LC-MS/MS is a powerful tool for the analysis of Pharmaceuticals and Personal Care Products in environmental samples. The combination of high resolution LC separation and high sensitivity MS/MS is the most powerful tool to screen and quantify targeted compounds.
The aim of the coupling is to obtain an information-rich detection for both identification and quantification compared to that with a single analytical technique.
The aim of the coupling is to obtain an information-rich detection for both identification and quantification compared to that with a single analytical technique.
Key Learning Objectives:
• Identify emerging triple quadrupole Gas Chromatography-Mass Spectrometry/Mass Spectrometry (GC-MS/MS) technology designed to address increasing regulatory demands and requirements
• Explore potential time savings in sample prep, method development/transition, and data analysis
• Demonstrate how to optimize the GC-MS/MS workflow from sample prep to sample analysis to automated data analysis
Overview:
Regulatory lab requirements continue to drive detection limits lower with an ever increasing list of compounds to analyze. These requirements also demand greater precision at these lower limits. Triple quadrupole GC-MS/MS is a viable option for enhanced analysis and increased productivity with an emphasis on simplicity. We discuss emerging trends and technologies designed to ensure that laboratories are well-equipped to address these increased demands with minimal investment in training and method development. Find out how you can adopt triple quadrupole GC-MS/MS technology in your laboratory using existing methods and source parameters in most instances while requiring less sample prep and enjoying the benefits of automated data analysis for increased simplicity and productivity.
For more information: www.thermoscientific.com/tsq8000
Today’s analytical laboratory is faced with tight deadlines to produce results from testing environmental samples. Too often, solid-phase extraction (SPE) presents a bottleneck in the analytical testing process and may cause poor analyte recoveries and highly variable. Despite advances in analytical instrumentation, sample prep often relies on tedious, manual, and expensive techniques such as liquid-liquid extraction.
Sample preparation of environmental water samples can be automated, however.. Use of automated sample preparation addresses the many challenges that laboratories face when preparing samples and can help improve sample processing turnaround times.
Chromatography presentation goes with this free on-demand webinar. Link to webinar: https://event.on24.com/eventRegistration/EventLobbyServlet?target=registration.jsp&eventid=832348&sessionid=1&key=7401504685427A0804ABBD1F956E617C&partnerrefthermo=undefined&sourcepage=register
mass spectrometry, also called mass spectroscopy, analytic technique by which chemical substances are identified by the sorting of gaseous ions in electric and magnetic fields according to their mass-to-charge ratios.
• It is the combination of liquid chromatography and the mass spectrometry.
• Liquid chromatography-mass spectrometry (LC-MS) is an analytical chemistry
technique that combines the physical separation capabilities of liquid
chromatography with the mass analysis capabilities of mass spectrometry.
• The combination of these two powerful techniques gives the chemical analyst the
ability to analyze virtually any molecular species; including, thermally labile, non
volatile, and high molecular weight species.
This ppt consist of basic principle of GC-MS, instrumentation of GC-MS, components of GC-MS ,Advantages and disadvantages of GC-MS and application of GC-MS
This webinar will provide pesticides residue analysts with valuable information on the development and optimization of chromatographic separations and mass spectrometry methods for the analysis of pesticide residues in food. The expert speakers will share their knowledge in understanding the critical aspects of the method, assisting analysts in optimizing their methods for the most challenging analyses.
Industrial Laboratories around the world are trying to find ways to minimize sample preparation and enhance productivity. The adaptation of modern mass spectrometry instrumentation is desired due to the high sensitivity and selectivity they provide. This presentation will describe how different sample preparation techniques can be simplified and automated for LC/MS/MS analyses.
