The document contains a collection of 100 multiple choice questions and answers focusing on pharmacology principles, drug interactions, metabolism, and therapeutic monitoring. It covers key topics such as drug absorption, protein binding, first-pass metabolism, and the effects of various drugs on the body, along with examples and exceptions. This compilation serves as a resource for students and professionals in the field of pharmacology to assess their knowledge and understanding.

1. 100 TOP
PHARMACOLOGY
Multiple Choice
Questions and
Answers pdf
1.Acetyl salicylate & phenobarbitone are
better absorbed from stomach because
they are
a) Weak acids remain non-ionic in gastric
pH
b) Weak acids remain ionic in gastric pH
c) Strong acids fully ionized in gastric pH
d) Weak bases which are ionized at
gastric pH
Ans:a
2.Chlorpropamide metabolism is
enhanced by
a) Ethyl alcohol
b) Diazepam
c) Lorazepam
d) Chloridazepoxide
Ans:a
3.Plasma concentration of drug at time 0
is 96(g/ml).f t Vi is 2 hours concentration
in plasma at 10 hours will be
a) 48
b)24
c)12
d)3
Ans:d
4.The factors contributing to the unequal
distribution of drugs are all except:
a) Heterogenesity of the drug
b) Binding to plasma proteins
c) Cellular binding
d) Concentration in body fat
e) Blood-brain barrier
Ans:a
5.Protein binding of a drug helps in
a) Distribution
b) Prolonging half life
c) Limiting metabolism
d) All of the above
Ans:d
6.All of following are examples of
prodrugs except
a) Levodopa
b) Enlapril
c) Omeprazole
d) Indomethacin
Ans:d
7.Drug levels should be monitored in the
treatment of
a) Diabetes
b) Epilepsy
c) Status Asthmatics
d) Hypertension
Ans:b
8.AH are prodrugs except
a)Enalapril
b) Paracetamol
c) Sulphamethoxazole
d) Trimethoprim
Ans:d
9.Which drug has a high first pass effect
a) Amiodarone
b) Phenytoin
c) Verapamil
d) Disopyramide

2. Ans:c
10.AH of the following do not cross the
blood brain barrier except
a) Pyridostigmine
b) Neostigmine
c) Physostigmine
d) Ambenonium
Ans:c
11.Secobarbital and ethanol when given
together show:
a) Additive sedative action
b) Reduced sedative action
c) Competitive antagonism
d) Chemical antagonism
e) None of the above
Ans:a
12.Administration of sulfonamide may
intensify the action of tolbutamide,
through:
a) Activation of the islets of pancreas
b) Direct action on the utilization of
glucose
c) Synergistic action
d) Competing with tolbutamide in plasma
protein binding
Ans:d
13.The major factor in terminating the
action of ethanol is
a) Biotransformation
b) Excretion through lungs
c) Excretion unchanged in urine
d)Excretion in feces
e) None of the above
Ans:a
14.The study of dose, distribution,
metabolism & excretion of drugs in the
body is known as
a) Pharmacognosia
b) Pharmacodynamics
c) Dose effective study
d) Pharmacotherapy
Ans:b
15.Which of the following is seenin first
order kinetics
a) Rate depends upon plasma cone.
b) Rate does not depend on plasma cone.
c) Rate depends upon plasma protein
binding
d) Elimination depends upon amount of
drug
Ans:a
16.All of the following pairs of drug
compete for the same receptors except
a) Ranitidine and histamine
b) Metoclopramide and dopamine
c) Dicyclomine and adrenaline
d) Benzhexol and acetylcholine
Ans:c
17.All are true except
a)Acidic drugs bind to albumin & basic to
acid glucoprotein
b)All drugs have the same binding sites
and mev compete for them
c)Increased dosage will cause decrease in
free drug in plasma throughout the
therapeutic range
Ans:b
18. Idiosyncrasy is:
a)A genetically determined abnormal
reaction to drugs
b)A characteristic toxic effect at
therapeutic doses
c)An altered physiological state produced
by repeated drug use
d)An immunologically mediated reaction

