The document discusses oxidation, disease reversal, and cellular metabolism. It explains that oxidation leads to breakdown at the cellular level and causes disease, while proper metabolism supports cellular buildup and regeneration for health. Maintaining reduced oxidation and optimal metabolism can reverse disease by supporting healthy cellular function and structure replacement at rates up to 1 million new cells per day. Factors like diet, pollution, and lifestyle choices can increase or decrease oxidation levels and affect health and disease.
This document discusses various topics related to cancer, including increasing cancer rates, flaws in conventional cancer treatments, and alternative natural treatments. It notes that cancer rates have increased significantly in recent decades and survival rates have not improved much in 55 years. It questions the suppression of alternative cancer cures and discusses how various foods, drugs, and other toxins may contribute to cancer development and rates. Natural alternative treatments for cancer are presented, along with cases of cancer being cured without conventional treatments.
Did you know that the right kind of salt actually HELPS your heart? How about that blood pressure drugs slow down the heart which decreases oxygen to the brain. Does that sound like a good idea to you? Did you also know that cholesterol is critical for hormone production in the body? It's time for some common sense! You are built to be healthy!
The document discusses the rise of non-communicable diseases (NCDs), focusing on neurological conditions like Alzheimer's, dementia, autism, and more. It lists various causes like lifestyle factors, toxins, gut health issues, vaccines, and more. Key points made include that NCDs will bankrupt healthcare systems by 2030, Americans get sick more than others, and conditions like autism and diabetes have sharply increased with the rise of genetically modified foods and food additives. The document also discusses how gut health impacts immunity and the immune system response to foods and vaccines. Various food additives and drugs are also linked to increased disease risk.
The Healing Hearts program seeks to prevent recurrences of coronary artery disease (CAD) through community centers that teach healthy lifestyle habits. CAD remains a leading cause of death in the US. Millions are at increased risk from inactivity and unhealthy diets. The program aims to reduce CAD rates in Texas, which has a high prevalence. It would teach individuals who have received CAD treatments about diet, exercise, and lifestyle changes to prevent future incidents through mobile apps and education.
This document discusses autoimmune diseases and provides statistics about their prevalence. It notes that autoimmune diseases affect one in 12 people, and one in 9 women. Common autoimmune diseases include lupus, multiple sclerosis, type 1 diabetes, and rheumatoid arthritis. The document also suggests that environmental factors may be contributing to rising rates of some autoimmune diseases.
This document discusses the benefits of juicing vegetables and fruits. It states that juicing allows for greater absorption of nutrients by removing fiber. It also notes that juicing can help consume more vegetables in an efficient way by allowing one to add variety. The document recommends juicing 1 pound of raw vegetables per 50 pounds of body weight daily for optimal health benefits.
The document discusses how brain structure and function can change with depression and bipolar disorder. It describes how the hippocampus shrinks with these conditions, increasing risks for memory problems and dementia. Exercise and meditation are highlighted as ways to potentially reverse hippocampal shrinkage and improve brain plasticity and cognitive function. Drug therapies are noted to have risks of worsening symptoms or converting unipolar depression to bipolar disorder.
The document discusses oxidation, disease reversal, and cellular metabolism. It explains that oxidation leads to breakdown at the cellular level and causes disease, while proper metabolism supports cellular buildup and regeneration for health. Maintaining reduced oxidation and optimal metabolism can reverse disease by supporting healthy cellular function and structure replacement at rates up to 1 million new cells per day. Factors like diet, pollution, and lifestyle choices can increase or decrease oxidation levels and affect health and disease.
This document discusses various topics related to cancer, including increasing cancer rates, flaws in conventional cancer treatments, and alternative natural treatments. It notes that cancer rates have increased significantly in recent decades and survival rates have not improved much in 55 years. It questions the suppression of alternative cancer cures and discusses how various foods, drugs, and other toxins may contribute to cancer development and rates. Natural alternative treatments for cancer are presented, along with cases of cancer being cured without conventional treatments.
Did you know that the right kind of salt actually HELPS your heart? How about that blood pressure drugs slow down the heart which decreases oxygen to the brain. Does that sound like a good idea to you? Did you also know that cholesterol is critical for hormone production in the body? It's time for some common sense! You are built to be healthy!
The document discusses the rise of non-communicable diseases (NCDs), focusing on neurological conditions like Alzheimer's, dementia, autism, and more. It lists various causes like lifestyle factors, toxins, gut health issues, vaccines, and more. Key points made include that NCDs will bankrupt healthcare systems by 2030, Americans get sick more than others, and conditions like autism and diabetes have sharply increased with the rise of genetically modified foods and food additives. The document also discusses how gut health impacts immunity and the immune system response to foods and vaccines. Various food additives and drugs are also linked to increased disease risk.
The Healing Hearts program seeks to prevent recurrences of coronary artery disease (CAD) through community centers that teach healthy lifestyle habits. CAD remains a leading cause of death in the US. Millions are at increased risk from inactivity and unhealthy diets. The program aims to reduce CAD rates in Texas, which has a high prevalence. It would teach individuals who have received CAD treatments about diet, exercise, and lifestyle changes to prevent future incidents through mobile apps and education.
This document discusses autoimmune diseases and provides statistics about their prevalence. It notes that autoimmune diseases affect one in 12 people, and one in 9 women. Common autoimmune diseases include lupus, multiple sclerosis, type 1 diabetes, and rheumatoid arthritis. The document also suggests that environmental factors may be contributing to rising rates of some autoimmune diseases.
This document discusses the benefits of juicing vegetables and fruits. It states that juicing allows for greater absorption of nutrients by removing fiber. It also notes that juicing can help consume more vegetables in an efficient way by allowing one to add variety. The document recommends juicing 1 pound of raw vegetables per 50 pounds of body weight daily for optimal health benefits.
The document discusses how brain structure and function can change with depression and bipolar disorder. It describes how the hippocampus shrinks with these conditions, increasing risks for memory problems and dementia. Exercise and meditation are highlighted as ways to potentially reverse hippocampal shrinkage and improve brain plasticity and cognitive function. Drug therapies are noted to have risks of worsening symptoms or converting unipolar depression to bipolar disorder.
This document summarizes major developments in understanding cardiovascular disease risk factors over three eras. Era 1 focused on traditional risk factors like cholesterol. Era 2 identified additional non-traditional factors. Era 3 explores novel inflammatory markers. While risk calculators only use Era 1 factors, studies increasingly show the significance of Era 2 and 3 markers. However, the 2002 AHA guideline was cautious to fully incorporate newer findings, focusing primarily on traditional risk factors and recommending further research on controversial interventions and use of inflammatory markers in screening.
This document summarizes major developments in understanding cardiovascular disease risk factors over three eras. Era 1 focused on traditional risk factors like cholesterol. Era 2 identified additional non-traditional factors. Era 3 explores novel inflammatory markers. While risk calculators only use Era 1 factors, studies increasingly show the significance of Era 2 and 3 markers. However, the 2002 AHA guideline was cautious to fully incorporate newer findings, focusing primarily on lifestyle changes and aspirin rather than additional drugs or tests. Questions are raised about better integrating multiple risk factors and cut-points into prevention strategies.
Heart disease and stroke are the first and third leading causes of death in the United States. They account for over one-third of all deaths and cost over $444 billion each year. While death rates have declined, incidence and death rates remain high for some groups. Lifestyle changes such as not smoking, healthy diet and exercise can significantly reduce risks. The CDC works with states to promote prevention through monitoring risks, supporting local programs, and improving emergency response systems.
- Chronic diseases like heart disease, cancer and diabetes account for most deaths in the US and costs over $700 billion annually, yet less than 3% of healthcare spending goes to prevention.
- Adopting therapeutic lifestyle changes focusing on diet, exercise and avoiding tobacco has been shown to help patients achieve health goals without medication and reduce risk of chronic diseases.
- Studies have found that a low glycemic index diet combined with soy protein and phytosterols helped obese post-menopausal women significantly reduce weight, blood pressure, cholesterol and triglycerides.
This document discusses several aspects of managing elderly patients with multiple chronic conditions (multimorbidity). It notes that multimorbidity is highly prevalent in the elderly and impacts physical and cognitive functioning, depression, mortality and hospitalization. It also discusses how multimorbidity affects the management of specific conditions like COPD, diabetes, heart failure, osteoporosis, dementia and hypertension. The document emphasizes that clinical guidelines focused on single diseases do not adequately address the complexity of multimorbid elderly patients.