Key Learning Objectives:
• Identify emerging triple quadrupole Gas Chromatography-Mass Spectrometry/Mass Spectrometry (GC-MS/MS) technology designed to address increasing regulatory demands and requirements
• Explore potential time savings in sample prep, method development/transition, and data analysis
• Demonstrate how to optimize the GC-MS/MS workflow from sample prep to sample analysis to automated data analysis
Overview:
Regulatory lab requirements continue to drive detection limits lower with an ever increasing list of compounds to analyze. These requirements also demand greater precision at these lower limits. Triple quadrupole GC-MS/MS is a viable option for enhanced analysis and increased productivity with an emphasis on simplicity. We discuss emerging trends and technologies designed to ensure that laboratories are well-equipped to address these increased demands with minimal investment in training and method development. Find out how you can adopt triple quadrupole GC-MS/MS technology in your laboratory using existing methods and source parameters in most instances while requiring less sample prep and enjoying the benefits of automated data analysis for increased simplicity and productivity.
For more information: www.thermoscientific.com/tsq8000
Today’s analytical laboratory is faced with tight deadlines to produce results from testing environmental samples. Too often, solid-phase extraction (SPE) presents a bottleneck in the analytical testing process and may cause poor analyte recoveries and highly variable. Despite advances in analytical instrumentation, sample prep often relies on tedious, manual, and expensive techniques such as liquid-liquid extraction.
Sample preparation of environmental water samples can be automated, however.. Use of automated sample preparation addresses the many challenges that laboratories face when preparing samples and can help improve sample processing turnaround times.
Chromatography presentation goes with this free on-demand webinar. Link to webinar: https://event.on24.com/eventRegistration/EventLobbyServlet?target=registration.jsp&eventid=832348&sessionid=1&key=7401504685427A0804ABBD1F956E617C&partnerrefthermo=undefined&sourcepage=register
mass spectrometry, also called mass spectroscopy, analytic technique by which chemical substances are identified by the sorting of gaseous ions in electric and magnetic fields according to their mass-to-charge ratios.
• It is the combination of liquid chromatography and the mass spectrometry.
• Liquid chromatography-mass spectrometry (LC-MS) is an analytical chemistry
technique that combines the physical separation capabilities of liquid
chromatography with the mass analysis capabilities of mass spectrometry.
• The combination of these two powerful techniques gives the chemical analyst the
ability to analyze virtually any molecular species; including, thermally labile, non
volatile, and high molecular weight species.
This ppt consist of basic principle of GC-MS, instrumentation of GC-MS, components of GC-MS ,Advantages and disadvantages of GC-MS and application of GC-MS
This webinar will provide pesticides residue analysts with valuable information on the development and optimization of chromatographic separations and mass spectrometry methods for the analysis of pesticide residues in food. The expert speakers will share their knowledge in understanding the critical aspects of the method, assisting analysts in optimizing their methods for the most challenging analyses.
Industrial Laboratories around the world are trying to find ways to minimize sample preparation and enhance productivity. The adaptation of modern mass spectrometry instrumentation is desired due to the high sensitivity and selectivity they provide. This presentation will describe how different sample preparation techniques can be simplified and automated for LC/MS/MS analyses.
Total workflow solutions that cater every budget, performance or throughput requirement for confirmatory dioxin analysis were discussed in the Thermo Scientific Lunch Seminar at the Dioxin 2014 conference. D. Hope, CEO & Owner Pacific Rim Laboratoris, presented about the economies of POPs analysis from the point of view of a leading laboratory using the very latest dioxin method kits. C. Cojocariu, Thermo Fisher Scientific, discussed recent changes in EU regulations which bring new opportunities for more labs to participate in dioxin analysis and about validating methods using Gas Chromatography triple quadrupole for PCDD/Fs with reference to the new EU Commission Regulation No. 709/2014.
Recently, a new technique was introduced the allows the automated supercritical extraction and SFC analysis of samples with minimal sample preparation and handling requirements to save analyst time and sample preparation expenses. This presentation demonstrates how automated SFE-SFC can be a quick way to screen up to 48 soil samples for explosives in a variety of soil types with minimal sample prep. For more information, go to http://www.ssi.shimadzu.com/industry/industrypage.cfm?market_id=4. Thanks for viewing.
