This document provides an overview of hypertension including:
1. Defining hypertension as a blood pressure over 140/90 mmHg.
2. Describing the global epidemiology of hypertension, noting its highest prevalence in Sub-Saharan Africa at 40%.
3. Discussing the impact of hypertension as a leading cause of cardiovascular disease death worldwide, responsible for over 9 million deaths in 2010.
SEMINAR ON BLOOD PRESSURE REGULATION, Determinants of Arterial BP
Functions Of Blood Pressure
Physiological Variations In Bp
Blood Pressure Regulation
Applied Physiology
SEMINAR ON BLOOD PRESSURE REGULATION, Determinants of Arterial BP
Functions Of Blood Pressure
Physiological Variations In Bp
Blood Pressure Regulation
Applied Physiology
1 billion people worldwide have high blood pressure, and this number is expected to increase to 1.56 billion people by the year 2025
Lets gear up to take on this future opportunity by offering
Range of brands benefitting the patients
Suffering from
Hypertension
Hypertension- High blood pressure is a common condition that affects the body's arteries. It's also called hypertension.
If you have high blood pressure, the force of the blood pushing against the artery walls is consistently too high. The heart has to work harder to pump blood.
A condition in which the force of the blood against the artery walls is too high.
Usually hypertension is defined as blood pressure above 140/90, and is considered severe if the pressure is above 180/120.
High blood pressure often has no symptoms. Over time, if untreated, it can cause health conditions, such as heart disease and stroke.
Eating a healthier diet with less salt, exercising regularly and taking medication can help lower blood pressure.
Hypertension is rarely accompanied by symptoms, and its identification is usually through health screening, or when seeking healthcare for an unrelated problem. Some people with high blood pressure report headaches (particularly at the back of the head and in the morning), as well as lightheadedness, vertigo, tinnitus (buzzing or hissing in the ears), altered vision or fainting episodes.[23] These symptoms, however, might be related to associated anxiety rather than the high blood pressure itself.[24]
On physical examination, hypertension may be associated with the presence of changes in the optic fundus seen by ophthalmoscopy.[25] The severity of the changes typical of hypertensive retinopathy is graded from I to IV; grades I and II may be difficult to differentiate.[25] The severity of the retinopathy correlates roughly with the duration or the severity of the hypertension
1 billion people worldwide have high blood pressure, and this number is expected to increase to 1.56 billion people by the year 2025
Lets gear up to take on this future opportunity by offering
Range of brands benefitting the patients
Suffering from
Hypertension
Hypertension- High blood pressure is a common condition that affects the body's arteries. It's also called hypertension.
If you have high blood pressure, the force of the blood pushing against the artery walls is consistently too high. The heart has to work harder to pump blood.
A condition in which the force of the blood against the artery walls is too high.
Usually hypertension is defined as blood pressure above 140/90, and is considered severe if the pressure is above 180/120.
High blood pressure often has no symptoms. Over time, if untreated, it can cause health conditions, such as heart disease and stroke.
Eating a healthier diet with less salt, exercising regularly and taking medication can help lower blood pressure.
Hypertension is rarely accompanied by symptoms, and its identification is usually through health screening, or when seeking healthcare for an unrelated problem. Some people with high blood pressure report headaches (particularly at the back of the head and in the morning), as well as lightheadedness, vertigo, tinnitus (buzzing or hissing in the ears), altered vision or fainting episodes.[23] These symptoms, however, might be related to associated anxiety rather than the high blood pressure itself.[24]
On physical examination, hypertension may be associated with the presence of changes in the optic fundus seen by ophthalmoscopy.[25] The severity of the changes typical of hypertensive retinopathy is graded from I to IV; grades I and II may be difficult to differentiate.[25] The severity of the retinopathy correlates roughly with the duration or the severity of the hypertension
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Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
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Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
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Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
2. Objectives
By the end of this module participants should be able to:
1. Define hypertension
2. Describe the epidemiology and impact of hypertension
3. Describe Blood Pressure physiology
4. Describe factors that affect peripheral vascular resistance
5. Discuss the factors that affect cardiac output
2
3. Case Study 1
At an international Cardiology conference held in UK
four delegates had the following preconference BP
measurements made at the gate of conference venue:
•James , 50 year old, British, BP= 170/95 mmHg
•Ibrahim, 38 year old, Iranian, BP 130/100 mmHg
•Adamu, 65 year old, Ethiopian, BP 160/80 mmHg
•Carlos, 56 year old, Brazilian, BP 130/85 mmHg
3
4. Case Study 1
Answers:
1. Which delegate has hypertension?
None ,any raised BP is not hypertension , it should be confirmed on repeated
measurements to say it is hypertension.
2. Which delegate has normal blood pressure?
None, optimal(“normal”) Blood pressure is below 120/80mmHG.
3. In which delegate is the likelihood of complications higher?
Complications is higher with Adamu due to older age and black race.
4. Which delegate lives in high prevalent area of hypertension in the world?
Adamu lives in higher prevalence area, Sub-Saharan Africa has the highest
prevalence.
4
5. Hypertension
Definition:Persistently elevated, systolic and/or
diastolic blood pressure of 140/90 mmHg or more
in subjects aged 18 years and above.
Systolic blood pressure is the pressure exerted when
the heart contracts.
