All of the perturbative approaches to multidimensional wave
equation processing. for example. wave equation migration (see,
e.g., Claerbout, 1971; French, 1975: Schneider, 1978; Stolt, 1978;
Sattlegger et al, 1980), or Born approximation inversion (see,
e.g., Cohen and Bleistein, 1979; Raz, 1981: Clayton and Stolt,
1981) require some input velocity information. In the Born approximation
to inversion, a reference or background velocity is
chosena nd a perturbationa boutt his velocity is determined.S imilarly,
a velocity model is a required input to all wave equation
migration techniques.
Prospects for CMB lensing-galaxy clustering cross-correlations and initial co...Marcel Schmittfull
The lensing convergence measurable with future CMB experiments will be highly correlated with the clustering of galaxies that will be observed by imaging surveys such as LSST. I will discuss prospects for using that cross-correlation signal to constrain local primordial non-Gaussianity, the amplitude of matter fluctuations as a function of redshift, halo bias, and possibly the sum of neutrino masses. A key limitation for such analyses and large-scale structure analyses in general is that the mapping from initial conditions to observables is nonlinear for wavenumbers k>0.1h/Mpc. This can destroy cosmological information or move it to non-Gaussian tails of the probability distribution that are difficult to measure. I will describe how we can use recently developed initial condition reconstruction methods to help us recover some of that information in the nonlinear regime.
Obtaining three-dimensional velocity information directly from reflection sei...Arthur Weglein
This paper present a formalism for obtaining the subsurface
velocity configuration directly from reflection seismic data.
Our approach is to apply the results obtained for inverse
problems in quantum scattering theory to the reflection
seismic problem. In particular, we extend the results of
Moses (1956) for inverse quantum scattering and Razavy
(1975) for the one-dimensional (1-D) identification of the
acoustic wave equation to the problem of identifying the
velocity in the three-dimensional (3-D) acoustic wave equation
from boundary value measurements. No a priori knowledge
of the subsurface velocity is assumed and all refraction,
diffraction, and multiple reflection phenomena are
taken into account. In addition, we explain how the idea of
slant stack in processing seismic data is an important part
of the proposed 3-D inverse scattering formalism.
A Novel Space-time Discontinuous Galerkin Method for Solving of One-dimension...TELKOMNIKA JOURNAL
In this paper we propose a high-order space-time discontinuous Galerkin (STDG) method for
solving of one-dimensional electromagnetic wave propagations in homogeneous medium. The STDG
method uses finite element Discontinuous Galerkin discretizations in spatial and temporal domain
simultaneously with high order piecewise Jacobi polynomial as the basis functions. The algebraic
equations are solved using Block Gauss-Seidel iteratively in each time step. The STDG method is
unconditionally stable, so the CFL number can be chosen arbitrarily. Numerical examples show that the
proposed STDG method is of exponentially accuracy in time.
Prospects for CMB lensing-galaxy clustering cross-correlations and initial co...Marcel Schmittfull
The lensing convergence measurable with future CMB experiments will be highly correlated with the clustering of galaxies that will be observed by imaging surveys such as LSST. I will discuss prospects for using that cross-correlation signal to constrain local primordial non-Gaussianity, the amplitude of matter fluctuations as a function of redshift, halo bias, and possibly the sum of neutrino masses. A key limitation for such analyses and large-scale structure analyses in general is that the mapping from initial conditions to observables is nonlinear for wavenumbers k>0.1h/Mpc. This can destroy cosmological information or move it to non-Gaussian tails of the probability distribution that are difficult to measure. I will describe how we can use recently developed initial condition reconstruction methods to help us recover some of that information in the nonlinear regime.
Obtaining three-dimensional velocity information directly from reflection sei...Arthur Weglein
This paper present a formalism for obtaining the subsurface
velocity configuration directly from reflection seismic data.