The document discusses several topics related to lung health:
1. Geoengineering practices like solar radiation management have led to increased nanoparticles in the air, water, and food, causing inflammation and damage to lung tissue which can result in conditions like pneumonia, lung diseases, and cancer.
2. Nanoparticles from sources like cosmetics, electronics, and agriculture are inhaled and ingested, potentially damaging lungs over time.
3. Chronic conditions like asthma, COPD, and bronchitis have numerous risk factors including cured meats, acetaminophen, antibiotics, and air pollution. Strengthening immunity and lifestyle changes can help address some lung ailments.
This document discusses guidelines for diagnosing and treating hypertension according to the JNC VII report. It begins by defining classifications of prehypertension, stage 1 hypertension, and stage 2 hypertension. It emphasizes treating the underlying vascular biology of hypertension rather than just the blood pressure numbers. Key points include that cardiovascular risk doubles with each 20/10 mm Hg increase in blood pressure starting at 115/75 mm Hg, and lifestyle modifications should be initiated for those with prehypertension.
This document discusses how the nervous system controls and regulates every system in the body. It explains how problems with the nervous system can lead to issues like neuropathy, heart/blood pressure problems, digestive issues, hormone imbalances, and more. It emphasizes looking at the whole person and nervous system rather than just symptoms. Maintaining a healthy nervous system involves diet, exercise, rest, and chiropractic care to allow the body to function properly.
Hypokalemia in Emergency Medicine is an article that discusses potassium levels in the body and defines hypokalemia as a potassium level below 3.5 mEq/L. It notes that nearly 98% of the body's potassium is intracellular and plays an important role in cellular membrane potential. Hypokalemia can result from renal or GI losses, inadequate diet, medications, or a transcellular shift of potassium into cells. As many as 20% of hospitalized patients and 14% of outpatients undergoing testing may have mild hypokalemia, though it is clinically significant in only 4-5% of cases. Approximately 80% of patients on diuretics become hypokalemic.
The document discusses nerve health and peripheral neuropathy. It covers the nervous system and its divisions. Common causes of peripheral neuropathy include diabetes, vitamin deficiencies, medications, injuries, and more. Nearly 40 drugs are known to cause neuropathy side effects. Maintaining nerve health involves proper nutrition, exercise, rest, and avoiding toxins and allergens.
This document discusses several topics related to brain health and disease. It provides information on brain facts such as weight and calorie/oxygen consumption. It then discusses Parkinson's disease and links it to toxicities like pesticides and deficiencies like decreased folate. Folate deficiency is specifically linked to increased vulnerability of dopamine neurons. The document also discusses various medications that can cause toxicity and deficiencies leading to conditions like dementia. Overall, it emphasizes the importance of nutrition, avoiding toxins, and considers alternative perspectives on conditions like hypertension.
The document discusses several potential causes and risks associated with depression and Alzheimer's disease. It notes that depression affects over 40 million Americans and is the 4th leading cause of disability worldwide, costing over $200 billion per year. Several sections discuss research linking depression to factors like aluminum, MSG, chemical exposures, and nutritional deficiencies. The document also warns of risks associated with antidepressant medications, including increased suicidal thoughts in children and questions about their effectiveness compared to placebos.
This document discusses various causes and treatments for lung diseases like asthma and COPD. It states that smoking is a leading cause of lung disease and that medical treatments offer little relief. It then provides statistics on the prevalence and mortality rates of asthma in the US and discusses various environmental and lifestyle factors that can contribute to or help prevent lung diseases, such as pollution, diet, exercise, vaccinations, and chiropractic care.
Uric acid and htn saudi htn conference final 3JAFAR ALSAID
Uric acid plays a role in cardiovascular disease and hypertension. High levels of uric acid are associated with hypertension and lowering uric acid, such as through allopurinol, can reduce blood pressure. Treating hyperuricemia may help slow the progression of chronic kidney disease and loss of kidney function. Studies in adolescents with newly diagnosed hypertension found that allopurinol reduced both office and 24-hour blood pressure readings. Elevated uric acid may contribute to hypertension through various mechanisms like reducing nitric oxide, activating the renin-angiotensin-aldosterone system, causing renal vasoconstriction, and inducing microvascular renal disease.
Fibromyalgia is a disorder characterized by widespread musculoskeletal pain accompanied by fatigue, sleep issues, and mood problems. Researchers believe fibromyalgia amplifies pain signals by affecting how the brain processes pain. Symptoms sometimes begin after physical trauma, surgery or stress. Women are more likely to develop fibromyalgia than men. While there is no cure, medications and exercise can help manage symptoms.
Dr. Maureen McMahon Presents "“Heart Disease and Preventive Measures” at Lupu...LupusNY
Pro-inflammatory HDL (piHDL) may help predict risk of atherosclerosis (ATH) in patients with systemic lupus erythematosus (SLE). The study found 45% of SLE patients and none of the healthy controls had piHDL. PiHDL was significantly associated with carotid plaque and greatly increased the risk of plaque in SLE patients. Traditional risk factors did not fully explain the risk of ATH in SLE. PiHDL could be a useful marker for predicting ATH risk in SLE patients. Further research is needed to develop new treatments targeting piHDL and risk profiles including piHDL.
Risk factors of Acute Coronary Syndrome at Prince Ali Bin Alhussein hospitalMinistry of Health
Objective:The aim of this survey to identify the relationship between ACS and its risk factors and the association between the risks factors themselves. Method: A retrospective study depends on the registered files of the admitted patients to Prince Ali Bin Alhussein hospital with ACS since April 2013 till October of 2013 included 174 patients. Result:The above mentioned data and results show a strong relationship between ACS and the mentioned risk factors. Conclusion: There is a strong relationship between risks factors themselves as D.M and hypertension, and between hypertension with the sex and smoking.There's an association between D.M and the patient's gender
The document discusses biblical revelations about nutrition and health based on passages from the Bible. It states that sickness and disease plague mankind due to a lack of knowledge, and that God's words in the Bible contain the truth about health and disease prevention. It provides examples from the Bible of the types of meat, fat, and plants that are healthy to eat according to biblical teachings.
This document summarizes research on vitamin D deficiency and cardiovascular risks. It discusses how vitamin D metabolism and mechanisms of action may impact cardiovascular outcomes. Several studies are cited showing associations between vitamin D deficiency and increased risks of hypertension, diabetes, heart disease, and mortality. However, the document also notes controversies in the research and calls for more rigorous randomized controlled trials. It outlines objectives and methods for a study examining vitamin D levels in patients with ischemic heart disease. The conclusion is that vitamin D levels correlate with cardiovascular disease and supplementation may help outcomes, but more clinical trials are still needed.
This document summarizes major developments in understanding cardiovascular disease risk factors over three eras. Era 1 focused on traditional risk factors like cholesterol. Era 2 identified additional non-traditional factors. Era 3 explores novel inflammatory markers. While risk calculators only use Era 1 factors, studies increasingly show the significance of Era 2 and 3 markers. However, the 2002 AHA guideline was cautious to fully incorporate newer findings, focusing primarily on traditional risk factors and recommending further research on controversial interventions and use of inflammatory markers in screening.
This document summarizes major developments in understanding cardiovascular disease risk factors over three eras. Era 1 focused on traditional risk factors like cholesterol. Era 2 identified additional non-traditional factors. Era 3 explores novel inflammatory markers. While risk calculators only use Era 1 factors, studies increasingly show the significance of Era 2 and 3 markers. However, the 2002 AHA guideline was cautious to fully incorporate newer findings, focusing primarily on lifestyle changes and aspirin rather than additional drugs or tests. Questions are raised about better integrating multiple risk factors and cut-points into prevention strategies.
Heart disease and stroke are the first and third leading causes of death in the United States. They account for over one-third of all deaths and cost over $444 billion each year. While death rates have declined, incidence and death rates remain high for some groups. Lifestyle changes such as not smoking, healthy diet and exercise can significantly reduce risks. The CDC works with states to promote prevention through monitoring risks, supporting local programs, and improving emergency response systems.
- Chronic diseases like heart disease, cancer and diabetes account for most deaths in the US and costs over $700 billion annually, yet less than 3% of healthcare spending goes to prevention.
