This document discusses issues facing gender-variant people of color in the United States who are of Asian or African descent. It notes that these individuals face compounded discrimination due to racism, transphobia, and other forms of oppression. Research on their experiences has been limited. Guidelines are provided for clinicians working with gender-variant people of color, including examining one's own biases, being aware of differences in acculturation, and respecting clients' cultural preferences. The document also summarizes issues specifically impacting transgender Eastern Asians, Pacific Islanders, and Southern Asians in the U.S., such as cultural barriers, family rejection, health risks, and experiences of isolation.