Collaborative Drug Discovery Inc, webinar slides. Learn about best practices from Dr. Nathan Coussens (Assay Guidance Manual, Associate Scientific Editor) and hear how Professor Paul Roepe (Georgetown) tackles the problem given the complexity of Malaria biology.

1. Archive, Mine, Collaborate© 2016 Collaborative Drug Discovery, Inc.
Town Hall Webinar
NIH & Georgetown University Discuss
Therapeutically Relevant Bioassays
December 7, 2016

2. Archive, Mine, Collaborate© 2016 Collaborative Drug Discovery, Inc.
Our Moderators
Kellan Gregory, CDD
Director of Product Excellence
Frank Cole, CDD
Head of Sales, Eastern USA

3. Archive, Mine, Collaborate© 2016 Collaborative Drug Discovery, Inc.
Our Panelists
Nathan Coussens,
Senior Research Scientist,
Biology, Division of Pre-Clinical
Innovation, National Center for
Advancing Translational
Sciences, NCATS/NIH
Paul Roepe,
Professor of Chemistry, Professor
of Biochemistry & Cell. and Mol.
Biol., Co-director, Center for
Infectious Disease, Georgetown
University

4. Archive, Mine, Collaborate© 2016 Collaborative Drug Discovery, Inc.
https://ncats.nih.gov/expertise/preclinical/agmWebsite:
Email us: NCATS_AGM_Editors@mail.nih.gov
Facebook: www.facebook.com/assayguide
“Dissemination of Tribal Knowledge in Drug
Discovery Assay Development” -Doug Auld,
Novartis

5. Archive, Mine, Collaborate© 2016 Collaborative Drug Discovery, Inc.
NCATS Hosts Inaugural Assay Guidance Workshop
for High-Throughput Screening and Lead Discovery

6. Archive, Mine, Collaborate© 2016 Collaborative Drug Discovery, Inc.
Paul Roepe

7. Archive, Mine, Collaborate© 2016 Collaborative Drug Discovery, Inc.
Nathan Coussens
“Development and Applications of the Bioassay Ontology
(BAO) to Describe and Categorize High-Throughput Assays”
(by Uma Vempati and Stephan Schurer)?

8. Archive, Mine, Collaborate© 2016 Collaborative Drug Discovery, Inc.
BioAssay Ontology & BioAssay Express
http://bioassayontology.org/
https://cheminf20.org/2016/09/29/bioassay-express-
finding-assays-and-doing-stuff-with-them/

9. Archive, Mine, Collaborate© 2016 Collaborative Drug Discovery, Inc.
"New Tools for Combinatorial Screening of Drug Libraries"

10. Archive, Mine, Collaborate© 2016 Collaborative Drug Discovery, Inc.
CDD Public Access
Malaria is represented in
via CDD Public Access
under Public Data
Projects descriptions
Projects to search and
mine

11. Archive, Mine, Collaborate© 2016 Collaborative Drug Discovery, Inc.
“I found the workshop highly illuminating, useful to those new to the field, but also to those who might be
experts focused on specific aspects.” Professor Jonathan Baell, Ph.D., Co-Director, Australian
Translational Medicinal Chemistry Facility
Monash Institute of Pharmaceutical Sciences
“I found the recent NIH Assay Guidance workshop an excellent refresher on assay development guidelines for
high-throughput screening, and I also learned a few important new facts. This was very worthy for new and
seasoned investigators.” Melvin Reichman, Ph.D., Director, LIMR Chemical Genomics Center
Senior Investigator, Lankenau Institute for Medical Research
Chairman of the Board, International Chemical Biology Society
NCATS and Promega Host Assay Guidance Workshop
for High-Throughput Screening and Lead Discovery

12. Archive, Mine, Collaborate© 2016 Collaborative Drug Discovery, Inc.
Next Assay Guidance Workshop will be with the
Society for Laboratory Automation and Screening
www.slas2017.org/program/assay-guidance.cfm

13. Archive, Mine, Collaborate© 2016 Collaborative Drug Discovery, Inc.
Mosquito Transmitted Disease

14. Archive, Mine, Collaborate© 2016 Collaborative Drug Discovery, Inc.
Nathan Coussens
“

15. Archive, Mine, Collaborate© 2016 Collaborative Drug Discovery, Inc.

16. Archive, Mine, Collaborate© 2016 Collaborative Drug Discovery, Inc.

17. Archive, Mine, Collaborate© 2016 Collaborative Drug Discovery, Inc.

18. Archive, Mine, Collaborate© 2016 Collaborative Drug Discovery, Inc.
Cytocidal Readout

19. Archive, Mine, Collaborate© 2016 Collaborative Drug Discovery, Inc.
Cytostatic vs Cytocidal assays

20. Archive, Mine, Collaborate© 2016 Collaborative Drug Discovery, Inc.
Nathan Coussens,
Senior Research Scientist,
Biology, Division of Pre-Clinical
Innovation, National Center for
Advancing Translational
Sciences, NCATS/NIH
Paul Roepe,
Professor of Chemistry, Professor
of Biochemistry & Cell. and Mol.
Biol., Co-director, Center for
Infectious Disease, Georgetown
University

21. Archive, Mine, Collaborate© 2016 Collaborative Drug Discovery, Inc.
Questions?

22. Archive, Mine, Collaborate© 2016 Collaborative Drug Discovery, Inc.
Q&A with our Panelists
Nathan Coussens,
Senior Research Scientist,
Biology, Division of Pre-Clinical
Innovation, National Center for
Advancing Translational
Sciences, NCATS/NIH
Paul Roepe,
Professor of Chemistry, Professor
of Biochemistry & Cell. and Mol.
Biol., Co-director, Center for
Infectious Disease, Georgetown
University

23. Archive, Mine, Collaborate© 2016 Collaborative Drug Discovery, Inc.
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