Urmil amazing facts
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This document contains facts about various animals, including that an ancient shark was as heavy as 7 elephants, eagles can see 5 basic colors, lions roar can be heard up to 8 km away, tiger roars carry over 2 km, snakes sleep with their eyes open, fangtooth fish have teeth too big to close their mouth, and alligators can grow up to 20 feet long weighing half a ton. It also discusses deer being one of the most hunted animals in North America and that dogs can understand up to 250 words and perform basic math, while horses can sleep both standing up or lying down.
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WILD ANIMALS
Підготувала Швед Анастасія,
гурток англійської мови “Enjoy English” Палацу дітей та юнацтва (кер. Бєльська С.М.)
Mammals leopard
The document discusses characteristics of leopards. It notes that there are 10 leopard species worldwide and that leopards have shorter legs than other cats. Some leopards are completely black due to a genetic mutation. Leopards have powerful jaws that allow them to climb trees while carrying prey. The document also provides curiosities about leopards, such as them being kept as pets by Egyptian queens and having existed for over 11 million years. It describes leopards' hunting techniques such as biting the neck of prey and their ability to swim while pursuing animals.
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Zebra sharks are found in the Indian Ocean. They are black and white with a tail almost as long as their body. They are nocturnal and can grow over 11 feet long. Zebra sharks search for small animals and fish to eat in reef crevices at night, using their barbels and long tail fin to maneuver. Though they may look intimidating, zebra sharks are actually harmless to humans.
CATS
The caracal cat is also known as the Persian or African Lynx. It is closely related to the African Golden Cat and is best known for its extraordinary climbing and jumping skills. Cheetahs were once found throughout parts of Asia and Africa but are now mostly found in eastern and southern Africa with less than 10,000 remaining worldwide. The clouded leopard is found in Asia from the Himalayas to China and has a dark grey fur with spots and two living subspecies.
Lion powerpoint
An adult male lion weighs between 330 to 550 pounds, has a brown fur mane, and walks with its heels raised. Lions live in grasslands and plains of Asia and India, hunt small animals like rodents and reptiles for food, and have live young. Their main enemy is humans who kill them for their fur, while males lead prides in hunting and are sometimes called the "king".
Leopards
Leopards are the smallest of the big cat family and can be found in Africa and Asia. They have an agile, long body with short legs and stalk prey at night. Despite their size, leopards can carry prey up trees that is three times their own weight. Leopards live in varied habitats like woodlands, forests, and savannas, giving them a survival advantage over other big cats.
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Підготувала Швед Анастасія,
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Mammals leopard
The document discusses characteristics of leopards. It notes that there are 10 leopard species worldwide and that leopards have shorter legs than other cats. Some leopards are completely black due to a genetic mutation. Leopards have powerful jaws that allow them to climb trees while carrying prey. The document also provides curiosities about leopards, such as them being kept as pets by Egyptian queens and having existed for over 11 million years. It describes leopards' hunting techniques such as biting the neck of prey and their ability to swim while pursuing animals.
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Zebra sharks are found in the Indian Ocean. They are black and white with a tail almost as long as their body. They are nocturnal and can grow over 11 feet long. Zebra sharks search for small animals and fish to eat in reef crevices at night, using their barbels and long tail fin to maneuver. Though they may look intimidating, zebra sharks are actually harmless to humans.
CATS
The caracal cat is also known as the Persian or African Lynx. It is closely related to the African Golden Cat and is best known for its extraordinary climbing and jumping skills. Cheetahs were once found throughout parts of Asia and Africa but are now mostly found in eastern and southern Africa with less than 10,000 remaining worldwide. The clouded leopard is found in Asia from the Himalayas to China and has a dark grey fur with spots and two living subspecies.
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An adult male lion weighs between 330 to 550 pounds, has a brown fur mane, and walks with its heels raised. Lions live in grasslands and plains of Asia and India, hunt small animals like rodents and reptiles for food, and have live young. Their main enemy is humans who kill them for their fur, while males lead prides in hunting and are sometimes called the "king".