Our approach is to apply the results obtained for inverse
problems in quantum scattering theory to the reflection
seismic problem. In particular, we extend the results of
Moses (1956) for inverse quantum scattering and Razavy
(1975) for the one-dimensional (1-D) identification of the
acoustic wave equation to the problem of identifying the
velocity in the three-dimensional (3-D) acoustic wave equation
from boundary value measurements. No a priori knowledge
of the subsurface velocity is assumed and all refraction,
diffraction, and multiple reflection phenomena are
taken into account. In addition, we explain how the idea of
slant stack in processing seismic data is an important part
of the proposed 3-D inverse scattering formalism.
A Novel Space-time Discontinuous Galerkin Method for Solving of One-dimension...TELKOMNIKA JOURNAL
In this paper we propose a high-order space-time discontinuous Galerkin (STDG) method for
solving of one-dimensional electromagnetic wave propagations in homogeneous medium. The STDG
method uses finite element Discontinuous Galerkin discretizations in spatial and temporal domain
simultaneously with high order piecewise Jacobi polynomial as the basis functions. The algebraic
equations are solved using Block Gauss-Seidel iteratively in each time step. The STDG method is
unconditionally stable, so the CFL number can be chosen arbitrarily. Numerical examples show that the
proposed STDG method is of exponentially accuracy in time.
Accuracy of the internal multiple prediction when a time-saving method based ...Arthur Weglein
The inverse scattering series (ISS) is a direct inversion method for a multidimensional acoustic,
elastic and anelastic earth. It communicates that all inversion processing goals can be
achieved directly and without any subsurface information. This task is reached through a taskspecific
subseries of the ISS. Using primaries in the data as subevents of the first-order internal
multiples, the leading-order attenuator can predict the time of all the first-order internal multiples
and is able to attenuate them.
Joint analysis of CMB temperature and lensing-reconstruction power spectraMarcel Schmittfull
Talk given by Marcel Schmittfull at The Pacific Cosmology Cooperative (PaCCo) 2014 workshop at JPL/Caltech, Pasadena
Topic: Combining CMB lensing reconstruction with CMB power spectrum measurements
Based on the paper http://arxiv.org/abs/1308.0286
Internal multiple attenuation using inverse scattering: Results from prestack...Arthur Weglein
The attenuation of internal multiples in a multidimensional
earth is an important and longstanding problem in exploration
seismics. In this paper we report the results of applying
an attenuation algorithm based on the inverse scattering
series to synthetic prestack data sets generated in on
and two dimensional earth models. The attenuation algorithm
requires no information about the subsurface structure
or the velocity field. However, detailed information about
the source wavelet is a prerequisite. An attractive feature of:
the attenuation algorithm is the preservation of the amplitude
(and phase) of primary events in the data; thus allowing for
subsequent AVO and other true amplitude processing.
The idea is to build an algebra of object to represent (water) budgets giving a clear idea of the type of interactions that the budget is subject to.
Any symbol should correspond to a mathematical term or a group of mathematical terms. The number and the collocation of parameters of the models should be clear.
Accuracy of the internal multiple prediction when a time-saving method based ...Arthur Weglein
The inverse scattering series (ISS) is a direct inversion method for a multidimensional acoustic,
elastic and anelastic earth. It communicates that all inversion processing goals can be
achieved directly and without any subsurface information. This task is reached through a taskspecific
subseries of the ISS. Using primaries in the data as subevents of the first-order internal
multiples, the leading-order attenuator can predict the time of all the first-order internal multiples
and is able to attenuate them.
Joint analysis of CMB temperature and lensing-reconstruction power spectraMarcel Schmittfull
Talk given by Marcel Schmittfull at The Pacific Cosmology Cooperative (PaCCo) 2014 workshop at JPL/Caltech, Pasadena
Topic: Combining CMB lensing reconstruction with CMB power spectrum measurements
Based on the paper http://arxiv.org/abs/1308.0286
Internal multiple attenuation using inverse scattering: Results from prestack...Arthur Weglein
The attenuation of internal multiples in a multidimensional
earth is an important and longstanding problem in exploration
seismics. In this paper we report the results of applying
an attenuation algorithm based on the inverse scattering
series to synthetic prestack data sets generated in on
and two dimensional earth models. The attenuation algorithm
requires no information about the subsurface structure
or the velocity field. However, detailed information about
the source wavelet is a prerequisite. An attractive feature of:
the attenuation algorithm is the preservation of the amplitude
(and phase) of primary events in the data; thus allowing for
subsequent AVO and other true amplitude processing.
