The document outlines what a reviewer should address when reviewing a manuscript, including evaluating the context and content of the manuscript. For context, the reviewer should assess if the manuscript is presented appropriately within published literature, is novel, and integrates findings into existing knowledge. For content, the reviewer should consider if the study design, methods, models, and analyses are appropriate and if results and conclusions are convincing and supported by evidence presented. The reviewer does not need to worry about spelling, grammar, or editorial guidelines.