A new development and validation of uv visible spectrophotometric method for ...IJARIIT
The two methods for simultaneous estimation of Etoricoxib and Paracetamol in a combination of two drug tablet
dosage form have been developed using Sodium Hydroxide (NaOH) as a solvent. The UV-visible Spectrophotometric was a
determination using the simultaneous or operating of the same time equation method was a determination using the
simultaneous equation method at 238.0 nm and 250.0 nm. The second UV Spectrometric method is the Q-analysis (absorption
ratio) method, which involves the formation of absorbance equation at 243.0 nm (isoabsorptive point) and at 250.0 nm the
maximum absorption of Paracetamol. The accuracy of the methods was assessed by recovery studies was found to be 100.3 ±
0.53 and 100.4 ± 0.80 for simultaneous equation method and 96.8 ± 0.55 and 98.18 ± 0.58 for Q analysis (absorption ratio)
method for Etoricoxib and Paracetamol respectively. These methods are no complicated involved also corrected and rapid those
require no in preparation of the more important separation and can, therefore, be used for routine analysis of both drugs. The
linearity ranges for Etoricoxib and Paracetamol were 4-12μg/ ml and 2-18μg/ml respectively. The linearity ranges for Etoricoxib
and Paracetamol were 2-18 μg/ml and 2-10 μg/ml respectively.
Formulation and evaluation of mouth dissolving film containing antiemetic dru...siddhant thakur
The final presentation on the research topic of "FORMULATION AND EVALUATION OF MOUTH DISSOLVING FILM CONTAINING ANTIEMETIC DRUG FOR THE TREATMENT OF MOTION SICKNESS"
This presentation includes the Introduction about MDFs, Literature reviews, Statement of the research problem, Objectives of the study, Plan of research work, Drug selections, Preformulation studies, Design expert 11, Preparation of MDFs and Evaluations, Optimization of formulations and final conclusion
Spectrophotometric Determination of Drugs and Pharmaceuticals by Cerium (IV) ...IOSR Journals
Simple, sensitive, accurate, and precise spectrophotometric methods for quantitative determination of drugs, viz., Darifenacin (DAR), Esmolol Hydrochloride (ESM), Montelukast Sodium (MON), Sildenafil citrate (SIL),Terbinafine (TER) and Tramadol Hydrochloride (TRA) were developed. The method of each drug depends upon oxidation of drugs by Ce (IV) (Excess) and estimating the amount of unreacted Ce (IV) by amaranth dye at 523nm. The calibration curves obeyed Beer’s law over the concentration range of 1.4-7.0 μg ml-1 (DAR), 2-14 μg ml-1 (ESM), 2-10 μg ml-1 (MON), 20-70 μg ml-1 (SIL), 3-21 μg ml-1 (TER) & 2-14 μg ml-1 (TRA). The methods have been validated in terms of guidelines of ICH and applied to analysis of pharmaceuticals.
A new precise accurate and reliable validated method for the determination of Capecitabine was developed by using
reverse phase high performance liquid chromatography in pharmaceutical dosage forms. Spectrophotometer
determination was carried out at an absorption maximum of 240nm by using methanol. The linearity was over the
concentration range of 20-120 μg/ml with correlation coefficient 0.999. Chromatographic separation was carried
out by using a mobile phase of methanol: Acetonitrile: water (80:20:80 V/V) on Waters 2487 dual absorbance
column in an isocratic mode at a flow rate of 1.1 ml/min with UV detection at 240 nm. The developed methods were
found to be precise and accurate for the estimation of Capecitabine in pharmaceutical dosage forms and could be
used for routine analysis.
Keywords: Capecitabine, RP-HPLC, Spectrophotometry, Waters 2487 dual absorbance detector, Nova pack 300 ×
3.9mm 5μ as column, 240nm
A new RP -HPLC method development and validation for simultaneous estimation ...SriramNagarajan19
A simple, accurate, precise method was developed for the simultaneous estimation of the Aspirin and Omeprazole in Tablet dosage form. Chromatogram was run through Discovery 250 x 4.6 mm, 5m. Mobile phase containing Buffer and Acetonitrile in the ratio of 70:30 v/v was pumped through column at a flow rate of 1 ml/min. Temperature was maintained at 30°C. Optimized wavelength for Aspirin and Omeprazole was 241 nm. Retention time of Aspirin and Omeprazole were found to be 2.454 min and 3.168 min %RSD of the Aspirin and Omeprazole were and found to be 1.1 and 0.8 respectively. Percentage recovery was obtained as 99.50% and 99.57%for Aspirin and Omeprazole. LOD, LOQ values were obtained from regression equations of Aspirin and Omeprazole were 0.26ppm, 0.80ppm and 0.06ppm, 0.17ppm respectively. Regression equation of Aspirin is y = 3524x + 3853, and of Omeprazole is y = 10438x+542.2.
