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The critically ill child
P a g e | 1
Emergency 2018
Kareem Alnakeeb
The critically ill child
(Initial evaluation and management)
1. Why children are different?
- Children are NOT young adults.
- They are different in:
(Weight, Anatomical factors, Physiological factors, Psychological factors).
Weight: • Scales
• The Broselow Tape → Most accurate
it uses the height (or length) of the child to estimate weight
• Formulas;
- 3-13 months: Weight (kg) = [ Age(months)+ 9] /2
- 1-6 years: Weight (kg) = [ Age(years) x 2 ] + 8
- 7-12 years: Weight (kg) = { [ Age(years) x 7 ] - 5 } /2
Anatomical factors:
(Airway)
- Large occiput and short neck → neck flexion and airway narrowing
- Relatively large tongue
(Most common cause of airway obstruction in the unconscious
pediatric victim is the tongue)
- The floor of the mouth is easily compressible
- Infants are obligate nasal breathers (Up to age of 6 months)
Physiological factors: - The infant has a relatively greater metabolic rate and oxygen
consumption than adults
- Hb F → has higher affinity for O2 than HbA1 & HbA2
- Tidal Volume (Air that enters lung with each quiet inspiration) is constant
o the only way to ↑ minute ventilation is to ↑ RR
o So, Tachypnea is the earliest sign of respiratory distress
- The diaphragm is the main respiratory muscle → easily fatigable
Psychological factors: - Communication
- Fear e.g. white coat hypertension
(++ Sympathetic → ↑HR, RR, sweating→ Overlap with the disease)
Minutevolume=TidalvolumexRespiratoryrate
Recognition of critical illness:
The critically ill child
P a g e | 2
Emergency 2018
Kareem Alnakeeb
2. What is cardiac arrest?
- Absence of palpable central pulse in;
 Carotid  in older children & adults
 Brachial / Femoral  in young children
3. What are the causes of cardiac arrest?
• Respiratory failure
(Hypoxemia is the most common cause of cardiac arrest in children)
• Circulatory failure
• Neurological failure
4. How to recognize serious illness?
Respiratory failure: 1. Airway problems
2. Efficacy of breathing
3. Effects of respiratory inadequacy
Circulatory failure: 1. Cardiovascular signs
2. Effects of circulatory inadequacy
Neurological failure: 1. Neurological function
2. Effects of neurological failure on other systems
The assessment of a seriously unwell child involves the following:
• Pediatric assessment triangle (PAT) (first impression)
• primary survey (ABCDE assessment)
• Secondary survey
- Vital signs
- Focused history
- Detailed physical examination
• Ongoing assessment.
Components of a pediatric initial assessment:
The critically ill child
P a g e | 3
Emergency 2018
Kareem Alnakeeb
A. Pediatric Assessment Triangle (first impression)
1. (Across-the-room) assessment
2. No equipment required
3. 60 seconds or less
 PAT purpose:
• To classify children into:
- Sick/Not sick
- Urgency of further investigations
 PAT decision
 Sick →
(Basic Life Support, Advanced Life Support)
 Not Sick →
(Primary survey, secondary survey, Repeated exam)
 PAT components:
1. Appearance
2. Breathing
3. Circulation
PAT components Reflect the adequacy of Assessment areas
1. Appearance - Oxygenation
- Ventilation
- Brain perfusion
- CNS function
Mnemonic: TICLS
- Tone (muscle tone)
- Interactivity/mental status
- Consolability (ability to calm the child)
- Look or gaze
- Speech or cry
2. Work of
Breathing
- Airway
- Oxygenation
- Ventilation
- Posture (e.g. Tripod or Sniffing position)
- Respiratory rate
- Respiratory effort
- Audible sounds
3. Circulation - Cardiac output
- Perfusion of vital organs
- Skin color
e.g. pallor, mottling and cyanosis
The critically ill child
P a g e | 4
