The stem cell is the future of medicine because it is capable of developing into almost any type of cell. R3 Stem Cells can replace, restore, and regenerate damaged, diseased, and inflamed tissues, cells, and organs without surgery. Dr. David Greene explains the benefit of stem cell therapy and platelet-rich plasma therapy for this purpose. Regenerative doctors use r3 stem cells, which allow for better circulation and new blood vessel growth, to repair damaged tissue.
The ISSCR is an independent, nonprofit organization providin.docxoreo10
The ISSCR is an independent, nonprofit
organization providing a global forum for
stem cell research and regenerative medicine.
Stem Cell
Facts
What are stem cells?
Stem cells are the foundation cells for every organ and
tissue in our bodies. The highly specialized cells that make
up these tissues originally came from an initial pool of stem
cells formed shortly after fertilization. Throughout our lives,
we continue to rely on stem cells to replace injured tissues
and cells that are lost every day, such as those in our skin,
hair, blood and the lining of our gut. Stem cells have two
key properties: 1) the ability to self-renew, dividing in a
way that makes copies of themselves, and 2) the ability to
differentiate, giving rise to the mature types of cells that
make up our organs and tissues.
Tissue-specific stem cells
Tissue-specific stem cells, which are sometimes referred to
as “adult” or “somatic” stem cells, are already somewhat
specialized and can produce some or all of the mature
cell types found within the particular tissue or organ in
which they reside. Because of their ability to generate
multiple, organ-specific, cell types, they are described as
“multipotent.” For example, stem cells found within the
adult brain are capable of making neurons and two types of
glial cells, astrocytes and oligodendrocytes.
Tissue-specific stem cells have been found in several organs
that need to continuously replenish themselves, such as the
blood, skin and gut and have even been found in other, less
regenerative, organs such as the brain. These types of stem
cells represent a very small population and are often buried
deep within a given tissue, making them difficult to identify,
isolate and grow in a laboratory setting.
Neuron – Dr. Gerry Shaw, EnCor Biotechnology Inc.
Astrocyte – Abcam Inc.
Oligodendrocyte – Dhaunchak and Nave (2007).
Proc Natl Acad Sci USA 104:17813-8
www.isscr.org
Embryonic stem cells
Embryonic stem cells have been derived from a variety
of species, including humans, and are described as
“pluripotent,” meaning that they can generate all the
different types of cells in the body. Embryonic stem cells
can be obtained from the blastocyst, a very early stage
of development that consists of a mostly hollow ball of
approximately 150-200 cells and is barely visible to the
naked eye. At this stage, there are no organs, not even
blood, just an “inner cell mass” from which embryonic stem
cells can be obtained. Human embryonic stem cells are
derived primarily from blastocysts that were created by
in vitro fertilization (IVF) for assisted reproduction but
were no longer needed.
The fertilized egg and the cells that immediately arise in the
first few divisions are “totipotent.” This means that, under
the right conditions, they can generate a viable embryo
(including support tissues such as the placenta). Within a
matter of days, however, these cells transition to become
pluripote ...
The ISSCR is an independent, nonprofit organization providin.docxoreo10
The ISSCR is an independent, nonprofit
organization providing a global forum for
stem cell research and regenerative medicine.
Stem Cell
Facts
What are stem cells?
Stem cells are the foundation cells for every organ and
tissue in our bodies. The highly specialized cells that make
up these tissues originally came from an initial pool of stem
cells formed shortly after fertilization. Throughout our lives,
we continue to rely on stem cells to replace injured tissues
and cells that are lost every day, such as those in our skin,
hair, blood and the lining of our gut. Stem cells have two
key properties: 1) the ability to self-renew, dividing in a
way that makes copies of themselves, and 2) the ability to
differentiate, giving rise to the mature types of cells that
make up our organs and tissues.
Tissue-specific stem cells
Tissue-specific stem cells, which are sometimes referred to
as “adult” or “somatic” stem cells, are already somewhat
specialized and can produce some or all of the mature
cell types found within the particular tissue or organ in
which they reside. Because of their ability to generate
multiple, organ-specific, cell types, they are described as
“multipotent.” For example, stem cells found within the
adult brain are capable of making neurons and two types of
glial cells, astrocytes and oligodendrocytes.