A new development and validation of uv visible spectrophotometric method for ...IJARIIT
The two methods for simultaneous estimation of Etoricoxib and Paracetamol in a combination of two drug tablet
dosage form have been developed using Sodium Hydroxide (NaOH) as a solvent. The UV-visible Spectrophotometric was a
determination using the simultaneous or operating of the same time equation method was a determination using the
simultaneous equation method at 238.0 nm and 250.0 nm. The second UV Spectrometric method is the Q-analysis (absorption
ratio) method, which involves the formation of absorbance equation at 243.0 nm (isoabsorptive point) and at 250.0 nm the
maximum absorption of Paracetamol. The accuracy of the methods was assessed by recovery studies was found to be 100.3 ±
0.53 and 100.4 ± 0.80 for simultaneous equation method and 96.8 ± 0.55 and 98.18 ± 0.58 for Q analysis (absorption ratio)
method for Etoricoxib and Paracetamol respectively. These methods are no complicated involved also corrected and rapid those
require no in preparation of the more important separation and can, therefore, be used for routine analysis of both drugs. The
linearity ranges for Etoricoxib and Paracetamol were 4-12μg/ ml and 2-18μg/ml respectively. The linearity ranges for Etoricoxib
and Paracetamol were 2-18 μg/ml and 2-10 μg/ml respectively.
Formulation and evaluation of mouth dissolving film containing antiemetic dru...siddhant thakur
The final presentation on the research topic of "FORMULATION AND EVALUATION OF MOUTH DISSOLVING FILM CONTAINING ANTIEMETIC DRUG FOR THE TREATMENT OF MOTION SICKNESS"
This presentation includes the Introduction about MDFs, Literature reviews, Statement of the research problem, Objectives of the study, Plan of research work, Drug selections, Preformulation studies, Design expert 11, Preparation of MDFs and Evaluations, Optimization of formulations and final conclusion
Spectrophotometric Determination of Drugs and Pharmaceuticals by Cerium (IV) ...IOSR Journals
Simple, sensitive, accurate, and precise spectrophotometric methods for quantitative determination of drugs, viz., Darifenacin (DAR), Esmolol Hydrochloride (ESM), Montelukast Sodium (MON), Sildenafil citrate (SIL),Terbinafine (TER) and Tramadol Hydrochloride (TRA) were developed. The method of each drug depends upon oxidation of drugs by Ce (IV) (Excess) and estimating the amount of unreacted Ce (IV) by amaranth dye at 523nm. The calibration curves obeyed Beer’s law over the concentration range of 1.4-7.0 μg ml-1 (DAR), 2-14 μg ml-1 (ESM), 2-10 μg ml-1 (MON), 20-70 μg ml-1 (SIL), 3-21 μg ml-1 (TER) & 2-14 μg ml-1 (TRA). The methods have been validated in terms of guidelines of ICH and applied to analysis of pharmaceuticals.
A new precise accurate and reliable validated method for the determination of Capecitabine was developed by using
reverse phase high performance liquid chromatography in pharmaceutical dosage forms. Spectrophotometer
determination was carried out at an absorption maximum of 240nm by using methanol. The linearity was over the
concentration range of 20-120 μg/ml with correlation coefficient 0.999. Chromatographic separation was carried
out by using a mobile phase of methanol: Acetonitrile: water (80:20:80 V/V) on Waters 2487 dual absorbance
column in an isocratic mode at a flow rate of 1.1 ml/min with UV detection at 240 nm. The developed methods were
found to be precise and accurate for the estimation of Capecitabine in pharmaceutical dosage forms and could be
used for routine analysis.
Keywords: Capecitabine, RP-HPLC, Spectrophotometry, Waters 2487 dual absorbance detector, Nova pack 300 ×
3.9mm 5μ as column, 240nm
A new RP -HPLC method development and validation for simultaneous estimation ...SriramNagarajan19
A simple, accurate, precise method was developed for the simultaneous estimation of the Aspirin and Omeprazole in Tablet dosage form. Chromatogram was run through Discovery 250 x 4.6 mm, 5m. Mobile phase containing Buffer and Acetonitrile in the ratio of 70:30 v/v was pumped through column at a flow rate of 1 ml/min. Temperature was maintained at 30°C. Optimized wavelength for Aspirin and Omeprazole was 241 nm. Retention time of Aspirin and Omeprazole were found to be 2.454 min and 3.168 min %RSD of the Aspirin and Omeprazole were and found to be 1.1 and 0.8 respectively. Percentage recovery was obtained as 99.50% and 99.57%for Aspirin and Omeprazole. LOD, LOQ values were obtained from regression equations of Aspirin and Omeprazole were 0.26ppm, 0.80ppm and 0.06ppm, 0.17ppm respectively. Regression equation of Aspirin is y = 3524x + 3853, and of Omeprazole is y = 10438x+542.2.
