The document describes the Comprehensive Primary Care Plus (CPC+) initiative, which aims to strengthen primary care through multi-payer partnerships and alternative payment models. It has three main goals: 1) allow practices to provide more comprehensive care, 2) accommodate practices at different transformation levels, and 3) achieve better care, smarter spending and healthier people. CPC+ will run in up to 20 regions over 5 years, selecting practices to participate in one of two tracks. It emphasizes the importance of aligning Medicare, Medicaid, and commercial payers to support practice transformation.