This document discusses the importance of maintaining a healthy lifestyle through diet and exercise. It defines health as a state of complete physical, mental and social well-being according to the WHO. It outlines the essential components of a balanced diet including nutrients, food groups, and daily requirements that vary by age, sex and physiological status. Maintaining healthy diet and lifestyle is important for preventing diseases and achieving overall wellness.
The document summarizes a diet survey conducted for a family using the 24-hour oral questionnaire method. It details the family's intake of different food groups and nutrients compared to their daily requirements. The survey found the family to be deficient in calories by 19.69%, visible fat by 21.5%, and calcium by 20.26%. However, their protein intake was sufficient and exceeded requirements by 3.45%.
For more information, visit https://www.timberlandmedical.com
This presentation is by Dr LO SIAW PING, a visiting dietician at Timberland Medical Centre
Timberland Medical Centre is a private hospital that has been in operation since 1994. We are strategically located at the 3rd Mile roundabout on Jalan Rock, Kuching, Sarawak, East Malaysia. Our hospital is 10 minutes from the Kuching International Airport and 15 minutes from the Central Bus Terminal. We continually seek to improve and upgrade our services and facilities, as we strive to provide the best medical care for our patients and customers.
The document discusses nutrition, weight management, and dieting. It states that weight gain occurs when energy intake from food exceeds energy expenditure from physical activity. Successful weight loss requires creating a calorie deficit through a balanced diet and increased exercise, rather than drastic changes that are hard to sustain long-term. The most important factors for weight loss are creating an energy balance and maintaining lifestyle changes permanently rather than relying on short-term diets.
This document provides information on balanced diets and diet prescriptions. It defines a balanced diet as one containing a variety of foods in quantities and proportions to meet energy, nutrient and vitamin needs for health. Diet prescriptions consider factors like age, sex, socioeconomic status, food availability, nutritional requirements and diseases. Information needed includes food groups, nutritive values, requirements and balanced diet principles. Various foods are classified by nutritive value and examples of nutrients in common foods are provided along with energy and protein requirements for adults based on activity level. Criteria for calculating a balanced diet and a sample diet for an adult male doing sedentary work are also outlined.
The document provides guidance on planning a healthy diet including:
- Using food groups and exchanges to create balanced meals with adequate nutrients and energy.
- Choosing foods with high nutrient density by focusing on whole grains, vegetables, fruits, lean proteins and low-fat dairy.
- Reading nutrition labels to select processed foods lower in sugars, salt and saturated fat.
A detailed investigation in the wellness and dietary habits of local high school students. This power-point supplements a portfolio, which contains detailed evidence as to the ineffectiveness of the young American diet. This project, entitled "The Invisible Epidemic" received the National Champion of the Future Career and Community Leaders of America (FCCLA) Southern Region Nutrition and Wellness Contest. This presentation has been evaluated by qualified FCCLA judges and given to many audiences as a means of changing American diets to a better balance.
This document discusses the importance of maintaining a healthy lifestyle through diet and exercise. It defines health as a state of complete physical, mental and social well-being according to the WHO. It outlines the essential components of a balanced diet including nutrients, food groups, and daily requirements that vary by age, sex and physiological status. Maintaining healthy diet and lifestyle is important for preventing diseases and achieving overall wellness.
The document summarizes a diet survey conducted for a family using the 24-hour oral questionnaire method. It details the family's intake of different food groups and nutrients compared to their daily requirements. The survey found the family to be deficient in calories by 19.69%, visible fat by 21.5%, and calcium by 20.26%. However, their protein intake was sufficient and exceeded requirements by 3.45%.
For more information, visit https://www.timberlandmedical.com
This presentation is by Dr LO SIAW PING, a visiting dietician at Timberland Medical Centre
Timberland Medical Centre is a private hospital that has been in operation since 1994. We are strategically located at the 3rd Mile roundabout on Jalan Rock, Kuching, Sarawak, East Malaysia. Our hospital is 10 minutes from the Kuching International Airport and 15 minutes from the Central Bus Terminal. We continually seek to improve and upgrade our services and facilities, as we strive to provide the best medical care for our patients and customers.
