Preliminary research conclusions on improving bone health with the additional effects by introducing radicals like Vitamin D and K within the human foodchain

1. Haim R. Branisteanu
12 Gotlieb Street Tel Aviv 03-523-2744 e-mail haimbranisteanu@gmail.com
Vitamin K and D and their interactions January 19 2016 Page 1 of 5
Summary of January 19, 2016
Discussing the issue of Vitamin D and Vitamin K
Vitamin K works in conjunction with D to improve bone health. There are 2+
types of K (K1 & K2) and 2+ types of D (D2 & D3). K is found also in dark leafy
green vegetables and also it is contained in chicken or cow manure.
Discussing the issue of the of Vitamin D and Vitamin K, refers to several different forms of
those vitamins, which combination is substantially improving skeleton bone health and it
is missing from our diets for the simple reason that a big part of the consumed meat and
other farm products is grown in shades, away from sunshine and the specific light
wavelength that generates Vitamin D in the skin. The net result is Vitamin D deficiencies,
growing demand for expensive anti-osteoporosis medication including synthetic Vitamin
D, easily broken bones at advanced age and the elderly with long hospitalization time
expenses and suffering.
Introducing my concept in chicken cops, cattle barns etc., will increase the content of
Vitamin D in the produce from farm animal husbandry, (chicken eggs to meat) but there
again is the formality of controlled prices and no farmer will invest a penny without
reward that covers his investment plus some benefits.
Please take notice that (http://lpi.oregonstate.edu/mic/vitamins/vitamin-K ) the Vitamins
D and K are actually not vitamins but so called “radicals”. Vitamin D transports
calcium to the bones and through a complex metabolism process with Vitamin K cement
the calcium in the bone structure, resulting over time in stronger bones within the human
skeleton (based on new evolving research - Vitamin K deficiency may impair
the activity of VKDPs and increase the risk of osteoporosis and fractures).
Vitamin K is the essential cofactor for the carboxylation of glutamic acid residues in
many vitamin K-dependent proteins (VKDPs) are involved in blood coagulation, bone
metabolism, prevention of vessel mineralization, and regulation of various cellular
functions. The adequate intake level for vitamin K is set at 90 μg/day for women and 120
μg/day for men.
An important issue to remember is, that a German funded research, found that chicken
eggs or cooking of chicken meat rich in Vitamin D does not remove the
vitamin from the cooked chicken flesh, and I assume other farm products derived
from farm animals rich in vitamin D. Therefore supply of food rich in Vitamin D is
beneficial and not everything can be solved with “correct diet” or exercise.
Study Shows Early Promise Vitamin K2 Can Prevent GC-Induced Bone Loss –
Robust inhibition of glucocorticoid (GC) on angiogenesis has been illustrated both in vitro
and in vivo, as well as decreased bone formation and increased bone resorption.
Furthermore, GC administration has been attributed to the most common cause of
atraumatic osteonecrosis of the femoral head and secondary osteoporosis. Therefore there
is a need, of a combination of Vitamin D and K to achieve the necessary results.

