The Manhattan Project originated systems engineering as a way to manage the complex integration of science, engineering, and technology required to develop nuclear weapons during World War II. It involved coordinating research at multiple sites, managing diverse personnel, and developing processes to meet tight deadlines while working with unproven technologies. Systems engineering practices applied included requirements identification and verification, trade studies, critical path management, testing, and managing risks from hazardous operations. The Manhattan Project laid the foundations for modern nuclear technology applications in energy, medicine, industry, and research.