read. To sift through the noise we used Quid to identify what patterns are important. Read our analysis and then make your way over to MacWorld for further coverage.
In this update of his past presentations on Mobile Eating the World -- delivered most recently at The Guardian's Changing Media Summit -- a16z’s Benedict Evans takes us through how technology is universal through mobile. How mobile is not a subset of the internet anymore. And how mobile (and accompanying trends of cloud and AI) is also driving new productivity tools.
In fact, mobile -- which encompasses everything from drones to cars -- is everything.
M S Reza Jony is presently pursuing his MBA degree at Postgraduate Institute of Management, University of Sri Jayewardenepura, Sri Lanka. He wrote this report on Google Glass during his participation in the Information Management (IM) course........
Agenda for a Healthy City: Kapil Khandelwal, www.kapilkhandelwal.com Kapil Khandelwal (KK)
My Fortnightly Column, A Dose of IT that discusses Six point agenda for health and well being of Bangalore citizens
Kapil Khandelwal
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www.kapilkhandelwal.com
Integrative medicine becons ICT vendors: Kapil Khandelwal, www.kapilkhandelwa...Kapil Khandelwal (KK)
My fortnightly column, A Dose of IT that discusses the digital opportunity in integrative medicine in India
Kapil Khandelwal
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www.kapilkhandelwal.com
Its time for BDA to wake up to reality : Kapil Khandelwal, www.kapilkhandelwa...Kapil Khandelwal (KK)
My fortnightly column, A Dose of IT discusses on Urban census and public health and well being
Kapil Khandelwal
www.kapilkhandelwal.com
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Integration is a modern necessity : Kapil Khandelwal, www.kapilkhandelwal.com Kapil Khandelwal (KK)
My fortnightly column, A Dose of IT that discusses the The 5 Ps Of Universal Healthcare Access
Kapil Khandelwal
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Medical study needs reform : Kapil Khandelwal, www.kapilkhandelwal.comKapil Khandelwal (KK)
My fortnightly column A Dose of IT that discusses about Medical education reform in India
Kapil Khandelwal
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Speculation about the Apple Car has kicked into high gear. The amount of news chatter, hiring trends, and investments would take someone years to read. To sift through the noise we used Quid to identify what patterns are important. Read our analysis and then make your way over to MacWorld for further coverage.
In this update of his past presentations on Mobile Eating the World -- delivered most recently at The Guardian's Changing Media Summit -- a16z’s Benedict Evans takes us through how technology is universal through mobile. How mobile is not a subset of the internet anymore. And how mobile (and accompanying trends of cloud and AI) is also driving new productivity tools.
In fact, mobile -- which encompasses everything from drones to cars -- is everything.
M S Reza Jony is presently pursuing his MBA degree at Postgraduate Institute of Management, University of Sri Jayewardenepura, Sri Lanka. He wrote this report on Google Glass during his participation in the Information Management (IM) course........
201207 Insurance and Technology: Next Gen Mobile Strategies Table StakesSteven Callahan
Article on how companies not joining in rolling out strategies for leveraging mobile technology may end up at a competitive disadvantage. Discussion of key factors associated with mobile strategies and why all companies should be looking at ways to leverage.
the foreword written by Brad Smith for Microsoft’s report Governing AI: A Blueprint for India. The first part of the report details five ways India could consider policies, laws, and regulations around AI. The second part focuses on Microsoft’s internal commitment to ethical AI, showing how the company is both operationalizing and building a culture of responsible AI. The final part shares case studies from India demonstrating how AI is already helping address major societal issues in the country.
India Investment: Returning hope for healthcare and life sciences in the year...Kapil Khandelwal (KK)
Kapil Khanelwal KK article in CNBC-TV18 on investing in 2023 in Healthcare and Lifesciences in India
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Toro Finserve LLP
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QuoteUnquote with KK 2023 Season 4 is all about ‘Growing Positively’
Announcement of 2023 Season 4 by QuoteUnquote with KK
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QuoteUnquote with KK (Kapil Khandelwal) Season 2 premiers as the first podcas...Kapil Khandelwal (KK)
New on afaqs! on QuoteUnquote with KK (Kapil Khandelwal) Season 2 premiers as the first podcast on Dailyhunt
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From Telegraph Road to US$50 Billion Digital Health Silk Road : Kapil Khandel...Kapil Khandelwal (KK)
My article in VC Circle on the Digital Health Investment and Opportunities in India Post Covid
Kapil Khandelwal
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Virtual Fireside Chat between Kapil Khandelwal and Dr. Mark Mobius on Reviving the Indian Economy
Kapil Khandelwal
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Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Where is the vision? : Kapil Khandelwal, www.kapilkhandelwal.com
1. c m y k c m y k
Bengaluru ●● Monday ●● 7 June 2010
Facebook is
cracking down
on rogue apps
with a new
programme.