2. Haim R. Branisteanu
12 Gotlieb Street Tel Aviv 03-523-2744 e-mail haimbranisteanu@gmail.com
Vitamin K and D and their interactions January 19 2016 Page 2 of 5
To implement the above, problems will arise, and I anticipate the main issue, would be
transfer of funds from the Ministry of Health to the Ministry of Agriculture in an orderly
and strictly supervised fashion to improve substantially of the public health.
Vitamin K may improve bone health, according to a 2001 research review published in
Nutrition. Sizing up the available data on vitamin K and bone health, the review's authors
found that vitamin K can increase bone mineral density and reduce fracture rates in
people with osteoporosis. The authors note that vitamin K may be particularly effective
when combined with vitamin D, a nutrient known to play a critical role in bone
metabolism. Preliminary findings from animal-based studies indicate that vitamin K may
protect against atherosclerosis (hardening of the arteries). However, in a 2008 report from
Current Opinion in Lipidology, scientists caution that human-based research
on vitamin K1 and heart disease has yielded mixed results.
Chickens legs are the generators of D in chickens and synthesis by modified duckweed that
emphasis absorption of vitamin K between other in chicken manure lagoon or cow manure
lagoon and added to the animal diets or administered with my other BWW (threated bark
and woody waste) product can be a winning solution. (I discussed this in my proposed
project at the time but with cow manure)
2. Vitamin K2 Protects Your Heart
Vitamin K2 helps to prevent hardening of the arteries, which is a common factor in
coronary artery disease and heart failure. Research suggests vitamin K2 may help to keep
calcium out of your artery linings and other body tissues, where it can cause damage. The
latest studies show it is vitamin K2, rather than K1, in concert with vitamin D, that
prevents calcification in your coronary arteries, thereby preventing cardiovascular disease.
3. Vitamin K2 Helps Prevent Osteoporosis
The absolute best way to achieve healthy bones is a diet rich in fresh, raw whole foods that
maximizes natural minerals so your body has the raw materials it needs to do what it was
designed to do. Vitamin K2 is one of the most important nutritional interventions for
improving your bone density. It serves as the biological "glue" that helps plug calcium and
other important minerals into your bone matrix. There have been some remarkable
research studies about the protective effects of vitamin K2 against osteoporosis [1]
https://www.ncbi.nlm.nih.gov/pubmed/23525894 :
A number of Japanese trials have shown that vitamin K2 completely reverses bone loss
and in some cases even increases bone mass in people with osteoporosis.
The pooled evidence of seven Japanese trials show, that vitamin K2 supplementation
produces a 60 percent reduction in vertebral fractures and an 80 percent reduction in hip
and other non-vertebral fractures.
1
Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy
postmenopausal women.

3. Haim R. Branisteanu
12 Gotlieb Street Tel Aviv 03-523-2744 e-mail haimbranisteanu@gmail.com
Vitamin K and D and their interactions January 19 2016 Page 3 of 5
Researchers in the Netherlands showed vitamin K2 is three times more effective than
vitamin K1 in raising osteocalcin, which controls the building of bone.
Your bone strength depends on more than just calcium. Your bones are actually composed
of more than aozen minerals. If you focus just on calcium, you will likely weaken your
bones and increase your risk of osteoporosis, as Dr. Robert Thompson explains in his book
The Calcium Lie. It's more likely your body can use calcium correctly if it's plant-derived
calcium. Good sources include raw milk from pasture-raised cows (who eat the calcium-
rich plants), leafy green vegetables, the pith of citrus fruits, carob, and wheatgrass, to
name a few.
4. Vitamin K Helps Prevent Cancer
A number of studies have shown that vitamins K1 and K2 are effective against cancer.
Consider the following:
One study published in September 2003 in the International Journal of Oncology1, found
that treating lung cancer patients with vitamin K2 slowed the growth of cancer cells, and
previous studies have shown benefit in treating leukemia. In an August 2003 study
published in the Alternative Medicine Review2 involving 30 patients with a type of liver
cancer called hepatocellular carcinoma, who took oral vitamin K1, the disease stabilized in
six patients; seven patients had a partial response; and seven others had improved liver
function. In 15 patients, abnormal prothrombin normalized.
In 2008, a German research group discovered vitamin K2 provides substantial protection
against prostate cancer, one of the most common types of cancer among men in the United
States. According to Dr. Vermeer,[2] men taking the highest amounts of K2 had
about 50 percent less prostate cancer.
Vitamin K has also been found beneficial in the fight against non-Hodgkin lymphoma,
colon, stomach, nasopharynx, and oral cancers.
2
OSLO, NORWAY -- Renowned vitamin K2 researcher, Dr. Cees Vermeer, Professor of the Cardiovascular
Research Institute Maastricht, University of Maastricht, the long-time research partner of NattoPharma
ASA, Oslo, Norway, has been identified as being among the top 2.5% of all scientists worldwide by the
independent monitoring agency Research Gate. Recently, Dr. Vermeer has led a research team that studied
vitamin K2 menaquinone-7 for three years and that has shown the most significant bone health finding in
recent history: vitamin K2, taken daily for the long-term such as a multivitamin, can prevent bone
loss/porosity in women -- even after menopause.
Professor Vermeer belongs to the world’s top-2½ % of scientists, received an Honorary Doctorate (in 2001)
at the Iuliu Hatieganu University of Medicine and Pharmacy in Cluj Napoca, Romania, is a Visiting
Professor at the American University and has been a temporary advisor of the World Health Organization.
Professor Vermeer’s current research activities include molecular biology, biochemistry, animal and human
nutrition, pharmacology, and clinical trials in arteriosclerosis and osteoporosis. He has held a wide variety
of administrative positions within the Maastricht University, including Chairman of the Department of
Biochemistry and Member of Medical Faculty Board (portfolio R&D). Professor Vermeer has supervised 17
PhD students, is author of over 350 international scientific publications and inventor of 14 patents and
patent applications.

