Toll-like receptors (TLRs) are immune sensors that detect pathogen-associated molecular patterns and induce inflammatory responses. TLRs activate signaling cascades that lead to the production of cytokines and immune cell activation through adaptor proteins and kinases. Dysregulation of TLR signaling can cause or contribute to immune deficiencies, autoimmune diseases, and cancers. The document discusses TLR structure and function, downstream signaling pathways, regulation of the response, and diseases associated with TLR signaling abnormalities.
Plant epigenetic memory in plant growth behavior and stress response. Sally M...CIAT
Speaker: Sally Mackenzie, Lloyd and Dottie Huck Chair for Functional Genomics, Department of Biology, Pennsylvania State University. Fellow in the American Society of Plant Biologists and the American Association for the Advancement of Science (AAAS).
Event: Robert D. Havener Seminar on “Innovations for Crop Productivity”.
http://ciat.cgiar.org/event/robert-d-havener-seminar-on-innovations-for-crop-productivity/
Epigenetic silencing of MGMT (O6-methylguanine DNA methyltransferase) gene in...arman170701
O6–methylgunine-DNA methyltransferace (MGMT) is a DNA binding protein that is involved in repairing mutations.
MGMT gene - a tumor suppressor gene that codes MGMT (O6-methylguanine DNA methyltransferase) protein.
The MGMT protein removes mutagenic methyl groups from guanines through the methyltransferase activity.
Dr. Laura Miller - Comparative analysis of signature genes in PRRSV-infected ...John Blue
Comparative analysis of signature genes in PRRSV-infected porcine monocyte-derived dendritic cells at differential activation statuses - Dr. Laura Miller, Virus and Prion Diseases of Livestock Research Unit, National Animal Disease Center, USDA-ARS, from the 2015 North American PRRS Symposium, December 4 - 5, 2015, Chicago, IL, USA.
More presentations at http://www.swinecast.com/2015-north-american-prrs-symposium
This ppts is based upon the recent adavancement and methodology about mitochondrial transformation. What is organellar transformation and what is the importance in contemporary time.
Regulation of KDM5 by multiple cofactors regulates cancer and stem cellsChristopher Wynder
Presentation of data regarding proteins that regulate the activity of KDM5b.
The studies use multiple disciplines including in vitro enzymology, ES cell studies of differentiation, Mass spectrometry to detect protein protein interactions.
These studies resulted in a comprehensive view of KDM5b function. It required development of at least three novel assays that are focused on moving epigenetic research from yeast and HeLa cell types to primary, clinically relevant cell types.
The techniques have been successfully used in Embryonic stem cells (human and mouse), Neural stem cells (mouse and patient derived as well as iPSCs.
Plant epigenetic memory in plant growth behavior and stress response. Sally M...CIAT
Speaker: Sally Mackenzie, Lloyd and Dottie Huck Chair for Functional Genomics, Department of Biology, Pennsylvania State University. Fellow in the American Society of Plant Biologists and the American Association for the Advancement of Science (AAAS).
Event: Robert D. Havener Seminar on “Innovations for Crop Productivity”.
http://ciat.cgiar.org/event/robert-d-havener-seminar-on-innovations-for-crop-productivity/
Epigenetic silencing of MGMT (O6-methylguanine DNA methyltransferase) gene in...arman170701
O6–methylgunine-DNA methyltransferace (MGMT) is a DNA binding protein that is involved in repairing mutations.
MGMT gene - a tumor suppressor gene that codes MGMT (O6-methylguanine DNA methyltransferase) protein.
The MGMT protein removes mutagenic methyl groups from guanines through the methyltransferase activity.
Dr. Laura Miller - Comparative analysis of signature genes in PRRSV-infected ...John Blue
Comparative analysis of signature genes in PRRSV-infected porcine monocyte-derived dendritic cells at differential activation statuses - Dr. Laura Miller, Virus and Prion Diseases of Livestock Research Unit, National Animal Disease Center, USDA-ARS, from the 2015 North American PRRS Symposium, December 4 - 5, 2015, Chicago, IL, USA.
More presentations at http://www.swinecast.com/2015-north-american-prrs-symposium
This ppts is based upon the recent adavancement and methodology about mitochondrial transformation. What is organellar transformation and what is the importance in contemporary time.
Regulation of KDM5 by multiple cofactors regulates cancer and stem cellsChristopher Wynder
Presentation of data regarding proteins that regulate the activity of KDM5b.
The studies use multiple disciplines including in vitro enzymology, ES cell studies of differentiation, Mass spectrometry to detect protein protein interactions.
These studies resulted in a comprehensive view of KDM5b function. It required development of at least three novel assays that are focused on moving epigenetic research from yeast and HeLa cell types to primary, clinically relevant cell types.