The document discusses nutrition, weight management, and dieting. It states that weight gain occurs when energy intake from food exceeds energy expenditure from physical activity. Successful weight loss requires creating a calorie deficit through a balanced diet and increased exercise, rather than drastic changes that are hard to sustain long-term. The most important factors for weight loss are creating an energy balance and maintaining lifestyle changes permanently rather than relying on short-term diets.
This document provides information on balanced diets and diet prescriptions. It defines a balanced diet as one containing a variety of foods in quantities and proportions to meet energy, nutrient and vitamin needs for health. Diet prescriptions consider factors like age, sex, socioeconomic status, food availability, nutritional requirements and diseases. Information needed includes food groups, nutritive values, requirements and balanced diet principles. Various foods are classified by nutritive value and examples of nutrients in common foods are provided along with energy and protein requirements for adults based on activity level. Criteria for calculating a balanced diet and a sample diet for an adult male doing sedentary work are also outlined.
The document provides guidance on planning a healthy diet including:
- Using food groups and exchanges to create balanced meals with adequate nutrients and energy.
- Choosing foods with high nutrient density by focusing on whole grains, vegetables, fruits, lean proteins and low-fat dairy.
- Reading nutrition labels to select processed foods lower in sugars, salt and saturated fat.
A detailed investigation in the wellness and dietary habits of local high school students. This power-point supplements a portfolio, which contains detailed evidence as to the ineffectiveness of the young American diet. This project, entitled "The Invisible Epidemic" received the National Champion of the Future Career and Community Leaders of America (FCCLA) Southern Region Nutrition and Wellness Contest. This presentation has been evaluated by qualified FCCLA judges and given to many audiences as a means of changing American diets to a better balance.
The document presents a portfolio diet created by Wendy Carlile and other students. The portfolio diet focuses on fruits, vegetables, whole grains, soluble fiber, nuts, soy protein, and margarines enriched with plant sterols. It avoids foods containing partially hydrogenated oils, processed meats, sugary beverages, sweets, and baked goods made with refined grains. Wendy describes a day of foods following the portfolio diet and provides a detailed table analyzing the nutrients and calorie content of each food.
This document provides information from a health seminar on nutrition. It discusses how most North Americans have poor diets and health, with high rates of obesity, diabetes, and other diseases. It promotes adopting a healthy lifestyle through proper nutrition, exercise, and supplementation to reduce inflammation and achieve health goals like weight loss or increased energy. The seminar emphasizes balancing blood sugar through low glycemic foods and meals with protein, fat and fiber at each meal to improve insulin sensitivity and reverse insulin resistance over time.
This document provides information about improving health, with a focus on issues common in the African-Caribbean population. It discusses the importance of health from a scriptural perspective and defines health. Key topics covered include factors that influence health, common health issues like hypertension, diabetes and obesity, and actions individuals can take to improve their health such as diet, exercise, reducing salt intake, and screening for conditions like prostate cancer.
The document provides an overview of nutrition basics including defining nutrition, reputable nutrition research methods, categorizing nutrient needs, understanding calories and energy nutrients, analyzing the standard American diet, calculating percentages of calories from carbohydrates, fat and protein, functions of vitamins, minerals and water, factors influencing food choices, assessing nutritional status, establishing dietary reference intakes, using food guides to plan meals, and using exchange lists to plan meals.
Health promotion and promotion of healthwtyh9q78py
The lecture discusses carbohydrates and their digestion. Carbohydrates provide energy and spare protein. They include monosaccharides like glucose and fructose, disaccharides like sucrose and lactose, and polysaccharides like starch and glycogen. Dietary fiber is not digested. Soluble fiber is fermented in the colon while insoluble fiber is not fermented. Carbohydrate digestion begins in the mouth with salivary amylase and continues in the small intestine with pancreatic amylase and maltase. Cooking softens foods and makes them easier to digest.
This document provides information on weight, nutrition, and healthy eating. It discusses why weight is important, including for health, disease prevention, sports, and self-esteem. It notes the struggle between eating foods we enjoy and maintaining a healthy weight. The document then covers nutrition basics like macronutrients and micronutrients. It provides recommendations for carbohydrate, protein, and fat intake and discusses concepts like calorie needs, portion sizes, meal timing, snacking, and weight loss. The overall message is that small, sustainable changes to diet and lifestyle can promote long-term health and well-being.
