Welcome Basic Principles of Cancer Management
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This document outlines an oncology lecture discussing the basic approach to cancer diagnosis and treatment. It will cover understanding cancer staging and how that affects treatment decisions. The lecturer will evaluate different cancer treatment approaches and how treatment decisions are made through a multidisciplinary team.
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Ineffective Cancer treatments leading to deaths
Name
Course
Tutor
Date
Abstract
The main focus of the report will be to research on the various methods through which cancer can be treated with a keen eye on why some methods are ineffective and lead to death. A discussion on different cancer treatment will be done followed by the types of cancer that cause millions of death today. Presentation of answers to the research questions will be done in line with ineffective cancer treatment methods. Relevant literature review will be conducted and used to support the claims of ineffective cancer treatments. Lastly, recommendations on the best cancer treatment will be done.
Introduction
Cancer is an ailment caused by the unrestrained division of abnormal cells in the body. The cancer cells are malignant meaning they can spread from the origin to distant organs and tissues. The disease can be genetically hereditary hence can be crossed over from one generation to another. Some of the forms of cancer treatment include targeted therapy, hormone therapy, chemotherapy, precision medicine, surgery, immunotherapy, and stem cell transplant. Some of the common types of this disease include lung, liver, stomach, and bowel cancers.
Cancer is also called as malignancy which means abnormal cells growth. More than 100 types of cancer are found in this world today, including breast cancer (widely spread among women), skin cancer (found in the person of almost every age), lung cancer (common among smokers), colon cancer, lymphoma and prostate cancer. Each kind of cancer has varying symptoms. Cancer differs with respect to the cell it affects first. The uncontrollable division of cells harm the body and form lumps and the masses of tissues which are known as tumors. The tumor grows in size and sometimes even intervene the digestive system, circulatory system, excretory system and nervous system. In the case of leukemia, cancer inhibits the normal blood functioning which is caused due to the abnormal cell division into the blood stream. Cancer also causes the systems of the body to secrete hormones that alter the body functioning. Tumors that do not grow and remain limited to one spot are considered to slightly less harmful and benign. The sign of the more dangerous and malignant cells is:
1. The harmful cancerous cells move from one spot to another throughout the body using blood as a medium and invade the organs and the healthy tissues of the body.
2. These cells grow and divide rapidly, they make blood vessels of their own which are used by them in the process of feeding, called as angiogenesis.
Then comes a stage is known as metastasized in which the tumor spread successfully to the other parts of the body, penetrating into the healthy tissues of the body and damaging them badly. The process is known as metastasis. It cause ...
1578185 - McGraw-Hill Professional ©CHAPTER 175Overview
1578185 - McGraw-Hill Professional ©
CHAPTER 175
Overview of Cancer and Treatment
Jennifer Duff, MD
Merry Jennifer Markham, MD
Key Clinical Questions
What types of biopsies can aid in the diagnostic workup of cancer?
How is the cancer stage determined?
What are the goals of therapy in the neoadjuvant, adjuvant, and palliative setting?
What are the different types of systemic therapies commonly used in the
treatment of cancer?
What are the approaches to treating chemotherapy-related nausea, vomiting and
mucositis?
When are modified blood products recommended for cancer patients and what
are the transfusion thresholds for anemia and thrombocytopenia?
EPIDEMIOLOGY
Cancer is a group of diseases characterized by uncontrolled proliferation of abnormal
cells that invade surrounding tissue and carry the potential to metastasize. Environmental
1578185 - McGraw-Hill Professional ©
and lifestyle risk factors and genetic susceptibility all contribute to an individual’s risk of
developing cancer. In 2015, more than 1.6 million Americans will be diagnosed with
cancer, and approximately 600,000 cancer-related deaths will occur. The most common
cancers afflicting men and women are prostate and breast, respectively, followed by lung
and colorectal. Overall, lung cancer is the leading cause of cancer-related mortality,
followed by colorectal cancer. The incidence of lung and colon cancer in men is steadily
declining, perhaps reflecting decreased tobacco use and emphasis on colorectal cancer
screenings. Lung cancer incidence in women is finally starting to decrease after rising over
the last few decades, reflecting the delayed uptake in smoking (and later, smoking
cessation) by women compared to men.
DIAGNOSIS AND STAGING
Biopsy of a primary and/or metastatic site of a presumed malignancy is necessary to
provide histologic confirmation of a cancer diagnosis. Involving a hematologist-oncologist
early in the workup of a newly diagnosed cancer patient can be helpful in guiding the
appropriate testing, biopsy sites, or biopsy techniques. For example, different biopsy
techniques—including fine needle aspiration (FNA), core needle biopsy, excisional biopsy,
or laparotomy—may be utilized depending on the type of cancer suspected. An FNA alone
is inadequate in the diagnosis of lymphomas as the morphology of the nodal tissue is
crucial in determining lymphoma subtype. Core needle biopsies and excisional or
incisional biopsies provide a larger volume of tissue for pathologic evaluation of
morphology and for molecular or genetic analysis. When a hematologic malignancy, such
as lymphoma, is suspected, sending a fresh, not fixed, specimen for comprehensive
immunophenotyping using flow cytometry is important in yielding the correct diagnosis.
Finally, in addition to confirming a cancer diagnosis, the biopsied tissue specimen may
guide therapeutic decisions. For example, molecular biomarkers, such as HER2Neu for
breast cancer and KRAS/NRAS for colon cancer ...