The techniques have been successfully used in Embryonic stem cells (human and mouse), Neural stem cells (mouse and patient derived as well as iPSCs.
CELLULAR REPROGRAMMING: Current Technology, Perspectives and Generation of iP...Munna Yadav
Reprogramming refers to erasure and remodelling of epigenetic marks, such as DNA methylation, during mammalian development. Exposure of a differentiated cell nucleus to the cytoplasm of less differentiated cell leads to erasure of the stable epigenetic code that maintains the differentiated cell’s phenotype. Gradually, the nucleus acquires a new epigenetic code that is characteristic of the dedifferentiated cell donating the cytoplasm, a process termed cellular reprogramming.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Hemodialysis: Chapter 3, Dialysis Water Unit - Dr.Gawad
Tlr signaling 2013-lim-
1. Toll-Like Receptor Signaling
Kian-Huat Lim and Louis M. Staudt
Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda,
Maryland 20892
Correspondence: lstaudt@mail.nih.gov
Toll-like receptors (TLRs) are protective immune sen-
tries that sense pathogen-associated molecular patterns
(PAMPs) such as unmethylated double-stranded DNA
(CpG), single-stranded RNA (ssRNA), lipoproteins, lipo-
polysaccharide (LPS), and flagellin. In innate immune
myeloid cells, TLRs induce the secretion of inflammatory
cytokines (Newton and Dixit 2012), therebyengaging lym-
phocytes to mount an adaptive, antigen-specific immune
TRAF6
TAB1/2
Proteasomal
degradation
Inflammation
Immune regulation
Survival
Proliferation
TLR
TLR
TAK1
p38/JNK
MKKs
IKK
IRAK1
IRAK4
IRAK2
MyD88
Cytoplasm
Nucleus
IκBα
p65/RelA
NF-κB
p65/RelA
NF-κB
Transcription
factors
PAMP
Figure 1. TLR signaling (simplified view).
Editors: Lewis Cantley, Tony Hunter, Richard Sever, and Jeremy Thorner
Additional Perspectives on Signal Transduction available at www.cshperspectives.org
Copyright # 2013 Cold Spring Harbor Laboratory Press; all rights reserved; doi: 10.1101/cshperspect.a011247
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on September 8, 2015 - Published by Cold Spring Harbor Laboratory Presshttp://cshperspectives.cshlp.org/Downloaded from
2. response (see Fig. 1) that ultimately eradicates the invading
microbes (Kawai and Akira 2010).
Identification of TLR innate immune function began
with the discovery that Drosophila mutants in the Toll gene
are highly susceptible to fungal infection (Lemaitre et al.
1996). This was soon followed by identification of a human
Toll homolog, now known as TLR4 (Medzhitovet al. 1997).
To date, 10 TLR family members have been identified in
humans, and at least 13 are present in mice. All TLRs
consist of an amino-terminal domain, characterized by
multiple leucine-rich repeats, and a carboxy-terminal TIR
domain that interacts with TIR-containing adaptors. Nu-
cleic acid–sensing TLRs (TLR3, TLR7, TLR8, and TLR9)
are localized within endosomal compartments, whereasthe
other TLRs reside at the plasma membrane (Blasius and
Beutler 2010; McGettrick and O’Neill 2010). Trafficking of
most TLRs from the endoplasmic reticulum (ER) to either
the plasma membrane or endolysosomes is orchestrated by
Transcription
factors
UEV1A
TAB1/2
Triacyl
lipopeptides
Diacyl
lipopeptides
dsRNACpG
Endolysosome
Proteasomal
degradation
Inflammation
Immune regulation
Survival
Proliferation
Antiviral
compounds,
ssRNA
TLR1
TLR2
TLR6
TLR2
Flagellins
LPS
TLR5
TLR5
TLR4
TLR4
TAK1
TBK1
JNK
MKK4/7
MKK3/6
MEKK1
p38 MAPK
IKKβIKKα
IKKε
IRAK1
IRAK4
IRAK2IRAK-M
IRF3
IRF7 IRF3
IRF7
TIRAP
MyD88
TIRAP
MyD88
TIRAP
TLR3
TLR3
TRIF
TLR8
MyD88
TLR7
MyD88
TLR9
TLR9
MyD88
MyD88
TRIF
TRAM
CD14
MyD88
Cytoplasm
Nucleus
MD2
FADD
TOLLIP
ECSIT
IKKγ
IκBα
Ubc13
p65/RelA
NF-κB
CD14
TLR8
TLR7
CD14
Ub
Ub
Ub
Ub
Ub
Ub
K48-ubiquitin linkage
K63-ubiquitin linkage
TRAF6
pellino 1
cIAP
SHP2
SHP1
A20
TRAF3
TRAF3
Proteasomal
degradation
Ub
Ub
Ub
Figure 2. TLR signaling. (Adapted with kind permission of Cell Signaling Technology [http://www.cellsignal.com].)