Bethany Doerfler MS, RD, LDN discusses top nutrition concerns of scleroderma patients, as well as the results of a recent medical nutrition therapy study. She also discusses strategies for healthy eating, combating GI issues, maintaining muscle, a Mediterranean diet, supplements and more.
This document provides guidance on food intake according to different life stages. It recommends consuming a variety of nutritious foods including vegetables, fruits, whole grains, proteins and dairy or alternatives. The number of recommended daily servings from each food group varies depending on age, from 2-10 servings of vegetables and fruits and 3-8 servings of grain products. It also provides examples of one serving from each food group and tips for making healthy choices.
The document discusses nutrition and nutrients. It defines nutrition as the study of how the body uses food, and defines nutrients as substances in food that help maintain the body. It lists the main nutrients - vitamins, minerals, water, protein, carbohydrates, and fats. It discusses calories and variables that affect nutrient needs like age, gender, activity level, climate, health, and state of nutrition. It provides guidelines on healthy eating and weight management. Finally, it discusses some nutrition-related health issues that disproportionately affect women.
30 min health awareness campaign nbc healthy life wellness hubShelly Sandoval
This document summarizes the before and after health conditions and weight loss results of several individuals who started using Herbalife nutritional products. It describes cases such as a woman who lost 11 pounds in 4 weeks and saw improvements in her health issues including myoma and ovarian cysts. Another individual lost 25 pounds and 7 inches from their waist. The document promotes Herbalife as providing a natural nutrition program for weight loss and improved health and energy levels. It shares photos and stories of multiple people who lost weight and had improvements to health problems after beginning the Herbalife program.
The document discusses nutrition and healthy eating. It defines nutrition as the study of how the body uses food, and nutrients as substances in food that help maintain bodily functions. Key nutrients include vitamins, minerals, water, protein, carbohydrates, and fats. The document provides tips for healthy eating like following the nutrition pyramid, choosing whole grains and fruits/vegetables, and balancing calories. Issues like obesity, eating disorders, and women's health are also addressed.
The document discusses the Swiss Body Shape weight loss program. The 90-day program is based on 5 principles: detoxing, purifying, drinking supplements, workouts, and a healthy diet. It promotes achieving a natural balance through the body by replacing bad eating habits with a healthy pattern. The program includes supplements like Clear Start, Lean Complete Protein, Bios Life Slim, and Chlorophyll to support weight loss, energy, and detoxification. Participants follow a meal plan, workout routine, and supplement schedule tailored to their needs and goals. The program aims to help people lose fat while maintaining muscle and improving overall health and wellness.
Here are some key factors that can affect a balanced diet:
- Age - Nutritional needs vary depending on age (e.g. children, adults, elderly)
- Gender - Men and women have some differences in nutritional needs
- Activity level - More active individuals need more calories and certain nutrients
- Medical conditions - Certain illnesses may require dietary modifications
- Medications - Some medications can impact nutrient absorption or requirements
- Food preferences/culture - Personal tastes and cultural traditions influence food choices
- Financial resources - Cost is a consideration for some in accessing a variety of healthy foods
- Knowledge of nutrition - Understanding balanced diet principles helps with planning meals
- Time available for food prep - Con
This document provides information from Susan Hargreaves, a registered dietitian, on obstructive sleep apnoea (OSA) and associated health risks such as heart disease, diabetes, and obesity. It discusses lifestyle factors that can impact OSA like diet, physical activity, smoking, and alcohol consumption. The document offers advice on maintaining a healthy, balanced diet through proper food portion sizes, choosing lower glycemic index foods, and limiting caffeine and alcohol intake. Individualized dietary recommendations are provided based on specific health needs or diets.
Holiday cooking and coping with diabetesSummit Health
You can still enjoy holiday desserts while on a modified diet! This program will offer a presentation by Margaret Eckler, RD, Certified Diabetes Educator on how to effectively manage your diabetes during the holidays. Recipes, samples and taste testing will be provided.
This document summarizes the key points from a nutrition and wellness class. It discusses healthy eating guidelines like the Harvard Healthy Eating Plate, the importance of avoiding restrictive dieting, and the benefits of diets like the Mediterranean diet. Specific topics covered include anti-inflammatory eating, elimination diets, sample meal plans emphasizing whole foods, and the health effects of spices and dark chocolate. Body weight and composition are also addressed, discussing ideal body weight calculations and better methods to assess health than BMI alone. The overall message is that a balanced, plant-based diet focusing on real foods is important for long-term wellness.
