1) Prenatal diagnosis identified 23 cases of cardiac tumors over 16 years at two Polish centers, including 12 cases of multiple tumors. 2) Survival was not significantly different between cases of single versus multiple tumors or those with versus without congestive heart failure. 3) The main tumors identified were rhabdomyomas, and all cases of multiple tumors were later diagnosed as tuberous sclerosis.
Histomorphological Profile and Immunohistochemical Analysis of Endometrium in...iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
Histomorphological Profile and Immunohistochemical Analysis of Endometrium in...iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
Natural history of caesarean scar pregnancy on prenatal ultrasound the cross...Võ Tá Sơn
Natural history of caesarean scar pregnancy on prenatal ultrasound the cross-over sign Cali 2016
Dấu hiệu cross-over trong siêu âm tiền sản tiên lượng tiến triển của thai ở sẹo mổ lấy thai, võ tá sơn
The International Journal of Engineering and Science (The IJES)theijes
The International Journal of Engineering & Science is aimed at providing a platform for researchers, engineers, scientists, or educators to publish their original research results, to exchange new ideas, to disseminate information in innovative designs, engineering experiences and technological skills. It is also the Journal's objective to promote engineering and technology education. All papers submitted to the Journal will be blind peer-reviewed. Only original articles will be published.
Nutcracker syndrome in children presenting with recurrent gross hematuriaApollo Hospitals
Nutcracker syndrome is a rare cause of hematuria. Two children who presented to us with recurrent gross hematuria were evaluated. Renal parenchymal disease and abnormalities in the urinary tract were ruled out. CT angiography revealed a compressed left renal vein with dilatation and hence a diagnosis of nutcracker syndrome was made. A high index of suspicion is required for diagnosis of nutcracker syndrome.
Advances in the diagnosis and treatment for benign and malignant thyroid diseaseHealthXn
Thyroid disorders are common. This presentation reviews the causes of benign thyroid disease as well as therapy, including new therapies for advanced thyroid cancer.
Case Presentation - breast cancer in pregnancyLobna Shash
This is an undergraduate role playing case presentation scenario for a breast MDTM imitation, students personalised different disciplines of the MDT each presenting his/her part of the case in a 'retrospective summary of the outcome of a supposedly previously discussed case'
Natural history of caesarean scar pregnancy on prenatal ultrasound the cross...Võ Tá Sơn
Natural history of caesarean scar pregnancy on prenatal ultrasound the cross-over sign Cali 2016
Dấu hiệu cross-over trong siêu âm tiền sản tiên lượng tiến triển của thai ở sẹo mổ lấy thai, võ tá sơn
The International Journal of Engineering and Science (The IJES)theijes
The International Journal of Engineering & Science is aimed at providing a platform for researchers, engineers, scientists, or educators to publish their original research results, to exchange new ideas, to disseminate information in innovative designs, engineering experiences and technological skills. It is also the Journal's objective to promote engineering and technology education. All papers submitted to the Journal will be blind peer-reviewed. Only original articles will be published.
Nutcracker syndrome in children presenting with recurrent gross hematuriaApollo Hospitals
Nutcracker syndrome is a rare cause of hematuria. Two children who presented to us with recurrent gross hematuria were evaluated. Renal parenchymal disease and abnormalities in the urinary tract were ruled out. CT angiography revealed a compressed left renal vein with dilatation and hence a diagnosis of nutcracker syndrome was made. A high index of suspicion is required for diagnosis of nutcracker syndrome.
Advances in the diagnosis and treatment for benign and malignant thyroid diseaseHealthXn
Thyroid disorders are common. This presentation reviews the causes of benign thyroid disease as well as therapy, including new therapies for advanced thyroid cancer.
Case Presentation - breast cancer in pregnancyLobna Shash
This is an undergraduate role playing case presentation scenario for a breast MDTM imitation, students personalised different disciplines of the MDT each presenting his/her part of the case in a 'retrospective summary of the outcome of a supposedly previously discussed case'
Stratified Management of Cardiac Surgery for Structural Heart Disease during ...semualkaira
We study pregnancy outcomes of cardiac surgery
under cardiopulmonary bypass (CPB) at different stages and discuss stratified management of cardiac surgery under CPB in pregnant women with structural heart disease (SHD) from pre-pregnancy counseling through postpartum management.
