This document outlines the EXCEL clinical trial which compared the XIENCE stent to coronary artery bypass graft surgery for treating left main coronary artery disease. The aim was to establish the safety and efficacy of the XIENCE stent by comparing it to CABG surgery. The trial measured outcomes including major adverse events, stent thrombosis rates, and graft stenosis or occlusion rates. The results showed that PCI was statistically inferior to CABG for treating left main coronary artery disease and was also likely clinically inferior. However, PCI may still be an appropriate option for some high risk patients.