This document summarizes the health benefits of vitamins B9, B12, and B6. It states that these vitamins contribute to cell multiplication and division, synthesis of amino acids, and reducing the risk of neural tube defects and cardiovascular disease. It also lists several studies that show relationships between these vitamins and reducing homocysteine levels and cardiovascular risks.

2. Especialmente diseñado
a mujeres embarazadas
y mayores de 50 años
Alto contenido de
ácido fólico,
vitaminas B6 y B12
Elsa Campo Gómez.
Sandra Campos Fdez.
Raquel Martínez Díaz.
María Odriozola López.

3. EFECTOS SALUDABLES ESTUDIOS
Contribuye a la multiplicación y
división celular celular y a síntesis de • Homocysteine and vitamins in
Vitamina B9 los aa. cardiovascular disease
Prevenir defectos del tubo neuronal. http://www.clinchem.org/content/44/8/1833.full.
Reducir el riesgo de ECV.
• Coagulation parameters and plasma
Contribuye al metabolismo de la total homocysteine levels in
Vitamina B12 homocisteina. Behcet'sdisease.
http://www.sciencedirect.com/science/article/pii/S00493848020
Contibuye al metabolismo de la 00853
homocisteina.
Vitamina B6 Función inmune, y ↓ [ ] plasmáticas • DACH-LIGA homocystein (german,
se asocian con enfermedades del austrian and swiss homocysteine
corazón. society): consensus paper on the
Ayuda a mantener los niveles de rational clinical use of homocysteine,
homocisteina en sangre.
folic acid and B-vitamins in
Vitamina B9 , B12 y B6
Están implicados en la sintesis de cardiovascular and thrombotic
neurotransmisores. diseases: guidelines and
recommendations.
http://www.ncbi.nlm.nih.gov/pubmed/14656016
Los niveles de homocisteina en sangre
ayudan a las propiedades innatas del
alimento.
Vit B1:Colabora con la Vit E : Posee función antioxidante
actividad del corazón y el
SCV. Fibra: Entre otras funciones ayuda a que previene las ECV.
↓ el nivel de colesterol en sangre,
por tanto ↓ el riesgo de ECV.

4. ESTUDIOS
• Homocysteine and vitamins in
cardiovascular disease
http://www.clinchem.org/content/44/8/1833.full.
• Coagulation parameters and plasma
total homocysteine levels in
Behcet'sdisease.
http://www.sciencedirect.com/science/article/pii/S00493848020
00853
• DACH-LIGA homocystein (german,
austrian and swiss homocysteine
society): consensus paper on the
rational clinical use of homocysteine,
folic acid and B-vitamins in
cardiovascular and thrombotic
diseases: guidelines and
recommendations.
http://www.ncbi.nlm.nih.gov/pubmed/14656016
Vit B1:Colabora con la
actividad del corazón y el
SCV.

5. ESTUDIOS
• Reduction of plasma
homocysteine and serum
methylmalonate concentrations
in apparently healthy elderly
subjects after treatment with
folic acid, vitamin B12 and
vitamin B6: a randomised trial.
http://www.ncbi.nlm.nih.gov/pubmed/14576756
• Homocysteine, folic acid and B12
serum levels in pregnancy
complicated with preeclampsia.
http://link.springer.com/article/10.1007%2Fs00404
-006-0223-2?LI=true
• Breakfast cereal fortified with folic
acid, vitamin B-6, and vitamin B-12
increases vitamin concentrations
and reduces homocysteine
concentrations: a randomized trial.
http://ajcn.nutrition.org/content/79/5/805.short
Vit B6 poco afectada
Vit B12 tiene efecto negativo.
FIBRA
Ác. Fólico muy variable

6. ESTUDIOS
• Reduction of plasma
homocysteine and serum
methylmalonate concentrations
in apparently healthy elderly
subjects after treatment with
folic acid, vitamin B12 and
vitamin B6: a randomised trial.
http://www.ncbi.nlm.nih.gov/pubmed/14576756
• Homocysteine, folic acid and B12
serum levels in pregnancy
complicated with preeclampsia.
http://link.springer.com/article/10.1007%2Fs00404
-006-0223-2?LI=true
• Breakfast cereal fortified with folic
acid, vitamin B-6, and vitamin B-12
increases vitamin concentrations
and reduces homocysteine
concentrations: a randomized trial.
http://ajcn.nutrition.org/content/79/5/805.short

7. BIBLIOGRAFÍA
 UE. Reglamento 1169/2011 de DEL PARLAMENTO EUROPEO Y DEL CONSEJO de 25 octubre de 2011, Diario Oficial
de la Unión Europea, de 22 de noviembre de 2011. p. L 304/61.
 UE. Reglamento No 1924/2006 DEL PARLAMENTO EUROPEO Y DEL CONSEJO de 20 de diciembre de 2006. Diario
Oficial de la Unión Europea, de 30 de diciembre de 2006. p. L 404/25.
 SORIANO DEL CASTILLO, J.M. Nutrición básica humana. Ed Universidad de Valencia, 2006.
 JACOBSEN, D.W. et al. Homocysteine and vitamins in cardiovascular disease. Clinical Chemistry, Agosto
1998; Vol. 44, nº 8, pp 1833-1843. Disponible en internet: [http://www.clinchem.org/content/44/8/1833]
 JONG LEE, Y. et al. Coagulation parameters and plasma total homocysteine levels in Behcet's disease. Thrombosis
Research, Abril 2002 Vol. 106, Issue 1, pp 19-24 . Disponible en internet:
[http://www.sciencedirect.com/science/article/pii/S0049384802000853]
 STANGER, O. et al. DACH-LIGA homocystein (german, austrian and swiss homocysteine society): consensus paper
on the rational clinical use of homocysteine, folic acid and B-vitamins in cardiovascular and thrombotic diseases:
guidelines and recommendations. Clinical chemistry and laboratory medicine. Enero 2004, Vol. 42, Issue 1, pp
113-6. Disponible en internet: [http://www.ncbi.nlm.nih.gov/pubmed/14656016]
 LEWERIN, C. et al. Reduction of plasma homocysteine and serum methylmalonate concentrations in apparently
healthy elderly subjects after treatment with folic acid, vitamin B12 and vitamin B6: a randomised trial. European
Journal of Clinical Nutrition. 2003. Vol. 57, pp 1426–1436. Disponible en internet:
[http://www.ncbi.nlm.nih.gov/pubmed/14576756]
 MAKEDOS, G. et al. Homocysteine, folic acid and B12 serum levels in pregnancy complicated with preeclampsia.
Archives of Gynecology and Obstetrics. Febrero 2007, Vol. 275, Issue 2, pp 121-124. Disponible en internet:
[http://link.springer.com/article/10.1007%2Fs00404-006-0223-2?LI=true]
 TUCKER, K.L. et al. Breakfast cereal fortified with folic acid, vitamin B-6, and vitamin B-12 increases vitamin
concentrations and reduces homocysteine concentrations: a randomized trial. American Society for Clinical
Nutrition. Mayo 2004. Vol. 79 no. 5, pp 805-811. Disponible en internet:
[http://ajcn.nutrition.org/content/79/5/805.short]