- Adopting therapeutic lifestyle changes focusing on diet, exercise and avoiding tobacco has been shown to help patients achieve health goals without medication and reduce risk of chronic diseases.
- Studies have found that a low glycemic index diet combined with soy protein and phytosterols helped obese post-menopausal women significantly reduce weight, blood pressure, cholesterol and triglycerides.
This document discusses several aspects of managing elderly patients with multiple chronic conditions (multimorbidity). It notes that multimorbidity is highly prevalent in the elderly and impacts physical and cognitive functioning, depression, mortality and hospitalization. It also discusses how multimorbidity affects the management of specific conditions like COPD, diabetes, heart failure, osteoporosis, dementia and hypertension. The document emphasizes that clinical guidelines focused on single diseases do not adequately address the complexity of multimorbid elderly patients.
The document discusses several topics related to lung health:
1. Geoengineering practices like solar radiation management have led to increased nanoparticles in the air, water, and food, causing inflammation and damage to lung tissue which can result in conditions like pneumonia, lung diseases, and cancer.
2. Nanoparticles from sources like cosmetics, electronics, and agriculture are inhaled and ingested, potentially damaging lungs over time.
3. Chronic conditions like asthma, COPD, and bronchitis have numerous risk factors including cured meats, acetaminophen, antibiotics, and air pollution. Strengthening immunity and lifestyle changes can help address some lung ailments.
This document discusses guidelines for diagnosing and treating hypertension according to the JNC VII report. It begins by defining classifications of prehypertension, stage 1 hypertension, and stage 2 hypertension. It emphasizes treating the underlying vascular biology of hypertension rather than just the blood pressure numbers. Key points include that cardiovascular risk doubles with each 20/10 mm Hg increase in blood pressure starting at 115/75 mm Hg, and lifestyle modifications should be initiated for those with prehypertension.
This document discusses how the nervous system controls and regulates every system in the body. It explains how problems with the nervous system can lead to issues like neuropathy, heart/blood pressure problems, digestive issues, hormone imbalances, and more. It emphasizes looking at the whole person and nervous system rather than just symptoms. Maintaining a healthy nervous system involves diet, exercise, rest, and chiropractic care to allow the body to function properly.
Hypokalemia in Emergency Medicine is an article that discusses potassium levels in the body and defines hypokalemia as a potassium level below 3.5 mEq/L. It notes that nearly 98% of the body's potassium is intracellular and plays an important role in cellular membrane potential. Hypokalemia can result from renal or GI losses, inadequate diet, medications, or a transcellular shift of potassium into cells. As many as 20% of hospitalized patients and 14% of outpatients undergoing testing may have mild hypokalemia, though it is clinically significant in only 4-5% of cases. Approximately 80% of patients on diuretics become hypokalemic.
The document discusses nerve health and peripheral neuropathy. It covers the nervous system and its divisions. Common causes of peripheral neuropathy include diabetes, vitamin deficiencies, medications, injuries, and more. Nearly 40 drugs are known to cause neuropathy side effects. Maintaining nerve health involves proper nutrition, exercise, rest, and avoiding toxins and allergens.
This document discusses several topics related to brain health and disease. It provides information on brain facts such as weight and calorie/oxygen consumption. It then discusses Parkinson's disease and links it to toxicities like pesticides and deficiencies like decreased folate. Folate deficiency is specifically linked to increased vulnerability of dopamine neurons. The document also discusses various medications that can cause toxicity and deficiencies leading to conditions like dementia. Overall, it emphasizes the importance of nutrition, avoiding toxins, and considers alternative perspectives on conditions like hypertension.
The document discusses several potential causes and risks associated with depression and Alzheimer's disease. It notes that depression affects over 40 million Americans and is the 4th leading cause of disability worldwide, costing over $200 billion per year. Several sections discuss research linking depression to factors like aluminum, MSG, chemical exposures, and nutritional deficiencies. The document also warns of risks associated with antidepressant medications, including increased suicidal thoughts in children and questions about their effectiveness compared to placebos.
This document discusses various causes and treatments for lung diseases like asthma and COPD. It states that smoking is a leading cause of lung disease and that medical treatments offer little relief. It then provides statistics on the prevalence and mortality rates of asthma in the US and discusses various environmental and lifestyle factors that can contribute to or help prevent lung diseases, such as pollution, diet, exercise, vaccinations, and chiropractic care.
Uric acid and htn saudi htn conference final 3JAFAR ALSAID
Uric acid plays a role in cardiovascular disease and hypertension. High levels of uric acid are associated with hypertension and lowering uric acid, such as through allopurinol, can reduce blood pressure. Treating hyperuricemia may help slow the progression of chronic kidney disease and loss of kidney function. Studies in adolescents with newly diagnosed hypertension found that allopurinol reduced both office and 24-hour blood pressure readings. Elevated uric acid may contribute to hypertension through various mechanisms like reducing nitric oxide, activating the renin-angiotensin-aldosterone system, causing renal vasoconstriction, and inducing microvascular renal disease.
Fibromyalgia is a disorder characterized by widespread musculoskeletal pain accompanied by fatigue, sleep issues, and mood problems. Researchers believe fibromyalgia amplifies pain signals by affecting how the brain processes pain. Symptoms sometimes begin after physical trauma, surgery or stress. Women are more likely to develop fibromyalgia than men. While there is no cure, medications and exercise can help manage symptoms.
Dr. Maureen McMahon Presents "“Heart Disease and Preventive Measures” at Lupu...LupusNY
Pro-inflammatory HDL (piHDL) may help predict risk of atherosclerosis (ATH) in patients with systemic lupus erythematosus (SLE). The study found 45% of SLE patients and none of the healthy controls had piHDL. PiHDL was significantly associated with carotid plaque and greatly increased the risk of plaque in SLE patients. Traditional risk factors did not fully explain the risk of ATH in SLE. PiHDL could be a useful marker for predicting ATH risk in SLE patients. Further research is needed to develop new treatments targeting piHDL and risk profiles including piHDL.
Risk factors of Acute Coronary Syndrome at Prince Ali Bin Alhussein hospitalMinistry of Health
Objective:The aim of this survey to identify the relationship between ACS and its risk factors and the association between the risks factors themselves. Method: A retrospective study depends on the registered files of the admitted patients to Prince Ali Bin Alhussein hospital with ACS since April 2013 till October of 2013 included 174 patients. Result:The above mentioned data and results show a strong relationship between ACS and the mentioned risk factors. Conclusion: There is a strong relationship between risks factors themselves as D.M and hypertension, and between hypertension with the sex and smoking.There's an association between D.M and the patient's gender
The document discusses biblical revelations about nutrition and health based on passages from the Bible. It states that sickness and disease plague mankind due to a lack of knowledge, and that God's words in the Bible contain the truth about health and disease prevention. It provides examples from the Bible of the types of meat, fat, and plants that are healthy to eat according to biblical teachings.
This document summarizes research on vitamin D deficiency and cardiovascular risks. It discusses how vitamin D metabolism and mechanisms of action may impact cardiovascular outcomes. Several studies are cited showing associations between vitamin D deficiency and increased risks of hypertension, diabetes, heart disease, and mortality. However, the document also notes controversies in the research and calls for more rigorous randomized controlled trials. It outlines objectives and methods for a study examining vitamin D levels in patients with ischemic heart disease. The conclusion is that vitamin D levels correlate with cardiovascular disease and supplementation may help outcomes, but more clinical trials are still needed.
“Nutraceutical” is any substance that may be considered as a food or part of food and provides medical or health benefits, encompassing, prevention and treatment of diseases.
It is the combination of two term "Nutrition" and "pharmaceuticals"
The effects of_the_mediterranean_diet_on_chronic_dArnon Ngoenyuang
This document summarizes the effects of the Mediterranean diet on chronic diseases. It discusses how the Mediterranean diet, characterized by high consumption of vegetables, fruits, whole grains, nuts, legumes, olive oil and fish, is associated with reduced risk of cardiovascular diseases, diabetes, cancer, neurodegenerative diseases and obesity. The Mediterranean diet contains beneficial compounds like polyphenols, flavonoids, phytosterols and omega-3 fatty acids that are anti-inflammatory and antioxidant, and have been shown to lower risk of chronic diseases through various mechanisms like reducing oxidative stress and inflammation. Adherence to the Mediterranean diet is associated with significant reductions in mortality, cardiovascular disease incidence and incidence of neurodegenerative diseases.
