4. Polymorphism in the NRAMP 1 gene NRAMP1 Transmembrane protein in lysosomes Pumps Ca++ out of lysosome May inihibit growth by Limiting availability of ions needed by bacteria Susceptiblity Gene
5. Stimulate macrophages to kill TB bacteria Stimulates formation of phagolysosome in infected macrophages Stimulates expression of NO synthase Nitric oxide ( destroy bacterial cell wall to DNA ) Differantiation of macrophages Epitheloidhistiocytes Halts infection Mature TH1
10. Slowly progressive infection Low Communicability Affecting the skin & peripheral nerves Disabling deformity Most are contained in the skin Likely transmitted by aerosols from lesions in the Upper Respiratory Tract Hematogenous grows only in relatively Cool Tissues of the skin & Extremities Leprosy
14. Paucibacillary Leprosy Have dry , scaly, skin lesions Lack sensation , Asymmetric peripheral nerve involvement Have TH1 response Normal immune response Granuloma containing less microbe Damage neurons Production of IL-2 & IFN- g Lepromin skin test is strongly (+) T cell response – Delayed Hypersensitivity rxn to lepromin Tuberculoid Leprosy
