The Vietnam National Mekong Committee conducted a Mekong Dam Study, the results of which were presented at the Greater Mekong Forum on Water, Food and Energy in Phnom Penh on Oct. 21, 2015. This is part one of their overview presentation.
The Vietnam National Mekong Committee conducted a Mekong Dam Study, the results of which were presented at the Greater Mekong Forum on Water, Food and Energy in Phnom Penh on Oct. 21, 2015. This presentation overviews their Fisheries Impact Assessment.
The Vietnam National Mekong Committee conducted a Mekong Dam Study, the results of which were presented at the Greater Mekong Forum on Water, Food and Energy in Phnom Penh on Oct. 21, 2015. This presentation overviews their Modelling for the study.
This presentation was delivered by Simon Tilleard at the Lancang – Mekong Environmental Study Workshop that took place at the 2016 Greater Mekong Forum on Water, Food and Energy.
The presentation documents the current condition and drivers of change for hydrology and sediment transport in the study section. It also provides information for biodiversity teams so that they can understand habitat availability.
The Vietnam National Mekong Committee conducted a Mekong Dam Study, the results of which were presented at the Greater Mekong Forum on Water, Food and Energy in Phnom Penh on Oct. 21, 2015. This presentation overviews their Fisheries Impact Assessment.
The Vietnam National Mekong Committee conducted a Mekong Dam Study, the results of which were presented at the Greater Mekong Forum on Water, Food and Energy in Phnom Penh on Oct. 21, 2015. This presentation overviews their Modelling for the study.
This presentation was delivered by Simon Tilleard at the Lancang – Mekong Environmental Study Workshop that took place at the 2016 Greater Mekong Forum on Water, Food and Energy.
The presentation documents the current condition and drivers of change for hydrology and sediment transport in the study section. It also provides information for biodiversity teams so that they can understand habitat availability.
Presented by Vladimir Smakhtin at the Ministry of Water Resources, New Delhi, India, November 4, 2014.
The flows of India’s rivers are increasingly being modified by dams and weirs and abstractions for agriculture and urban use. These interventions have caused significant alteration of flow regimes mainly by reducing total flow and affecting its variability and seasonality. An Environmental Flow (EF) is the water regime provided within a river, wetland or coastal zone to maintain ecosystems and their benefits. Environmental Flows describe the quantity, quality and timing of water flows required to sustain freshwater and estuarine ecosystems and the human livelihoods and well-being that depend on these ecosystems. This presentation looks at how the EF approach has been tested in India and describes a project to apply EF methodology to the upper Ganga.
Environmental Flows in the Indian Context - Challenges and Potential Latha Anantha
Presentation made at Workshop held to felicitate Prof Ramaswamy Iyer, New Delhi 25- 27th November 2013, IIC - IHC New Delhi. Gives an overview of the status, potential and implementation challenges of E flows in Indian context
On 17 and 18 June 2020 the EPA held its National Water Event as an online conference.
This year's theme was 'Restoring our waters'.
This years event was free to attend. It was the EPA's largest water event ever, with over 1250 attending.
To everyone who joined us: thanks for attending; thanks for your probing questions; thanks for your passion; thanks for caring about our waters. We can achieve more working together.
Special thanks to all our presenters and the team who worked behind the scenes to make sure this years conference happened.
For science and stories about water quality in Ireland, check out www.catchments.ie
On 17 and 18 June 2020 the EPA held its National Water Event as an online conference.
This year's theme was 'Restoring our waters'.
This years event was free to attend. It was the EPA's largest water event ever, with over 1250 attending.
To everyone who joined us: thanks for attending; thanks for your probing questions; thanks for your passion; thanks for caring about our waters. We can achieve more working together.
Special thanks to all our presenters and the team who worked behind the scenes to make sure this years conference happened.
For science and stories about water quality in Ireland, check out www.catchments.ie
On 17 and 18 June 2020 the EPA held its National Water Event as an online conference.
This year's theme was 'Restoring our waters'.
This years event was free to attend. It was the EPA's largest water event ever, with over 1250 attending.
To everyone who joined us: thanks for attending; thanks for your probing questions; thanks for your passion; thanks for caring about our waters. We can achieve more working together.
Special thanks to all our presenters and the team who worked behind the scenes to make sure this years conference happened.