This study evaluated the relationship between self-reported 3-day diets and cardiovascular markers in 92 young adult participants. Diet characteristics were analyzed using diet logs and correlated with blood pressure and body composition measurements. Sodium intake was positively correlated with BMI. Dietary fiber and iron intake were inversely correlated with systolic blood pressure, suggesting fiber and iron may help lower blood pressure. The results provide some insight into how specific nutrients in the diets of young adults may impact cardiovascular health markers.
Hypertension, or high blood pressure, is a growing global health concern that disproportionately affects minority populations like African Americans. The literature review examined 15 research articles on managing hypertension in these high-risk groups. Key findings included: (1) multiple-drug regimens are often needed to control blood pressure; (2) lifestyle modifications can help reduce cardiovascular events; and (3) improving patient education and adherence through culturally-appropriate strategies may enhance health outcomes. Overall, the studies emphasized the importance of early detection, treatment, and prevention to reduce hypertension's harmful effects.
Psychology plays an important role in cystic fibrosis care. People with CF and their caregivers are at higher risk for depression and anxiety due to the challenges of managing a chronic disease. Screening and treatment of mental health issues is critical because psychological distress can negatively impact adherence, pulmonary function, quality of life, and healthcare costs. The presentation outlined guidelines for integrating mental health screening and treatment into CF care through annual assessments, brief therapies, and connecting patients and families to local resources. Managing depression and anxiety is key to optimizing health outcomes and disease management for those living with cystic fibrosis.
Nutraceuticals provide health benefits and can help prevent cardiovascular disease. Green tea contains antioxidants like epigallocatechin that can lower cholesterol and blood pressure, reducing heart disease risk. Turmeric contains curcumin which improves endothelial function and decreases heart attack risk by 65%. Ginger contains gingerol which has anti-inflammatory effects. These nutraceuticals provide cardiovascular benefits through their antioxidant and other pharmacological properties and can be considered as alternatives to pharmaceuticals.
Polypill for primary and secondary preventions of cardiovascularBhaswat Chakraborty
This document discusses cardiovascular diseases (CVDs) and strategies for primary and secondary prevention. It summarizes that CVDs are caused by risk factors like hypertension, diabetes, smoking, obesity, and high cholesterol. Modifying these risk factors can prevent CVDs. The document outlines that a polypill containing multiple drugs can provide primary prevention by lowering risk factors. Studies on Cadila Pharmaceuticals' polypill product Polycap found it reduced blood pressure and LDL cholesterol similarly to the individual drugs. Polycap was also found to have no drug interactions and preserve the bioavailability of components, establishing its potential for CVD prevention.
Strokes are a major health issue and a leading cause of death in the US. According to the CDC, 80% of strokes can be prevented. Diet plays an important role in prevention, as maintaining a healthy diet with fruits, vegetables, fiber, dairy, nuts, olive oil, and fish is associated with a lower risk of stroke. Other lifestyle factors like physical activity and healthy weight are also important. Some research also suggests that herpes zoster vaccination may help reduce stroke risk by preventing herpes zoster infections, which are linked to an increased risk of stroke. Preventing and controlling conditions like diabetes, hypertension, high cholesterol, obesity, and atrial fibrillation can further reduce stroke risk.
This document discusses varicella zoster virus (VZV) which causes chickenpox and shingles. It provides statistics on the incidence of chickenpox pre- and post-vaccine era in the US. It also discusses risk factors for shingles and strategies to reduce its incidence including exposure to children with chickenpox and the shingles vaccine.
2014 Report: Medicines in Development for Older AmericansPhRMA
As life expectancy continues to climb—up to more than 81 years for women and 76 years for men—the growing number of Americans age 65 and older will face new challenges from chronic conditions such as arthritis, Alzheimer’s disease, cardiovascular disease and diabetes, which impact their health, productivity and independence. Those diseases not only impact the individuals living with them, but burden their families and cost the health care system billions of dollars.
Biopharmaceutical research companies are developing 435 medicines targeting 15 leading chronic conditions affecting seniors—Alzheimer’s and dementia, anemia, arthritis, benign prostatic hyperplasia, cataracts and glaucoma, chronic
kidney disease, chronic obstructive pulmonary disease (COPD), depression, diabetes, heart failure, hyperlipidemia,
hypertension, hypothyroidism and ischemic heart disease.
This document discusses strategies for preventing stroke through lifestyle modifications. It recommends maintaining a healthy diet low in salt and sugar and high in fruits and vegetables. It also stresses the importance of regular physical activity, maintaining a healthy weight, not smoking, and managing risk factors like blood pressure, cholesterol and blood sugar. Following these lifestyle guidelines can significantly reduce one's risk of having a stroke.
Nutrition management in systemic lupus erythematosus (SLE) was explored. A search found few randomized trials on nutrition for SLE. The best results were from trials on dehydroepiandrosterone (DHEA), which reduced SLE activity, and N-acetylcysteine (NAC), which reduced SLE disease activity. However, trials on omega-3 fatty acids found no clear benefits and some potential adverse effects. Overall, the evidence is limited and inconclusive on specific nutrition interventions for SLE due to small sample sizes and limitations of current studies. Further large randomized controlled trials are still needed.
This document contains summaries of several recent health-related studies and articles:
1) A study found that mental health disorders increase mortality risk by over 2 times, and account for 8 million deaths worldwide annually. Efforts are needed to reduce risks from severe mental illnesses and common disorders.
2) Research suggests smoking may cause over 540,000 US deaths per year when including other conditions like kidney disease and cancer. This challenges the current estimate of 480,000 smoking deaths.
3) A study links following the Mediterranean diet to a lower risk of ischemic stroke due to the diet's emphasis on plants, fish and limits on meat and dairy.
Cardiorespiratory Fitness, Health Outcomes, and Health Care Costs: The Case f...Matti Salakka 🐠
Physical inactivity is becoming a world-wide epidemic – and the consequences can be both costly and deadly. This was outlined by Dr. Jonathan Myers who, citing a range of studies and recent research results, was able to show hard-hitting data related to the correlation between fitness (or lack thereof) and poor health. Myers argues fitness may well be a better marker than traditional risk factors for CVD and all-cause mortality. Amongst the eye-opening findings presented to the audience was that, for the first time, global deaths-per-year due to physical inactivity are higher than for smoking.
By 2020, chronic lifestyle diseases are expected to claim 7.63 million lives in India, a significant increase from 3.78 million in 1990. India will have 30 million diabetics by 2020, with 6.6 million suffering from complications. The number of people with hypertension is estimated to rise to 213.5 million by 2025, an 80% increase from 2000. Lifestyle diseases contribute to most deaths globally due to risk factors like physical inactivity, unhealthy diet, tobacco use, and alcohol use. Addressing lifestyle risk factors through policy measures could prevent a large proportion of chronic diseases.
This document discusses lifestyle medicine as a solution for chronic disease prevention and treatment. It defines lifestyle medicine as involving therapeutic lifestyle approaches like nutrition, exercise, stress management and tobacco cessation to prevent and sometimes reverse chronic diseases. The document outlines tools of lifestyle medicine including motivational interviewing, group medical visits, intensive lifestyle treatment, and residential treatment. It promotes a whole food, plant-based diet as the optimal fuel for the body and discusses evidence that such a diet can prevent and treat chronic conditions like heart disease and diabetes.
The effects of dietary fats on the risk of coronary artery disease (CAD) have traditionally
been estimated from their effects on LDL cholesterol. Fats, however, also affect HDL
cholesterol, and the ratio of total to HDL cholesterol is a more specific marker of CAD than is
LDL cholesterol. Hypolipidemic drugs and fruits can play a part to reduce LDL particles
decreasing chances of CAD development. This study was conducted to compare
hypolipidemic effects of Niacin and Jujube fruit in primary as well as secondary
hyperlipidemic patients. Study was conducted from November 2018 to February 2019 at
Jinnah Hospital Lahore. Sixty participants were enrolled of both gender male and female
patients age range from 20 to 70 years. Consent was taken from all patients. They were
divided in two groups. Group-I was advised to take 2 grams Niacin in divided doses for the
period of two months. Group-II was advised to take 500 grams of fruit Jujube daily for the
period of two months. Their baseline LDL and HDL cholesterol was determined by
conventional method of measuring Lipid Profile. After two months therapy, their post
treatment lipid profile was measured and mean values with ± SEM were analyzed
biostatistically. Group-I which was on Niacin their LDL cholesterol decreased significantly and
HDL cholesterol was increased significantly. In group-II patients LDL cholesterol was
decreased significantly but HDL increase was not significant with p-value of >0.05. It was
concluded from the research work that Niacin is potent in lowering LDL and increasing HDL
cholesterol, while Jujube has significant effect as LDL cholesterol lowering potential, but it
does not increase HDL cholesterol significantly.