Tissue-specific stem cells have been found in several organs
that need to continuously replenish themselves, such as the
blood, skin and gut and have even been found in other, less
regenerative, organs such as the brain. These types of stem
cells represent a very small population and are often buried
deep within a given tissue, making them difficult to identify,
isolate and grow in a laboratory setting.
Neuron – Dr. Gerry Shaw, EnCor Biotechnology Inc.
Astrocyte – Abcam Inc.
Oligodendrocyte – Dhaunchak and Nave (2007).
Proc Natl Acad Sci USA 104:17813-8
www.isscr.org
Embryonic stem cells
Embryonic stem cells have been derived from a variety
of species, including humans, and are described as
“pluripotent,” meaning that they can generate all the
different types of cells in the body. Embryonic stem cells
can be obtained from the blastocyst, a very early stage
of development that consists of a mostly hollow ball of
approximately 150-200 cells and is barely visible to the
naked eye. At this stage, there are no organs, not even
blood, just an “inner cell mass” from which embryonic stem
cells can be obtained. Human embryonic stem cells are
derived primarily from blastocysts that were created by
in vitro fertilization (IVF) for assisted reproduction but
were no longer needed.
The fertilized egg and the cells that immediately arise in the
first few divisions are “totipotent.” This means that, under
the right conditions, they can generate a viable embryo
(including support tissues such as the placenta). Within a
matter of days, however, these cells transition to become
pluripote ...
Stem cells are unspecialized cells capable of renewing themselves through cell division, sometimes after long periods of inactivity.
Stem cell therapy is the most advance therapy which use stem cells to treat or prevent a disease or condition.
Properties, types and uses of stem cells are summarized in this presentation.
Stem cells are unspecialized cells capable of renewing themselves through cell division, sometimes after long periods of inactivity.
Stem cell therapy is an advance therapy technique used to treat or prevent a disease or condition using stem cells.
Stem cell Therapy in Neurological diseases Ibad khan
Stem cell Therapy in Neurological diseases
difinition
mechanism
types
history
advantages or disadvantages
in this presentation all theses information include ,
This slide is about the potential uses of stem cells. It describes how they are useful and also puts froward the extraction process and the ares in which stem cells prove to be extremely useful. This slide also lists the various from of cells and the difference between stem cells and the normal differentiated cells. It is also richly supplied with photos and content which would altogether increase the quality of the slide. Hope you enjoy and learn. Please do like and follow. Share with your friends who might benefit from this.
Dr. David Greene R3 stem cell Breakthroughs: Stem Cell Therapy in CardiologyR3 Stem Cell
Dr. David Greene, founder and CEO of R3 Stem Cell, is at the forefront of groundbreaking research in the field of cardiology, focusing on the transformative potential of stem cell therapy. His latest work emphasizes innovative approaches to treating heart disease, aiming to repair damaged heart tissue and improve heart function through the use of advanced stem cell techniques. This research promises not only to enhance the quality of life for patients with chronic heart conditions but also to pave the way for new, more effective treatments. Dr. Greene's work is notable for its focus on safety, efficacy, and the potential to significantly reduce the need for invasive surgeries and long-term medication, positioning stem cell therapy as a key player in the future of cardiac care.
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R3 Stem Cell is at the forefront of revolutionizing respiratory health, offering cutting-edge stem cell therapies for lung disease. This innovative approach promises to open a new era in treatment options, potentially transforming patient outcomes by harnessing the regenerative power of stem cells to heal and restore lung function.
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Stem cells are unspecialized cells capable of renewing themselves through cell division, sometimes after long periods of inactivity.
Stem cell therapy is the most advance therapy which use stem cells to treat or prevent a disease or condition.
Properties, types and uses of stem cells are summarized in this presentation.
Stem cells are unspecialized cells capable of renewing themselves through cell division, sometimes after long periods of inactivity.
Stem cell therapy is an advance therapy technique used to treat or prevent a disease or condition using stem cells.