The idea is to build an algebra of object to represent (water) budgets giving a clear idea of the type of interactions that the budget is subject to.
Any symbol should correspond to a mathematical term or a group of mathematical terms. The number and the collocation of parameters of the models should be clear.
A Study of Non-Gaussian Error Volumes and Nonlinear Uncertainty Propagation f...Justin Spurbeck
The ever-growing resident space object population poses a continual threat in that a hyper velocity impact is likely to be catastrophic to an active satellite. To avoid these scenarios, space operators compute a probability of collision metric for each potential conjunction. Uncertainty trends are studied in the conjunction plane and operational decisions to mitigate any high-risk situations are made based off this information. There are many methods of uncertainty propagation and probability of collision formulations and knowledge of their realism is required to maintain a sustainable space environment. Thus, this research studies the effect of Chan, Alfano, Foster, Gaussian mixture, and Monte Carlo probability of collision calculations and their correlation to uncertainty realism metrics. The linear, unscented transform, entropy-based, and Monte Carlo propagation techniques are utilized alongside the collision calculations and it is shown that there are important correlations any space operator should be aware of to support maintenance of a healthy spacecraft.
OPTIMAL BEAM STEERING ANGLES OF A SENSOR ARRAY FOR A MULTIPLE SOURCE SCENARIOcsandit
We present the gradient and Hessian of the trace of the multivariate Cramér-Rao bound (CRB)
formula for unknown impinging angles of plane waves with non-unitary beamspace measurements,. These gradient and Hessian can be used to find the optimal beamspace
transformation matrix, i.e., the optimum beamsteering angles, using the Newton-Raphson iteration. These trace formulas are particularly useful to deal with the multiple source senario.
We also show the mean squred error (MSE) performance gain of the optimally steered beamspace measurements compared with the usuall DFT steered measurements, when the angle
of arrivals (AOAs) are estimated with stochastic maximum likelihood (SMLE) algorithm.
OPTIMAL BEAM STEERING ANGLES OF A SENSOR ARRAY FOR A MULTIPLE SOURCE SCENARIOcscpconf
We present the gradient and Hessian of the trace of the multivariate Cramér-Rao bound (CRB)
formula for unknown impinging angles of plane waves with non-unitary beamspace
measurements,. These gradient and Hessian can be used to find the optimal beamspace
transformation matrix, i.e., the optimum beamsteering angles, using the Newton-Raphson
iteration. These trace formulas are particularly useful to deal with the multiple source senario.
We also show the mean squred error (MSE) performance gain of the optimally steered
beamspace measurements compared with the usuall DFT steered measurements, when the angle
of arrivals (AOAs) are estimated with stochastic maximum likelihood (SMLE) algorithm.
Linear inversion of absorptive/dispersive wave field measurements: theory and...Arthur Weglein
The use of inverse scattering theory for the inversion of viscoacoustic wave field
measurements, namely for a set of parameters that includes Q, is by its nature very
different from most current approaches for Q estimation. In particular, it involves an
analysis of the angle- and frequency-dependence of amplitudes of viscoacoustic data
events, rather than the measurement of temporal changes in the spectral nature of
events. We consider the linear inversion for these parameters theoretically and with
synthetic tests. The output is expected to be useful in two ways: (1) on its own it
provides an approximate distribution of Q with depth, and (2) higher order terms in
the inverse scattering series as it would be developed for the viscoacoustic case would
take the linear inverse as input.