For science and stories about water quality in Ireland, check out www.catchments.ie
EarthFx presentation on Assessing Cumulative Effects of SAGD Operations in the Mackay Watershed PowerPoint
To learn more visit us at http://www.earthfx.com/
Slide 33 video link https://www.youtube.com/watch?v=q95Zzt029E4
Slide 35 video link https://www.youtube.com/watch?v=v6siBetQgBI
Worldfish, along with the CGIAR Program on Climate Change, Agriculture and Food Security, gave this presentation on the role of fish in enhancing climate resilience of food production in the Lower Mekong Region.
On 17 and 18 June 2020 the EPA held its National Water Event as an online conference.
This year's theme was 'Restoring our waters'.
This years event was free to attend. It was the EPA's largest water event ever, with over 1250 attending.
To everyone who joined us: thanks for attending; thanks for your probing questions; thanks for your passion; thanks for caring about our waters. We can achieve more working together.
Special thanks to all our presenters and the team who worked behind the scenes to make sure this years conference happened.
For science and stories about water quality in Ireland, check out www.catchments.ie
Presented by Vladimir Smakhtin at the Ministry of Water Resources, New Delhi, India, November 4, 2014.
The flows of India’s rivers are increasingly being modified by dams and weirs and abstractions for agriculture and urban use. These interventions have caused significant alteration of flow regimes mainly by reducing total flow and affecting its variability and seasonality. An Environmental Flow (EF) is the water regime provided within a river, wetland or coastal zone to maintain ecosystems and their benefits. Environmental Flows describe the quantity, quality and timing of water flows required to sustain freshwater and estuarine ecosystems and the human livelihoods and well-being that depend on these ecosystems. This presentation looks at how the EF approach has been tested in India and describes a project to apply EF methodology to the upper Ganga.
Environmental Flows in the Indian Context - Challenges and Potential Latha Anantha
Presentation made at Workshop held to felicitate Prof Ramaswamy Iyer, New Delhi 25- 27th November 2013, IIC - IHC New Delhi. Gives an overview of the status, potential and implementation challenges of E flows in Indian context
On 17 and 18 June 2020 the EPA held its National Water Event as an online conference.
This year's theme was 'Restoring our waters'.
This years event was free to attend. It was the EPA's largest water event ever, with over 1250 attending.
To everyone who joined us: thanks for attending; thanks for your probing questions; thanks for your passion; thanks for caring about our waters. We can achieve more working together.
Special thanks to all our presenters and the team who worked behind the scenes to make sure this years conference happened.
For science and stories about water quality in Ireland, check out www.catchments.ie
On 17 and 18 June 2020 the EPA held its National Water Event as an online conference.
This year's theme was 'Restoring our waters'.
This years event was free to attend. It was the EPA's largest water event ever, with over 1250 attending.
To everyone who joined us: thanks for attending; thanks for your probing questions; thanks for your passion; thanks for caring about our waters. We can achieve more working together.
Special thanks to all our presenters and the team who worked behind the scenes to make sure this years conference happened.
For science and stories about water quality in Ireland, check out www.catchments.ie
On 17 and 18 June 2020 the EPA held its National Water Event as an online conference.
This year's theme was 'Restoring our waters'.
This years event was free to attend. It was the EPA's largest water event ever, with over 1250 attending.
To everyone who joined us: thanks for attending; thanks for your probing questions; thanks for your passion; thanks for caring about our waters. We can achieve more working together.
Special thanks to all our presenters and the team who worked behind the scenes to make sure this years conference happened.
For science and stories about water quality in Ireland, check out www.catchments.ie
EarthFx presentation on Assessing Cumulative Effects of SAGD Operations in the Mackay Watershed PowerPoint
To learn more visit us at http://www.earthfx.com/
Slide 33 video link https://www.youtube.com/watch?v=q95Zzt029E4
Slide 35 video link https://www.youtube.com/watch?v=v6siBetQgBI
Worldfish, along with the CGIAR Program on Climate Change, Agriculture and Food Security, gave this presentation on the role of fish in enhancing climate resilience of food production in the Lower Mekong Region.
On 17 and 18 June 2020 the EPA held its National Water Event as an online conference.
This year's theme was 'Restoring our waters'.
This years event was free to attend. It was the EPA's largest water event ever, with over 1250 attending.
To everyone who joined us: thanks for attending; thanks for your probing questions; thanks for your passion; thanks for caring about our waters. We can achieve more working together.
Special thanks to all our presenters and the team who worked behind the scenes to make sure this years conference happened.