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Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
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The Role Of Nutritional Therapies In The Care
1. 'The role of Nutritional Therapy in the care of individuals with cardiovascular related problems' Michael Ash BSc (Hons) DO ND F DipION mBANT NTCC Osteopath Naturopath Nutritional Therapist Researcher Author
2. A Functional Medicine approach to optimise outcomes, ease of engagement and compliance. 8 Practical strategies & how to avoid common pitfalls. Interaction of the immune system with the heart. GastroCentric Perspective. How food selection can provide a multi faceted benefit. Supplements of benefit. NutritionalTherapy
3. Question? 60% reduction in heart disease throughout entire country. the drug treatment does not seem to account for more than 5-6% of the observed fall of blood pressure, and 10-15% of the decrease in deaths from strokes and ischaemic heart disease -Marked increases in intake of alcohol and obesity in men, increased smoking in women. Karppanen H, Mervaala E. Adherence to and population impact of non-pharmacological and pharmacological antihypertensive therapy. J Hum Hypertens. 1996 Feb;10 Suppl 1:S57-61. View Abstract Don’t ask me a question already... It’s been a long day....
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5. Overview Client Goals Determine their aims and outcomes – the purpose of the plan is to support the patients goals with evidence based strategies Identify realistic goals, obtain agreement that these are achievable and describe plan ASSESMENT ANTECEDENTS TRIGGERS MEDIATORS Medical history review and systems analysis assess the: Antecedents: Sex, Age, Genetics, Lifestyle, Experiences, Trauma, Childhood, Stress, etc. Triggers: Events that initiate illness or symptoms – stress, infection, environmental toxins, food. etc. – look to see if they can be removed or controlled Mediators: Cytokines, prostaglandins, free radicals, neurotransmitters, fear, personal value, behavioural conditioning, poverty, etc.
6. In physiology, foetal nutritional stress appears to flip an evolved switch that sets the body into a state that protects against starvation. When these individuals encounter modern diets, they respond with the deadly metabolic syndrome of obesity, hypertension, and diabetes. Barker DJ, Eriksson JG, Forsén T, Osmond C.Fetal origins of adult disease: strength of effects and biological basis. Int J Epidemiol. 2002 Dec;31(6):1235-9. View Abstract Barker DJ. The malnourished baby and infant. Br Med Bull. 2001;60:69-88. Review. View Abstract Neel JV, Julius S, Weder A, Yamada M, Kardia SL, Haviland MB. Syndrome X: is it for real? Genet Epidemiol. 1998;15(1):19-32. View Abstract Evolutionary Nutritional Therapy
7. Overview INDIVIDUALISED PROGRAMME Set outcomes attached to strategic benchmarks Have patient agree to terms of recommendation, establish review points, share information with medical professional or other colleagues, be prepared to adapt and evolve Individualised Strategies The hall mark of Functional Medicine approaches to health care. Nutritional Therapy is the cornerstone of Functional Medicine and needs to play a key role in the therapeutic journey. Other vital components are required to be part of the overall strategy and comprehension of these reduces likelihood of conflict, contraindication, adverse events and professional clashes.
8. 8 Components Prioritise According To Evidence/Competence INDIVIDUALISED PROGRAMME Each one may represent a significant event Each one should have evidence based strategy Each one requires co-operation Each one has a component either partially or fully related to nutrition Each practitioner will have personal and professional influences that need to be managed in relation to the needs of the patient and the approved outcomes. Berlin EA, Fowkes WC Jr. A teaching framework for cross-cultural health care. Application in family practice. West J Med. 1983;39:934-938. View Paper 8
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10. Feinstein M, Liu K, Ning H, Fitchett G, Lloyd-Jones DM. Burden of cardiovascular risk factors, subclinical atherosclerosis, and incident cardiovascular events across dimensions of religiosity. The Multi-Ethnic Study of Atherosclerosis. Circulation. 2010;121:659-666 View AbstractMind & Spirit Our results do not confirm those of previous studies associating greater religiosity with overall better health risks and status, at least with regard to CVD. There was no reduction in risk for CVD events associated with greater religiosity. “
11. Exercise INDIVIDUALISED PROGRAMME Set outcomes attached to strategic benchmarks Approximately 2.5 hours per week of moderate to vigorous physical activity has been shown to lower the risk of cardiovascular disease, but the dose-response curve is not well defined. Total volume of activity may be associated with the greatest reduction in risk, however, ....and that increased physical activity, even vigorous activity, did not appear to have any detrimental effects. Chomistek AK, Rimm EB. Physical activity and incident cardiovascular disease: investigation of the effect of high amounts of vigorous-intensity activity. EPI|PNAM 2010; March 3, 2010; San Francisco, CA. View Abstract Environmental Inputs – inc Diet, Exercise
12. The X Factor – Wide Shoulders, Narrow waist Plus normal hips. Evolutionarily, secondary sex traits are associated with high fertility. For both genders, a narrow waist signifies high hormones – testosterone (not hair-losing-DHT), oestrogen, progesterone, DHEA, pregnenolone, etc. And... Low insulin, low insulin resistance and low inflammation and, thus, high immunity and resistance to lethal infections, the biggest killer of ancestral man besides predators and famine/drought.
13. Fat & Immunity – CVD risk Adiponectin is another adipose hormone that is receiving a lot of attention in the medical literature for the last several years. adiponectin levels decrease with visceral obesity. Most abundantly produced adipokine, appears to be a strong link in the metabolic syndrome: diabetes, hypertension, high cholesterol, high uric acid levels, and obesity. Calorie restriction, muscle mass, niacin, curcumin and resveratrol increase adiponectin levels Shibata R, Ouchi N, Murohara T: Adiponectin and cardiovascular disease. Circ J. 2009 Apr;73(4):608-14. Epub 2009 Mar 3. View Abstract
14. Adiponectin Sensitises insulin. < adiponectin causes insulin resistance - Type II Diabetes Reduces liver glucose production Increases glucose uptake in the muscles and adipose tissues Causes oxidation of fats which leads to less lipid production Has anti-inflammatory properties Protects the heart against ischemia and reduces myocardial infarct size Acts as an anti-clotting factor Increases NO production in the vasculature leading to a greater dilation of the vessels.
15. Adiponectin Adiponectin has several anti-inflammatory properties that leads to the overall health of the body. Obesity leads to a decrease in adiponectin which increases the risk of developing the metabolic syndrome. High fructose intake, Vitamin D deficiency, and a high carbohydrate intake all contribute to lowering adiponectin levels. Resveratrol, in red wine, increases adiponectin levels - partially explains the French Paradox.
16. Resveratrol Because of resveratrol's antiplatelet property, patients who take anticoagulants or antiplatelet medications or who use herbs that have the potential to increase bleeding risk, such as garlic, feverfew, ginger, gingko, ginseng, red clover, and turmeric, should be cautious in their consumption of resveratrol. In vitro, resveratrol has been shown to be more potent as an anti-inflammatory agent than aspirin and ibuprofen; to inhibit nitric oxide generation in activated macrophages; to improve mitochondrial function; and to reduce interleukin-1 (IL-1), IL-8, and granulocyte macrophage colony-stimulating factor.