Stratified Management of Cardiac Surgery for Structural Heart Disease during ...semualkaira
: We study pregnancy outcomes of cardiac surgery
under cardiopulmonary bypass (CPB) at different stages and discuss stratified management of cardiac surgery under CPB in pregnant women with structural heart disease (SHD) from pre-pregnancy counseling through postpartum management.
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
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Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
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Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
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Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
Thyroid Gland- Gross Anatomy by Dr. Rabia Inam Gandapore.pptx
Tumores cardíacos
1. PRENATAL DIAGNOSIS
Prenat Diagn 2010; 30: 882–887.
Published online 16 August 2010 in Wiley Online Library
(wileyonlinelibrary.com) DOI: 10.1002/pd.2586
Prenatal diagnosis and follow-up of 23 cases of cardiac
tumors
Katarzyna Niewiadomska-Jarosik1
*, Jerzy Sta´nczyk1
, Katarzyna Janiak2
, Piotr Jarosik3
, Jacek Jan Moll3
,
Justyna Zamojska1
and Maria Respondek-Liberska2
1
Fetal Echocardiography Laboratory, Department of Pediatric Cardiology of the 2nd Chair of Pediatrics, Medical University of
Lodz, Lodz, Poland
2
Department for Diagnosis and Prevention of Congenital Malformations, Chair of Embryology and Morphology, Polish Mother’s
Memorial Hospital, Medical University of Lodz, Lodz, Poland
3
Department of Cardiosurgery, Polish Mother’s Memorial Hospital, Lodz, Poland
Objective To evaluate the prenatal characteristics and postnatal outcome of cardiac tumors diagnosed at two
prenatal Polish cardiology centers.
Methods Descriptive analysis of 23 fetuses with cardiac tumors (12 multiple and 11 single) diagnosed over
16 years (from 1993 to 2009). Congestive heart failure was diagnosed when the cardiovascular profile score
was seven or less.
Results Associated structural congenital heart defects were present in three fetuses, extracardiac anomalies
in three, and chromosomal anomalies in two. Congestive heart failure developed in five cases. Perinatal
survival was not different between cases with and without cardiac failure (2/5 vs 12/18, p = 0.28). The
main ultrasonographic signs observed prenatally in association with cardiac tumors were cardiomegaly, left
ventricular outflow tract obstruction, pericardial effusion, and hypokinesis. A diagnosis of tuberous sclerosis
was eventually made in all 12 fetuses with multiple tumors. Perinatal death occurred in 4/11 cases with single
tumors and in 5/12 with multiple tumors (p = 0.57). Surgical resection of the tumor was performed in 3/11
neonates with single tumors (histopathologically: rhabdomyoma, teratoma, and fibroma) and in 2/12 with
multiple tumors (both rhabdomyomas).
Conclusions Survival is not different between neonates with single and multiple tumors and between those
with and without congestive heart failure. Copyright 2010 John Wiley & Sons, Ltd.
KEY WORDS: prenatal diagnosis; cardiac tumors; fetus; neonate; management algorithm
INTRODUCTION
Primary cardiac tumors are rare in fetuses, although their
incidence is unknown. Among live births, the incidence
of cardiac tumors varies between 0.0017 and 0.028%
(Palmer et al., 1986; Todros et al., 1991; Bulas et al.,
1992; Cartagena et al., 1993; Munoz et al., 1995; Tseng
et al., 1999; Paladini et al., 2003; Garcia Martinez et al.,
2004; Issacs, 2004; Zhou et al., 2004). They can be
asymptomatic or can lead to significant hemodynamic
disturbances and even can cause death in utero or in the
neonatal period (DeVore et al., 1982; Geipel et al., 2001;
Garcia Martinez et al., 2004; Issacs, 2004; Zhou et al.,
2004). Prenatal diagnosis allows to monitor the progress
of these tumors and, if needed, provide proper man-
agement during pregnancy, choose the appropriate time
and type of delivery, and plan treatment in the postnatal
period (Respondek-Liberska, 2000; Geipel et al., 2001;
D’Addario et al., 2002; Soongswang et al., 2002).
The aim of our study was to evaluate prenatal
and postnatal outcomes of a series of cases of fetal
*Correspondence to: Katarzyna Niewiadomska-Jarosik, Depart-
ment of Pediatric Cardiology of the 2nd Chair of Pediatrics, Med-
ical University of Lodz, Ul. Sporna 36/50, 91-738 Lodz, Poland.