Stem cell Therapy in Neurological diseases Ibad khan
Stem cell Therapy in Neurological diseases
difinition
mechanism
types
history
advantages or disadvantages
in this presentation all theses information include ,
This slide is about the potential uses of stem cells. It describes how they are useful and also puts froward the extraction process and the ares in which stem cells prove to be extremely useful. This slide also lists the various from of cells and the difference between stem cells and the normal differentiated cells. It is also richly supplied with photos and content which would altogether increase the quality of the slide. Hope you enjoy and learn. Please do like and follow. Share with your friends who might benefit from this.
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New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
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This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
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What is R3 stem cell therapy - David Greene, M.D..pdf
1. What is Stem Cell
Therapy?
A stem cell is a unique cell with the
ability to develop into any cell and is
the future of medicine. Stem Cells can
replace, restore, and regenerate
organs, tissues, cells that have been
damaged, diseased, and inflammed
with a non-surgical procedure.
2. What Exactly is Stem
Cells Therapy?
Autoimmune conditions
Neurological conditions
Sports injuries
Spinal injuries
Anti-aging
Stem cell therapy is a kind of regenerative medicine. It aims
to treat diverse ailments by exploiting the natural healing
ability of the body. In other words, stem cells can regenerate
areas of the body. This is why they are helpful in various
medical conditions. Treatment is non-surgical and can be for
inflamed, damaged, or diseased tissues. Some of the
conditions treated with stem cells and extra growth factors
include:
3. How Stem
Cell Therapy
Works
The stem cell therapy process is
simple. This is unlike invasive surgery
that can bring about various forms of
complications. Stem cell therapy
involves the use of cells from your own
body. Hence, the chances of immune
rejection are minimal. The therapy starts
with a physician reaching your bone
marrow to extract stem cells. This
activity is often conducted around the
hip area. Before extraction, the area is
first tidied up and made numb. The
physician will then insert a needle
around your iliac crest.
4. Post Therapy
Care
If you are a worker, there’s no need
to fear stem cell therapy preventing
you from work. This is because of
the possibility of resuming work
immediately after treatment. But be
sure not to lift heavy items for at
least a fortnight after the process. It
is also important not to ingest non-
steroidal, anti-inflammatory
medications for a while. Such
substances may negatively impact
the healing process.
5. Types of
Stem Cells
Stem cells have two similar
attributes: self-renewal and
differentiation. The former
means an ability to make
copies of themselves. The
latter implies an ability to
develop into more
specialized cells. Despite
these two essential abilities,
some dissimilarities also exist
among them.
6. Embryonic
Stem Cells
These stem cells form in the
blastocyst, a hollow ball of cells that
emerges between 72 to 120 hours
after fertilizing an egg by a sperm.
The blastocyst is what later becomes
the embryo. Cell differentiation begins
with the implanting of the embryo in
the uterus. This type of stem cell
differentiates into more cell types
than the adult type. Embryonic stem
cells are pluripotent.
7. Adult Stem
Cells
Adult stem cells are also known as
tissue-specific or somatic stem cells.
They start forming as soon as the
embryo emerges and can be found in
adult tissues like bone marrow. They
are not as abundant as embryonic
cells. Scientists previously believed
that tissue-specific cells could not
differentiate into other cells. But this
notion no longer holds, according to
recent research. For instance, bone
marrow cells can differentiate into
brain cells, etc.
8. Induced
Pluripotent
Stem Cells
These are adult cells that are genetically
programmed to exhibit the
characteristics of embryonic stem cells.
They help scientists in the invention and
testing of new therapies and
medications, among other uses. Notable
advancements in this field include
reprogramming regular connective tissue
cells into functional heart cells in animals.
Injecting these new heart cells into
animals with failing hearts led to
improvements in heart function and
survival time.
9. Perinatal
Stem Cells
Perinatal stem cells were
discovered in amniotic fluid and
umbilical cord blood. Amniotic fluid
is found in the sac that surrounds
and protects a growing fetus in the
womb. One of their characteristics is
the ability to develop into
specialized cells. This area requires
more scientific scrutiny for further
comprehension of the potentials of
amniotic fluid stem cells.