19. Wt Loss – Effective Immune Controller A modest weight loss of as little as 13.2 pounds (6kg) is enough to bring the pro-inflammatory nature of circulating immune cells back to that found in lean people. 80% reduction of pro-inflammatory immune cells, which circulate in the blood. These inflammatory cells are involved in promoting coronary artery disease and other illnesses associated with obesity Viardot A, Lord RV, Samaras K. The Effects of Weight Loss and Gastric Banding on the Innate and Adaptive Immune System in Type 2 Diabetes and Prediabetes. J Clin Endocrinol Metab. 2010 Apr 7 View Abstract
20. Vitamin D - Observational Study Inadequate levels of vitamin D are associated with an increase in the risk of cardiovascular disease and death 27,000 > 50 no Hx of CVD for just over a year very low levels of vitamin D <15 ng/mL - 77% more likely to die, - 45% more likely to develop CAD, and - 78% more likely to have a stroke than those >30 ng/mL < Vit D - 2 x likely to develop heart failure Bair TL, et al. Vitamin D Deficiency is Strongly Associated With Incident Death and Cardiovascular Disease in a General Healthcare Population (Circulation. 2009;120:S455.) View Abstract
21. In general, a supplement of 100 IU of vitamin D per day will increase blood levels of vitamin D by 1 ng/mL, Those taking 1000 IU per day should have blood levels in the range of 25-32 ng/mL and those taking 4000 IU should have levels of 40-50 ng/mL. Right now, I think the evidence for vitamin D is probably stronger than the evidence for other vitamins. “
22. Mechanics of Cardiovascular Health INDIVIDUALISED PROGRAMME Principle focus is to facilitate physical activity and maintain optimal mobility STRUCTURAL INTEGRITY
23. Stress, Inflammation, And Yoga Practice. CONCLUSION: The ability to minimise inflammatory responses to stressful encounters influences the burden that stressors place on an individual. If yoga dampens or limits stress-related changes, then regular practice could have substantial health benefits. Houts CR, Malarkey WB, Emery CF, Glaser R.Stress, Kiecolt-Glaser JK, Christian L, Preston H, inflammation, and yoga practice. Psychosom Med. 2010 Feb;72(2):113-21. Epub 2010 Jan 11. View Abstract
24. Thyroid Health INDIVIDUALISED PROGRAMME Thyroid hormone has many effects on the heart and vascular system Hormone Neurotransmitter Regulation Iodine Supplementation Cardiac contractility In conclusion, the occurrence of iodine deficiency in cardiovascular disease is frequent. Iodine supplementation might prevent the worsening effect of iodine deficiency on cardiovascular disease. Molnár I, Magyari M, Stief L.Iodine deficiency in cardiovascular diseases Orv Hetil. 1998 Aug 30;139(35):2071-3. View Abstract
25. Adrenal Health Stress and emotions associated with stress are important risk factors for cardiovascular disease. The Mayo Clinic reported that among individuals with existing coronary artery disease psychological stress is the strongest risk factor predictive of future cardiac events, including myocardial infarction (MI) and cardiac death.
27. Immune Suppression Siga The ability to produce secretory IgA (sIgA) also appears to be influenced by stress, inability to manage stress through Adrenal Fatigue may result in increased risk for mucosal immune activation. Martin RA, Dobbin JP. Sense of humor, hassles, and immunoglobulin A: evidence for a stress-moderating effect of humor. Int J Psychiatry Med 1988;18:93-105. View Abstract
28. Multiple facets of intestinal permeability and epithelial handling of dietary antigens S Ménard, N Cerf-Bensussan and M Heyman Mucosal Immunology (2010) 3, 247–259
29. AntiOxidants INDIVIDUALISED PROGRAMME Chronic and acute overproduction of reactive oxygen species (ROS) under pathophysiologic conditions forms an integral part of the development of cardiovascular diseases (CVD), and in particular atherosclerosis. These ROS are released from different sources, such as xanthine oxidase, lipoxygenase, nicotinamide adenine dinucleotide phosphate oxidase, the uncoupling of nitric oxide synthase and, in particular, mitochondria. Victor VM, Apostolova N, Herance R, Hernandez-Mijares A, Rocha M.Oxidative stress and mitochondrial dysfunction in atherosclerosis: mitochondria-targeted antioxidants as potential therapy.Curr Med Chem. 2009;16(35):4654-67. Review. View Abstract ENERGY PRODUCTION/ OXIDATIVE STRESS
30. What About Antioxidants While a significant body of epidemiological and clinical data suggests that antioxidant-rich diets reduce blood pressure and cardiovascular risk. Yet randomised trials and population studies using natural antioxidants have yielded disappointing results. Fat soluble antioxidant derived from seaweed, ecklonia cava has shown ability to reverse atherosclerosis, reduce cholesterol, regenerate endothelial lining, inhibit antiplasmin and ACE. Read Article here
31. Reasons May Include Combination Of: Ineffective dosing regimens, The potential pro-oxidant capacity of some of these agents, Selection of subjects less likely to benefit from antioxidant therapy (too healthy or too sick), Inefficiency of nonspecific quenching of prevalent ROS versus prevention of excessive ROS production. Commonly used antioxidants include Vitamins A, C and E, L-arginine, flavanoids, and mitochondria-targeted agents (Coenzyme Q10, acetyl-L-carnitine, and alpha-lipoic acid).
32. CoQ10 CoQ10 depletion may also be a contributory factor for why statin intervention has not improved outcomes in CHF. There is an emerging evidence base in support of CoQ10 as an adjunctive therapy in CHF. Statins inhibit the HMG-CoA pathways , shared by COQ-10 so depletion and associated myopathy may be managed with supplementation. Molyneux SL, et al Coenzyme Q10; an adjunctive therapy for congestive heart failure? N Z Med J. 2009 Oct 30;122(1305):74-9. View Abstract Young JM, Florkowski CM, Molyneux SL, McEwan RG, Frampton CM, George PM, Scott RS.Effect of coenzyme Q(10) supplementation on simvastatin-induced myalgia. Am J Cardiol. 2007 Nov 1;100(9):1400-3. Epub 2007 Aug 16. View Abstract
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34. Detoxification INDIVIDUALISED PROGRAMME The role of heavy metals, xenobiotics, and other exogenous and endogenous chemicals on cardiovascular health. Genetics /environment – epigenetic’s Poor elimination of naturally and non naturally occurring chemicals may reduce the stress on liver function allowing for reduction in oxidation and cholesterol metabolism DETOXIFICATION/ BIOTRANS - FORMATION
35. Pharmacology emphasises individual variation in genes encoding cytochrome P450s, but their evolutionary origins in processing dietary toxins are just being fully appreciated. Cytochrome p450s support the oxidative, peroxidative and reductive metabolism of such endogenous and xenobiotic substrates as environmental pollutants, agrochemicals, plant allelochemicals, steroids, prostaglandins and fatty acids amongst others. Danielson PB. The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans. Curr Drug Metab. 2002 Dec;3(6):561-97. Review. View Abstract Kizhakekuttu TJ, Widlansky ME. Natural Antioxidants and Hypertension: Promise and Challenges. Cardiovasc Ther. 2010 Mar 29. View Abstract Evolutionary Nutritional Therapy
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37. Krack A, Sharma R, Figulla HR, Anker SD. The importance of the gastrointestinal system in the pathogenesis of heart failure. Eur Heart J. 2005 Nov;26(22):2368-74. Epub 2005 Jun 24. Review. View AbstractGIT Function
38. Leaky GUT Gut barrier function is maintained by a well-balanced intestinal flora, an intact mucosa, and a normal functioning immune system. If one or more of these three protective mechanisms are disrupted, viable bacteria [or bacterial products like endotoxin (i.e. lipopolysaccharide, LPS)] may cross the gut mucosa and spread to the mesenteric lymph nodes or more distant organs, such as the liver and the spleen, a process termed bacterial translocation
41. Leaky Gut Psychological stress is known to exacerbate symptoms of IBD and to decrease mucosal barrier function. The increased intestinal permeability is an early biological change that often precedes the onset of autoimmune diseases, such as CD or type I diabetes. the failure of the intestinal barrier to contain the macromolecular luminal content, a phenomenon likely to exacerbate unwanted immune responses. Gareau, M.G., Silva, M.A. & Perdue, M.H. Pathophysiological mechanisms of stress-induced intestinal damage. Curr. Mol. Med. 8, 274–281 (2008). View Abstract
42. Immune and Inflammation INDIVIDUALISED PROGRAMME Current thinking suggests "damage" rather than "foreignness" as the actual trigger of the immune system, which has caused a dramatic change in how we tend to view the aetiopathology of most types of heart disease. (P.Matzingers work) Cell injury can release endogenous ’damage associated molecular patterns’ (DAMPs) that activate innate immunity Promoted by innate receptor activation and first promoted by Virchow in terms of infection, there is increasing interest in the role of commensal bacteria in the generation of metabolic syndrome etc. ‘abnormal activation of the host's innate immune system, characterised by low-grade, chronic inflammation, and a role for the gut microbiota have both been implicated’ complex communication between the gut microbiota and the innate immune system is involved in metabolic homeostasis. Th1 &Th2 &Th17 and Treg IMMUNE & INFLAMMATORYPROCESSES
43. Ping Li & Gökhan S. Hotamisligil. Metabolism: Host and microbes in a pickle. Nature Volume: 464, Pages: 1287–1288 Date published: (29 April 2010) DOI: doi:10.1038/4641287a Published online 28 April 2010 View Abstract Nakamura T, et al Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis. Cell. 2010 Feb 5;140(3):338-48. View Abstract
44. Role for Immunomodulation CVD and atherosclerosis are linked to adverse inflammation events. Th1, Th17Cytokine induction Treg, IL-10, TGF-B potent inhibitors of atherosclerosis Probiotics are able to induce local and systemic benefits offering a novel therapy. Hansson GK. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med. 2005 Apr 21;352(16):1685-95. View Abstract Mallat Z et al. Protective role of interleukin-10 in atherosclerosis. Circ Res. 1999 Oct 15;85(8):e17-24. View Abstract
45. Hygiene Hypothesis If immune dysregulation means alteration in Treg function, which is the preferred explanation linking the hygiene hypothesis to the susceptibility to immuno inflammatory disorders – the atherosclerosis and other inflammatory driven episodes may be initiated and amplified by loss of immunological tolerance. The gut is the largest source of Tregs and greatest site of immunological activity.