E-mail: kasiajarosik@wp.pl
cardiac tumors diagnosed at two prenatal cardiology
centers in Lodz, Poland, in order to determine whether
ultrasonographic characteristics of the tumors (single or
multiple, with or without associated heart failure) affect
survival, and to design a management algorithm.
METHODS
From the databases of the Department for Diagnosis
and Prevention of Congenital Malformations at Polish
Mother’s Memorial Hospital and of the Fetal Echocar-
diography Laboratory at the Department of Pediatric
Cardiology at the Medical University of Lodz, all
cases of prenatal diagnoses of cardiac tumors in sin-
gleton pregnancies were compiled over a 16-year period
(1993–2009). The first Institution is located next to the
Obstetric Department and it registers more than 100
cases of heart defects per year. The second Institution
is located next to the Pediatric Cardiology Department
and diagnoses more than 50 heart defects per year.
Pregnant women were most frequently referred for
echocardiographic examination because of abnormal
four-chamber views observed during obstetric ultrasono-
graphic scans. If a cardiac tumor was suspected, we
performed fetal echocardiographic examination to assess
Copyright 2010 John Wiley & Sons, Ltd. Received: 11 January 2010
Revised: 7 June 2010
Accepted: 8 June 2010
Published online: 16 August 2010
2. PRENATAL DIAGNOSIS AND FOLLOW-UP 883
cardiac anatomy, number of tumors, their localization,
and the hemodynamic status. After the initial exami-
nation, follow-up echocardiographic examinations were
performed every 2 weeks until 32 weeks of gestation,
and weekly thereafter. After delivery, prenatal diagno-
sis was confirmed and liveborn infants were followed
up to establish the need for medical or surgical therapy.
We used Cardiovascular Profile Score (CVPS), which
has been proposed as an echocardiographic method of
assessing cardiovascular well-being in fetuses (Huhta,
2004, 2005). A diagnosis of congestive heart failure was
made when CVPS was 7 points or less.
Differences between survival rates of infants with
single and multiple tumors, and of those with and
without congestive heart failure were compared using
Fisher’s exact test, with p < 0.05 considered significant.
RESULTS
During the 16 years of the study period, 17 525 echocar-
diographic examinations were performed in fetuses, and
cardiac tumors were diagnosed in 23 cases (0.0013%).
Of the 23 fetuses included, 12 had multiple cardiac
tumors. Localization of the tumors is shown in Table 1.
Table 2 displays the population characteristics.
Twenty fetuses had normal heart anatomy, whereas
three had cardiac anomalies, including one atrioven-
tricular septal defect, one tetralogy of Fallot, and one
Table 1—Localization of the cardiac tumors
Tumors RV LV
RV +
LV P
Single 5 5 — 1
Multiple — — 12 —
RV, right ventricle; LV, left ventricle; RV + LV, both (right and left)
ventricles; P, pericardium.
Table 2—Characteristics of study population—mean (range)
or number (%)
Feature
Mean (range)
or number (%)
Maternal age (years) 28.6 (19.6–37.6)
Gestational age at first
echocardiographic examination
(weeks)
23.2 (23.3–40.1)
Number of echocardiographic
examinations
1.6 (1–16)
Gestational age at delivery 37 (31–40)
Birth weigh (g) 2950 (2000–3950)
Apgar score 6.6 (0–9)
Appropriate for gestational age 21 (91.3%)
Birth weight <10th percentile 2 (8.7%)
Live births 21 (91.3%)
Male neonates 13 (61.9%)
Female neonates 8 (38.1%)
Intrauterine death 2 (8.7%)
Delivery by cesarean section 14 (60.9%)
Spontaneous delivery 9 (39.1%)
with aortic atresia and total anomalous pulmonary
venous return. In addition, three fetuses had extrac-
ardiac anomalies: one with hydrocephalus and kidney
anomaly (without congenital heart defect); one with pul-
monary hypoplasia (fetus mentioned above with aortic
atresia and total anomalous pulmonary venous return);
and one fetus had multiple tumors in the heart, central
nervous system, kidneys, and eyeball (without congeni-
tal heart defect). Echocardiographic findings at diagnosis
of the cardiac tumors in the examined group are listed in
Table 3. Two fetuses had chromosomal anomalies: one
trisomy 21 (neonate with cardiac tumor and tetralogy of
Fallot) and one with balanced Robertsonian translocation
(neonate with cardiac tumor complicated by aortic atre-
sia with total anomalous pulmonary venous return). In
all fetuses with multiple tumors a diagnosis of tuberous
sclerosis (TS) was made. In one case there was familial
occurrence of TS.