Leopards
Leopards are the smallest of the big cat family and can be found in Africa and Asia. They have an agile, long body with short legs and stalk prey at night. Despite their size, leopards can carry prey up trees that is three times their own weight. Leopards live in varied habitats like woodlands, forests, and savannas, giving them a survival advantage over other big cats.
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The zebra is a white and black striped animal that lives in Africa, eating grass and drinking water. It has flat teeth for eating grass, hooves to walk on, and lives in both plains and near humans in East Africa. Zebras have live babies that look like smaller versions of their mothers, and protect themselves from enemies like humans and animals by constantly moving around.
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Zebras are equids that live in East and South Africa. They have unique black and white stripes and live in herds on the open grasslands. Zebras stand out for their social nature, running fast on their long legs to escape predators, and showing affection through grooming.
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Tigers are the largest cats, with stripes, and live in forests in Asia. Zebras have stripes that can confuse predators and help with camouflage in their groups. Bald eagles live in North America and have white feathers on their heads rather than being truly bald. Wolves live in family packs and the females give birth to litters each spring. Bats are the only flying mammals and there are almost 1,000 different species around the world.
Wild animals
Wild animals are those that live in nature without domestication by humans. They include animals that live in forests, savannas, and deserts. Wild animals hunt, fish, or eat plants to survive on their own in the wild. The document then provides descriptions of several specific wild animals, including their physical characteristics, behaviors, habitats, and lifespans. These animals are the lion, tiger, elephant, snake, giraffe, gorilla, crocodile, bear, eagle, and kangaroo.
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Foxes
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Foxes
Foxes are small to medium-sized bushy tailed canines that are members of the dog family. There are two main types of foxes: red foxes, which have orange-red fur on their back and sides with white fur on their chest and a white tipped tail, and live in wooded and farmland areas, mostly at night; and Arctic foxes, which have adaptations like thick fur and small ears that allow them to survive in cold tundra, and use incredible hearing to hunt prey beneath the snow.
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This document summarizes a first grade science lesson about four feline species - lions, tigers, cheetahs, and snow leopards. It discusses where each species lives, their physical characteristics, hunting styles, and other facts. The lesson aims to teach students about the basic needs of living things and how environments affect characteristics. It includes key vocabulary words and resources for further reading. At the end is a short quiz to assess what students learned about differentiating between the felines.
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Zebra sharks are found in the Indian Ocean, have tails almost as long as their bodies, and can grow over 11 feet long. They are black and white invertebrates that live in crevices and holes in the reef, feeding at night on small animals like snails, shrimp, and fish. Their upper caudal fin lobe is long and they have fleshy barbels at their mouths.
Foxes
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Facts About Tigers_ Characteristics, species, lifespan and More.pdf
Tigers are one of the most popular animals in the world. These majestic creatures are famous for their stunning stripes, powerful build, and ferocious hunting skills.
This article will delve deeper into the fascinating world of tigers, exploring their unique characteristics, behavior, and importance in the ecosystem.
Tiger is the largest-member of the cat family. Tigers can grow to be 11 feet long and weigh over 660 pounds.
They are carnivores animal, and their foods are meat. Another characteristic of tigers is that they are good swimmers. They can even swim long distances. Tigers can jump over 20 feet in the air.
They are usually nocturnal creatures, meaning they are most active at night. Tigers also have very good eyesight and can see six times better than humans in low-light conditions.
In addition, tigers have an excellent sense of smell. Tigers can find their prey by smelling from up to two miles away. Finally, tigers have powerful front legs and can run up to 60 miles per hour.
They also have sharp claws that can be up to four inches long. Tigers use their tails to help them balance running and climbing.
Tigers can weigh up to 660 pounds and be up to 11 feet long.
The biggest tiger ever recorded was a male Bengal tiger that weighed in at 1,025 pounds and was over 12 feet long!
Females are usually smaller than males. The smallest tiger on record was a female Sumatran tiger that weighed only 120 pounds.