13
Technomics
Microsoft has
retired Bing
Cashback, which
gave shoppers a
2-10% cashback.
Dell shares surged
after its CEO said
he had considered
taking the
company private.
DDCC
JAD MOUAWAD
NEW YORK
June 6: Continental Airlines
has built this check-in kiosk
and luggage drop area to
speed passengers through
George Bush Intercontinen-
tal Airport in Houston.
The airlines are still catch-
ing up with the technology
many of their customers
already carry in their pock-
ets.
That’s a problem for an
industry whose core purpose
is customer service. Still,
there is some hope for
change.
The carriers are finally rec-
ognizing that many of their
antiquated systems con-
tribute to passenger frustra-
tions. They have begun
developing hand-held
devices, a little bigger than
cellphones, that have much
quicker access to airline data
and allow gate agents to
assist passengers throughout
the terminal.
In theory, gate agents with
these devices can anticipate
the need to rebook a flight
after a missed connection,
instead of waiting for pas-
sengers to ask.
In the future, new technol-
ogy may allow airlines to
know if travelers are stuck in
traffic on their way to the
airport, thanks to GPS-
enabled smartphones, or
offer an earlier flight if a
traveler shows up with time
to spare.
Passengers traveling this
summer will see only a
glimpse of the new technol-
ogy, though it will be intro-
duced at airports over the
next year or two. For now,
the airlines remain depend-
ent on computer systems
first built a half century ago
that have been layered with
updates upon updates — “a
spaghetti of networks,” as
one analyst described it —
that do not always commu-
nicate well with one another,
or with passengers.
So some airport screens
may say a flight is on time,
while the gate information
shows it has been moved to
another terminal and the air-
line employees standing
behind their monitors say
the flight has, in fact, been
delayed two hours.
And the experiences of
passengers are more like Dr.
Joan Bengtson’s. Dr. Bengt-
son, a gynecologist who
lives in Boston, said that she
was once str anded because
of a snowstorm, and it took
two days for the airline to
rebook her. Meanwhile the
phone number she was given
remained busy for hours.
“Once a problem comes
up, their ability to deal with
the consequences is woeful-
ly inadequate,” she said
while traveling through
O’Hare International Air-
port in Chicago last week.
That is why the airlines,
including American Airlines
and Continental Airlines,
have started updating their
systems.
At its major hubs, includ-
ing Dallas-Fort Worth,
American recently started
using a technology called
Yada — for “your assistance
delivered anywhere” — that
allows its agents to promptly
rebook passengers on a dif-
ferent flight, advise on a
gate change or track down a
lost bag.
Travelers do not have to
wait in line anymore. Yada
also prints boarding passes
using small printers that
agents strap to their belts.
Because the devices also
read credit cards, Ameri-
can’s agents can check over-
size carry-on bags and
charge a bag fee directly at
the boarding gate.
It seems simple enough.
But modernizing the tech-
nology has been complicat-
ed, said Monte E. Ford,
American’s chief informa-
tion officer.
“It’s like changing the
engine of a plane in flight,”
he said. The airline industry
was once a technology pio-
neer. It introduced comput-
erized reservations in the
1960s, for instance.
And airlines run complex
systems to schedule flights,
choreograph thousands of
simultaneous operations,
and carry millions of pas-
sengers every day. But the
technology was developed
to first serve the airlines, not
the passengers. And as other
industries continued to inno-
vate over the last decade, the
airlines, struggling with
losses, cut their technology
budgets. The carriers say
they know they need to sim-
plify their computer systems
and make them easier to use.
And they benefit, too, with
reduced operating costs and
increased consumer loyalty.
—NYT
G
eneral Motors said
Friday that it was
committing $100
million to form its own ven-
ture capital firm as it seeks
new technologies that can
provide an advantage over
competitors. The sub-
sidiary, known as General
Motors Ventures, plans to
invest in start-up companies
working in a variety of
fields, including renewable
fuels, information and
entertainment systems and
advanced materials. G.M.
already has identified some
potential targets and
expects to announce its first
investments soon, a spokes-
woman, Sherrie Childers-
Arb, said. General Motors
said Friday that it was com-
mitting $100 million to
form its own venture capital
firm as it seeks new tech-
nologies that can provide
an advantage over competi-
tors. The subsidiary, known
as General Motors Ven-
tures, plans to invest in
start-up companies work-
ing in a variety of fields,
including renewable fuels,
information and entertain-
ment systems and advanced
materials. G.M. already has
identified some potential
targets and expects to
announce its first invest-
ments soon, a spokes-
woman, Sherrie Childers-
Arb, said.