We will begin, following Innanen (2003) by casting and manipulating the linear
inversion problem to deal with absorption for a problem with arbitrary variation of
wavespeed and Q in depth, given a single shot record as input. Having done this, we
will numerically and analytically develop a simplified instance of the 1D problem. This
simplified case will be instructive in a number of ways, first of all in demonstrating
that this type of direct inversion technique relies on reflectivity, and has no interest in
or ability to analyse propagation effects as a means to estimate Q. Secondly, through
a set of examples of slightly increasing complexity, we will demonstrate how and where
the linear approximation causes more than the usual levels of error. We show how
these errors may be mitigated through use of specific frequencies in the input data,
or, alternatively, through a layer-stripping based, or bootstrap, correction. In either
case the linear results are encouraging, and suggest the viscoacoustic inverse Born
approximation may have value as a standalone inversion procedure.
The Inverse Scattering Series (ISS) is a direct inversion method
for a multidimensional acoustic, elastic and anelastic earth. It
communicates that all inversion processing goals are able to
be achieved directly and without any subsurface information.
This task is reached through a task-specific subseries of the
ISS. Using primaries in the data as subevents of the first-order
internal multiples, the leading-order attenuator can predict the
time of all the first-order internal multiples and is able to attenuate
them.
However, the ISS internal multiple attenuation algorithm can
be a computationally demanding method specially in a complex
earth. By using an approach that is based on two angular
quantities and that was proposed in Terenghi et al. (2012), the
cost of the algorithm can be controlled. The idea is to use the
two angles as key-control parameters, by limiting their variation,
to disregard some calculated contributions of the algorithm
that are negligible. Moreover, the range of integration
can be chosen as a compromise of the required degree of accuracy
and the computational time saving.
This time-saving approach is presented
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Internal multiple attenuation using inverse scattering: Results from prestack 1 & 2D acoustic and
elastic synthetics
R. T. Coates*, Schlumberger Cambridge Research, A. B. Weglein, Arco Exploration and Production Technology
Summary
The attenuation of internal multiples in a multidimensional
earth is an important and longstanding problem in exploration
seismics. In this paper we report the results of applying
an attenuation algorithm based on the inverse scattering
series to synthetic prestack data sets generated in on
and two dimensional earth models. The attenuation algorithm
requires no information about the subsurface structure
or the velocity field. However, detailed information about
the source wavelet is a prerequisite. An attractive feature of:
the attenuation algorithm is the preservation of the amplitude
(and phase) of primary events in the data; thus allowing for
subsequent AVO and other true amplitude processing.
Linear regression [Theory and Application (In physics point of view) using py...ANIRBANMAJUMDAR18
Machine-learning models are behind many recent technological advances, including high-accuracy translations of the text and self-driving cars. They are also increasingly used by researchers to help in solving physics problems, like Finding new phases of matter, Detecting interesting outliers
in data from high-energy physics experiments, Founding astronomical objects are known as gravitational lenses in maps of the night sky etc. The rudimentary algorithm that every Machine Learning enthusiast starts with is a linear regression algorithm. In statistics, linear regression is a linear approach to modelling the relationship between a scalar response (or dependent variable) and one or more explanatory variables (or independent
variables). Linear regression analysis (least squares) is used in a physics lab to prepare the computer-aided report and to fit data. In this article, the application is made to experiment: 'DETERMINATION OF DIELECTRIC CONSTANT OF NON-CONDUCTING LIQUIDS'. The entire computation is made through Python 3.6 programming language in this article.
Similar to Seismic 13- Professor. Arthur B Weglein (20)
Wavelet estimation for a multidimensional acoustic or elastic earthArthur Weglein
A new and general wave theoretical wavelet estimation
method is derived. Knowing the seismic wavelet
is important both for processing seismic data and for
modeling the seismic response. To obtain the wavelet,
both statistical (e.g., Wiener-Levinson) and deterministic
(matching surface seismic to well-log data) methods
are generally used. In the marine case, a far-field
signature is often obtained with a deep-towed hydrophone.
The statistical methods do not allow obtaining
the phase of the wavelet, whereas the deterministic
method obviously requires data from a well. The
deep-towed hydrophone requires that the water be
deep enough for the hydrophone to be in the far field
and in addition that the reflections from the water
bottom and structure do not corrupt the measured
wavelet. None of the methods address the source
array pattern, which is important for amplitude-versus-
offset (AVO) studies.