Part A: To developed analytical (UV) method for determination of TOPIRAMATE in bulk and in oral solid dosage form.
Part B: To validate developed method as per ICH guidelines for parameters:
COLORIMETRY
It is the science & technology used to quantify & describe physically the Human color perception.
selection of drug
1. Drugs which not have strong UV absorbance.
2. Drugs for which Colorimetric methods are not available.
3. Drugs for which methods are available but they are time consuming & complex.
Eg. Dicloxacillin, Topiramate etc.
conclusion
Colorimetric method was developed and validated as per ICH guidelines for estimation of Topiramate in tablets.
Development of color is by reaction of amino group of drug with Ninhydrin reagent in presence of pyridine.
The method was found to be simple, accurate, precise and specific.
So, the proposed method can be used for the routine quality control analysis of the bulk drug as well as oral dosage forms.
Spectrophotometric Determination of Cardiovascular DrugsIJMER
International Journal of Modern Engineering Research (IJMER) is Peer reviewed, online Journal. It serves as an international archival forum of scholarly research related to engineering and science education.
Development and Validation of Analytical Methods for Simultaneous Spectrophot...ijtsrd
A simple, rapid UV Visible spectrophotometric method for the quantification of Pioglitazone hydrochloride and Glimepiride in bulk drug and tablet formulation was developed and validated. UV Visible spectrophotometric methods have been developed for the Derivative Spectrophotometric Method, of Pioglitazone and glimepiride in bulk and pharmaceutical dosage forms. the sampling wavelengths selected are 210 nm and 218 nm over the concentration ranges of 1.5 7.5 µg ml and 0.2 1.0 µg ml for pioglitazone and glimepiride respectively. Tejaswini Kande | Pallavi Dhekale | Supriya Khatal | Priyanka Borude "Development and Validation of Analytical Methods for Simultaneous Spectrophotometric Determination of Pioglitazone and Glimepiride by Derivative Method" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-1 , December 2019, URL: https://www.ijtsrd.com/papers/ijtsrd29699.pdf Paper URL: https://www.ijtsrd.com/pharmacy/analytical-chemistry/29699/development-and-validation-of-analytical-methods-for-simultaneous-spectrophotometric-determination-of-pioglitazone-and-glimepiride-by-derivative-method/tejaswini-kande
Estimation of Pioglitazone hydrochloride in Bulk and Pharmaceutical dosage fo...SriramNagarajan15
A simple, fast and reliable Spectrophotometric method was developed for determination of Pioglitazone hydrochloride in bulk and Pharmaceutical formulation. Spectrophotometrically, Pioglitazone hydrochloride was determined by measuring the maximum absorption at 270nm. Analytical Calibration curves were linear within a concentration range from 10 to 50µg/ml. The developed method was applied to directly and easily to the analysis of the pharmaceutical tablet preparations. % R.S.D was found to be 0.51 for piosis 30 mg Tablet. The %R.S.D values for all method validation parameters were found within 2% for the developed method. The method was completely validated. The results showed that this method can be used for rapid determination of Pioglitazone hydrochloride in bulk and Pharmaceutical tablet formulation with linearity, precision, accuracy specificity.
Determination of metronidazole from the solid dosage formAtai Rabby
Metronidazole is determined or assayed spectrophotometrically as the present methods abbeys Beer’s Law in the concentration range of 100-150 µg at about 500nm. By using the absorbance of standard solution of Metronidazole, the unknown amount of this drug in the sample can be calculated. The unknown amount of metronidazole is generally calculated by drawing the standard curve.
UV Spectrophotometric Method Development and Validation for Quantitative Esti...Sagar Savale
U.V Spectrophotometric method have been widely employed in determination of individual components in a mixture or fixed dose combination. Our aim is to develop spectroscopic method for estimation of the paracetamol in ternary mixture by using U.V spectrophotometry.
Analytical method Development and Validation for the estimation of Pioglitazo...SriramNagarajan15
This paper describes the analytical method suitable for validation of Pioglitazone hydrochloride by UV Spectrophotometric method. The method utilized UV spectroscopy and the solvent system was consists of 6 N Glacial acetic acid at wave length 270 nm. Validation experiments were performed to demonstrate Specificity, Precision, Linearity, Accuracy, ruggedness. The method was linear over the concentration range of 10-50 µg/ml. The Proposed method was simple, sensitive & reliable with good Precise, Accurate, and Reproducible and rapid for the determination of Pioglitazone. The commercial formulations are estimated without interference. Hence this method can be used for routine determination of Pioglitazone hydrochloride in bulk and their pharmaceutical dosage forms.