Tigers are native to Asia in countries like India, China, Indonesia, and Russia. Totally, there are nine different subspecies of tigers.
The most common subspecies is the Bengal tiger. Other subspecies include the Sumatran tiger, the Siberian tiger, and the South China tiger.
The Siberian tiger is the largest subspecies. Male Siberian tigers can weigh up to 1,000 pounds! These tigers have the thickest fur of all the subspecies.
They also have the longest tails. The South China tiger is on the list of the most endangered subspecies. There are only 100 of these tigers are in the wild.
Tigers are carnivores and eat mostly meat. They will eat anything they can catch, including deer, pigs, and even elephants! Tigers usually hunt alone but will sometimes hunt in groups.
Did you know that tigers have striped fur? Tigers use their stripes for camouflage when they are hunting.
Tigers are an endangered species. It is a human failure that only around 3,900 tigers are there in the wild. This number is decreasing every year.
The main reasons tigers are becoming extinct are habitat loss and hunting. You can help save tigers by donating to organizations working to protect them.
Mating season for tigers usually occurs from November to April.
During mating, the male will bite the back of the female’s neck to show his dominance.
The gestation period for tigers is about 103 days.
Tiger cubs are weaned at around 3-6 months old.
Cubs stay with their mother for 18-24 months before leaving to fend for themselves.
There are six species of Tiger
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all informations are taken from the web
some of thes slides contain animation if you want you have to download it
follow me for more environment ppts
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Breast cancer: Post menopausal endocrine therapy
Breast cancer in postmenopausal women with hormone receptor-positive (HR+) status is a common and complex condition that necessitates a multifaceted approach to management. HR+ breast cancer means that the cancer cells grow in response to hormones such as estrogen and progesterone. This subtype is prevalent among postmenopausal women and typically exhibits a more indolent course compared to other forms of breast cancer, which allows for a variety of treatment options.
Diagnosis and Staging
The diagnosis of HR+ breast cancer begins with clinical evaluation, imaging, and biopsy. Imaging modalities such as mammography, ultrasound, and MRI help in assessing the extent of the disease. Histopathological examination and immunohistochemical staining of the biopsy sample confirm the diagnosis and hormone receptor status by identifying the presence of estrogen receptors (ER) and progesterone receptors (PR) on the tumor cells.
Staging involves determining the size of the tumor (T), the involvement of regional lymph nodes (N), and the presence of distant metastasis (M). The American Joint Committee on Cancer (AJCC) staging system is commonly used. Accurate staging is critical as it guides treatment decisions.
Treatment Options
Endocrine Therapy
Endocrine therapy is the cornerstone of treatment for HR+ breast cancer in postmenopausal women. The primary goal is to reduce the levels of estrogen or block its effects on cancer cells. Commonly used agents include:
Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
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June 14, 2024Cell Therapy Expansion and Challenges in Autoimmune Disease
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
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Urmil amazing facts
- 2. SHARK The biggest predator in olden times was an ancient shark. Scientist looked at its fossiled teeth, it was as heavy as the weight of 7 elephants.
- 4. EAGLES • While humans see just three basic colours, eagles see five basic colours.they have an excellent eye site.
- 6. LIONS • Lions roar to communicate their position to other prides. A lion’s roar is the loudest of any big cat and can be heard up to 8 km away.
- 8. TIGER The roar of a Bengal tiger can carry for over 2km at night.
- 10. SNAKES • Snakes sleep with their eyes open so they search for a good place to sleep and a good posture to sleep.
- 12. FANGTOOTH • Fangtooth is a strange looking deep water fish that has so big teeth that it cannot close its mouth properly.
- 14. DEER • Deer are one of the most hunted, loved and irritating animals in North America
- 16. ALLIGATORS • A male alligator can grow up to 20 feet long and weigh up to half a ton, (500 kg).
- 18. DOGS • Dogs are capable of understanding up to 250 words and gestures, can count up to five and can perform simple mathematical calculations. The average dog is as intelligent as a two-yearold child.
- 20. HORSES • Horses can sleep both lying down and standing up