The inverse scattering series for tasks associated with primaries: direct non...Arthur Weglein
The inverse scattering series for tasks associated with primaries: direct non-linear inversion of 1D elastic media. In this paper, research on direct inversion for two pa-
rameter acoustic media (Zhang and Weglein, 2005) is
extended to the three parameter elastic case. We present
the first set of direct non-linear inversion equations for
1D elastic media (i.e., depth varying P-velocity, shear
velocity and density). The terms for moving mislocated
reflectors are shown to be separable from amplitude
correction terms. Although in principle this direct
inversion approach requires all four components of elastic
data, synthetic tests indicate that consistent value-added
results may be achieved given only ˆDPP measurements.
We can reasonably infer that further value would derive
from actually measuring ˆDPP , ˆD PS, ˆDSP and ˆDSS as
the method requires. The method is direct with neither
a model matching nor cost function minimization.
Inverse scattering series for multiple attenuation: An example with surface a...Arthur Weglein
A multiple attenuation method derived from an inverse scattering
series is described. The inversion series approach allows a
separation of multiple attenuation subseries from the full series.
The surface multiple attenuation subseries was described and illustrated
in Carvalho et al. (1991, 1992). The internal multiple
attenuation method consists of selecting the parts of the odd
terms that are associated with removing only multiply reflected
energy. The method, for both types of multiples, is multidimensional
and does not rely on periodicity or differential moveout,
nor does it require a model of the reflectors generating the multiples.
An example with internal and surface multiples will be
presented.
In this paper we present a multidimensional method for attenuating internal multiples that derives from
an inverse scattering series . The method doesn't depend on periodicity or differential moveout, nor does it
require a model for the multiple generating reflectors.
Summary
Methods for removal of free-surface and internal multiples have been developed from bath a feedback model approach and inverse scatterin g theory. White these two formulations derive from different mathematica) viewpoints,
the resulting algorithm s for free-surface multiple are very similar. By contrast , the feedback and inverse scattering
method for internal multiple are totally different and have different requirements for sub surface information or
interpretive intervention . The former removes all multiple related to a certain boundary with the a of a surface
integral along this boundary ; the alter wilt predict and attenuate a ll internal multiple a t the same time . In this paper, we continue our comparison study of these internal multiple attenuation method ; specifically , we examine two
different realizations of the feedback method and the inverse scattering technique .
Wavelet estimation for a multidimensional acoustic or elastic earth- Arthur W...Arthur Weglein
A new and general wave theoretical wavelet estimation
method is derived. Knowing the seismic wavelet
is important both for processing seismic data and for
modeling the seismic response. To obtain the wavelet,
both statistical (e.g., Wiener-Levinson) and deterministic
(matching surface seismic to well-log data) methods
are generally used. In the marine case, a far-field
signature is often obtained with a deep-towed hydrophone.
The statistical methods do not allow obtaining
the phase of the wavelet, whereas the deterministic
method obviously requires data from a well. The
deep-towed hydrophone requires that the water be
deep enough for the hydrophone to be in the far field
and in addition that the reflections from the water
bottom and structure do not corrupt the measured
wavelet. None of the methods address the source
array pattern, which is important for amplitude-versus-
offset (AVO) studies
Inverse scattering series for multiple attenuation: An example with surface a...Arthur Weglein
A multiple attenuation method derived from an inverse scattering
series is described. The inversion series approach allows a
separation of multiple attenuation subseries from the full series.
The surface multiple attenuation subseries was described and illustrated
in Carvalho et al. (1991, 1992). The internal multiple
attenuation method consists of selecting the parts of the odd
terms that are associated with removing only multiply reflected
energy. The method, for both types of multiples, is multidimensional
and does not rely on periodicity or differential moveout,
nor does it require a model of the reflectors generating the multiples.
An example with internal and surface multiples will be
presented.
Deghosting is a longstanding seismic objective and problem that has received considerable renewed attention due to : (1). an interest in so-called "broadband seismology" and the low frequency /low vertical wave number.