K.-H. Lim and L.M. Staudt
2 Cite this article as Cold Spring Harb Perspect Biol 2013;5:a011247
on September 8, 2015 - Published by Cold Spring Harbor Laboratory Presshttp://cshperspectives.cshlp.org/Downloaded from
3. ER-resident proteins such as UNC93B (for TLR3, TLR7,
TLR8, and TLR9) and PRAT4A (for TLR1, TLR2, TLR4,
TLR7, and TLR9) (Blasius and Beutler 2010). Once in the
endolysosomes, TLR3, TLR7, and TLR9 are subject to step-
wise proteolytic cleavage, which is required for ligand bind-
ing and signaling (Barton and Kagan 2009). For some
TLRs, ligand binding is facilitated by coreceptors, includ-
ing CD14 and MD2.
Following ligand engagement, the cytoplasmic TIR do-
mains of the TLRs recruit the signaling adaptors MyD88,
TIRAP, TRAM, and/or TRIF (see Fig. 2). Depending on the
nature of the adaptor that is used, various kinases (IRAK4,
IRAK1, IRAK2, TBK1, and IKK1) and ubiquitin ligases
(TRAF6 and pellino 1) are recruited and activated, culmi-
nating in the engagement of the NF-kB, type I interferon,
p38 MAP kinase (MAPK), and JNK MAPK pathways (Ka-
wai and Akira 2010; Morrison 2012). TRAF6 is modified by
K63-linked autoubiquitylation, which enables the recruit-
ment of IkB kinase (IKK) through a ubiquitin-binding do-
main of the IKKg (also known as NEMO) subunit. In
addition, a ubiquitin-binding domain of TAB2 recognizes
ubiquitylated TRAF6, causing activation of the associated
TAK1kinase,whichthenphosphorylatestheIKKbsubunit.
Pellino 1 can modify IRAK1 with K63-linked ubiquitin,
allowing IRAK1 to recruit IKK directly. TLR4 signaling
via the TRIF adaptor protein leads to K63-linked polyubi-
quitylation of TRAF3, thereby promoting the type I inter-
feron response via interferon regulatory factor (IRFs)
(Hacker et al. 2011). Alternatively, TLR4 signaling via
MyD88 leads to the activation of TRAF6, which modifies
cIAP1 or cIAP2 with K63-linked polyubiquitin (Hacker
et al. 2011). The cIAPs are thereby activated to modify
TRAF3 with K48-linked polyubiquitin, causing its protea-
somal degradation. This allows a TRAF6–TAK1 complex to
activate the p38 MAPK pathway and promote inflammato-
ry cytokine production (Hacker et al. 2011). TLR signaling
is turned off by various negative regulators: IRAK-M and
MyD88 short (MyD88s), which antagonize IRAK1 activa-
tion; FADD, which antagonizes MyD88 or IRAKs; SHP1
and SHP2, which dephosphorylate IRAK1 and TBK1, re-
spectively; and A20, which deubiquitylates TRAF6 and IKK
(Flannery and Bowie 2010; Kawai and Akira 2010).
Deregulation of the TLR signaling cascade causes sev-
eral human diseases. Patients with inherited deficiencies
of MyD88, IRAK4, UNC93B1, or TLR3 are susceptible to
recurrentbacterialor viralinfections(Casanovaetal.2011).
Chronic TLR7 and/or TLR9 activation in autoreactive
B cells, in contrast, underlies systemic autoimmune dis-
eases (Green and Marshak-Rothstein 2011). Furthermore,
oncogenic activating mutations of MyD88 occur frequently
in the activated B-cell-like subtype of diffuse large B-cell
lymphoma and in other B-cell malignancies (Ngo et al.
2011). Inhibitors of various TLRs or their associated kinas-
es are currently being developed for autoimmune or in-
flammatory diseases and also hold promise for the
treatment of B-cell malignancies with oncogenic MyD88
mutations. Many TLR7 and TLR9 agonists are currently in
clinical trials as adjuvants to boost host antitumor respons-
es in cancer patients (Hennessy et al. 2010).
REFERENCES
∗Reference is also in this collection.
Barton GM, Kagan JC. 2009. A cell biological view of Toll-like receptor
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nol 9: 535–542.
Blasius AL, Beutler B. 2010. Intracellular Toll-like receptors. Immunity
32: 305–315.
Casanova JL, Abel L, Quintana-Murci L. 2011. Human TLRs and IL-1Rs
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Toll-Like Receptor Signaling
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