Determination of Satranidazole through Ion-Associative Complex ReactionRatnakaram Venkata Nadh
A simple, selective, accurate and low-cost spectrophotometric method
has been described for determination of satranidazole in bulk and
pharmaceutical formulations. The developed method involves the
formation of chloroform extractable colored ion-association complex
of satranidazole with Tropaeolin OOO (TPooo). The extracted colored
complex showed absorbance maximum at wavelength 484 nm and
obeying Beer′s law in the concentration 4-20 μg mL-1 with the
correlation coeffiecent of 0.9998. The results of statistical analysis of
the proposed method reveals high accuracy and good precession. Thus,
the proposed method can be used commercially for the determination
of satranidazole in bulk and pharmaceutical formulations.
Spectrophotometric Oxidation Method for the Determination of Teneligliptin by...ijtsrd
A sensitive, precise, accurate, simple and rapid spectrophotometric method has been developed for the estimation of Teneligliptin in pharmaceutical formulations and in the drug dosage form. During the course of study, it is observed that acidic solution of the drug formed the oxidation product with Bromate "“ Bromide mixture. This property of the drug is exploited for the development of spectrophotometric method for the determination and analysis of the drug. The oxidation product showed ?max at 250 nm. The linearity range for Teneligliptin is found to be 10 µgml to 250 µgml. Recovery studies gave satisfactory results indicating that none of common additives and excipients interfere the assay method. The molar absorptivity and the sandell sensitivity of the method are evaluated and the values are found to be to be 1.1645×104 lit molecm and 0.0366 µg mlcm2 respectively. I. Lakshmi Prasanna | G. T. Naidu | G. Abdul Huq"Spectrophotometric Oxidation Method for the Determination of Teneligliptin by Using Bromate "“ Bromide Mixture" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-2 | Issue-5 , August 2018, URL: http://www.ijtsrd.com/papers/ijtsrd18253.pdf http://www.ijtsrd.com/physics/other/18253/spectrophotometric-oxidation-method-for-the-determination-of-teneligliptin-by-using-bromate---bromide-mixture/i-lakshmi-prasanna
formulation and evaluation of microbeadsgurleen kaur
Microencapsulation has been employed to sustain the drug release, reduce or eliminate drug related adverse effects, dose intake and improve the bioavailability inspite drug undergo extensive first pass metabolism ultimately improve the compliance in pharmacotherapy of inflammation and pain.
Microencapsulation by ionotropic gelation technique is one of the widely used method for preparation of calcium alginate beads which has ability to form gels reaction with calcium salts .
Microencapsulation has been employed to sustain the drug release, reduce or eliminate drug related adverse effects, dose intake and improve the bioavailability inspite drug undergo extensive first pass metabolism ultimately improve the compliance in pharmacotherapy of inflammation and pain.
Microencapsulation by ionotropic gelation technique is one of the widely used method for preparation of calcium alginate beads which has ability to form gels reaction with calcium salts .
Part A: To developed analytical (UV) method for determination of TOPIRAMATE in bulk and in oral solid dosage form.
Part B: To validate developed method as per ICH guidelines for parameters:
COLORIMETRY
It is the science & technology used to quantify & describe physically the Human color perception.
selection of drug
1. Drugs which not have strong UV absorbance.
2. Drugs for which Colorimetric methods are not available.
3. Drugs for which methods are available but they are time consuming & complex.
Eg. Dicloxacillin, Topiramate etc.
conclusion
Colorimetric method was developed and validated as per ICH guidelines for estimation of Topiramate in tablets.
Development of color is by reaction of amino group of drug with Ninhydrin reagent in presence of pyridine.
The method was found to be simple, accurate, precise and specific.
So, the proposed method can be used for the routine quality control analysis of the bulk drug as well as oral dosage forms.
Spectrophotometric Determination of Cardiovascular DrugsIJMER
International Journal of Modern Engineering Research (IJMER) is Peer reviewed, online Journal. It serves as an international archival forum of scholarly research related to engineering and science education.
