2. Vitamin K2 puts calcium in
balance, supporting strong
bones and a healthy
cardiovascular system
2
3. ▪ Vitamin K2 is an essential fat-soluble vitamin
that actives proteins transporting calcium
▪ It plays an important role in the prevention of
cardiovascular diseases (CVD) such as
coronary heart disease (CHD) which is the major
cause of mortality worldwide
▪ Vitamin K2 is also essential for bone density,
and also on physical activity
▪ Vitamin K2 MK-7 is the most scientifically
studied form of K2 with clearly proven health
benefits. It has the longest half-life and is more
effective than other forms of vitamin K2, e.g.
MK-4*
▪ In most cases it needs to be supplemented as
diets today do not provide consumers with
enough vitamin K2
3
▪ Consumers of all ages and life-styles can benefit
from vitamin K2 with children, adults and sports
people and benefiting the most
▪ A healthy bone development is crucial for children
to reach their full potential
▪ The number of persons aged 60 years or over
will more than double in the next 30 years,
reaching more than 2 billion people in 2050.
Elderly people want to retain their mobility in
order to lead an active and independent life
▪ Consumers are very concerned about heart
health (~ 45%) as well as about staying fit and
active
▪ The number of products launches with vitamin K2
has increased by more than 50% since 2017
(North America)
▪ BASF offers a comprehensive and
complementary portfolio of health
ingredients for cardiovascular support and
bone & muscle support
▪ BASF owned microencapsulation
technology protects the sensible nutrient
from degradation in challenging dosages
(e.g. calcium, magnesium, or other minerals)
▪ To ensure maximum manufacturing flexibility,
BASF offers vitamin K2 MK-7 in powder and
liquid form
▪ Both products are free from allergens such
as soy and gluten and GMO
▪ European production ensures highest
quality standards
Vitamin K2 Menaquinone 7 (MK-7) – the underestimated nutrient for a
healthy and active life
B
A
D
Ω
K
E
* Sato T et al, 2012; Takeuchi A et al, 2005
Sources: WHO; Health Focus international, Mintel; w ww.aarp.com; Euromonitor 2015; AYTM 2018, Innova Market Insights 2018
4. Vitamin K2 is essential for a healthybone development,
impacting growth and reducing the risk of fractures.
4
Strong bones and a healthy heart are essential for consumers in all
stages of life – Vitamin K2 plays an important part here
Clinical studies demonstrate that vitamin K2 has an important role in
maintaining healthybone mass and a healthycoagulation system.
By maintaining functionality of arteries and stable bones, vitamin K2
reducesthe risk of strokes, osteoporosis and other serious NCDs.
Source: Based on health claims US
5. The most effective – and scarcest – form of vitamin K2 to ensure
these health benefits is the long-chain Menaquinone-7 or MK-7
5
Benefits of MK-7 compared to Vitamin K2 MK-4:
◼ Higher and more stable blood levels
◼ Very long half-life (up to 3 days vs. few hours)
◼ Better availability in blood for bones and blood vessels
◼ More complete carboxylation of osteocalcin in bones
45 µg MK-7
has more
effect than
420 - 500 µg
MK-4
6-fold better
availability
in blood
Carboxylation
rate of MK-7
is 4 times
higher than
with MK-4
Dietary sources and RDI:
◼ Natto (>900µg/100g) and hard cheeses such as Emmental (20-
65µg/100g) are the only relevant sources.
◼ To date, there is no official RDI. However, scientific evidence suggests
recommending a daily long-term DS intake of 100µg – 375µg.
Source: Schurgers LJ et al, 2007
6. Calcium
moves
into bones
Vitamin K2 MK-7 Vitamin K2 MK-7
Carboxylated
Osteocalcin
Carboxylated
Osteocalcin
Bone
cells
▪ Vitamin D is required for the production of
osteocalcin, a protein found in bones.
▪ Vitamin K2 MK-7 activates osteocalcin, which then
takes up calcium from the blood supply and binds it
into the bone matrix.
▪ Low vitamin K2 MK-7 levels lead to low bone matrix
density and increase the risk of soft bones, bending,
fractures and osteoporosis.
▪ High vitamin K2 MK-7 levels increase bone matrix
density and make bones harder and more stable.
6
Calcium
moves
into bones
Bone matrix
density
Bone matrix
density
In combination with vitamin D, vitamin K2 MK-7 transports calcium
into bones making them harder and stronger
Source: ???
7. Vascular smooth
muscle cells in
arterial walls
7
Carboxylated
matrix Gla protein
Calcium
moves back
to blood
Smoothness
of arterial
walls
Carboxylated
matrix Gla protein
Calcium
moves back
to blood
Smoothness
of arterial
walls
Vitamin K2 MK-7 removes calcium from arterial walls making the
blood vessels softer
Vitamin K2 MK-7 ▪ Vitamin K2 MK-7 activates the matrix GLA protein in
blood vessels. The protein then binds calcium in
blood cells and transports it back into the blood
stream.