For science and stories about water quality in Ireland, check out www.catchments.ie
Trans-disciplinary science to impact tropical forest landscapes - Jeff Sayer, University of British Columbia. Measuring the Impact of Integrated Systems Research (September 27, 2021 – September 30, 2021). Three-day virtual workshop co hosted by the CGIAR Research Programs on Water Land and Ecosystems (WLE); Forests, Trees and Agroforestry (FTA); Policies, Institutions, and Markets (PIM); and SPIA, the Standing Panel on Impact Assessment of the CGIAR. The workshop took stock of existing and new methodological developments of monitoring, evaluation and impact assessment work, and discussed which are suitable to evaluate and assess complex, integrated systems research.
Theory-Based Approaches for Assessing the Impact of Integrated Systems Research - Brian Belcher, Royal Roads University. Measuring the Impact of Integrated Systems Research (September 27, 2021 – September 30, 2021). Three-day virtual workshop co hosted by the CGIAR Research Programs on Water Land and Ecosystems (WLE); Forests, Trees and Agroforestry (FTA); Policies, Institutions, and Markets (PIM); and SPIA, the Standing Panel on Impact Assessment of the CGIAR. The workshop took stock of existing and new methodological developments of monitoring, evaluation and impact assessment work, and discussed which are suitable to evaluate and assess complex, integrated systems research.
Challenges and opportunities for using remote sensing data - Kathy Baylis, University of California, Santa Barbara. Measuring the Impact of Integrated Systems Research (September 27, 2021 – September 30, 2021). Three-day virtual workshop co hosted by the CGIAR Research Programs on Water Land and Ecosystems (WLE); Forests, Trees and Agroforestry (FTA); Policies, Institutions, and Markets (PIM); and SPIA, the Standing Panel on Impact Assessment of the CGIAR. The workshop took stock of existing and new methodological developments of monitoring, evaluation and impact assessment work, and discussed which are suitable to evaluate and assess complex, integrated systems research.
Reviewing the evidence on implementation and long-term impact of integrated landscape approaches - James Reed, CIFOR. Measuring the Impact of Integrated Systems Research (September 27, 2021 – September 30, 2021). Three-day virtual workshop co hosted by the CGIAR Research Programs on Water Land and Ecosystems (WLE); Forests, Trees and Agroforestry (FTA); Policies, Institutions, and Markets (PIM); and SPIA, the Standing Panel on Impact Assessment of the CGIAR. The workshop took stock of existing and new methodological developments of monitoring, evaluation and impact assessment work, and discussed which are suitable to evaluate and assess complex, integrated systems research.
Some musings on evaluating the impacts of integrated systems research - Karl Hughes, PIM. Measuring the Impact of Integrated Systems Research (September 27, 2021 – September 30, 2021). Three-day virtual workshop co hosted by the CGIAR Research Programs on Water Land and Ecosystems (WLE); Forests, Trees and Agroforestry (FTA); Policies, Institutions, and Markets (PIM); and SPIA, the Standing Panel on Impact Assessment of the CGIAR. The workshop took stock of existing and new methodological developments of monitoring, evaluation and impact assessment work, and discussed which are suitable to evaluate and assess complex, integrated systems research.
What makes impact research challenging? What have been done so far? Results from CGIAR research - Natalia Estrada Carmona. Measuring the Impact of Integrated Systems Research (September 27, 2021 – September 30, 2021). Three-day virtual workshop co hosted by the CGIAR Research Programs on Water Land and Ecosystems (WLE); Forests, Trees and Agroforestry (FTA); Policies, Institutions, and Markets (PIM); and SPIA, the Standing Panel on Impact Assessment of the CGIAR. The workshop took stock of existing and new methodological developments of monitoring, evaluation and impact assessment work, and discussed which are suitable to evaluate and assess complex, integrated systems research.
Use of Qualitative Approaches for Impact Assessments of Integrated Systems Research: Our Experience - Monica Biradavolu, SPIA. Measuring the Impact of Integrated Systems Research (September 27, 2021 – September 30, 2021). Three-day virtual workshop co hosted by the CGIAR Research Programs on Water Land and Ecosystems (WLE); Forests, Trees and Agroforestry (FTA); Policies, Institutions, and Markets (PIM); and SPIA, the Standing Panel on Impact Assessment of the CGIAR. The workshop took stock of existing and new methodological developments of monitoring, evaluation and impact assessment work, and discussed which are suitable to evaluate and assess complex, integrated systems research.