“Psychiatry and the Humanities”: An Innovative Course at the University of Mo...Université de Montréal
“Psychiatry and the Humanities”: An Innovative Course at the University of Montreal Expanding the medical model to embrace the humanities. Link: https://www.psychiatrictimes.com/view/-psychiatry-and-the-humanities-an-innovative-course-at-the-university-of-montreal
5-hydroxytryptamine or 5-HT or Serotonin is a neurotransmitter that serves a range of roles in the human body. It is sometimes referred to as the happy chemical since it promotes overall well-being and happiness.
It is mostly found in the brain, intestines, and blood platelets.
5-HT is utilised to transport messages between nerve cells, is known to be involved in smooth muscle contraction, and adds to overall well-being and pleasure, among other benefits. 5-HT regulates the body's sleep-wake cycles and internal clock by acting as a precursor to melatonin.
It is hypothesised to regulate hunger, emotions, motor, cognitive, and autonomic processes.
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The document presents a portfolio diet created by Wendy Carlile and other students. The portfolio diet focuses on fruits, vegetables, whole grains, soluble fiber, nuts, soy protein, and margarines enriched with plant sterols. It avoids foods containing partially hydrogenated oils, processed meats, sugary beverages, sweets, and baked goods made with refined grains. Wendy describes a day of foods following the portfolio diet and provides a detailed table analyzing the nutrients and calorie content of each food.
This document provides information from a health seminar on nutrition. It discusses how most North Americans have poor diets and health, with high rates of obesity, diabetes, and other diseases. It promotes adopting a healthy lifestyle through proper nutrition, exercise, and supplementation to reduce inflammation and achieve health goals like weight loss or increased energy. The seminar emphasizes balancing blood sugar through low glycemic foods and meals with protein, fat and fiber at each meal to improve insulin sensitivity and reverse insulin resistance over time.
This document provides information about improving health, with a focus on issues common in the African-Caribbean population. It discusses the importance of health from a scriptural perspective and defines health. Key topics covered include factors that influence health, common health issues like hypertension, diabetes and obesity, and actions individuals can take to improve their health such as diet, exercise, reducing salt intake, and screening for conditions like prostate cancer.
The document provides an overview of nutrition basics including defining nutrition, reputable nutrition research methods, categorizing nutrient needs, understanding calories and energy nutrients, analyzing the standard American diet, calculating percentages of calories from carbohydrates, fat and protein, functions of vitamins, minerals and water, factors influencing food choices, assessing nutritional status, establishing dietary reference intakes, using food guides to plan meals, and using exchange lists to plan meals.
Health promotion and promotion of healthwtyh9q78py
The lecture discusses carbohydrates and their digestion. Carbohydrates provide energy and spare protein. They include monosaccharides like glucose and fructose, disaccharides like sucrose and lactose, and polysaccharides like starch and glycogen. Dietary fiber is not digested. Soluble fiber is fermented in the colon while insoluble fiber is not fermented. Carbohydrate digestion begins in the mouth with salivary amylase and continues in the small intestine with pancreatic amylase and maltase. Cooking softens foods and makes them easier to digest.
This document provides information on weight, nutrition, and healthy eating. It discusses why weight is important, including for health, disease prevention, sports, and self-esteem. It notes the struggle between eating foods we enjoy and maintaining a healthy weight. The document then covers nutrition basics like macronutrients and micronutrients. It provides recommendations for carbohydrate, protein, and fat intake and discusses concepts like calorie needs, portion sizes, meal timing, snacking, and weight loss. The overall message is that small, sustainable changes to diet and lifestyle can promote long-term health and well-being.
Bethany Doerfler MS, RD, LDN discusses top nutrition concerns of scleroderma patients, as well as the results of a recent medical nutrition therapy study. She also discusses strategies for healthy eating, combating GI issues, maintaining muscle, a Mediterranean diet, supplements and more.
This document provides guidance on food intake according to different life stages. It recommends consuming a variety of nutritious foods including vegetables, fruits, whole grains, proteins and dairy or alternatives. The number of recommended daily servings from each food group varies depending on age, from 2-10 servings of vegetables and fruits and 3-8 servings of grain products. It also provides examples of one serving from each food group and tips for making healthy choices.