3. Ans:a
19.Not metabolized in liver
a)Cimetidine
b) Phenytoin
c) Diazepam
d) Penicillin G
Ans:d
20.The following drug is not secretedin
bile
a) Penicillin
b) Phenolphthalein
c) Novobiocin
d) Erythromycin
Ans:a
21.Alcohol should not be given with
a) Sulphonamides
b) Clonidine
c) Reserpine
d) Metronidazole
Ans:d
22.Methanol causes blindness due to its
a) Hypersensitivity reactions
b) Conjugated products
c) Idiosyncratic reaction
d) Oxidative products
Ans:d
23. The combination of propranolol &
nifedipine in essential hypertension is
used because
a) CNS effects of propanolol are
prevented
b) Pedal edema of nifedipine is prevented
c)Alteration of serum lipids by
propranolol is prevented
d)Reflex sympathetic activity of
nifedipine is prevented
Ans:d
24.Which cytochrome is responsible for
drug metabolism?
a)P-450
b)C-3b
c)C-3a
d)C-2a
Ans:a
25. Drugs significantly affected by enzyme
induction include the following except:
a) Barbiturate
b) Chlorpromazine
c) Diphenyl hydantoin
d) Warfarin
Ans:b
26.What is a prodrug
a) Drag which increases efficiency of
another drug
b) Metabolic end product
c) Inactive drag which gets activated in
the body
d) Drag which competes with another for
metabolism
Ans:c
27. The Alkaline Drug (Amidopyrine) is
absorbed from
a) Stomach
b) Proximal small intestine
c) Distal small intestine
d) Colon
Ans:b
28.Which of the following statements is
correct?
a) Most drags are absorbed in ionized
form
b) Basic drags are generally bound to
plasma albumin

4. c)Microsomal enzymes are located in the
mitochondria of hepatic cells
d)Blood brain barrier is deficient at the
chemo receptor trigger-zone
Ans:d
29.Substrate concentration & velocity
curve indicates
a) Michelis-Mentons equation
b) Inverse relation
c) Zero order kinetics
d) All of the above
Ans:c
30. Drugs mostly cross biological
membranes by
a) Passive diffusion
b) Active diffusion
c) Active transport
d) Carrier mediated transport
e) All of the above
Ans:a
31. All the following cross placenta except
a) Warfarin
b) Heparin
c) Phenindione
d) Morphine
Ans:b
32. The drug, which interferes with
metabolism of theophylline
a) Gentamicin
b) Penicillin
c) Erythromycin
d) Sulfonamide
Ans:c
33. Km value indicates
a) Purity of enzyme
b) Physiological role
c) Half life enzyme drug complex
d) Affinity
Ans:c
34.All of following drugs are metabolized
in body by acetylation except:
a) INH
b) Hydralazine
c) Procainamide
d) Dilantin
Ans:d
35.All are explained on pharmacogenetic
conditions except
a) G6PD deficiency
b) Warfarin insensitivity
c) Adenosine deaminase deficiency
d) Malignant hyperthermia
Ans:c
36.Most common indication for
therapeutic monitoring of plasma levels of
a drug is
a) Hit & run drugs
b) Drugs with irreversible action
c) Narrow therapeutic range
d) Failure of response
Ans:c
37. Which of the following drugs do not
cross the placenta
a) Dilantin
b) Diazepam
c) Acinocoumarin
d) Heparin
Ans:d
38.TVi of a drug can determine all the
following
a) Closing interval
b) Elimination time

5. c) Steady Plasma Concentration
d) Therapeutic dosage
Ans:d
39.Zero order kinetics is seenwith
a) Phenytoin
b) Phenobarbital
c) Erythromycin
d) Digoxin
Ans:a
40.Drug which crosses the placental
barrier is:
a) Phenytoin
b) Diazepam
c) Corticosterioids
d) All of the above
Ans:d
41.The following drugs are excreted in the
bile except:
a) Erythromycin
b) Novobiocin
c) Chloramphenicol
d) Rifampicin
Ans:c
42.The Combination of amoxycillin +
clavulanic acid is used because
a) It broadens the spectrum of
amoxycillin
b) It decreases the side effect of
amoxycillin
c) It decreases the toxicity of clavulanic
acid
d) It increases the oral bio availability of
amoxycillin
Ans:a
43. Flushing occurs when alcohol is taken
along with
a) Phenformin
b) Chlorpropamide
c) Glibenclamide
d) Tolbutamide
Ans:b
44. Which of the following avoids first
pass effect of drugs
a) Oral ingestion
b) Rectal Suppository
c) Intra venous injection
d) Intra-arterial injection
Ans:d
45. All are pro drugs except
a) Sulindac
b) Codeine
c) Talampicillin
d) Chlorpromazine
Ans:d
46.The elimination of following drugs is
dose dependant except
a) Phenytoin
b) Salicylate
c) Theophylline
d) Chlorpromazine
Ans:d
47.Drug which interferes with metabolism
of theophylline is:
a) Erythromycin
b)Gentamicin
c) Penicillin
d) Furazolidone
Ans:a
48.What is the interaction of pheno
barbiton and warfarin
a) Displacement of warfarin from binding
site