Development and Validation of Analytical Methods for Simultaneous Spectrophot...ijtsrd
A simple, rapid UV Visible spectrophotometric method for the quantification of Pioglitazone hydrochloride and Glimepiride in bulk drug and tablet formulation was developed and validated. UV Visible spectrophotometric methods have been developed for the Derivative Spectrophotometric Method, of Pioglitazone and glimepiride in bulk and pharmaceutical dosage forms. the sampling wavelengths selected are 210 nm and 218 nm over the concentration ranges of 1.5 7.5 µg ml and 0.2 1.0 µg ml for pioglitazone and glimepiride respectively. Tejaswini Kande | Pallavi Dhekale | Supriya Khatal | Priyanka Borude "Development and Validation of Analytical Methods for Simultaneous Spectrophotometric Determination of Pioglitazone and Glimepiride by Derivative Method" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-1 , December 2019, URL: https://www.ijtsrd.com/papers/ijtsrd29699.pdf Paper URL: https://www.ijtsrd.com/pharmacy/analytical-chemistry/29699/development-and-validation-of-analytical-methods-for-simultaneous-spectrophotometric-determination-of-pioglitazone-and-glimepiride-by-derivative-method/tejaswini-kande
Estimation of Pioglitazone hydrochloride in Bulk and Pharmaceutical dosage fo...SriramNagarajan15
A simple, fast and reliable Spectrophotometric method was developed for determination of Pioglitazone hydrochloride in bulk and Pharmaceutical formulation. Spectrophotometrically, Pioglitazone hydrochloride was determined by measuring the maximum absorption at 270nm. Analytical Calibration curves were linear within a concentration range from 10 to 50µg/ml. The developed method was applied to directly and easily to the analysis of the pharmaceutical tablet preparations. % R.S.D was found to be 0.51 for piosis 30 mg Tablet. The %R.S.D values for all method validation parameters were found within 2% for the developed method. The method was completely validated. The results showed that this method can be used for rapid determination of Pioglitazone hydrochloride in bulk and Pharmaceutical tablet formulation with linearity, precision, accuracy specificity.
Determination of metronidazole from the solid dosage formAtai Rabby
Metronidazole is determined or assayed spectrophotometrically as the present methods abbeys Beer’s Law in the concentration range of 100-150 µg at about 500nm. By using the absorbance of standard solution of Metronidazole, the unknown amount of this drug in the sample can be calculated. The unknown amount of metronidazole is generally calculated by drawing the standard curve.
UV Spectrophotometric Method Development and Validation for Quantitative Esti...Sagar Savale
U.V Spectrophotometric method have been widely employed in determination of individual components in a mixture or fixed dose combination. Our aim is to develop spectroscopic method for estimation of the paracetamol in ternary mixture by using U.V spectrophotometry.
Analytical method Development and Validation for the estimation of Pioglitazo...SriramNagarajan15
This paper describes the analytical method suitable for validation of Pioglitazone hydrochloride by UV Spectrophotometric method. The method utilized UV spectroscopy and the solvent system was consists of 6 N Glacial acetic acid at wave length 270 nm. Validation experiments were performed to demonstrate Specificity, Precision, Linearity, Accuracy, ruggedness. The method was linear over the concentration range of 10-50 µg/ml. The Proposed method was simple, sensitive & reliable with good Precise, Accurate, and Reproducible and rapid for the determination of Pioglitazone. The commercial formulations are estimated without interference. Hence this method can be used for routine determination of Pioglitazone hydrochloride in bulk and their pharmaceutical dosage forms.
Determination of Satranidazole through Ion-Associative Complex ReactionRatnakaram Venkata Nadh
A simple, selective, accurate and low-cost spectrophotometric method
has been described for determination of satranidazole in bulk and
pharmaceutical formulations. The developed method involves the
formation of chloroform extractable colored ion-association complex
of satranidazole with Tropaeolin OOO (TPooo). The extracted colored
complex showed absorbance maximum at wavelength 484 nm and
obeying Beer′s law in the concentration 4-20 μg mL-1 with the
correlation coeffiecent of 0.9998. The results of statistical analysis of
the proposed method reveals high accuracy and good precession. Thus,
the proposed method can be used commercially for the determination
of satranidazole in bulk and pharmaceutical formulations.
Spectrophotometric Oxidation Method for the Determination of Teneligliptin by...ijtsrd
A sensitive, precise, accurate, simple and rapid spectrophotometric method has been developed for the estimation of Teneligliptin in pharmaceutical formulations and in the drug dosage form. During the course of study, it is observed that acidic solution of the drug formed the oxidation product with Bromate "“ Bromide mixture. This property of the drug is exploited for the development of spectrophotometric method for the determination and analysis of the drug. The oxidation product showed ?max at 250 nm. The linearity range for Teneligliptin is found to be 10 µgml to 250 µgml. Recovery studies gave satisfactory results indicating that none of common additives and excipients interfere the assay method. The molar absorptivity and the sandell sensitivity of the method are evaluated and the values are found to be to be 1.1645×104 lit molecm and 0.0366 µg mlcm2 respectively. I. Lakshmi Prasanna | G. T. Naidu | G. Abdul Huq"Spectrophotometric Oxidation Method for the Determination of Teneligliptin by Using Bromate "“ Bromide Mixture" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-2 | Issue-5 , August 2018, URL: http://www.ijtsrd.com/papers/ijtsrd18253.pdf http://www.ijtsrd.com/physics/other/18253/spectrophotometric-oxidation-method-for-the-determination-of-teneligliptin-by-using-bromate---bromide-mixture/i-lakshmi-prasanna
formulation and evaluation of microbeadsgurleen kaur
Microencapsulation has been employed to sustain the drug release, reduce or eliminate drug related adverse effects, dose intake and improve the bioavailability inspite drug undergo extensive first pass metabolism ultimately improve the compliance in pharmacotherapy of inflammation and pain.
