This study explored using online crowdsourcing platforms like Amazon Mechanical Turk (MTurk) to identify and prioritize back pain research topics from patient perspectives. Researchers surveyed patients in a back pain registry (BOLD) and through MTurk to rank existing research topics and propose new ones. MTurk yielded over twice as many responses at a lower cost and faster timeline. Both groups prioritized identifying causes and effective diagnosis of back pain highest. BOLD proposed additional topics on comorbidities and healthcare systems, while MTurk proposed information on medication and work disability benefits. Using online crowdsourcing is a low-cost method to incorporate diverse patient input on research priorities.