The document discusses nutrition and nutrients. It defines nutrition as the study of how the body uses food, and defines nutrients as substances in food that help maintain the body. It lists the main nutrients - vitamins, minerals, water, protein, carbohydrates, and fats. It discusses calories and variables that affect nutrient needs like age, gender, activity level, climate, health, and state of nutrition. It provides guidelines on healthy eating and weight management. Finally, it discusses some nutrition-related health issues that disproportionately affect women.
30 min health awareness campaign nbc healthy life wellness hubShelly Sandoval
This document summarizes the before and after health conditions and weight loss results of several individuals who started using Herbalife nutritional products. It describes cases such as a woman who lost 11 pounds in 4 weeks and saw improvements in her health issues including myoma and ovarian cysts. Another individual lost 25 pounds and 7 inches from their waist. The document promotes Herbalife as providing a natural nutrition program for weight loss and improved health and energy levels. It shares photos and stories of multiple people who lost weight and had improvements to health problems after beginning the Herbalife program.
The document discusses nutrition and healthy eating. It defines nutrition as the study of how the body uses food, and nutrients as substances in food that help maintain bodily functions. Key nutrients include vitamins, minerals, water, protein, carbohydrates, and fats. The document provides tips for healthy eating like following the nutrition pyramid, choosing whole grains and fruits/vegetables, and balancing calories. Issues like obesity, eating disorders, and women's health are also addressed.
The document discusses the Swiss Body Shape weight loss program. The 90-day program is based on 5 principles: detoxing, purifying, drinking supplements, workouts, and a healthy diet. It promotes achieving a natural balance through the body by replacing bad eating habits with a healthy pattern. The program includes supplements like Clear Start, Lean Complete Protein, Bios Life Slim, and Chlorophyll to support weight loss, energy, and detoxification. Participants follow a meal plan, workout routine, and supplement schedule tailored to their needs and goals. The program aims to help people lose fat while maintaining muscle and improving overall health and wellness.
Here are some key factors that can affect a balanced diet:
- Age - Nutritional needs vary depending on age (e.g. children, adults, elderly)
- Gender - Men and women have some differences in nutritional needs
- Activity level - More active individuals need more calories and certain nutrients
- Medical conditions - Certain illnesses may require dietary modifications
- Medications - Some medications can impact nutrient absorption or requirements
- Food preferences/culture - Personal tastes and cultural traditions influence food choices
- Financial resources - Cost is a consideration for some in accessing a variety of healthy foods
- Knowledge of nutrition - Understanding balanced diet principles helps with planning meals
- Time available for food prep - Con
This document provides information from Susan Hargreaves, a registered dietitian, on obstructive sleep apnoea (OSA) and associated health risks such as heart disease, diabetes, and obesity. It discusses lifestyle factors that can impact OSA like diet, physical activity, smoking, and alcohol consumption. The document offers advice on maintaining a healthy, balanced diet through proper food portion sizes, choosing lower glycemic index foods, and limiting caffeine and alcohol intake. Individualized dietary recommendations are provided based on specific health needs or diets.
Holiday cooking and coping with diabetesSummit Health
You can still enjoy holiday desserts while on a modified diet! This program will offer a presentation by Margaret Eckler, RD, Certified Diabetes Educator on how to effectively manage your diabetes during the holidays. Recipes, samples and taste testing will be provided.
This document summarizes the key points from a nutrition and wellness class. It discusses healthy eating guidelines like the Harvard Healthy Eating Plate, the importance of avoiding restrictive dieting, and the benefits of diets like the Mediterranean diet. Specific topics covered include anti-inflammatory eating, elimination diets, sample meal plans emphasizing whole foods, and the health effects of spices and dark chocolate. Body weight and composition are also addressed, discussing ideal body weight calculations and better methods to assess health than BMI alone. The overall message is that a balanced, plant-based diet focusing on real foods is important for long-term wellness.
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5-HT is utilised to transport messages between nerve cells, is known to be involved in smooth muscle contraction, and adds to overall well-being and pleasure, among other benefits. 5-HT regulates the body's sleep-wake cycles and internal clock by acting as a precursor to melatonin.
