There are several examples of uses for a range of biologically-based products that are currently being developed. Even though crude oil has historically been used as a raw material in numerous everyday objects, renewable raw materials can now provide an alternative to crude-oil-based industrial production thanks to industrial biotechnology. M+W Central Europe GmbH's Specialty Chemicals Unit supports such initiatives and projects through feasibility studies, plant and process simulations, de-bottlenecking measures and other engineering services, such as technology transfer and operationalization. Engineering service providers play an important role in the successful industrialization of biobased products. Dr. Anton Volkov, Lead Process Engineer for Industrial Biotechnology, held a talk on this subject, titled, "The Role of Engineering Providers in Successful Industrialization of Bio-Based Products" where he examined how process innovation and technology can help manufacturing sustainable and cost competitive bio-based and green innovations.

1. The Role of Engineering Providers in Successful
Industrialization of Bio-Based Products
May 31st , 2017 I Dr. Anton Volkov

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The Project Road-Map
The way of successful decisions…

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Industrialization Path for Bio-Based Products
Scale-Up Purpose
Pilot Plant Demonstration Plant Commercial Plant
• Confirm scale-up parameters
• Equipment scale-up
• Performance of equipment on a variety
of raw materials
• Confirm economics of commercial
plant
• Produce large samples of products for
test by customers
• Staffing requirements & training
• Define materials of construction,
components, subsystems
• Product of defined quality
• Continuous operation
• OPEX
• Recycling solvents and gases
• Recovering heat from effluent
streams
• Utilizing value of process waste
• Proof of concept
• Initial process scale-up
• Raw materials testing
• Equipment size requirements
• Materials information and safety data
• Design of special equipment and
subsystems

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Engineering Providers Can Help Your Project:
Broad hands-on technological expertise
Broad hands-on engineering expertise
Projects execution expertise
Benchmarking know-how
20-50% cheaper than in-house services

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Pros and Cons of Engineering Providers
Finding the right answers to common concerns
IP Protection IP rights transfer or remuneration?
Costs
In-house expertise Is expertise sufficient for your project?
Are internal personnel not more expensive?

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IP Protection Is your know-how state of the art?
Costs
In-house expertise Personnel training or fast project start?
Services costs vs costs of failure?
Pros and Cons of Engineering Providers
Finding the right answers to common concerns

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Lack of in-house scale-up expertise
Common Industrialization Challenges
From process concept to operational plant
R&D solutions incompatible with industrial scale
Upstream/Downstream interfaces management
Equipment design and manufacturing
Start-Up Expertise

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How Engineering Providers Can Help
Securing Efficient Scale-Up
Lack of in-house scale-up expertise
 Trial and error experiments
 Raw materials selection
 Media composition
 Process parameters
 Fermenter design
 Utilities requirements
 DOE and broad technological expertise
 Raw materials applicable to industrial scale
 Equipment & environmentally friendly composition
 Scale dependent adjustment
 Appropriate dimensions, composition & mixing
 Process air, water and cooling requirements

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How Engineering Providers Can Help
Securing Efficient Scale-Up
Lack of in-house scale-up expertise

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How Engineering Providers Can Help
Finding right equipment for your process
R&D solutions incompatible with industrial scale
 Environmental impact
 Equipment selection
 Material and energy balances
 Solids handling
 Process and product safety
 Product formulation & stability
 Recycling solvents and gases
 Continuous operation & up-time
 Costs reduction via water & energy recovery
 Equipment scale-up & feedstock variability
 HAZOP analysis
 Mixing, dosing and storage concepts

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How Engineering Providers Can Help
Finding right equipment for your process
R&D solutions incompatible with industrial scale

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How Engineering Providers Can Help
Debottlenecking your process early on
Upstream/Downstream interfaces management
 Process bottlenecks
 Fermentation broth storage
 Biomass separation & treatment
 Batch vs continuous operation
 Off-spec fermentation broth
 Lots traceability
 Process modeling & simulation
 Mixing and parameters adjustment concepts
 Biomass recycling, filtration & centrifugation
 Maintenance concepts
 Handling concepts
 Product labeling & process data recording

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How Engineering Providers Can Help
Debottlenecking your process early on
Upstream/Downstream interfaces management

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How Engineering Providers Can Help
Developing automation concept for stable process & product quality
Equipment design and manufacturing
 Internal surfaces
 Materials selection
 Automation level
 Valves and pipes selection
 Welding
 QA/QC
 Modeling & process relevant know-how
 Corrosion protection and value matching
 Securing critical inputs/outputs
 Easy cleaning & sterilization
 Leakage prevention & process contamination
 Documentation and acceptance testing

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How Engineering Providers Can Help
Developing automation concept for stable process & product quality
Equipment design and manufacturing

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How Engineering Providers Can Help
Supporting technology transfer and start-up
Start-Up Expertise
 Commissioning
 Personnel hiring & training
 Technology transfer
 Process adjustment
 Off-spec product handling
 Troubleshooting
 Cold & hot commissioning work
 Operational planning & training
 Documentation & on-site assistance
 Plant trials and equipment set-up
 Recycling and disposal concepts
 Root cause analysis and correction measures

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How Engineering Providers Can Help
Supporting technology transfer and start-up
Start-Up Expertise

20. Contact
www.mwgroup.net
Dr. Anton Volkov, Lead Process Engineer - Industrial Biotechnology
anton.volkov@mwgroup.net
Specialty Chemicals
M+W Central Europe GmbH
A Company of the M+W Group
Birkengartenstr. 7
51372 Leverkusen
Germany
Thank you!