Outcomes research examines the end results of health services on individuals and is intended to provide scientific evidence relating to decisions made by all who participate in health care. This presentation examines two leading organizations in outcomes research: the Agency for Healthcare Research and Quality (AHRQ) and the Patient Centered Outcomes Research Institute (PCORI). AHRQ funds research to improve quality and safety, focusing on priority populations like children and the elderly. PCORI funds research allowing patients and providers to make informed decisions, with mental/behavioral health being the most studied condition. While outcomes research considers patient preferences, it is difficult to satisfy all patients regardless of efforts to provide evidence-based care.