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Giloy in Ayurveda - Classical Categorization and SynonymsPlanet Ayurveda
Giloy, also known as Guduchi or Amrita in classical Ayurvedic texts, is a revered herb renowned for its myriad health benefits. It is categorized as a Rasayana, meaning it has rejuvenating properties that enhance vitality and longevity. Giloy is celebrated for its ability to boost the immune system, detoxify the body, and promote overall wellness. Its anti-inflammatory, antipyretic, and antioxidant properties make it a staple in managing conditions like fever, diabetes, and stress. The versatility and efficacy of Giloy in supporting health naturally highlight its importance in Ayurveda. At Planet Ayurveda, we provide a comprehensive range of health services and 100% herbal supplements that harness the power of natural ingredients like Giloy. Our products are globally available and affordable, ensuring that everyone can benefit from the ancient wisdom of Ayurveda. If you or your loved ones are dealing with health issues, contact Planet Ayurveda at 01725214040 to book an online video consultation with our professional doctors. Let us help you achieve optimal health and wellness naturally.
This presentation gives information on the pharmacology of Prostaglandins, Thromboxanes and Leukotrienes i.e. Eicosanoids. Eicosanoids are signaling molecules derived from polyunsaturated fatty acids like arachidonic acid. They are involved in complex control over inflammation, immunity, and the central nervous system. Eicosanoids are synthesized through the enzymatic oxidation of fatty acids by cyclooxygenase and lipoxygenase enzymes. They have short half-lives and act locally through autocrine and paracrine signaling.
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GASTROINTESTINAL INFECTIONS AND GASTRITIS
Osvaldo Bernardo Muchanga
Gastrointestinal Infections
GASTROINTESTINAL INFECTIONS result from the ingestion of pathogens that cause infections at the level of this tract, generally being transmitted by food, water and hands contaminated by microorganisms such as E. coli, Salmonella, Shigella, Vibrio cholerae, Campylobacter, Staphylococcus, Rotavirus among others that are generally contained in feces, thus configuring a FECAL-ORAL type of transmission.
Among the factors that lead to the occurrence of gastrointestinal infections are the hygienic and sanitary deficiencies that characterize our markets and other places where raw or cooked food is sold, poor environmental sanitation in communities, deficiencies in water treatment (or in the process of its plumbing), risky hygienic-sanitary habits (not washing hands after major and/or minor needs), among others.
These are generally consequences (signs and symptoms) resulting from gastrointestinal infections: diarrhea, vomiting, fever and malaise, among others.
The treatment consists of replacing lost liquids and electrolytes (drinking drinking water and other recommended liquids, including consumption of juicy fruits such as papayas, apples, pears, among others that contain water in their composition).
To prevent this, it is necessary to promote health education, improve the hygienic-sanitary conditions of markets and communities in general as a way of promoting, preserving and prolonging PUBLIC HEALTH.
Gastritis and Gastric Health
Gastric Health is one of the most relevant concerns in human health, with gastrointestinal infections being among the main illnesses that affect humans.
Among gastric problems, we have GASTRITIS AND GASTRIC ULCERS as the main public health problems. Gastritis and gastric ulcers normally result from inflammation and corrosion of the walls of the stomach (gastric mucosa) and are generally associated (caused) by the bacterium Helicobacter pylor, which, according to the literature, this bacterium settles on these walls (of the stomach) and starts to release urease that ends up altering the normal pH of the stomach (acid), which leads to inflammation and corrosion of the mucous membranes and consequent gastritis or ulcers, respectively.
In addition to bacterial infections, gastritis and gastric ulcers are associated with several factors, with emphasis on prolonged fasting, chemical substances including drugs, alcohol, foods with strong seasonings including chilli, which ends up causing inflammation of the stomach walls and/or corrosion. of the same, resulting in the appearance of wounds and consequent gastritis or ulcers, respectively.
Among patients with gastritis and/or ulcers, one of the dilemmas is associated with the foods to consume in order to minimize the sensation of pain and discomfort.
Pictorial and detailed description of patellar instability with sign and symptoms and how to diagnose , what investigations you should go with and how to approach with treatment options . I have presented this slide in my 2nd year junior residency in orthopedics at LLRM medical college Meerut and got good reviews for it
After getting it read you will definitely understand the topic.