47. Hypertension Immunosuppressive effects of transferredTreg cells ameliorated cardiac damage and accounted for theimproved electric remodeling independently of blood pressure–loweringeffects. Results provide new insights into the pathogenesisof hypertensive cardiac damage and could therefore lead to newtherapeutic approaches that involve manipulation of the immunesystem.
48. The Cytokine Cascade Although cytokines at all steps have important biologic effects, their amplification at each step of the cascade makes the measurement of downstream mediators such as Hs CRP particularly useful for clinical diagnosis. Hansson G. N Engl J Med 2005;352:1685-1695
49. Immune Response and Atherosclerosis Diet & Lifestyle Role of innate and adaptive immunity in atherogenesis. NKC, natural killer cells; EC, endothelial cells; PAMP, pathogen-associated molecular pattern; Ig, Immunoglobulin's; MHC, major histocompatibility complex; TCR, T-cell receptor; CMV, cytomegalovirus; HSP, heat shock proteins; oxLDL, oxidized LDL. Methe H, Weis M. Atherogenesis and inflammation--was Virchow right? Nephrol Dial Transplant. 2007 Jul;22(7):1823-7. Epub 2007 Apr 16. Review. View Paper
51. Question? a 75% to 80% decrease in both stroke and coronary heart disease mortality (Finland) Taiwan study noted similar benefits. Australian study the same. Pansalt is the Finish product: sodium reduced, potassium, magnesium and L-Lysine enriched Nationwide use. Karppanen H, Mervaala E. Sodium intake and hypertension. Prog Cardiovasc Dis. 2006 Sep-Oct;49(2):59-75. Review. View Abstract Chang HY, et al. Effect of potassium-enriched salt on cardiovascular mortality and medical expenses of elderly men. Am J Clin Nutr. 2006 Jun;83(6):1289-96. View Abstract Nowson CA, Morgan TO, Gibbons C. Decreasing dietary sodium while following a self-selected potassium-rich diet reduces blood pressure.J Nutr. 2003 Dec;133(12):4118-23. View Abstract I hoped he’d forgotten... Unless he asks someone else I’d quite like to know really... http://www.imi.com.sg/index.htm
52. Niacin Risk of heart attack, stroke or mortality from hypertension is nearly negligible at < 115/75. At 135/85, the risk doubles. At 155/95, the risk quadruples. Statins are used to treat an isolated number (LDL) and pathetically fail to deliver meaningful reductions in cardiac death or events (15-22% average relative risk reduction versus Vitamin B3/niacin 70-90% relative risk reduction) or coronary calcification progression.
53. Niacin and Immune Function Niacin lowers LDL, raises HDL, and decreases triglycerides Niacin may lower BP when administered over a longer period of time. Recent studies indicate that niacin increases vascular endothelial cell redox state, resulting in the inhibition of oxidative stress and vascular inflammatory genes, key cytokines involved in atherosclerosis Bays HE, Rader DJ. Does nicotinic acid (niacin) lower blood pressure. Int J Clin Pract. 2009 Jan;63(1):151-9. Epub 2008 Nov 28. Review. View Abstract Kamanna VS, Kashyap ML. Mechanism of action of niacin. Am J Cardiol. 2008 Apr 17;101(8A):20B-26B. Review. View Abstract
54. Evolutionary Aspects Of Diet, Essential Fatty Acids And Cardiovascular Disease Palaeolithic period intake of Ω6 & Ω3 estimated equal. Epidemiological, experimental and clinical intervention studies have shown that Ω3 fatty acids: Modify eicosanoid products in the cyclooxygenase and lipoxygenase pathways, reduce synthesis of cytokines and platelet-derived growth factor by influencing gene expression and alterations in leukocyte and endothelial cell properties Simopoulos AP. Evolutionary aspects of diet, essential fatty acids and cardiovascular disease. Eur Heart J Suppl (2001) 3 (suppl D): D8-D21. View Abstract
55. EFA’s Immune Gene Expression Ω6 & Ω3 influence gene expression. Ω3 suppress IL-1β TNFα, IL-6 Ω6 tend to be pro-inflammatory. Inflammation is at the base of coronary heart disease, dietary intake of Ω3 an important role in the manifestation of disease, esp. genetic variation, as for example in individuals with genetic variants at the 5-lipoxygenase (5-LO).
56. Type of Fats & Ratio Increased dietary arachidonic acid (AA) significantly enhances the apparent atherogenic effect of genotype, whereas increased dietary intake of omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) blunts this effect. In the secondary prevention of cardiovascular disease, a ratio of 4/1 was associated with a 70% decrease in total mortality Simopoulos AP. The omega-6/omega-3 fatty acid ratio, genetic variation, and cardiovascular disease. Asia Pac J Clin Nutr. 2008;17 Suppl 1:131-4. Review. View Abstract
57. Ratio’s ? Studies indicate that the optimal ratio may vary with the disease under consideration. This is consistent with the fact that chronic diseases are multigenic and multifactorial. Therefore, it is quite possible that the therapeutic dose of omega-3 fatty acids will depend on the degree of severity of disease resulting from the genetic predisposition. The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. Simopoulos AP.Exp Biol Med (Maywood). 2008 Jun;233(6):674-88. Epub 2008 Apr 11. Review. View Abstract
58. Nut Consumption and Blood Lipid Levels A Pooled Analysis of 25 Intervention Trials Reductions in total cholesterol (5.1%) LDL reduction (7.4%) Triglyceride reduction (10.2%) LDL C reduction (8.3%) Conclusion Nut consumption improves blood lipid levelsin a dose-related manner, particularly among subjects with higherLDL-C or with lower BMI Arch Intern Med. 2010;170(9):821-827. View Abstract
59. Soluble Fibre and CVD Immunity Psyllium seed husks - soluble (Plantago Ovata husk) In a randomised, crossover, controlled, single-blind design, 28 men with CVD (myocardial infarction or stable angina) and an LDL-cholesterol concentration </=3.35 mmol/L consumed for 8 wk, under controlled conditions, a low-saturated-fat diet supplemented with 10.5 g P. ovata husk/d or 10.5 g P. ovata seeds/d. Fasting plasma lipid concentrations and polymorphisms of genes involved in lipid metabolism, such as apo A-IV, apo E, and fatty acid-binding protein, were measured. RESULTS:Plasma triacylglycerol decreased (6.7%; P < 0.02), the ratio of apo B 100 to apo A-I decreased (4.7%; P < 0.02), and apo A-I increased (4.3%; P < 0.01) in the P. ovata husk consumers On the soluble fibre had a 50% reduction in symptoms compared to the insoluble group. They also recovered 50% faster. It seems that just 6 weeks of an increased soluble fibre intake change their immune responses in a very positive manner. Solà R, et all. Soluble fibre (Plantago ovata husk) reduces plasma low-density lipoprotein (LDL) cholesterol, triglycerides, insulin, oxidised LDL and systolic blood pressure in hypercholesterolaemic patients: A randomised trial. Atherosclerosis. 2010 Mar 17. View Abstract Co-authors are Stephanie S. Kim, Ryan N. Dilger, Laura L. Bauer, Morgan L. Moon, Richard I. Tapping, George C. Fahey Jr., and Kelly A. Tappenden, all from the U of I. Sherry is now a postdoctoral fellow at the University of Michigan. The research was funded by the National Institutes of Health, the American Heart Association, and the USDA among others. View Article
60. Laughter as Immune Medicine Annual Meeting of Single, Straight, Emotionally Stable, Financially Secure, Intelligent men, Looking for a long term commitment
61. Mirthful Laughter – Equivalent to exercise They had increased HDL (good) cholesterol. The laughter group also had lower levels of TNF-α, IFN-γ, IL-6 and hs-CRP levels, indicating lower levels of immune/inflammation. At the end of one year, the research team saw significant improvement in Group L: HDL cholesterol had risen by 26 % in Laughter Group Vs 3 percent in the Group C (control). Harmful C-reactive proteins decreased 66 % in the laughter group Vs. 26 % for the control group. Mirthful Laughter, As Adjunct Therapy in Diabetic Care, Increases HDL Cholesterol and Attenuates Inflammatory Cytokines and hs-CRP and Possible CVD Risk. 122nd Annual Meeting of the American Physiological Society April 18-22, 2009 View Abstract
62.