FTA’s experience in measuring impacts of research on integrated systems - Vincent Gitz, FTA. Measuring the Impact of Integrated Systems Research (September 27, 2021 – September 30, 2021). Three-day virtual workshop co hosted by the CGIAR Research Programs on Water Land and Ecosystems (WLE); Forests, Trees and Agroforestry (FTA); Policies, Institutions, and Markets (PIM); and SPIA, the Standing Panel on Impact Assessment of the CGIAR. The workshop took stock of existing and new methodological developments of monitoring, evaluation and impact assessment work, and discussed which are suitable to evaluate and assess complex, integrated systems research.
Measuring the impact of integrated systems research
Panel Speakers: Vincent Gitz, Natalia Estrada Estrada Carmona, Monica Biradavolu and Karl Hughes. Measuring the Impact of Integrated Systems Research (September 27, 2021 – September 30, 2021). Three-day virtual workshop co hosted by the CGIAR Research Programs on Water Land and Ecosystems (WLE); Forests, Trees and Agroforestry (FTA); Policies, Institutions, and Markets (PIM); and SPIA, the Standing Panel on Impact Assessment of the CGIAR. The workshop took stock of existing and new methodological developments of monitoring, evaluation and impact assessment work, and discussed which are suitable to evaluate and assess complex, integrated systems research.
Why does OneCGIAR need Integrated Systems Research? - Holger Meinke, University of Tasmania & ISDC. Measuring the Impact of Integrated Systems Research (September 27, 2021 – September 30, 2021). Three-day virtual workshop co hosted by the CGIAR Research Programs on Water Land and Ecosystems (WLE); Forests, Trees and Agroforestry (FTA); Policies, Institutions, and Markets (PIM); and SPIA, the Standing Panel on Impact Assessment of the CGIAR. The workshop took stock of existing and new methodological developments of monitoring, evaluation and impact assessment work, and discussed which are suitable to evaluate and assess complex, integrated systems research.
Agronomic advances for understanding soil health
By Job Kihara, Agronomist, Alliance of Bioversity International and CIAT
Innovations in soil health monitoring for nature and people
From Research to Resilience
WLE webinar series
October 28, 2021
Innovations in Soil Health Monitoring: Combining Systematic Field Assessments with Spectroscopy and Earth Observation
By Leigh Ann Winowiecki, WLE/CIFOR-ICRAF
Innovations in soil health monitoring for nature and people
From Research to Resilience
WLE webinar series
October 28, 2021
By Padmaja Ravula
Senior Scientist – Sociologist, Gender and Nutrition Research
Global Research Program: Enabling Systems Transformation Cluster: Gender and Youth
Securing inclusive land restoration
From Research to Resilience
WLE webinar series
October 25, 2021
By Ermias Betemariam, Land Health Scientist, World Agroforestry (ICRAF)
Securing inclusive land restoration
From Research to Resilience
WLE webinar series
October 25, 2021
By Deepa Joshi, Gender, Youth and Inclusion Lead, WLE (IWMI)
Securing inclusive land restoration
From Research to Resilience
WLE webinar series
October 25, 2021
By Fabrice DeClerck, Science Director, EAT Forum & Senior Scientist, Alliance of Bioversity International and CIAT
Boosting synergies and managing trade-offs in food systems
From Research to Resilience
WLE webinar series
October 21, 2021
Sustainable management of commons to boost synergies: A case study on India
By Wei Zhang, Senior Research Fellow, International Food Policy Research Institute
Boosting synergies and managing trade-offs in food systems
From Research to Resilience
WLE webinar series
October 21, 2021
Building climate resilience across scales
participatory – farmer-led – community action
By Sander Zwart, IWMI
Managing water for climate adaptation and mitigation
From Research to Resilience
WLE webinar series
October 19, 2021
Lessons learnt towards building pathways for innovation: India
By Apoorve Khandelwal, CEEW India
Innovation investment for impact
From Research to Resilience
WLE webinar series
October 14, 2021
Mining the Gaps: Mapping The Research on Small Farms in the Global South
By Jaron Porciello, Cornell University
Innovation investment for impact
From Research to Resilience
WLE webinar series
October 14, 2021
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
The increased availability of biomedical data, particularly in the public domain, offers the opportunity to better understand human health and to develop effective therapeutics for a wide range of unmet medical needs. However, data scientists remain stymied by the fact that data remain hard to find and to productively reuse because data and their metadata i) are wholly inaccessible, ii) are in non-standard or incompatible representations, iii) do not conform to community standards, and iv) have unclear or highly restricted terms and conditions that preclude legitimate reuse. These limitations require a rethink on data can be made machine and AI-ready - the key motivation behind the FAIR Guiding Principles. Concurrently, while recent efforts have explored the use of deep learning to fuse disparate data into predictive models for a wide range of biomedical applications, these models often fail even when the correct answer is already known, and fail to explain individual predictions in terms that data scientists can appreciate. These limitations suggest that new methods to produce practical artificial intelligence are still needed.