The Inverse Source Problem in The Presence of External Sources- Dr. Arthur B....Arthur Weglein
This paper presents a brief review of the various integral equation formuiations that have been employed
for the inverse source problem for the inhomogeneous scalar Heimhoitz equation. It is shown that these
formulations apply only in cases where either the data are prescribed on a closed surface surrounding the
unknown source or where the unknown source lies entirely on one side of an open measurement surface.
A generalized integral equation is derived that applies to the more general case where unknown sources
can exist on both sides of an open measurement surface. This latter problem arises in geophysical remote
sensing and the derived integral equation offers an approach to this class of problems not offered by
currently employed techniques.
Direct non-linear inversion of multi-parameter 1D elastic media using the inv...Arthur Weglein
In this paper, we present the first non-linear direct target identification method and algorithm
for 1D elastic media (P velocity, shear velocity and density vary in depth) from the inverse
scattering series. Direct non-linear means that we provide explicit formulas that: (1) input data
and directly output changes in material properties, without the use or need for any indirect procedures
such as model matching, searching, optimization or other assumed aligned objectives or
proxies, and (2) the algorithms recognize and directly invert the intrinsic non-linear relationship
between changes in material properties and changes in the concomitant wave-field. The results
clearly demonstrate that, in order to achieve full elastic inversion, all four components of data
(ˆD PP , ˆDPS, ˆD SP and ˆDSS) are needed. The method assumes that only data and reference
medium properties are input, and terms in the inverse series for moving mislocated reflectors
resulting from the linear inverse term, are separated from amplitude correction terms. Although
in principle this direct inversion approach requires all four components of elastic data, synthetic
tests indicate that a consistent value-added result may be achieved given only ˆDPP measurements,
as long as the ˆD PP were used to approximately synthesize the ˆD PS, ˆDSP and ˆD SS
components. We can reasonably infer that further value would derive from actually measuring
ˆD
PP , ˆDPS, ˆDSP and ˆD SS as the method requires. For the case that all four components of
data are available, we give one consistent method to solve for all of the second terms (the first
terms beyond linear). The method’s nonlinearity and directness provides this unambiguous data
requirement message, and that unique clarity, and the explicit non-linear formulas casts doubts
and reasonable concerns for indirect methods, in general, and their assumed aligned goals, e.g.,
using model matching objectives, that would never recognize the fundamental inadequacy from
a basic physics point of view of using only PP data to perform elastic inversion. There are important
conceptual and practical implications for the link between data acquisition and target
identification goals and objectives.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
1. Seismic 13176
FIG.6. Reconstructionwith depthcorrection.100percentcontrast,
Cr = 2000 misec.
ity contrasts(50 and 100percent)in Figures5 and7, distortionin
thereconstructionsis quiteserious.The improvementof thedepth
correctionshownin Figures4, 6, and 8 is apparent.
Futurework
We intendto examinethe effectsof the two nonlinearcorrec-
tionson different scatteringgeometrieswhich includesingleand
multiple scatterers.When this is done successfully,we intendto
apply the inversionalgorithmto real seismicreflectiondata.
Sensitivity of Born Inversion to the Choice
of Reference Velocity: A Simple Example
A. B. Weglein, Cities Service; und S. H. Gray,
Amoco Production Research
S13.6
We examine the sensitivity of the Born model to the input
backgroundvelocity. We usea one-dimensionalanalyticexample
to point out the difference between a correctiveprocedureand
merely a perturbativeone. We examine variousaspectsof the
sensitivityissue,includingthetrade-offbetweenvelocitydetermi-
nationand mappingof reflectorlocation. Lnparticular,we show
thatonechoicefor thebackground,orreference,velocityCx leads
to an accuratedeterminationof thelocationof thefirstreflectorbut
an inaccurateestimationof the velocity below that reflector. A
secondchoice for CR can reversethis situation,accuratelyesti-
matingthe velocitybutnot thereflectorlocation.Also, thereis a
rangeof choicesfor C, for whichtheresultsof an inversionmay
actuallyyield lessaccuratevelocityestimatesthantheestimateCR
itself. Althoughthisproblemisdiscussedwithin thecontextof the
Born model, it is an issuecommon to all perturbativemethods
(e.g., migrationmethods)which transformsurfacereflectiondata
into a mapof subsurfacereflectors.