63. Fat included raw nuts and seeds, avocados, olives and olive oil, flax oil and cod liver oil
64. Protein included sardines, fish, eggs, tofu, chicken, turkey, wild meats, low-fat cheeses (cottage, ricotta, swiss), seafood, and veggie burgers.
66. L-carnitine 2000mg, alpha-lipoic acid 400mg, coenzyme Q10 100 mg, 1 tbsp cod liver oil, magnesium 300mg, potassium 300mg, vitamin C 1000mg, vitamin E 800mg daily, and a multivitamin consisting of all essential B vitamins and minerals.31 Pts Av 57.6 53% F 47% M
67. Outcomes In conclusion, a nutritional program recommendation originally designed to treat chronic diseases of aging led to weight loss and metabolic changes currently thought to be beneficial in reducing the aging process Rosedale R, Westman EC, Konhilas JP. Clinical Experience of a Diet Designed to Reduce Aging. J Appl Res. 2009 Jan 1;9(4):159-165. View Paper
68. Effect of Combination Pantethine, Plant Sterols, Green Tea Extract, Delta-tocotrienol and Phytolens on Lipid Profiles in Patients with Hyperlipidemia Conclusions: The non-pharmacological treatment of hyperlipidemic individuals with a nutraceutical supplement containing pantethine, plant sterols, green tea extract, delta-tocotrienols and Phytolens® improves lipid profiles and diastolic blood pressure as measured at the end of a two-month trial. Dr Mark Houston MD published the results of his trial using LipidSirt in the Journal of American Nutraceutical Association Full Paper Further Information on the natural treatment of hypertension Can be found here www.nleducation.co.uk/
69. The End Thank you. More information available on: www.nleducation.co.uk
Editor's Notes
Example of antecedents from pregnancy and triggers from foods
Listens by first asking him how he believed his condition should be treated and what he believed would help his condition hears about spirituality or religious beliefs. explains to him that religious participation alone was not adequate to protect him from cardiovascular events in the future, citing the most recent evidencethe literature demonstrates a positive link between religious behaviours among teens and positive health behaviours, including abstinence from alcohol, drugs, and later sexual debut. The physician congratulates Pt on not smoking and being motivated to stay healthy. She expresses understanding of his perspective and acknowledges the culture of food as a "social glue" in Pt’s belief system. She then recommends that Pt and his wife consider some alternative ingredients for their cooking recipes to incorporate heart-healthy components.negotiateswith Pt to add family activities around Sunday church attendance that involves brisk walking. Aks if Pt is willing to start a heart-healthy social interest group at his church to encourage others to attend to their lifestyle goals, including weight loss. Offers to be a future speaker at such a group. Pt is delighted and agrees to pursue the idea.
The x shape is not only attractive to us, but has become so partly due to evolutionary defences that we have learned to associate this shape with increased longevity – albeit not a universal approach.
I said to the Gym instructor: “Can you teach me to do the splits?” He said: “How flexible are you?” I said: “I can't make Tuesdays.”
The diagram shows the way in which triiodothyronine increases cardiac output by affecting tissue oxygen consumption (thermogenesis), vascular resistance, blood volume, cardiac contractility, and heart rateKlein I, Levey GS. The cardiovascular system in thyrotoxicosis. In: Braverman LE, Utiger RD, eds. Werner & Ingbar's the thyroid: a fundamental and clinical text. 8th ed. Philadelphia: Lippincott Williams & Wilkins, 2000:596-604
Experiencing a stressful situation, as perceived by the brain, results in the stimulation of the hypothalamic–pituitary–adrenal (HPA) axis and the sympathetic–adrenal–medullary (SAM) axis. The production of adrenocorticotropic hormone by the pituitary gland results in the production of glucocorticoid hormones. The SAM axis can be activated by stimulation of the adrenal medulla to produce the catecholamines adrenaline and noradrenaline, as well as by 'hard-wiring', through sympathetic-nervous-system innervation of lymphoid organs. Leukocytes have receptors for stress hormones that are produced by the pituitary and adrenal glands and can be modulated by the binding of these hormones to their respective receptors. In addition, noradrenaline produced at nerve endings can also modulate immune-cell function by binding its receptor at the surface of cells within lymphoid organs. These interactions are bidirectional in that cytokines produced by immune cells can modulate the activity of the hypothalamus. APC, antigen-presenting cell; IL-1, interleukin-1; NK, natural killer.
Immunoglobulin (Ig)A-mediated retrotransport of luminal antigens. IgA is a protective mucosal immunoglobulin secreted in the intestinal lumen through polymeric IgR (pIgR) in the form of secretory IgA (SIgA). Whereas the major role of SIgA is to contain microbial and food antigens in the intestinal lumen, in some pathological situations, an abnormal retrotransport of SIgA immune complexes can allow bacterial or food antigens entry in the intestinal mucosa, with various outcomes. Indeed, SIgA can mediate the intestinal entry of SIgA/Shigella flexneri immune complexes through M cells and interact with dendritic cells, inducing an inflammatory response aimed at improving bacterial clearance and the restoration of intestinal homeostasis. In celiac disease, however, SIgA allows the protected transcytosis of gliadin peptides, a mechanism more likely to trigger exacerbated adaptive and innate immune responses in view of the constant flow of gluten in the gut and to precipitate mucosal lesions. Indeed, whereas in healthy individuals, undigested gliadin peptides are taken up by nonspecific endocytosis in enterocytes and entirely degraded/detoxified during transepithelial transport, in contrast, in active celiac disease, the ectopic expression of CD71 (the transferrin receptor also known as IgA receptor) at the apical membrane of epithelial cells, favors the retrotransport of IgA immune complexes and inappropriate immune responses.
Products or structural components of the gut microbiota, such as short-chain fatty acids (SCFA) and peptidoglycan (PG), could cross the intestinal epithelium to activate receptors, for example GPR43 and NOD1, of innate immune cells. Moreover, gut microbiota modulate circulating levels of lipopolysaccharides (LPS), possibly contributing to obesity-associated inflammation through TLR4. Vijay-Kumar et al.2 now add another layer of complexity to this picture by showing that, in the absence of TLR5, the crosstalk between the innate immune system and the gut microbiota alters the specific composition of the microbiota, which in turn contributes to inflammation by signalling back to the innate immune system through as-yet-unidentified pattern-recognition receptors (PRRs) or another cascade, resulting in metabolic syndrome.
Atherosclerosis is the most common pathological process leadingto cardiovascular disease. The development of endothelial dysfunction,the earliest stage of atherosclerosis, involves genetic andhaemodynamic factors as well as other acquired and modifiablerisk factors, including smoking, hypercholesterolaemia, diabetesmellitus and hypertension. In addition, it has become clearthat innate and adaptive immune systems are involved in theinitiation and progression of atherogenesis
Immediate therapy
Forcing through opinion even when the evidence is against you should not put you off questioning and researching to find out the truths.
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