1578185 - McGraw-Hill Professional ©CHAPTER 175Overview
1578185 - McGraw-Hill Professional ©
CHAPTER 175
Overview of Cancer and Treatment
Jennifer Duff, MD
Merry Jennifer Markham, MD
Key Clinical Questions
What types of biopsies can aid in the diagnostic workup of cancer?
How is the cancer stage determined?
What are the goals of therapy in the neoadjuvant, adjuvant, and palliative setting?
What are the different types of systemic therapies commonly used in the
treatment of cancer?
What are the approaches to treating chemotherapy-related nausea, vomiting and
mucositis?
When are modified blood products recommended for cancer patients and what
are the transfusion thresholds for anemia and thrombocytopenia?
EPIDEMIOLOGY
Cancer is a group of diseases characterized by uncontrolled proliferation of abnormal
cells that invade surrounding tissue and carry the potential to metastasize. Environmental
1578185 - McGraw-Hill Professional ©
and lifestyle risk factors and genetic susceptibility all contribute to an individual’s risk of
developing cancer. In 2015, more than 1.6 million Americans will be diagnosed with
cancer, and approximately 600,000 cancer-related deaths will occur. The most common
cancers afflicting men and women are prostate and breast, respectively, followed by lung
and colorectal. Overall, lung cancer is the leading cause of cancer-related mortality,
followed by colorectal cancer. The incidence of lung and colon cancer in men is steadily
declining, perhaps reflecting decreased tobacco use and emphasis on colorectal cancer
screenings. Lung cancer incidence in women is finally starting to decrease after rising over
the last few decades, reflecting the delayed uptake in smoking (and later, smoking
cessation) by women compared to men.
DIAGNOSIS AND STAGING
Biopsy of a primary and/or metastatic site of a presumed malignancy is necessary to
provide histologic confirmation of a cancer diagnosis. Involving a hematologist-oncologist
early in the workup of a newly diagnosed cancer patient can be helpful in guiding the
appropriate testing, biopsy sites, or biopsy techniques. For example, different biopsy
techniques—including fine needle aspiration (FNA), core needle biopsy, excisional biopsy,
or laparotomy—may be utilized depending on the type of cancer suspected. An FNA alone
is inadequate in the diagnosis of lymphomas as the morphology of the nodal tissue is
crucial in determining lymphoma subtype. Core needle biopsies and excisional or
incisional biopsies provide a larger volume of tissue for pathologic evaluation of
morphology and for molecular or genetic analysis. When a hematologic malignancy, such
as lymphoma, is suspected, sending a fresh, not fixed, specimen for comprehensive
immunophenotyping using flow cytometry is important in yielding the correct diagnosis.
Finally, in addition to confirming a cancer diagnosis, the biopsied tissue specimen may
guide therapeutic decisions. For example, molecular biomarkers, such as HER2Neu for
breast cancer and KRAS/NRAS for colon cancer ...
Prof.Arshad Cheema
This document discusses early detection of cancer, with a focus on breast cancer. It notes that early detection is important as one third of cancers could be cured if detected early and treated adequately. It emphasizes the need for public health education so patients can get screened and diagnosed at earlier stages when conservation treatments are possible and long-term survival chances are higher. Locally advanced disease is common in Pakistan, presenting challenges for treatment. The document promotes efforts like breast self-exams, clinical exams, and mammography to enable earlier detection when options are more favorable.
Meet the team
FirstHealth Moore Regional Hospital was ranked 5th best hospital in North Carolina, awarded top performer in 9 service lines including cancer. Let’s meet the individuals who make this program outstanding.
Dr. Andre Mitchell's CV
This document provides biographical information on Dr. Andre L. Mitchell including his education, training, employment history, affiliations, and research experience. He received his MD from the University of Missouri-Columbia School of Medicine and has since served in various roles including founder and CEO of Mitchell Global Holdings, radiation oncologist, and medical director. His experience includes clinical trials research with the Radiation Therapy Oncology Group and he maintains active medical licenses in Minnesota and Florida.
Dr. Andre Mitchell's CV
This document provides biographical information on Dr. Andre L. Mitchell including his education, training, employment history, affiliations, and research experience. He received his MD from the University of Missouri-Columbia School of Medicine and has since served in various roles including founder and CEO of Mitchell Global Holdings, radiation oncologist, and medical director. His experience includes clinical trials research with the Radiation Therapy Oncology Group and leadership positions with Coborn Cancer Center.
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Welcome Basic Principles of Cancer Management
- 1. Winston Tan MD FACP Associate Professor of Medicine Vice Chair of Hematology/Oncology Education Program Director Hematology/Oncology Fellowship Program Chair Genitourinary Medical Oncology Mayo Clinic Florida
- 2. Learner be able to understand and review the basic approach to the diagnosis and treatment of cancer Discuss and comprehend the staging and how this affects the approach to treatment Evaluate the different approaches to cancer treatment and how decisions are made
- 4. Biopsy Surgery Complex cases monitoring
- 5. Stage I local Stage II local Stage III locally advanced Stage IV metastasis
- 6. Team Surgeon Oncologist Radiation oncologist Physical Medicine Cardiologist Social worker Psychiatrist Gastroenterologist Cancer geneticist Nurse Pharmacist