All of the perturbativeapproachesto multidimensionalwave
equationprocessing.for example. wave equationmigration(see,
e.g., Claerbout,1971;French, 1975:Schneider,1978;Stolt, 1978;
Sattleggeret al, 1980), or Born approximationinversion(see,
e.g., Cohenand Bleistein, 1979;Raz, 1981:Clayton and Stolt,
1981) requiresome input velocity information.In the Born ap-
proximationto inversion,a referenceor backgroundvelocity is
chosenanda perturbationaboutthis velocityis determined.Simi-
larly, a velocity model is a requiredinput to all wave equation
migrationtechniques.
The purposeof this paperis to examine the sensitivityof the
Born approximationto this inputinformation.One importantas-
pect of this questionis whetherthe perturbation,asgiven by the
Born inversion, will be of a corrective nature. In this context
correctivemeansthat an improvementof, or correctionto, the
estimatedbackgroundvelocitytakesplaceafterapplyingtheBorn
inversion.Specifically,onewouldlike resultsof theBornapproxi-
mationfor the velocityto be closerto the actualvelocitythanthe
backgroundvelocity is. A secondaspectof thisissueis thetrade-
off betweenvelocitydeterminationandreflectormapping.Thatis,
one would hopethat it would be possibleto determinecorrectly
both the locationof a reflectorand the velocity below that re-
flector. We illustrate,by meansof a simpleexample, thesetwo
aspectsof the sensitivityissue.
Considera I-D acousticmediumwhere the propagationof the
wave field P(z ,r) is governedby:
(1)
wherec(:) is thelocalacousticvelocity. Characterizetheacoustic
velocityc(: ) in termsof a homogeneousreferencevelocityCKand
a variationin the indexof refractionu(z) asfollows:
1
-=$I WZ)].
c*(2)
In equation(2), the numberC, is an input into the model; it is
chosen(or guessed)beforethe inversionis carriedout.
For simplicity, we assumethat an impulsivesourceis usedto
probethemedium,andthatthissourceis locatedat; = 0, within a
half-spacewherethe acousticvelocityhastheconstantvalueC,.
Thus the incident field is given by P,(;,,) = 6(t -z/C,,). The
total field is the sum of the incident field and a scatteredfield
P,(z,t). Under these circumstances,Gray and Bleistein (1980)
showedthat, within the Born approximation,the variationin the
indexof refractiona(:) can beexpressedin termsof thescattered
field PJz ,t) at ; = 0 by
I
nz:r,
a(:) = -4 P,(o,t)c~r.
0
(3)
From equations(2) and (3), the reconstructedvelocity depends
explicitly on the choiceof referencevelocity.
To simplify our examplefurther, we assumethat the medium
consistsof two half-spacesin contact,with acousticvelocitiesC0
andC , andthe interfacebetweenthem locatedat a depthZ0 (see
Figure 1). Thenthereflectedfield returnedto a receiveratz = 0 is
given by
4v(O,r)= = S(t - 2Z,,/C,J.
C, +c,,
For our examplewe set C,, = 1, C, = 917, andZ,, = 1, and find
from equation(4) that
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2. Seismic 13 177
-fz= 0
t +Z
FIG. I. Two half-spaceswith acousticvelocitiesC,, andC
P,(O,f) = * S(1~ 2) = $6(f - 2),
which is independentof the referencevelocity C,<. Now we can
calculatethe Born CX(:)from equation(3):
From this resultandequation(2). it is clear that
(,“(,) = c‘,f_
i
; cc,
v2 c,, : > c,,
The superscriptB indicatesa Born inversion velocity CH(:) =
C,( 1 + (Y)~“’ given by equation(3).