In this talk, I will discuss our work in (1) building an integrative knowledge infrastructure to prepare FAIR and "AI-ready" data and services along with (2) neurosymbolic AI methods to improve the quality of predictions and to generate plausible explanations. Attention is given to standards, platforms, and methods to wrangle knowledge into simple, but effective semantic and latent representations, and to make these available into standards-compliant and discoverable interfaces that can be used in model building, validation, and explanation. Our work, and those of others in the field, creates a baseline for building trustworthy and easy to deploy AI models in biomedicine.
Bio
Dr. Michel Dumontier is the Distinguished Professor of Data Science at Maastricht University, founder and executive director of the Institute of Data Science, and co-founder of the FAIR (Findable, Accessible, Interoperable and Reusable) data principles. His research explores socio-technological approaches for responsible discovery science, which includes collaborative multi-modal knowledge graphs, privacy-preserving distributed data mining, and AI methods for drug discovery and personalized medicine. His work is supported through the Dutch National Research Agenda, the Netherlands Organisation for Scientific Research, Horizon Europe, the European Open Science Cloud, the US National Institutes of Health, and a Marie-Curie Innovative Training Network. He is the editor-in-chief for the journal Data Science and is internationally recognized for his contributions in bioinformatics, biomedical informatics, and semantic technologies including ontologies and linked data.
1. Study of the Impacts of Mainstream Hydropower on the Mekong Delta
MDS Impact Assessment Framework, Approach, and Results Overview
Greater Mekong Forum on Water, Food and Energy
Phnom Penh, Cambodia
October 2015
2. Study of the Impacts of Mainstream Hydropower on the Mekong Delta
Outline
Project overview
Study area
Impact assessment
– Objectives
– Approach
Baseline data
Historical data
Research studies
Data issues
Impact assessment results overview
3. Study of the Impacts of Mainstream Hydropower on the Mekong Delta
Project objectives and study area
MDS Evaluation Area MDS Impact Assessment Area IAA Sub-divisions
To assess the overall impacts of the proposed LMB mainstream
hydropower cascade on the natural, social, and economic systems of
Cambodian and Vietnamese floodplains.
4. Study of the Impacts of Mainstream Hydropower on the Mekong Delta
Cambodian Floodplains Kratie to Phnom Penh (includes
the Great Lake - Tonle Sap System
(approx 5,690,683 hectares)
Cambodian Delta Phnom Penh to Vietnamese
Border (approx 930,811 hectares)
Vietnamese Delta Vietnamese border to East Sea
(approx 3,926,565 hectares)
The IAA covers approx 10.5 M hectares
Includes Ecozones 4, 5, and 6
5. Study of the Impacts of Mainstream Hydropower on the Mekong Delta
13 provinces in Viet Nam
– 128 Districts, 1,589 Communes
14 provinces in Cambodia
– 121 Districts, 1,057 Communes
The IAA includes 27 provinces
6. Study of the Impacts of Mainstream Hydropower on the Mekong Delta
Impact assessment was focused on areas that are
hydrologically connected to the Mekong River
mainstream
Flooded area duration map (7 days_10 cm)
Hydrological connection =
inundation potential
Flooding defined as:
– 10 cm inundation over 7 days
Using this definition the year 2000
flood would have inundated
approx. 40,955 km2 within the IAA
– About 40% is in the Vietnamese delta
(15,970 Km2)
7. Study of the Impacts of Mainstream Hydropower on the Mekong Delta
Drivers and receptors
Key drivers of change: Flow regime, sediment
loading, water quality,
longitudinal connectivity
(barrier effects)
Potential impacts on:
– Natural systems Biological habitats, biodiversity
– Social systems Livelihood
– Economic sectors Fisheries, Agriculture, Navigation
8. Study of the Impacts of Mainstream Hydropower on the Mekong Delta
Linkages between drivers and resources are complex, dynamic,
and multifaceted and include multiple feedback loops.