Diastolic blood pressure is the pressure exerted
when the heart muscle relaxes.
5
6. Epidemiology
Overall, approximately 22% of the world's adults are
estimated to have hypertension.
Sub Saharan Africa has the highest prevalence(40%).
In SSA Patients are younger, have more aggressive HTN,
present late and with complications.
Most studies done in Ethiopia show prevalence of raised
BP of 20-30 % (included more urban)
The recently conducted national NCD STEPS survey
which involved more than 10,000 participants from all
regions showed (unpublished data) that prevalence of
raised BP to be 16% (men 15.7%, women16.5%)
6
7. Percentage of respondents with raised blood
pressure, or currently taking medication for raised
blood pressure, by sex, Ethiopia NCD STEPS, 2015
7
8. Impact of hypertension
Of the 17 million global CVD deaths in 2010,
hypertension was responsible for the 9.4 million deaths
Hypertension is the main driver of Cardio Vascular
Disease killing twice as many women aged 60 and above
in Lower and Middle Income Countries compared to
developed countries.
It accounts for loss of 57 million disability adjusted life
years (DALYS).
For every increase in 20 mmHg systolic or 10 mmHg
diastolic blood pressure the lifetime risk of heart
disease DOUBLES.
Hypertensive Heart Disease(HHD) is the second most
common CVD in major referral hospitals of Ethiopia.
8
9. Blood Pressure Physiology
Blood Pressure is the amount of force exerted on vessel wall
by blood per unit area at a given point in time.
It is the product of Cardiac output(CO) and Total peripheral
resistance (TPR).
9
10. Physiology of blood pressure
Cardiac output is the amount of blood the heart pumps
through the circulatory system in one minute.
Peripheral vascular resistance is the degree of resistance
opposing ejection of blood by the heart . It is determined by
the diameter and stiffness of the arteries.
Blood pressure is determined by the amount of blood the
heart pumps and the amount of resistance to blood flow in
the arteries.
The more blood the heart pumps and the narrower the
arteries, the higher the blood pressure.
Consequently high blood pressure requires the heart to
work harder than normal to circulate blood through the
blood vessels.
10
11. Blood Pressure Determinants
Blood Pressure
Cardiac Output
Stroke Volume
Preload
(Venous return)
Myocardial
Contractility
After load
(Forward resistance to
ejection of blood by the
heart)
Heart Rate
Total Peripheral
Resistance
Figure 2 : Interrelationships of the various determinants of
Blood Pressure .
12. Factors affecting blood pressure:
Peripheral Vascular Resistance
Vascular resistance is mainly determined by the structure
(anatomic) and functional changes in muscular small
arteries and arterioles.
There are factors that reduce vascular diameter
(constrictors) and those that enlarge it (dilators)
Examples of vascular endogenous constrictors include
angiotensin II, catecholamines (Adrenaline and
noradrenaline), endothelin.
Examples of vascular Dilators: include Prostaglandins, and
Beta-adrenergic receptor activators, calcium channel
blockers
12
13. Factors affecting blood pressure:
Cardiac output
Cardiac output is affected by the following factors:
• Heart Rate: the number of times the heart beats per minute
• Stroke volume ( amount of blood pumped out in one heart
beat) - depends on the following:
oPreload : the amount of blood returning to the heart)
oMyocardial Contractility: Force of contraction which is
increased by the sympathetic nervous system.
oAfterload : the resistance to ejection of blood by heart
13
14. Blood Pressure Regulation
Blood pressure is regulated by a negative feedback mechanism.
The main regulatory systems in the body which maintain normal blood
pressure are:
1. Autonomic Nervous system :
Responsible for rapid control of BP .
With drop in blood pressure sympathetic outflow will increase with the final
effect of raising blood pressure by increasing heart rate, myocardial contractility
and increasing peripheral vasoconstriction.
Change in blood pressure is sensed by baroreceptors in carotid sinus, aortic
sinus and heart muscles.
14
16. Blood Pressure Regulation…..
2. Renin-Angiotensin-Aldosterone system:
Is slow but the effect is prolonged .
With drop in blood pressure the system is
activated resulting in conservation of
intravascualr volume by decreasing GFR and
urinary sodium excretion.
The change in blood pressure is sensed by
special cells in the kidney.
16
17. Regulation of Blood Pressure
Renin- Angiotensin- Aldosterone System Control
17
18. Pathogenesis of Hypertension
The exact pathogenesis of hypertension is not clearly
understood in the majority of cases.
It is believed that the different environmental and
genetic factors interact at different levels of blood
pressure regulation to result in persistent elevation of
blood pressure.
Therefore majority of hypertension is not curable but
various drug treatment modalities can reduce blood
pressure by acting on either cardiac output or total
peripheral resistance .
18
19. Proposed interaction between cardiac out put and
peripheral resistance in the pathogenesis of
essential hypertension
This definition applies to both newly diagnosed patients with BP > or equal to 140/90mmHG and other patients who were previously diagnosed and currently on treatment even if their current BP is less than 140/90mmHG
Figure 1
LMIC: Low and middle income countries
Figure 2: HTN as product of CO and TPR
Initially Cardiac out put increases due to increased blood volume. To mitigate that the peripheral resistance increases. The cardiac out put normalizes and subsequently may even drop below normal but the TPR continues to rise for unknown reasons and this perpetuates the hypertension.