Microencapsulation by ionotropic gelation technique is one of the widely used method for preparation of calcium alginate beads which has ability to form gels reaction with calcium salts .
Microencapsulation has been employed to sustain the drug release, reduce or eliminate drug related adverse effects, dose intake and improve the bioavailability inspite drug undergo extensive first pass metabolism ultimately improve the compliance in pharmacotherapy of inflammation and pain.
Microencapsulation by ionotropic gelation technique is one of the widely used method for preparation of calcium alginate beads which has ability to form gels reaction with calcium salts .
Aim: This diploma thesis focused on the study of the influence of two types of high-shear
mixers as well as the effect of poly(meth)acrylate concentrations on the properties of
prepared granules and consequently matrix tablets.
Methods: Caffeine was employed as the model drug and matrix tablets were prepared via
the wet granulation process using two different high-shear mixers either Stephan UMC5 or
Rotolab mixer. Eudragit® NM 30D was used in various concentrations as a wet granulation
agent for time controlled drug release with low permeability and pH independent swelling.
In addition, lactose monohydrate was added as indifferent soluble filler, magnesium
stearate served as the antiadhesive excipient and colloidal silica was added for flowability
improvement. Matrix tablets were evaluated for mass, content and dosage uniformity,
uniformity of dosage units, friability, hardness and dissolution according to Ph. Eur.
Results - Conclusions: All prepared tablets exhibited sustained drug release. The
employment of different mixers for sustained matrix tablets preparation did not
significantly influence the release profile of caffeine (Eudragit® NM concentrations 9-
14%), except when the lower Eudragit® NM concentration (7%) was used for granulation.
Furthermore, Eudragit® NM concentrations (7 – 14% per tablet) did not significantly affect
the release profile of caffeine from matrix tablets, neither in the Stephan UMC5 nor the
Rotolab mixer.
In the present study an attempt will be made to design oral disintegrating tablets of Sumatriptan succinate (anti migraine) by using treated agar and Croscarmellose sodium as a superdisintigrants with a view to provide a convenient means of administration to those patients suffering from difficulties in swallowing such as pediatric and geriatric patients and uncooperative mentally ill patients.
STUDY OF MPS UNDER STRESSED CONDITIONSvivatechijri
This study is done to access the chemical stability of the candidate compound in the pharmaceuticals.
Usually, it is performed at the preliminary stage in the process of drug development. Forced degradation/ stress
testing is performed under accelerated environment. The experimental conditions cause the candidate compound
to degrade under extreme conditions like acid and base hydrolysis, peroxide oxidation, photo-oxidation and
thermal stability to identify the resultant degradation products. This helps to establish degradation pathways and
thus intrinsic stability of a drug substance. The stability of product describes shelf life and storage conditions and
helps in the selection of appropriate formulations and their suitable packaging. This is compulsory for regulatory
documentation. The commonly used analytical approach for FDS is HPLC with UV and/ or MS but these
techniques consume a lot of time and not provide high resolution to confirm the precise detection of degradation
products. Use of UPLC with photodiode array and MS analysis supports the identification of degradation
products and also reduces the time needed to evolve stability indicating methods.
Expt. 2 Bioassay of acetylcholine using rat ileum by four point bioassayVISHALJADHAV100
Objective
Principle
Requirements
Experimental specifications (conditions)
Preparation of ACh stock and standard solutions
Preparation of Tyrode solution (PSS)
Procedure
Kymograph recording of contractions
Observation table
Calculation
Result and interpretation
International Journal of Pharmaceutical Science Invention (IJPSI) is an international journal intended for professionals and researchers in all fields of Pahrmaceutical Science. IJPSI publishes research articles and reviews within the whole field Pharmacy and Pharmaceutical Science, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online.
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What you will learn during the webinar:
- For beginners: discover PowSyBl's functionalities through a quick general presentation and the notebook, without needing any expert coding skills;
- For advanced developers: master the skills to efficiently apply PowSyBl functionalities to your real-world scenarios.