6. b) Decreasedabsorption of warfarin
c)Increased metabolism of warfarin
d) Decreasedmetabolism of warfarin
Ans:c
49.Therapeutic index of a drug is an
indicator of
a) Potency
b) Safety
c) Toxicity
d) Efficacy
Ans:c
50.Zero order kinetics are seenin all
except
a) Salicylate
b) Atenolol
c) Barbiturates
d) Ethanol
Ans:c
PHARMACOLOGY Objective type
Questions and Answers ::
51.All of the following are protein bound
except:
a) Propranolol
b) Atenolol
c) Phenylbutazone
d) Warfarin
Ans:b
52.Pick the true statement:
a)Amox- Clavulanic, Clavulanic increases
amox activity
b)Sublactum is used in treatment of
Leprosy
c) Aztreonam is a metabolite of
clarithromycin
d)Cilastatin imipenam- cilastatin prevents
hydrolysis of imipenam
Ans:b
53.Drug absorbed by active transport is
a) Propranolol
b) Ergotamine
c) Levodopa
d) Amantidine
Ans:c
54.Following are the true receptors,
except one
a) Beta adrenergic receptors
b) Na-K-ATP ase
c) Phosphodiesterase
d)Plasma proteins
Ans:d
55.Which of the following is not a dose
related reaction:
a) Myocardial Irritation of Quinidine
b) Hypoglycemia of tolbutamide
c)Digitalis induced arrythmia
d) Drug feverof sulpha
Ans:d
56.Theophylline levels in blood are
increased by:
a) Erythromycin
b) Ciprofloxacin
c) Smoking
d) Digitalis
Ans:a
57.What is the advantage of sublingual
route of administration of drugs
a) Prevents first pass effect
b) Easy to administer
c) Lipid soluble
d) Can be spitted out with signs of toxicity
Ans:a

7. 58.Ciprofloxacin increases the toxicity of
theophylline by
a) Inhibiting metabolism
b) Decreasing excretion
c) Decrease seizure threshold
d) Promote absorption
Ans:b
59.Elimination after 4 half lives in first
order kinetics is
a) 84%
b)93%
c)80.5%
d)4.75%
Ans:b
60.All the following induce hepatic
enzymes except
a) Rifampicin
b) Phenytoin
c) Barbiturates
d) Tolbutamide
Ans:d
61.Which of the following shows high first
pass metabolism:
a) Propranolol
b) Phenobarbitone
c) Phenylbutazone
d) Phenytoin
e)Reflex esophagitis
Ans:a
62.Enterohepatic circulation is seenin
a) Ampicillin
b) Benzylpenicillin
c) Norfloxacin
d) Streptomycin
Ans:d
63.Least half life is for which hormone
a) Nor adrenaline
b) Renin
c) Aldosterone
d) Thyroxine
Ans:a
64.Not a prodrug
a) Lisinopril
b) Enalapril
c) Ramipril
d) Famotidine
Ans:a
65.No physical dependence is seenin:
a) Dextropropoxyphene
b) Fortwin
c) Fluoxetine
d) Alprax
Ans:c
66.Slow channel syndrome is due to
a) Accumulation of Na + ions in channels
c) Accumulation of Mg++ ions in channels
b) Accumulation of K+ ions in channels
d) Accumulation of Ca++ ions in channels
Ans:d
67. First dose phenomenon is a
characteristic side effect on initiation of
antihypertensive therapy with
a) Minoxidil
b)Clonidine
c) Metroprolol
d) Prazosin
Ans:b
68. Serum level of drug is monitored
when the patient is on
a) Lithium
b) Haloperidol

8. c) Diazepam
d) Acetazolamide
Ans:a
69.L-Dopa is
a) Converted to methyl dopa in the body
b) Antagonised by riboflavine
c) Antagonized by nicotinic acid
d) Combined with carbidopa for
enhanced effect
Ans:d
70.All the following statements regarding
treatment of parkinson’s disese are
correct except
a)Levodopa is usually administered alone
(KAR93)
b)Amantadine is effective in the
treatment of early disease
c)Bromocryptine is a useful dopamine
receptor agonist
d)Patient may require medication every 2
hours
Ans:a
71.Which statement about clonidine is
false
a)Useful in the management of opiate
withdrawal syndrome
b)Claimed to have prophylactic value in
migraine
c) It is alpha-2 receptor stimulant
d) It is safe on abrupt termination of
treatment
Ans:d
72.Ipratropium bromide is
a) Bronchoselective anticholinergic
b) Used as mydriatic
c)A selective MI anticholinergic useful in
peptic ulcer
d) An antiparkinsonism drug
Ans:a
73.Beta blocker which has less first pass
metabolism and more excretion through
kidney is
a) Propranolol
b)Sotalol
c)Bisprolol
d) Nadolol
Ans:b
74. Which statement is false of
Domperidone
a) Chemically related to haloperidol
b) Pharmacologically related to
metoclopramide
c)Extra pyramidal symptoms are
common
d)It counteracts the emetic action but not
the therapeutic effect in parkinsonism
Ans:c
75.Which of the following causes rise in
systolic as well as diastolic BP for
prolonged period:
a) Ephedrine
b) Epinephrine
c) Dopamine
d) Norepinephrine
Ans:d
76. Amphetamine is used in
a) Narcolepsy
b) Psychosis
c) Anxiety disorders
d) Obsessive compulsive neurosis
Ans:a
77.Drug of choice in phenothiazine
induced parkinsonism is
a) Levodopa
b) Haloperidol