Congestive heart failure was diagnosed in 5 fetuses
(average CVPS of 5.8 points) at a mean gestational
age of 33.8 weeks (range 28–38), whereas 18 fetuses
remained without congestive heart failure (mean CVPS
was 8.88 points). There was no difference in perinatal
mortality between cases with and without congestive
heart failure (2/5 vs 12/18, p = 0.28).
Of the 11 neonates with single tumors, 3 required
neonatal surgery involving total tumor resection. Postop-
erative histopathological examination revealed teratoma
in one case, fibroma in one case, and rhabdomyoma
in one case (Figures 1–3). The infant with the fibroma
Table 3—Echocardiographic findings at diagnosis of cardiac
tumor
Fetuses
Cardiomegaly (HA/CA > 0.45) 10
Pericardial fluid (3–23 mm) 9
Arrhythmia (premature beats) 4
LVOTO 3
Hypokinesis 2
HA/CA, heart area/chest area; LVOTO, left ventricle outflow tract
obstruction.
Figure 1—Echocardiographic image of teratoma
Copyright 2010 John Wiley & Sons, Ltd. Prenat Diagn 2010; 30: 882–887.
DOI: 10.1002/pd
3. 884 K. NIEWIADOMSKA-JAROSIK et al.
Figure 2—Echocardiographic image of fibroma
Figure 3—Echocardiographic image of rhabdomyoma
of right ventricle developed large pericardial effusion
and congestive heart failure and died postoperatively,
whereas the other two infants survived the surgery. Eight
neonates were not candidates for surgery, three because
the tumors were small and caused no hemodynamic dis-
turbances, two because the tumors were massive (both
cases had congestive heart failure), and three died before
cardiosurgical intervention: one neonate with a tumor of
the left ventricle developed arrhythmia and congestive
heart failure and died at 28 days; the second had a tumor
of the left ventricle with hypokinesis, died at 11 days,
and a diagnosis of TS was eventually made; and the
third death occurred at 3 days in a neonate with pericar-
dial tumor, pulmonary hypoplasia, and congenital heart
defect (aortic atresia with total anomalous pulmonary
venous return).
Of the 12 cases with multiple tumors, 2 fetuses died
in utero, 3 neonates died in the preoperative period,
including 1 with associated atrioventricular septal defect
and left ventricle outflow tract obstruction (death at
3 days of life), 1 with renal tumor and congestive heart
failure (death at 7 days of life), and 1 with central
nervous system, kidney and eyeball tumors (death at
10 days of life). Two neonates qualified for surgery
and partial tumor resection was successfully performed.
Histopathological examination showed rhabdomyomas
in both cases. Five neonates with multiple tumors were
not candidates for surgery: three because of massive
multiple tumors and two because the tumors were small
and did not cause significant hemodynamic disturbances.
The follow-up of fetuses with single and multiple cardiac
tumors is presented in Figure 4.
In summary, among liveborn neonates with multiple
tumors (ten cases), successful partial resection of tumor
was performed in two, preoperative deaths occurred in
three cases (tumors complicated by congestive heart
failure or congenital heart defect), and five patients did
not qualify for surgery. Among liveborn neonates with
single tumors (11 cases), 3 underwent surgery, of which
2 survived and 1 died, 3 died preoperatively, and 5
did not qualify for surgery. There was no significant
difference in survival between neonates with single and
multiple tumors (p = 0.57).
Our analysis has enabled to design the manage-
ment algorithm depending on the cardiac tumor nature,
echocardiographic features in fetus, and prognosis
(Figure 5).
DISCUSSION
We have found that survival is not different between
neonates with single and multiple tumors and between
those with and without congestive heart failure. How-
ever, the small number of cases in our series, though one
of the largest in the literature, severely limits the statis-
tical power of these results. We did not observe cardiac
tumors in fetuses below 20 weeks of gestation. The ges-
tational age at diagnosis in our series (second half of
pregnancy) is consistent with what has been reported in
the literature: Geipel et al. (2001) and Zou et al. (2004)
reported diagnosis of cardiac tumors after 22 weeks of
gestation.
