This document provides guidance on developing a health research proposal. It discusses examining the cyclical nature of developing a proposal, describing principles of researchability and criteria for selecting topics. Key steps include preparing a problem description and objectives, reviewing literature, and formulating the proposal to describe rationale and methodology. The proposal is the basis for approval and funding, and its development is often iterative with necessary revisions. Factors like relevance, avoidance of duplication, feasibility, and ethics must be considered when prioritizing research topics. Sources of topics include experiences, news, literature, and experts.