What is NOT a difference between DNA and RNA? RNA uses uracil instead of thymine RNA has ribose as a sugar DNA uses uracil instead of thymine DNA is double stranded Where does protein synthesis take place? nucleus cytoplasm polypeptides messenger RNA Solution DNA uses Urasil instead of Thymine. This statement is Fals.This is not a difference between DNA and RNA. Instead DNA uses Thymine instead of Urasil. Urasil is used in RNA. Protein synthesis takes place in cytoplasm. Firstly mRNA is formed in nucleus from where it travels to the cytoplasm and supports in protein synthesis..