This study examines the mental health status, use of mental health services, and prescription of psychotherapeutic medications among US cancer survivors, their spouses, and the general population using national surveys. It finds that cancer survivors and their spouses have lower mental health status and higher rates of depression than the general population. They are also more likely to use psychotherapeutic medications. The study aims to describe and compare these factors between the oncology population and general public, and identify predictors of mental health outcomes within the oncology group.