Understanding research studies.pptx.pdf
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Concise parameters and factors to consider when designing a research study and a minute introduction to molecular docking as an approach in computational research studies.
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10 years the identification rate of disease-associated targets has been higher than the therapeutics identification rate.
Nevertheless, it is apparent that computational tools provide high hopes that many of the diseases under investigation can be brought under control.
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With increasing population, people need to rely on packaged food stuffs. Packaging of food materials requires the preservation of food. There are various methods for the treatment of food to preserve them and irradiation treatment of food is one of them. It is the most common and the most harmless method for the food preservation as it does not alter the necessary micronutrients of food materials. Although irradiated food doesn’t cause any harm to the human health but still the quality assessment of food is required to provide consumers with necessary information about the food. ESR spectroscopy is the most sophisticated way to investigate the quality of the food and the free radicals induced during the processing of the food. ESR spin trapping technique is useful for the detection of highly unstable radicals in the food. The antioxidant capability of liquid food and beverages in mainly performed by spin trapping technique.
Authoring a personal GPT for your research and practice: How we created the Q...
Thematic analysis in qualitative research is a time-consuming and systematic task, typically done using teams. Team members must ground their activities on common understandings of the major concepts underlying the thematic analysis, and define criteria for its development. However, conceptual misunderstandings, equivocations, and lack of adherence to criteria are challenges to the quality and speed of this process. Given the distributed and uncertain nature of this process, we wondered if the tasks in thematic analysis could be supported by readily available artificial intelligence chatbots. Our early efforts point to potential benefits: not just saving time in the coding process but better adherence to criteria and grounding, by increasing triangulation between humans and artificial intelligence. This tutorial will provide a description and demonstration of the process we followed, as two academic researchers, to develop a custom ChatGPT to assist with qualitative coding in the thematic data analysis process of immersive learning accounts in a survey of the academic literature: QUAL-E Immersive Learning Thematic Analysis Helper. In the hands-on time, participants will try out QUAL-E and develop their ideas for their own qualitative coding ChatGPT. Participants that have the paid ChatGPT Plus subscription can create a draft of their assistants. The organizers will provide course materials and slide deck that participants will be able to utilize to continue development of their custom GPT. The paid subscription to ChatGPT Plus is not required to participate in this workshop, just for trying out personal GPTs during it.
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Aleš Zamuda: Randomised Optimisation Algorithms in DAPHNE .
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https://ashpc.eu/
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Understanding research studies.pptx.pdf
- 1. INTERACTION PARAMETERS/MOLECULAR DOCKING UNDERSTANDING BIOMEDICAL RESEARCH STUDIES: SOREMEKUN OLADIMEJI
- 4. Interaction Parameters 🖜 Interaction parameter refers to the cellular, macromolecular, and atomistic effects of pathogenic and physiological interactions in a biological system. Every research study is designed to assay for key interaction parameters.
- 5. Interaction Parameters Assays(I.P.A) This is the jargon that defines the experiment type that will carried out to assess the interaction parameters in any biological system. There are two types. They are: • Biophysical interactions assays • Biological consequence(s) assays What is I.P.A? Types of I.P.A 🖜
- 7. Biophysical Interaction Assays What are these assays? Biophysical interactions, which are the macro and micro- molecular associations in the living system are assayed through the following experimental methods. • Macromolecular Crystallography e.g protein crystallography • Computer Aided Drug Design e.g molecular docking, molecular dynamics simulation. • Gravimetric Analysis e.g Quartz Crystal Microbalance(QCM) • Biolayer Interferometry(BLI). 🖜
- 8. Biological Consequence Assays What are these? We assess the outcome of the biomolecular interactions taking place in the living system. These biological outcomes can be transcriptomic, proteomic, cellular and/or morphological. • Blots e.g western blot, northern blot • Enzyme-linked Immunosorbent Assay(ELISA) • Spectrophotometry • Microscopy 🖜
- 9. Nota Bene! How do I choose the right assays for my study? 🖜 It's vital to remember that identifying and understanding the relevant biomolecular pathway(s) will help you choose the best assay(s) to utilize in your research project. This only suggests that the selection of an assay is dependent upon the biomolecular pathway(s) of the pathogenic condition being investigated in every given research.
- 11. Molecular docking? ● The goal of ligand-protein docking/protein-protein docking is to predict the predominant binding mode(s) of a ligand with a protein of known three-dimensional structure.
- 12. Steps involved in molecular docking Accession and Preparation of implicated protein targets. Protei ns Accession and Preparation of compounds/ligands/drugs of study. Ligand s Molecular docking and visualization of the docking analysis. D-R Complex
- 13. Final step! Druglikenes s Pharmacokinetic accession of the ligands of study using various cheminformatics parameters. Are they druggable ?
- 14. WHY PROTEINS? The knowledge of your protein target is the most crucial of all molecular docking steps. Protein(s) of study shouldn’t be retrieved without prior understanding of its structure(tertiary structure-3D) as this tells us a lot about it function(s).
- 16. Grazie!