9. Study of the Impacts of Mainstream Hydropower on the Mekong Delta
Linkages between direct and indirect impacts are mediated by
multiple bio-physical and social factors.
10. Study of the Impacts of Mainstream Hydropower on the Mekong Delta
Net impacts will be influenced by the macro-level feedback loops
between institutional, natural, social, and economic systems.
11. Study of the Impacts of Mainstream Hydropower on the Mekong Delta
Evaluate and quantify (where permitted by data availability and
quality) direct and indirect impacts of:
– Changes in flow regime, sediment loading, and water quality on
– Extent of wetlands, biodiversity, fisheries, agriculture, navigation,
livelihood, and economic impacts
– Impacts to aquatic species due to barrier effects were also evaluated
Alternative operational strategies were considered (dry year-dry
season and dry year-wet season drawdowns)
Positive and negative and short- and long-term impacts
Impact assessment approach
12. Study of the Impacts of Mainstream Hydropower on the Mekong Delta
Impacts were cumulatively assessed across geographic areas:
– Cambodian floodplains
– The Great Lake – Tonle Sap System
– Vietnamese Delta
– Provinces and districts (livelihood, agriculture, and economic impacts
only)
Where relevant, impacts were cumulatively assessed across
sectors
Impact assessment approach
Sectors Fisheries Biodiversi
ty Agriculture Navigation Livelihood Economics
Fisheries X X X X
Biodiversity X X X
Agriculture X X X X
Navigation X X X
Livelihood X X X X
Economics X X X X X
13. Study of the Impacts of Mainstream Hydropower on the Mekong Delta
Extremely large study area with very complex ecosystem
characteristics
– influenced the resolution of the analyses
Lack of existing scientific tools/knowledgebase
– No suitable off-the-shelf tool were available to correlate changes in
sediment and nutrient loading to potential changes in biodiversity and
fisheries yields
Vietnamese Delta is highly altered
– influenced outcome of the agriculture and aquaculture impact
assessments
Data issues
– Influenced level of quantification of impacts
Impact assessment challenges
14. Study of the Impacts of Mainstream Hydropower on the Mekong Delta
Quantity
– Available collected at disparate locations, at different times, using varying
methodologies, for different purposes
Quality
– Lack of raw data, little or no information on analytical and QA/QC procedures
Accessibility
– Many different institutions collect data for different purposes
– hard copy v/s electronic
Period of record
– Varying data collection periods and frequency
– Some data is simply too old
Critical gaps
– Focused research studies to fill the gaps
Data issues
15. Study of the Impacts of Mainstream Hydropower on the Mekong Delta
Biodiversity
– Field Surveys within selected land cover types (5 sites, 3 seasons)
– Characterization of water management practices within selected
national parks and wetland reserves
– Wetlands map update
Fishery
– Habitat-based fish sampling surveys (39 sites, 6 sampling events)
– Fish yield sampling surveys
– Fisher surveys.
– Aquaculture production assessment
Livelihood
– Household surveys
– 2,520 households in Vietnam
– 720 households in Cambodia
Research studies
16. Study of the Impacts of Mainstream Hydropower on the Mekong Delta
Sediment
– Quantification of sediment loads under dry and wet weather conditions
– Data collected in Laos PDR, Cambodia and Vietnam
– Compare to the 2011 – 2013 DSMP data
Water Quality
– Nutrient transport associated with sediment transport
– Nutrient dynamics related to the transport and deposition/re-
suspension of sediments
Navigation
– Data on key navigation parameters is being collected through
questionnaire interviews at 14 sites in Vietnam and 5 sites in Cambodia
Research studies
17. Study of the Impacts of Mainstream Hydropower on the Mekong Delta
Hydro-meteorological conditions for the 1985–2013 period of
record
– includes extreme years (very wet [2000 and 2011] and very dry [ 1998])
and average years [represented by 2007])
– hydrologically representative of the conditions likely to occur in the LMB
in future
Salinity in the Delta (2007-2013)
Sediment transport, nutrient transport (2009-2013)
Environmental, social and economic conditions – 2011 to 2012
(supplemented by data collected during 2014)
Baseline conditions
18. Study of the Impacts of Mainstream Hydropower on the Mekong Delta
Scenario 1 – Mainstream hydropower cascade
Scenario 2 – Mainstream hydropower cascade plus tributary
dams
Scenario 3 – Mainstream hydropower cascade plus water
diversions
Hydropower development scenarios