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We believe integration and automation are essential to user experience and the promise of efficient work through technology. Automation is the critical ingredient to realizing that full vision. We develop integration products and services for Bonterra Case Management software to support the deployment of automations for a variety of use cases.
This video focuses on the notifications, alerts, and approval requests using Slack for Bonterra Impact Management. The solutions covered in this webinar can also be deployed for Microsoft Teams.
Interested in deploying notification automations for Bonterra Impact Management? Contact us at sales@sidekicksolutionsllc.com to discuss next steps.
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In a second workflow supporting the same use case, you’ll see:
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After immersing yourself in the blue book and its red counterpart, attending DDD-focused conferences, and applying tactical patterns, you're left with a crucial question: How do I ensure my design is effective? Tactical patterns within Domain-Driven Design (DDD) serve as guiding principles for creating clear and manageable domain models. However, achieving success with these patterns requires additional guidance. Interestingly, we've observed that a set of constraints initially designed for training purposes remarkably aligns with effective pattern implementation, offering a more ‘mechanical’ approach. Let's explore together how Object Calisthenics can elevate the design of your tactical DDD patterns, offering concrete help for those venturing into DDD for the first time!
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Clients don’t know what they don’t know. What web solutions are right for them? How does WordPress come into the picture? How do you make sure you understand scope and timeline? What do you do if sometime changes?
All these questions and more will be explored as we talk about matching clients’ needs with what your agency offers without pulling teeth or pulling your hair out. Practical tips, and strategies for successful relationship building that leads to closing the deal.
1. Topical Niosomal Preparation Containing Combination of Benzoyl peroxide and Tretinoin: Formulation and Evaluation For Antiacne Activity Submitted by: Under the supervision of: Ankush Gupta Mr. Narendra Kumar Pandey Senior Lecturer (Pharmaceutics) Dr. Monica Gulati Dean LSAMS
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5. Remedy for problem persist in topical treatment of acne Proposed structure of niosomes Andrew.cmu.edu/jamesv/Research lab.html
9. Characterization of drugs Sigma Aldrich catalog. CAS (94-36-0) 3, 580B pp., 2924. Sr. No. Method Drugs Tretinoin Benzoyl peroxide 1 UV Spectroscopy 348.6 nm (reported 352 nm) 234.8 nm (reported 235 nm) 2 IR Spectroscopy Characterstic band at 1600.9 cm -1 for C=O str and 2945.4 cm -1 O-H str Characterstic band at 1759.4 cm -1 for C=O str ester and 1226.7 cm -1 C-O str 3 NMR Spectroscopy The taken 1 H-NMR signals was in agreement with their reference values. The taken 1 H-NMR signals was in agreement with their reference values. 4 Melting point 179°C (reported 180-181°C) 103°C (reported 104-106°C) 5 TLC analysis R f value 0.854 was found in (Hexane: EtoAc = 50:50) R f value 0.977 was found in (Hexane: EtoAc = 50:50)
13. Multicomponent scanning analysis of mixture of tretinoin and benzoyl peroxide Absorbance of tretinoin at 234.8 nm was -0.059 and absorbance of BPO at 348.6 nm was -0.026. The results shows that there was no interference in the mixture of both drugs.
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15. FTIR spectra of incompatible studies between drugs (a) Benzoyl peroxide (b) Tretinoin (c) Mixture of BPO and tretinoin
17. Antimicrobial susceptibility testing BPO was tested for antimicrobial activity against S taphylococcus epidermidis using nutrient agar growth media Photograph of zone of inhibition of Staphylococcus epidermidis using BPO as antibacterial agent