4. Haim R. Branisteanu
12 Gotlieb Street Tel Aviv 03-523-2744 e-mail haimbranisteanu@gmail.com
Vitamin K and D and their interactions January 19 2016 Page 4 of 5
5. Additional Health Benefits of Vitamin K
As written in the March 2004 Life Extension magazine 4, researchers have found many
other beneficial effects of vitamin K including:
Vitamin K2 deficiency may be a contributing factor to Alzheimer's disease, and vitamin
K2 supplementation may help in preventing it
Vitamin K2 improves insulin sensitivity; people who get the most vitamin K2 from their
foods are about 20 percent less likely to develop type 2 diabetes. Topical vitamin K
may help to reduce bruising. Vitamin K may have antioxidant properties
6. Vitamin K is a Fat-Soluble Vitamin
This is important because dietary fat is necessary for the absorption of this vitamin.
Therefore, in order for your body to absorb vitamin K effectively, you need to eat some fat
along with it.
7. Food Sources of Vitamin K2
Fermented foods, such as natto, typically have the highest concentration of vitamin K
found in the human diet and can provide several milligrams of vitamin K2 on a daily basis.
This level far exceeds the amount found in dark green vegetables. Unfortunately, most
Americans do not eat many fermented foods. Adding traditionally fermented foods to your
diet is a must, and although not widely known, the health benefits of these foods are
tremendous.
Precise K2 values for foods are difficult to find. However, I did find a few estimates for
comparison, which I've listed in the table below. Other foods high in K2 include raw dairy
products such ashard and soft cheeses, raw butter, and kefir, and sauerkraut. Realize that
the K2 content of pasteurized dairy and products from confined animal feeding
operations, which comprise most commercial sources, are NOT high in K2 and should be
avoided. Only grass fed animals (not grain fed) will develop naturally high K2 levels.
Top 9 Vitamin K Rich Foods List
1) Green Leafy Vegetables (Kale) ½ c: 444 mcg 5) Cabbage ½ cup: 82 mcg
2) Natto (fermented soy) 2 oz: 500 mcg 6) Broccoli ½ c: 46 mcg)
3) Spring onions (Scallions) ½ c: 103 mcg 7) Dairy (fermented) ½ c: 10 mcg
4) Brussels Sprouts. ½ c: 78 mcg 8) Prunes ½ c: 52 mcg
9) Cucumbers 1 medium: 49 mcg
Last Word; There are relative very simple solutions to include the above
mentioned vitamins D and K within our food chain, improve farm animal
husbandry health and save a lot of pain and troubles at older age, not to
mention money. But for the implementation of this concept full cooperation
of the relevant ministries are needed, that are not ignorant to the problem.

5. Haim R. Branisteanu
12 Gotlieb Street Tel Aviv 03-523-2744 e-mail haimbranisteanu@gmail.com
Vitamin K and D and their interactions January 19 2016 Page 5 of 5
A proposal was forwarded to the Knesset Economic Committee on January
12, 2016 to Mrs. Lea Varon and MK Eitan Cabel, with no response.
Implementation needs full cooperation and shifting of budgets funding
between the Ministry of Health and Ministry of Agriculture which is an uphill
battle with total disregard of the actual benefits to the Israeli population and
the substantial saving that will arose from less incidents of hospitalization
and improvement of public health. Anyone is encouraged to forward them
this analysis to the Knesset Economic Committee for re-evaluation.