Successfully reported this slideshow.
We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. You can change your ad preferences anytime.

Vitamin K2 - Connecting Bone and Heart Health

1,769 views

Published on

How Vitamin K2 MK7 ensures Calcium to enter bones and not arteries.

Published in: Health & Medicine, Technology

Vitamin K2 - Connecting Bone and Heart Health

  1. 1. Vitamin K2MK7 connecting bone & heart health © ppm.Ingredients KG, 2014
  2. 2. 1/3 women over 50 will experience osteoporotic fractures © ppm.Ingredients KG, 2014
  3. 3. 3 million UK residentes with osteoporosis © ppm.Ingredients KG, 2014
  4. 4. 190,000 osteoporosis-related fractures © ppm.Ingredients KG, 2014
  5. 5. Calcium © ppm.Ingredients KG, 2014
  6. 6. © ppm.Ingredients KG, 2014
  7. 7. Calcium in the body © ppm.Ingredients KG, 2014
  8. 8. Calcium in the body © ppm.Ingredients KG, 2014
  9. 9. Do you know Vitamin K2 ? © ppm.Ingredients KG, 2014
  10. 10. © ppm.Ingredients KG, 2014
  11. 11. How K2 works © ppm.Ingredients KG, 2014
  12. 12. Ca Ca Ca Ca © ppm.Ingredients KG, 2014
  13. 13. Osteoblast Osteoclast © ppm.Ingredients KG, 2014
  14. 14. Osteoblast under-carboxylated Osteocalcin (inactive) © ppm.Ingredients KG, 2014
  15. 15. Osteoblast carboxylation (activation of OC) C C C Gamma-glutamyl carboxylase + Vitamin K2 © ppm.Ingredients KG, 2014
  16. 16. Ca carboxylatied OC binds Calcium Ca Ca C C C © ppm.Ingredients KG, 2014
  17. 17. Osteoblast Osteoclast Ca Ca Ca © ppm.Ingredients KG, 2014
  18. 18. ucOC (inactive) Ca   Ca   Ca   Ca   Ca   Ca   Ca   Ca   Ca   Ca   Ca   Ca   Ca   Ca   Ca   Ca   Ca   Ca   Ca   Ca   Ca   Ca   Ca   Ca   Ca   Ca   Ca   Ca   Ca   Ca   Ca   Ca   Ca   Ca   Ca   Ca   Ca   Ca   Ca   Ca   Ca   Ca   Ca   Ca   Ca   Ca   © ppm.Ingredients KG, 2014
  19. 19. Bone Health Vitamin K2 Uptake of Ca2+ Production of OC Vit D Uptake of Ca2+ Intestine Ca2+ Activation of OC Vit K2 Bone mineralisation cOC Ca2+ Ca2+ Ca2+ © ppm.Ingredients KG, 2014
  20. 20. e risk of cardiovascular events is caused by missing Vitamin K – not by Calcium supplementation © ppm.Ingredients KG, 2014
  21. 21. Titel   The  Secrets  of  Ac1vator  X   K2 © ppm.Ingredients KG, 2014
  22. 22. Matrix Gla-protein (MGP) Calcium ions binding to activated MGP MGP is an important inhibitor of calcification in soft tissue carboxylated MGP (active) Ca Ca Ca Ca © ppm.Ingredients KG, 2014
  23. 23. Activated MGP reduces arterial calcification © ppm.Ingredients KG, 2014
  24. 24. 0 0,2 0,4 0,6 0,8 1 1,2 K2<21 K2 21-32 K2>32 Severe calcification Incidence of CHD CHD mortality All cause mortality e Rotterdam study RelativeRiskHazardRatio 4807 Dutch people followed 10 years Dietary vitamin K2 intake (µg/day) © ppm.Ingredients KG, 2014
  25. 25. Titel   The  Secrets  of  Ac1vator  X   K2 © ppm.Ingredients KG, 2014
  26. 26. Where do we get Vitamin K from? © ppm.Ingredients KG, 2014
  27. 27. Vitamin K1 Phylloquinone •  Made by plants and algae •  Bound to chloroplasts •  Only 5-10% reaches circulation © ppm.Ingredients KG, 2014
  28. 28. Vitamin K2 MK-4 Menaquinone-4 •  Synthetic feed grade •  Pharmacokinetics like K1 •  Drug in Japan: 45 mg/day •  Several older studies © ppm.Ingredients KG, 2014
  29. 29. Vitamin K2 MK-7 Menaquinone-7 •  Made by Bacillus subtilis natto •  Found in certain fermented foods •  Nearly 100% absorbable •  Not available in Western diet © ppm.Ingredients KG, 2014
  30. 30. Vitamin K co-factor for Activation of Gla-proteins Clotting factors activated by K1 and K2 Osteocalcin ativated by K1 and K2 Matrix Gla-protein activated mainly by K2 © ppm.Ingredients KG, 2014
  31. 31. Bioavailability K1 vs K2 MK-7 © ppm.Ingredients KG, 2014
  32. 32. Vitamin K2 MK-7 Menaquinone-7 •  Best absorption •  Longest half-life •  Non toxic •  Highest overall potential for Gla activation © ppm.Ingredients KG, 2014
  33. 33. Quality Aspects VitaminK2 Menaquinone-7 © ppm.Ingredients KG, 2014
  34. 34. 1 – 2 – 3 – 4 – 5 – 6 – 7 © ppm.Ingredients KG, 2014
  35. 35. cis isomer is bio-inactive! trans bond cis bond © ppm.Ingredients KG, 2014
  36. 36. stable in tablets and alkali environment © ppm.Ingredients KG, 2014
  37. 37. and other allergens and free of residual solvents © ppm.Ingredients KG, 2014
  38. 38. and reference standards available DETERMINATION OF MK-7 (VITAMIN I(r) IN K2VITAL MCT-OtrL Synthetica AS A_HPLC_SYN_OO6.03 Page I of5 1. INTRODUCTION This method is used for assay determination of MK-7(vitamin K2) in K2VITAL MCT- OIL product and quantification of impurities in the product. The MCT-oil product is diluted with ethyl acetate and the amount of MK-7 is determined by HPLC with UV detection. 2. ABBREVIATIONS MK.7: CV: DAD: HPLC: nm: RSD: RT: RRT: SD: UV: pL: mL: pm: w/w: vlv: EtOAc: Synthetic vitamin K2, menaquinone-7 Coeffi cient of Variation Diode Array Detector High Performance Liquid Chromatography Nanometer Relative Standard Deviation Retention Time Relative Retention Time Standard Deviation Ultraviolet Microliter Milliliter Micron (Micrometer) weight/weight volume/volume Ethyl acetate 3. APPARATUS HPLC-DAD high pressure system: Agilent, LC system I100 series (or equivalent). Analyical balance (Uncertainty + 0.05 mg) (or equivalent). © ppm.Ingredients KG, 2014
  39. 39. © ppm.Ingredients KG, 2014
  40. 40. © ppm.Ingredients KG, 2014 Manufacturer Kappa Bioscience AS www.k2vital.com www.kappabio.com Sales & Distribution ppm.Ingredients KG Jörg Büttinghaus k2vital@ppm-ingredients.de ++49-40-6094087-0

×