Determination of Common Counterions and Impurity Anions in Pharmaceuticals Using a Capillary HPIC System with Suppressed Conductivity and Charge Detection
Recently, identification and quantification of ions in early stage drug development has gained increasing attention, because the APIs maybe contaminated with different counter ions from synthesis steps, and because selecting the counter ion to enhance APIs’ solubility and stability is becoming a key step in formulation development. This presentation demonstrates the identification and quantification of 22 commonly found anions in pharmaceuticals in a single run using a high-pressure capillary IC system (HPIC) with 4-μm particle ion –exchange column, and CD-QD dual detectors.
A new reversed phase solid phase extraction device which simplifies sample preparation as no conditioning or equilibration steps are required. Matrix effects in MS can be reduced by removal of interferences, particularly fats and phospholipids.
Determination of pesticide multi-residues in river water by LC-Orbitrap-MSJorge Casado Agrelo
A quantitative targeted screening method for the determination of residues of a broad group of more than 250 pesticides in surface water samples was developed and validated.
Fast, selective, and sensitive methods can be developed for the analysis of impurities
Offering many business benefits using UPLC and UPC2
Increase in sample throughput
Reduction in toxic solvent usage
Using mass spectral detection over UV detection provides
Improvement in sensitivity and selectivity
Reduced matrix effects
PDA and mass detection provide complementary information for peak assignment and structural confirmation of impurities
In the past, measuring the total amount of an element was sufficient. Unfortunately, the effects of an element extend far beyond its absolute amount. Different forms of an element can exhibit very different physicochemical properties, including varying toxicities. The process of separation and quantification of different chemical forms of an element, more specifically termed speciation analysis, can be utilized to determine an element’s various chemical forms. The number of environmental applications of elemental speciation analysis has increased significantly. For example, both the United States EPA and the European Union have specified maximum admissible chromium concentrations in their respective drinking water directives and are evaluating the inclusion of hexavalent chromium in certain legislation. Learn about the latest developments in chromatography technology for speciation analysis that offer data for a wide variety of applications, including chromium in drinking water and both arsenic and sulfur in environmental waters.
3 Ways the New Thermo Scientific LC MS Triple Quads Improve Residue AnalysisThermo Fisher Scientific
Learn how the new Thermo Scientific LC-MS triple quadrupole mass spectrometers incorporate unique design features that improve analysis of food matrices for veterinary drug and pesticide residues.
This presentation describes the operation and application of the Waters APGC (Atmospheric Pressure Gas Chromatography) ion source which provides a highly sensitive GC-MS, MS/MS capability for tandem quadrupole and time of flight MS systems. It is very easy to swap between APGC, Electrospray (for UPLC) and other ion sources without instrument venting in minutes.
APGC provides significant performance advantages over traditional GC/MS ionisation methods, giving high sensitivity and less fragmented spectra.
Roti Bank Hyderabad: A Beacon of Hope and NourishmentRoti Bank
One of the top cities of India, Hyderabad is the capital of Telangana and home to some of the biggest companies. But the other aspect of the city is a huge chunk of population that is even deprived of the food and shelter. There are many people in Hyderabad that are not having access to
At Taste Of Middle East, we believe that food is not just about satisfying hunger, it's about experiencing different cultures and traditions. Our restaurant concept is based on selecting famous dishes from Iran, Turkey, Afghanistan, and other Arabic countries to give our customers an authentic taste of the Middle East
Ang Chong Yi Navigating Singaporean Flavors: A Journey from Cultural Heritage...Ang Chong Yi
In the heart of Singapore, where tradition meets modernity, He embarks on a culinary adventure that transcends borders. His mission? Ang Chong Yi Exploring the Cultural Heritage and Identity in Singaporean Cuisine. To explore the rich tapestry of flavours that define Singaporean cuisine while embracing innovative plant-based approaches. Join us as we follow his footsteps through bustling markets, hidden hawker stalls, and vibrant street corners.
Ang Chong Yi Navigating Singaporean Flavors: A Journey from Cultural Heritage...
Using LC-MS/MS and Advanced Software Tools to Screen for unknown and Non-targeted PPCP in Environmental Samples
1. Stacy Tremintin and André Schreiber
AB SCIEX
Using LC-MS/MS and Advanced Software Tools
to Screen for Unknown and Non-targeted PPCP
in Environmental Samples