Our series confirms several observations already
reported in the literature regarding the frequency and
behavior of the most common histological type of car-
diac tumors. Rhabdomyoma was the most common his-
tological diagnosis in our series of neonates who died or
Fetuses with tumors-
23
Live born neonates - 21
Death before
surgery - 6
Qualification to
surgery - 5
Survival
4 (19%)
Total
resection-
2
Partial
resection - 2
Death
1
Disqualification
from surgery-
10
Large,
infiltrating
or
numerous
tumors - 5
Small tumors,
without
hemodynamic
disorders - 5
Intrauterine
death - 2
Figure 4—Follow-up of fetuses with cardiac tumors
Copyright 2010 John Wiley & Sons, Ltd. Prenat Diagn 2010; 30: 882–887.
DOI: 10.1002/pd
4. PRENATAL DIAGNOSIS AND FOLLOW-UP 885
Management algorithm
hbd – weeks of gestation
NHA – normal heart anatomy
CVSP – Cardiovascular Profile Score
TS – tuberous sclerosis
Fetus with single or multiple cardiac
tumor diagnosed in II half of pregnancy
Echocardiographic monitoring of fetus
every 2 weeks < 32 hbd, every 7 days >
32 hbd
Heart defect
NHA NHA NHA
Consider additional
cytogenetic
diagnostics (In our
material –trisomy 21,
Robertsonian
translocation)
Congestive heart
failure
CVSP < 7
Probable death
(In our analysis 100%)
CVSP =/> 8
Resection of
tumor in
neonatal
period
Good
postoperative
outcome
CVSP=/> 8
Spontaneous
regression
Good prognosis in
neonatal period and
infancy
Possibility of TS
development
In 1 – 2 year of life
– neurological
consultation
(Looking for
mutation 9q34.3
and 16p13.3)
Spontaneous
regression
Without
hospitalization
in 2-3 year of
life
Conservative
treatment
Probable death
(In our analysis 100%)
Figure 5—Management algorithm
underwent surgery, and it was diagnosed in all multiple
tumors and in three single tumors. In line with our
findings, rhabdomyomas have been reported to account
for about 60% of all fetal tumors (Chang et al., 1992;
Groves et al., 1992; Gutierrez-Larraya et al., 1997;
Geipel et al., 2001; Garcia Martinez et al., 2004; Zhou
et al., 2004). Rhabdomyomas are typically multiple and
originate from the free wall of the ventricle and ventric-
ular septum. Most often they involve the left chamber of
the heart (Tseng et al., 1999; Lethor and de Moore, 2001;
Zhou et al., 2004). Many authors report that rhabdomy-
omas may cause left or right ventricle flow obstruction,
pericardial or pleural effusion, and alteration of atri-
oventricular valves, signs which we found in four cases.
Moreover, rhabdomyomas can cause different types of
arrhythmias, most often supraventricular tachycardia and
premature atrial contractions, depending on the localiza-
tion of the tumor (Geva et al., 1991; Groves et al., 1992;
Geipel et al., 2001; Nir et al., 2001; Issacs, 2004; Zhou
et al., 2004). Rhabdomyomas have the tendency for
spontaneous regression in the postnatal period (Groves
et al., 1992; Nir et al., 2001; D’Addario et al., 2002;
Pipitone et al., 2002; Tworetzky et al., 2003). In our
study, three neonates with small multiple tumors (diam-
eter <10 mm) without hemodynamic disturbances, in
good state of health did not require surgery, were dis-
charged from the hospital and were followed up as out-
patients. In 50–86% of cases, rhabdomyomas are asso-
ciated with TS, often presenting malformations of the
central nervous system, skin, and other internal organs
such as kidneys (Groves et al., 1992; Krapp et al., 1999;
Geipel et al., 2001; Lethor and de Moore, 2001; Tworet-
zky et al., 2003; Zhou et al., 2004). Cardiac tumors are
the earliest in utero manifestation of this disease (Krapp
et al., 1999; Geipel et al., 2001; Tworetzky et al., 2003;
Zhou et al., 2004; J´o´zwiak et al., 2008; J´o´zwiak and
Respondek-Liberska, 2010). TS is much more common
in multiple than single cardiac tumors (95 vs 35% in the
series of Tworetzky et al. (2003). In our series, all 12
fetuses with multiple tumors were eventually diagnosed
Copyright 2010 John Wiley & Sons, Ltd. Prenat Diagn 2010; 30: 882–887.
