The document describes the High 5s Initiative, a project aimed at reducing common patient safety issues in hospitals across multiple countries. It does this through developing standardized operating protocols for issues like surgical site identification and medication reconciliation. Hospitals that implement the protocols provide data to evaluate their impact on reducing errors and harm over 5 years. The initiative also creates an international learning community for hospitals to share best practices. Initial participating countries include Australia, Canada, Germany, Netherlands, New Zealand, UK, and US. The long term vision is for leading hospitals worldwide to learn from each other's experiences in implementing clinical safety standards.