29. Encapsulation efficiency of niosomes Note: Stock solution of benzoyl peroxide is 15 mg/ml. Percent encapsulation efficiency is mean of triplicate experiment. Sr. No. Niosomal Formulation loaded with Benzoyl peroxide Hydration Media % Encapsulation Efficiency 1. Span 60 : CH (69: 35) weight (mg) ratio Water 52.6 ±0.45 % 2. Span 60 : CH (69: 35) weight (mg) ratio Saline 51.1 ±0.34 % 3. Span 60: CH (138: 52) weight (mg) ratio Water 98.75 ±1.25 % 4. Span 60: CH (138: 52) weight (mg) ratio Saline 94.86 ±0.56 % 5. Span 60: CH (207: 52) weight (mg) ratio Water 92.4 ±0.49 % 6. Span 60: CH (207: 52) weight (mg) ratio Saline 89.06 ±0.76 %
30. Note: Stock solution of tretinoin is 4 mg/ml. Percent encapsulation efficiency is mean of triplicate experiment. Sr. No. Niosomal Formulation loaded with tretinoin Hydration Media % Encapsulation Efficiency 1. Span 60 : CH (69: 35) weight (mg) ratio Water 24.5 ±0.65 % 2. Span 60 : CH (69: 35) weight (mg) ratio Saline 43.25 ±0.35 % 3. Span 60: CH (138: 35) weight (mg) ratio Water 48.25 ±0.82 % 4. Span 60: CH (138: 35) weight (mg) ratio Saline 74.00 ±0.72 % 5. Span 60: CH (138: 52) weight (mg) ratio Water 52.05±0.85 % 6. Span 60: CH (138: 52) weight (mg) ratio Saline 86.45±0.54% 7. Span 60: CH (207: 52) weight (mg) ratio Water 74.75 ±0.34 % 8. Span 60: CH (207: 52) weight (mg) ratio Saline 96.25 ±0.56 % 9. Span 60: CH (276: 52) weight (mg) ratio Water 61.25 ±0.63 % 10. Span 60: CH (276: 52) weight (mg) ratio Saline 70.75 ±0.43 %
31. Effect of total lipid concentration on encapsulation efficiency on niosomes Sr. No Total lipid (mg/ml) % Encapsulation efficiency of Tretinoin Total lipid (mg/ml) % Encapsulation efficiency of BPO 1 10.4 43.25 ±0.35 10.4 52.6 ±0.45 % 2 17.3 74.00 ±0.72 19 98.75 ±1.25 % 3 19 86.45±0.54 25.9 92.4 ±0.49 % 4 25.9 96.25 ±0.56 - - 5 32.8 70.75 ±0.43 - -
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37. Result: 5.04 ± 0.014µg/cm 2 was permeated amount of BPO from niosomal gel in 24 h.
38. Result: 6.25 ± 0.14µg/cm 2 was permeated amount of tretinoin from niosomal gel in 24 h
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41. Comparison of permeation flux of cream, niosomal gel and alcoholic solution Formulation Tretinoin flux BPO flux Alcoholic solution 0.837±0.037 1.530±0.001 Antiacne cream 0.811±0.008 0.195±0.001 Antiacne niosomal gel 0.390±0.012 0.436±0.000
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43. In vitro retention study S. No. Formulation Drug retained (µg) 1. Anti acne Cream Tretinoin 11.54± 0.21 Benzoyl Peroxide 68.85± 0.40 2. Niosomal Gel Tretinoin 15.54± 0.33 Benzoyl Peroxide 143.78± 0.40 3. Alcoholic solution Tretinoin 2.68± 0.33 Benzoyl Peroxide 59.98 ± 0.50
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45. Stability studies of niosomal formulation Stability profile of niosomal formulation loaded with BPO Gupta et al., 2007. Trop. J. Pharm. Res. 6 (2), 687-693. Time (Days) Amount of BPO (mg) at room temperature Amount of BPO (mg) at refrigeration temperature Amount of BPO (mg) at 45°C 1 15 15 15 3 14.55 14.7 14.25 7 14.4 14.55 13.66 14 14.25 14.25 12.75 30 13.95 14.1 11.4
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47. Stability profile of niosomal formulation loaded with tretinoin Time (Days) Amount of Tretinoin (mg) at room temperature Amount of Tretinoin (mg) at refrigeration temperature Amount of Tretinoin (mg) at 45°C 1 3.85 3.85 3.85 3 3.73 3.77 3.65 7 3.69 3.73 3.5 14 3.65 3.65 3.27 30 3.58 3.61 2.92
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50. Formulations used for in vivo study Composition of niosomal gel Composition of antiacne cream (w/o) Nanda, S., et al., 2005. Skin Cosmetic. Birla Publication Pvt ltd, pp, 301. Sr. No Ingredients % w/w 1. Tretinoin 0.020 2. Benzoyl peroxide 0.600 3. Carbopol 934 1.2 4. Sodium hydroxide Up to pH 5. 5. Water q.s to 100 Sr. No Ingredients % w/w 1. Bees wax 4 2. Paraffin 10 3. White petrolatum 16.8 4. Mineral oil 55 5. Tretinoin 0.025 6. Benzoyl peroxide 2.5 7. Glycerin 1 8. Water 10.67
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53. Light micrograph of normal rabbit ear pinna (control sample) at 0 day at 10 X
54. Light micrograph of oleic acid treated rabbit ear pinna at 10X (treated pinna) at 7 th day
55. Light micrograph of oleic acid treated rabbit ear pinna at 10 X (treated pinna) at 28 th day
56. Light micrograph of treated rabbit ear pinna further treated with antiacne niosomal gel for 14 days at 10X magnification
57. Light micrograph of treated rabbit ear pinna further treated with antiacne cream for 14 days at 10X magnification
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