▪ Low vitamin K2 MK-7 levels lead to calcium deposits
in arterial walls. This causes stiffening of arterial
walls, impairing cardiovascular function and
increasing the risks of blood clots, lung embolism,
heart attacks and strokes.
▪ High vitamin K2 MK-7 levels make /keep arterial
walls smooth and help safeguard optimum
cardiovascular function.
Vitamin K2 MK-7
Source: ???
8. 8
Benefit from the highest quality standards of vitamin K2 MK-7 in
powder and liquid form!
Liquid
Dry Vitamin K2 1.0% GFP
• Cold water dispersible
• At least 24 months shelf-life @25°C
• Packaging: 3x1kg
Vitamin K2 5% in MCT Oil
• In MCT oil (coconut)
• At least 36 months shelf-life @25°C
• Packaging: 1 kg
GMO
Powder
- All product are classified:
No allergens1
No gluten2
No GMO3
1
No labelling requirementswith regard to allergensaccording EU Regulation(EC) No 1169/2011 (asamended) andthe US Food All ergen Labelingand Consumer ProtectionAct (FALCPA)
2
No ingredentsused containinggluten.However, productsare not explicitely tested on gluten.
3 No labelling requirementswith regard to GMO accordingEU Regulations(EC) No 1829/2003and 1830/2003
9. 9
The BASF micro-encapsulation technology protects the fat-soluble
vitamin K2 MK-7 from degrading
▪ „Internal“technology benchmarking- Vitamin K2 MK-7 beadlet
powder(s) are significantly more stable compared to a traditional
spray dried K2 powder
▪ Bulk product benchmarking - Encapsulated synthetic vitamin K2
MK-7 is more stable in contact with minerals, while fermented K2
powder degrades by 40% within 12 months (see figure).
100 100 99
96
100
85
72
60
START 1 MONTH 3 MONTHS 12 MONTHS
Stability of vitamin K2 MK-7 with
calcium carbonate stored at 25°C
BASF synthetic encapsulated Fermented powder
Dry Vitamin K2 1.0% GFP is produced with the established
BASF beadletpowder technology (used for other sensible
vitamins such as A and D3 since decades) to safeguard sufficient
protection of K2
Source: Synthetica AS 2018, BASF Human Nutrition 2018
10. 10
BASF vitamin K2 MK-7 offers you a broad global launch spectrum as
they are widely approved for use in food supplements and sports
nutrition
Possible in DS but not sports
nutrition
Not possible
Canada: not possible in fortified foods
Australia & NZ: Menaquinone is not
listed in Standards Code and therefore
not permitted in food stuffs/ sports
nutrition
Japan: Only approved as MK-4
Pending
China: Only fermented products approved
! Novel food approval in progress for
synthetic MK-7 (no BASF application)
Possible in DS and sports
nutrition
Source: BASF Human Nutrition
11. One-stop shop
BASF offers an extensive portfolio of health ingredients
(such as vitamin D3 and K1) for cardio & bone health
Get everything you need from us!
Free from …
BASF Vitamin K2 MK-7 is gluten,
dairy and allergen free
Flexibility
BASF Vitamin K2 MK-7 is suitable for
numerous dietary supplement and
functional nutrition solutions
Purity
BASF Vitamin K2 MK-7 is characterized
by highest purity standards
Get everything you need for your new cardio and bone health
products in one go: now also Vitamin K2 MK-7 in its best form!
✓
Vegan
BASF Vitamin K2 MK-7 is vegan
Outstanding stability
The BASF beadlet microencapsulation
technology offers unique stability even in
challenging environments (minerals)
11
Proven effectiveness
Science proves the effectiveness of
Vitamin K2 MK-7 for bone health and
cardiovascularsupport
12.
13. Vitamin K1 and K2 are complementary, while K2 is the preferred
choice for products addressing bone and heart health
Vitamin K1
(Phylloquinone)
Vitamin K2
(Menaquinone)
Essential to safeguard a functioning blood coagulation
system.
Prevents excessive bleedings and promotes wound
healing.
Very high availability in green leafy vegetables.
Activates proteins in bones and blood vessels that bind
calcium. Makes bones harder, makes blood vessels softer.
MK-7 is the most scientifically studied K2 with clearly
proven health benefits. It has the longest half-life and is
more effective than other forms of K2, e.g. MK-4.
There are only few dietary sources for MK-7, best of which
are hard cheeses and fermented soybeans.
13
14. 14
In combination with other nutrients, MK-7 is beneficial for consumers
of all ages, life-stages and gender
Infants Children & Teens Adults Seniors
Vitamin K2 MK-7
Vitamin D3
Vitamin K1
Omega-3
Vitamin A
Vitamin E
Nutrients in the
BASF Portfolio
15. 15
Pictogram Code
Bone and joint health Builds bone mass / increases bone density
Metabolic support
Eye health retinol, preventing night blindness
Child growth / development Preventing stunting
Brain development and memory Developing and maintaining brain health
Immunity support Strengthens immune system
Cardiovascular support
Mental health and well-being Influencing mood and potentially preventing depression
Skin health Slowing down aging and improving regeneration of damaged skin
Blood coagulation system Activation of blood clotting factors