— NYT
SANGEETHA CHENGAPPA
DC | BENGALURU
June 6: Imagine a roadtrip
to the majestic mountain
ranges of Uttaranchal, you
stop by to take a better look
at the sheer variety of flow-
ers, ferns, creepers and trees
that you have never seen
before. Wouldn't your expe-
rience be magnified a thou-
sand-fold, if you could iden-
tify these breathtaking flow-
ers, plants and trees by their
actual names?
Google has made it possi-
ble to whip out your
Android Phone, and click a
picture of the flower, fern or
tree and within seconds of
processing the picture you
will see an exact match of
your search, without having
to type or say a single word.
"Until now, the only option
for web search has been typ-
ing or speaking but, now one
can also search by simply
taking a picture. For eg,
click a picture of the Qutub
Minar or some other monu-
ment that you cannot identi-
fy and receive search results
including Wikipedia entries,
reviews, articles, movies
where the monument is fea-
tured within a few seconds.
With Google Goggles, you
can be your own guide while
on a visit to a historical site"
said Alok Goel, Product
Manager, Google India.
The application can also
translate from one language
to another. For instance, if
you are in Mexico and want
to order food in a local
restaurant, all you need to do
is click a picture of the menu
and see the text being
instantly translated into
English. For example, if you
want to order food from a
menu and you dont know
that particular language, all
you need to do is take a pic-
ture of the menu and it
instantly translates the text
into English.
Many a times one sees eye-
catching logos in a new city
or town which one cannot
identify - here again, just
click a picture of the logo
and discover what company,
product or event it is all
about. Google Goggles is
ideal to search for things
that are not easy to describe
in words. All you have to do
is access Google Goggles
from Market, which is the
Google store for Android
apps, download the app for
free, snap a picture and wait
for your search results. Cur-
rently, Market has around
50,000 apps contributed by
users as well as Google.
"We have also introduced
two advanced apps on
Android Phones - Google
Gesture Search and Google
Sky Map. In Gesture Search,
you can find your phone
contacts instantly by using
your finger to write the first
alphabet of the person's
name on the phone's screen
and it will throw up the
entire list of names begin-
ning with that alphabet. Oth-
erwise you would require 4-
5 clicks of buttons to get the
contact you want. Similarly,
search for apps, sms', mails
and pictures with text
attached, in your phone with
simple gestures. You can
mute a call through a pre-
decided gesture (for eg, by
shaking it up and down
twice) or redirect calls with
another gesture - the sensors
in the phone will detect the
gesture and redirect your
calls” said Goel.
Discover and browse the
night sky just by pointing
your phone to space, with
Google Sky Map. The
Android Phone's orientation
sensors, can help you learn
the name and location of
bodies in space and aid you
in exploring planets, stars,
constellations, meteorites
and more. Currently around
8-10 models of Android
Phones are available in India
from HTC, Sony Ericsson,
Motorola, Samsung, LG
etc,in the price range of Rs
11,000 to Rs 40,000. “Just
three months ago 60,000
Android Phones were being
sold around the globe every
day and that number has
grown to 100,000 units at
present” said Goel.
bITs
GM to form
$100 million
tech firm
Oracle Corp (ORCL.O)
said it plans to fire
more workers mainly in
Europe and Asia as it inte-
grates Sun Microsystems,
resulting in post-acquisi-
tion restructuring costs that
will be more than triple
what it previously dis-
closed. The move under-
scores the challenges the
world's No. 2 business soft-
ware maker faces in turn-
ing around Sun, a money-
losing hardware maker that
it took over in January.
Oracle said on Friday in a
filing with the U.S. Securi-
ties and Exchange Com-
mission that it expected
$675 million to $825 mil-
lion in restructuring costs -
- on top of the $325 million
it previously disclosed. It
said the bulk of the job cuts
and new costs associated
with the restructuring
would occur in Europe and
Asia. —Reuters
Oracle to fire
workers in
Europe, Asia
Google new search dictum: A
picture is worth a 1000 words
New York, June 6: Google
is bowing to the demands of
three European govern-
ments and says it will begin
surrendering the data it
improperly collected over
unsecured wireless net-
works.
Eric E. Schmidt, Google’s
chief executive, told The
Financial Times in an inter-
view in London that within
the next two days, the com-
pany would share the data
with regulators in Germany,
Spain and France. The data
is thought to include frag-
ments of personal informa-
tion like e-mail and bank
account numbers.