DOI: 10.1002/pd
5. 886 K. NIEWIADOMSKA-JAROSIK et al.
with TS and familial occurrence of the condition was
confirmed in 1 case. Conversely, the diagnosis of TS was
made only in 1 of the 11 neonates with single tumors.
If TS is considered, pertinent genetic studies can be per-
formed via amniocentesis or chorion villus biopsy to
enable a complete diagnosis and pertinent counseling.
The second commonest cardiac tumor in fetuses is ter-
atoma. Most often it arises from pericardium, although
there are reported cases of intraventricular occurrence
of this type of tumor (Campagne et al., 1998; Riskin-
Mashiah et al., 1998; Tseng et al., 1999; Zhou et al.,
2004). Almost all teratomas lead to pericardial effusion.
These tumors may also compress the heart and lungs
interrupting their proper development. Only one case of
teratoma occurred in our series: it was prenatally diag-
nosed as intrapericardial tumor with massive pericardial
effusion, complicated by pulmonary hypoplasia and con-
genital heart defect (aortic atresia with total anomalous
pulmonary venous return). The neonate was not consid-
ered a candidate for surgery and died at 3 days of life.
The diagnosis of teratoma was made at autopsy.
Fibroma accounts for 12% of primary cardiac tumors
(Munoz et al., 1995). In our series, there was one
histopathological diagnosis of fibroma: it presented as a
single tumor arising from the right ventricle, complicated
by congestive heart failure, large pericardial effusion,
and cardiomegaly. The neonate underwent resection of
the tumor on the 16th day of life, but died on the
19th day.
As pregnancy termination is not allowed under Pol-
ish law for cardiac tumors detected late in pregnancy
(>24 weeks), we were able to study the natural history
of cardiac tumors. Serial echocardiographic examina-
tions are necessary to follow cardiac tumors, to evaluate
the progression of the tumor, the occurrence of any sign
of heart failure, and thus assist the obstetrician to opti-
mize the decision about time and mode of delivery. In
general, primary benign cardiac tumors have little ten-
dency for growth (Bertolini et al., 1990; Stiller et al.,
2001).
Postnatally, the treatment of choice for cardiac tumors
is surgical resection, which should be reserved for cases
with hemodynamic disturbances at echocardiographic
examination (Bertolini et al., 1990; Abushaban et al.,
1993; Beghetti et al., 1997; Henglein et al., 1998; Stiller
et al., 2001; Tollens et al., 2003; Padalino et al., 2005;
Schreiber et al., 2006). Regrettably, some cases with
hemodynamic disturbances may not be candidates for
surgery as they may not be able to withstand it. The
decision regarding which fetuses with hemodynamic
disturbances are candidates for surgery should be based
on consultation of cardiological and cardiosurgery team
and estimation the surgery risk for the patient with
congestive heart failure. The aim of surgery should be
restoration of the best cardiac muscle function possible
which may not always be synonymous with total tumor
resection (Bertolini et al., 1990). Stiller et al. (2001) did
not observe recurrence of tumor after partial resection.
In cases of massive tumors, where resection is not
possible and clinical symptoms are likely to occur, the
only therapeutic option may be heart transplantation
(Padalino et al., 2005). This option was not taken into
consideration in our center because of lack of donors. In
case of asymptomatic lesions it is suggested to observe
the evolution of the tumor conservatively. In most cases
partial or total regression of tumor is observed over time
(Bertolini et al., 1990; Woskowicz et al., 1994; Stiller
et al., 2001).
In addition to two stillbirths, neonatal deaths occurred
in seven cases in our series: six in preoperative period
and one in the perioperative period. Of them, four
exhibited congestive heart failure (in three cases with
large tumor and in one case with associated arrhythmia),
two had an associated congenital heart defect, and
the last one had numerous tumors in multiple organs,
including the central nervous system. In line with our
findings, Chao et al. (2008) reported that neonatal deaths
with cardiac tumors are related to the size of the tumor,
the presence of severe heart failure (hydrops fetalis), and
arrhythmia.
CONCLUSION
1. Survival was not different between neonates with
prenatal diagnosis of single and multiple tumors.
2. There was also no difference in survival between
fetuses with and without congestive heart failure.
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