PGx Analysis in VarSeq: A User’s PerspectiveGolden Helix
Since our release of the PGx capabilities in VarSeq, we’ve had a few months to gather some insights from various use cases. Some users approach PGx workflows by means of array genotyping or what seems to be a growing trend of adding the star allele calling to the existing NGS pipeline for whole genome data. Luckily, both approaches are supported with the VarSeq software platform. The genotyping method being used will also dictate what the scope of the tertiary analysis will be. For example, are your PGx reports a standalone pipeline or would your lab’s goal be to handle a dual-purpose workflow and report on PGx + Diagnostic findings.
The purpose of this webcast is to:
Discuss and demonstrate the approaches with array and NGS genotyping methods for star allele calling to prep for downstream analysis.
Following genotyping, explore alternative tertiary workflow concepts in VarSeq to handle PGx reporting.
Moreover, we will include insights users will need to consider when validating their PGx workflow for all possible star alleles and options you have for automating your PGx analysis for large number of samples. Please join us for a session dedicated to the application of star allele genotyping and subsequent PGx workflows in our VarSeq software.
Breast cancer: Post menopausal endocrine therapyDr. Sumit KUMAR
Breast cancer in postmenopausal women with hormone receptor-positive (HR+) status is a common and complex condition that necessitates a multifaceted approach to management. HR+ breast cancer means that the cancer cells grow in response to hormones such as estrogen and progesterone. This subtype is prevalent among postmenopausal women and typically exhibits a more indolent course compared to other forms of breast cancer, which allows for a variety of treatment options.
Diagnosis and Staging
The diagnosis of HR+ breast cancer begins with clinical evaluation, imaging, and biopsy. Imaging modalities such as mammography, ultrasound, and MRI help in assessing the extent of the disease. Histopathological examination and immunohistochemical staining of the biopsy sample confirm the diagnosis and hormone receptor status by identifying the presence of estrogen receptors (ER) and progesterone receptors (PR) on the tumor cells.
Staging involves determining the size of the tumor (T), the involvement of regional lymph nodes (N), and the presence of distant metastasis (M). The American Joint Committee on Cancer (AJCC) staging system is commonly used. Accurate staging is critical as it guides treatment decisions.
Treatment Options
Endocrine Therapy
Endocrine therapy is the cornerstone of treatment for HR+ breast cancer in postmenopausal women. The primary goal is to reduce the levels of estrogen or block its effects on cancer cells. Commonly used agents include:
Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
3. FOOD FREQUENCY TABLE
FOOD ITEMS DAILY TWICE/WEEK ONCE/WEEK OCCASIONALLY NOT
CONSUMED
CEREALS ✔
LEGUMES/PULSES ✔
VEGETABLES ✔
FRUITS ✔
MILK AND MILK
PRODUCTS
✔
EGG ✔
FISH ✔
MEAT/CHICKEN ✔
NUTS
✔
JUNK FOODS ✔
OTHERS
4. DIETARY RECALL LAST 24 HOURS
ITEM AND QUANTITY CALORIE (kcal) PROTEIN (g) FAT (g)
MORNING Dosa - 2
Chutney- 2 tablespoons
Coffee- 1 cup
250
120
110
5
1
2
3
LUNCH Rice -1½ cup
Sambhar - ½ cup
Papaya upperi - 2 tablespoons
Curd- 2 tbsp
255
69
7
1.8
6.4
40.8
0.7
1.8
0.6
40.8
0.2
2.4
EVENING Coffee-1 cup 110
DINNER Dosa -1
Banana-1
125
40.8
2.5
1.8
1
0.4
TOTAL 1088.6 60 50.4
5. REQUIRED NUTRITION
● The daily requirement of this person is:
● 1680 kcal energy
● 61 g protein
● 19 g fats and oils
● 150 g green leafy vegetables
● 100 g roots and tubers
● 200 g other vegetables
● 150 g fruits
● 300 mL milk
6. INTERPRETATION
●The recommended calorie intake is 1680 kcal but the
calorie intake in the last 24 hour diet recall is 1088.6
with a calorie deficit of 591.4 kcal.
●The protein intake of the person is 60 gm, which is 1
gm less than of recommended protein intake of 61 gm
That is almost same considering an error of ±10%
7. RECOMMENDATIONS
●He can be advised to consume more calorie to meet his
daily calorie intake.
●He can be advised to consume more fish,nuts,dairy
products,vegetables to meet the required calorie.