9. c) Metoclopramide
d) None of the above
Ans:a
78.All of the following are adverse effects
of phenothiazines except
a) Rigidity and tremor
b) Menstrual irregularities
c) Cholestatic jaundice
d) Systolic hypertension
Ans:d
79. Which antiepileptic drug does not act
as GABA agonist?
a) Phenytoin
b) Sodium valproate
c) Diazepam
d) Phenbarbitone
Ans:a
80. Which phenothiazine has the least
extra pyramidal effect
a) Thioridazine
b) Chlorpromazine
c) Triflupromazine
d) Fluphenazine
Ans:a
81. Dopamine is:
a) Alpha and beta agonist
b) Beta agonist
c) A beta blocking agent
d) Alpha blocking agent
Ans:a
82. I.V. fluphenzine decanoate is drug of
choice in:
a) Simple Schizophrenia
b) Hebephrenic Schizophrenia
c) Catatonic Schizophrenia
d) Paranoid Schizophrenia
Ans:a
83. Bromocriptine is
a) A partial agonist of dopamine
b) A partial antagonist of dopamine
c) Used in the treatment of parkinsonism
d) Used to reduce GH secretion in
acromegaly
e) All except b are correct
Ans:e
84.In an acute attack of migraine, the
drug of choice is
a) Ergotamine tartrate
b) Methysergide
c) Propranolol
d) Caffeine
Ans:a
85.The ganglion blocking drugs act by
a)Competing with acetylcholine at
neuromuscular junctions
b)Preventing release of acetylcholine
c) Preventing nerve conduction in post
ganglionic segment
d)Preventing catecholamine release or
inactivating it
Ans:b
86.Not an antidepressant
a) Amitryptilline
b) Fluoxetin
c) Trazodone
d) Pimozide
Ans:d
87.Beta blocker are used in all, except
a) Variant angina
b) Mild hypertension
c) Glaucoma
d) Thyrotoxicosis

10. Ans:a
88.Which of the following is the longest
acting newer antihistamine:
a) Mequitazine
b) Loratidine
c) Astemizole
d) Terfenadine
Ans:c
89. Phenylephrine is useful for all of the
following except
a) Anaphylactic shock
b) Mydriasis
c) Nasal decongestant
d) Artial tachycardia
Ans:a
90. B-Blockers are contra indicated in
a) Hypertension
b) Congestive cardiac failure
c) Anxiety states
d) Hyperthyroidism
Ans:b
91.Drug of choice in motion sickness is
a) Metoclopramide
b) Transdermal scopalamine
c) Diphenhydramine
d) Chlorpromazine
Ans:b
92.All increase dopaminergic
transmission except
a) Bromocriptine
b) Metoclopramide
c) Chlorpromazine
d) Reserpine
Ans:b
93. Which antiepileptic drug in
therapeutic doses causes least sedation?
a) Primidone
b) Clonazepam
c) Phenytoin
d) Phenobarbitone
Ans:c
94.Tianeptin is
a) 5-HT antagonist
b) Nor adrenaline uptake inhibitor
c) 5-HT reuptake enhancer
d) Dopamine antagonist
Ans:c
95.The following are recognized effects of
propranolol except
a) Increases microcoronary blood flow
b) Decrease in heart rate
c) Decrease in cardiac output
d) Reduction in ventricular systolic
pressure
Ans:a
96.Nicotinic receptors are seenin
a) Skeletal muscle
b) Visceral smooth muscle
c) Cardiac muscle
d) Salivary glands
Ans:a
97.Antiemitic used to prevent aspiration
in emergency surgery
a) Ondansetrone
b) Promethazine
c) Metoclopromide
d)Ranitidine
Ans: b
98.Drugs which increase GABA levels in
brain

11. a) Diazepam
b) Phenobarbitone
c) Sodium valproate
d) Carbamazepine
Ans:c
99.Midazolam as compared to diazepam
is:
a) Less cerebroprotective
b) More cerebroprotective
c) Same as diazepam
d) No cerebroprotective effect
Ans:a
100. Which is a 5HT-receptor agonist?
a) Ondansetron
b) Ketanserine
c) Sumatriptan
d) Risperidone
Ans:c