Now we examinetheeffectsofdifferentchoices,or guesses,for
CKon thequalityof the inversion.lf we chooseCK = 1, thenthe
locationof thereflectorwill becorrectlydeterminedbutthecalcu-
lated velocity in the region: > 1 will be too large. On the other
hand, for a different choiceofC,( (i.e.. C,?= 9/7,/? = ,908).
the velocity below the reflector is correctlydeterminedbut the
location of the reflector is incorrect. We see from this simple
exercisethat it is impossibleto simultaneouslyfind the correct
locationandsizeofa singlereflectorin theBornapproximation.It
is alsoimpossibleto simultaneouslypredictthecorrectvelocityin
boththe half-spaces.
Next, we showthatacertainrangeofchoicesfor CHcanleadto
velocityestimatesin the lower layer [via equation(5)] which are
actuallyfurtherfrom the true velocity thanCK is. Thus, a certain
rangeof values for C,! can lead to incersions which are not correc-
tive. Moreover,it istruein generalthat therangeof valuesfor CH
cancontainvaluesvery close to C,, (for this example the range IS
1.065< C,(). In fact, it can be shownthat the closerC, is to C,,
(i.e.. the smallerthe computed(Yis in the secondhalf-space),the
closerthis noncorrectivesetof valuesfor C,, comesto containing
the numberC,,. This is dur to the fact thatthe bdundarybetween
corrective and noncorrectivechoices for referencevelocity lies
betweenC,, andC , This itnpliesthateventhoughthetruevalueof
N canbearbitrarilysmallfor; > C,, , thereconstructedvelocity(,’
can be a less accurateestimate for : >CCKthan the reference
velocityC,<.Thisisa somewhatsurpriarngresult,in thattheamall-
nessof thecyis usuallyusedtojustify the Bornapproximation.In
this sense.the Born inverxionis extremelysensitiveto the choice
of referencevelocity.
Thus, thissimpleexampledemonstrateshow the choiceof ref-
erencevelocityin theBornmethoddependson what isconsidered
theprincipalobjectiveof the inversion.We haveshownthatif the
primaryaim is to determinethe locationof the first reflectorthen
theoptimalreferencevelocityshouldbe chosento be thevelocity
of thefirstlayer. However, we haveshownthatthis isnotthebest
referencevelocity if the principalaim is to determinethe velocity
of thelowerhalfspace.In situationswherethevelocitystructureis
morecomplex,thechoiceof referencevelocitywill againdepend
on the objective of the inversion. If, for example, the velocity
increasesordecreasessteadilywithdepth,thechoiceC,<= C,,will
leadtolessandlessaccuratemappingof reflectorswithdepth(see,
e.g., Claytonand Stolt, 1981).
In conclusion,the sensitivityof Born inversionto the input
quantityCR leads to a trade-off between reflector location and
velocity determinationin the simplest possible example. Further
workwill be requiredtoevaluatemorecomplicatedmodelswhere,
perhaps,globalcorrectivemeasuresshouldbedefined.Thechoice
of a referencevelocityto optimizesomejudiciouscombinationof
velocity determinationand reflector mapping could be useful.
These issuesalso need to be investigatedfor nonconstantback-
groundBorn inversion(seee.g., Clayton and Stolt, 1981;Weg-
lein, 1982).
Explorationistsalreadyhavea qualitativeawarenessof someof
theissuesraisedin thispaperin relationtotheanalogousmigration
methods.This simple example, usingthe Born model, helpsUS
beginto quantifythis understanding.
References
Claerbout, J. F.. 1971, Toward a unified theory of reilector mapping:
Geophysics,v. 36.p, 467-481.
Clayton, R.W., andStolt, R. H., 1981. A Born-WKBJ inversion method
foracousticreflectiondata:Geophysics,v. 46. p. 1559-1567.
Cohen. I. K., and Bleistein, N., 1979, Velocity inversion for acoustw
waves: Geophysics, v. 44, p. 1077-1087.
French. W. S., 1974. Two-dimensional and three-dltnenaional migration
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Gray, S. H., and Bleistein, N., 1980, One-dimensional velocity inwrslon
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Raz. S., 1981, Three-dimensional velocity profile mversmn from tinite
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