Google had previously
resisted requests from Euro-
pean officials and privacy
advocates to hand over the
data, saying it needed time
to review legal issues.
Last month, Google
revealed it had been inad-
vertently collecting 600
gigabytes of personal data,
saying that the roving, cam-
era-mounted cars in its
Street View program had
collected not only photo-
graphs of neighborhoods but
snippets of private informa-
tion from people whose per-
sonal Wi-Fi networks were
left unencrypted.
In Thursday’s interview,
Mr. Schmidt said that the
software code responsible
for the data collection was in
“clear violation” of
Google’s rules.
Mr. Schmidt also said that
Google would make public
the results of internal and
external audits of its Wi-Fi
data collection practices.
Regulators in the United
States have not expressed
the same level of outrage
over the incident as Euro-
pean officials have.
The Federal Trade Com-
mission has said it will take
a close look at the practice,
and several lawmakers have
written letters to Google
asking for more informa-
tion. Lawsuits against
Google over Wi-Fi data col-
lection have also been filed
in at least three states.
—NYT
Search giant to ‘surrender’ map data
Airlines work hard to catch up with the digital age
Where is
the vision?
Kapil Khandelwal
O
ver the last few
months, Banga-
lore has been
host to number of events
in healthsciences and
ICT sectors to deliberate
various issues around
the implementation of
healthcare ICT. Last
week, Bangalore was
the host to the Global
Investors’ Meet and the
Bangalore Bio. All the
leaders are of the con-
sensus and agree that the
healthsciences ICT is a
big opportunity missed.
At all the events, the
leaders from health-
sciences and ICT indus-
try all agree that with
the 3G roll out soon
becoming a reality,
these technologies will
empower the consumer
and ‘aam admi’ in health
consumerism and roll
out healthsciences ICT
technology at a faster
pace. Bangalore boasts
of some of the best
biotech, healthcare and
ICT talent pool that has
been delivering solu-
tions and services to the
world’s biggest and the
best. Yet last week’s
meet there was some-
thing missing – partner-
ing on very big opportu-
nities in healthsciences
ICT for the State and the
country. It’s time we sit
back and reassess the
business models and put
our vision right on what
we want to achieve and
then put out scorecards
and banners. There are a
few factors that serve as
an advantage to us.
Firstly, the size of Indi-
an population and
mobile phone sub-
scribers provides a scale
that can be managed
along the state and
regional consolidation
of ICT infrastructure.
Secondly, the industry is
yet to mature and create
structural issues that
would make the roll out
of such initiatives a
major hurdle as we have
witnessed in major
health industry in the
US and Europe. Thirdly,
with the National UID
roll out, we would now
be in a position to roll
out unique patient iden-
tifiers at the national
level. Lastly, from the
last week’s meet, it
seems that the state gov-
ernment does have a
positive intent to spur
incentives and proactive
policies in engaging dif-
ferent stakeholders and
the health departments
into action. For any suc-
cessful business model
for healthsciences ICT
to emerge, let us look as
some of the lessons
learnt from the success
stories around the
world. Firstly, a strong
leadership is critical to
drive policies, spur
investments into creat-
ing viable business
models. The global lead-
ers—Denmark, Finland,
and Sweden—have all
implemented national-
level strategies to drive
and coordinate health IT
adoption. In contrast,
the strategy in the Unit-
ed States has focused on
building the network
from the bottom up by
establishing regional
health information
organizations (RHIOs)
or health information
exchanges (HIEs). The
U.S. approach, has
failed to produce a
nationwide system of
interoperable EHR sys-
tems. Secondly, a num-
ber of factors, including
the level of technologi-
cal sophistication of the
population, peer influ-
ences, and cultural
norms, have a signifi-
cant impact on health-
sciences ICT adoption.
With a billion mobile
phone subscriber base,
the doctors would have
to adopt newer 3G tech-
nologies to their advan-
tage. Thirdly, privacy
regulations need to be
enacted that are most
effective when they
strike a balance by reas-
suring citizens that their
privacy is being protect-
ed while not implement-
ing restrictive measures
that reduce data sharing
and result in lower qual-
ity care. Lastly, the ulti-
mate objective of such
ICT initiatives is to dra-
matically improve the
quality of biomedical
research as more and
more medical data is
electronic. Let us work
towards a strong leader-
ship that can work in
getting all the stakehold-
ers in the State to lever-
age the positive factors
and work on the experi-
ences and lessons leant
from the leaders global-
ly to bring the right part-
ners for healthcare ICT
roll out.
A dose
of IT
A dose
of IT
Google has introduced an option by which one can click a picture of a particular object and access information on
it from the internet on a phone. —DC Photo