The Django Admin Interface allows users to add, change, and delete content from the database through the admin site. To activate it, django.contrib.admin must be added to INSTALLED_APPS. Models can be customized using ModelAdmin classes to control the display and behavior of each model in the admin. The admin site URLs must be included in the project URLconf. ModelAdmin attributes like list_display, search_fields, and fieldsets control how models appear on admin pages. Admin actions allow performing the same operations on many objects at once.