Tuples can be created in Python in several ways such as using parentheses to contain a comma-separated list of values of different data types, creating a single element tuple by following a value with a comma, creating an empty tuple using parentheses or the tuple() function, nesting tuples within other tuples, slicing tuples to create new tuples, concatenating tuples using the + operator, and unpacking and packing tuples to extract or group values. Tuples are immutable and allow efficient lookup, storage, and retrieval of elements.