Emergency 2018
Kareem Alnakeeb
B. Primary survey: (ABCDE assessment)
• Hands-on assessment
 Purpose: determine if life-threatening conditions exist
 Components;
- Airway and cervical spine control
- Breathing
- Circulation
- Disability (neurologic status)
- Exposure
I. Potential respiratory failure:
(Airway, Breathing, Effects of respiratory inadequacy)
 Airway
- Determine if the airway is patent, maintainable, or unmaintainable
 Patent: able to be maintained independently
 Maintainable: with positioning, suctioning
 Unmaintainable: requires assistance
 Tracheal intubation
 Cricothyrotomy
 Foreign body removal
 If the airway is open → move on to evaluation of breathing
 If the airway is not open → assess for sounds of airway compromise:
 Snoring
 Stridor
 Wheeze
 If C-spine injury is suspected → manually stabilize head & neck in a neutral, in-line position
- Look in the mouth:
 Blood
 Broken teeth
 Gastric contents
 Foreign objects (loose teeth/gum/small toys)
Goals:
The critically ill child
P a g e | 5
Emergency 2018
Kareem Alnakeeb
 Spinal stabilization as needed for trauma (by history or physical examination)
 Jaw thrust without head tilt
 Suction
 Reposition
 Removal of foreign body
 Airway adjuncts
 Breathing
1. Adequate gas exchange with no signs of hypoxia
2. Absence of dyspnea, stridor, and signs of increased work of breathing
o Evaluation of breathing should take no more than 10 seconds
o Confirm child is breathing
o Breathing (Effort – Efficacy – Effect on other organs)
 If breathing adequate→ assess circulation.
A. Respiratory Rate:
-  RR with age
- In cardiac arrest  Early: ↑RR, Late: RR
- Normal RR in presence of other signs of
respiratory distress is a Bad sign.
B. Alar nasal flare: Dilatation of air passages →  Resistance → effort of breathing
C. Recessions:
- Indrawing of lower part of thoracic cage
- Represent the use of accessory muscles to help in breathing
D. Audible Noises
i. Stridor:
- Inspiratory sound that is usually indicating upper airway obstruction
ii. Wheeze:
- Expiratory sound that is usually indicating lower airway obstruction
iii. Grunting:
- Forced expiration against a partially closed glottis to increase the end expiratory
pressure to assist gas exchange and prevent alveolar collapse
- It indicates alveolar disease.
Age Respiratory Rate
First 2 months 50
2-12 months 40
1-5 years 25-30
6-12 years 20-25
>12 years 15-20
Interventions:
Goals:
1. Efforts of breathing:
The critically ill child
P a g e | 6
Emergency 2018
Kareem Alnakeeb
 Manifestations of increased effort of breathing are Absent in:
1. Central respiratory depression e.g. Morphine
2. Neuromuscular diseases e.g. spinal muscular atrophy or muscular dystrophy
3. Exhausted patients (with imminent respiratory arrest).
• Chest expansion
• Air entry (Note: Silent chest is a pre-terminal sign)
• Pulse oximetry (Note: Hypoxemia is a danger sign)
Early Late
A. Mental status Irritable “inconsolable” unresponsive
B. Heart rate ↑ 
C. Skin color - Pallor
- O2 saturation < 85% in room air is
a serious sign
- Cyanosis is a late & pre-terminal
sign
Respiratory distress Respiratory failure
• ↑ Respiratory Rate & depth of breathing
• Nasal flaring
• Inspiratory retractions
• Grunting / Stridor
• Restlessness
• Tachycardia
•  Respiratory rate, effort, or chest excursion
• Cyanosis
• Use of accessory muscles
•  breath sounds
•  skeletal tone
•  conscious level or response to pain
• Bradycardia
• Suction
• Oxygen
• Airway adjuncts
• Positive-pressure ventilation
2. Efficacy of breathing:
3. Effects of respiratory inadequacy:
Signs of Respiratory distress & Respiratory failure:
Interventions:
The critically ill child
P a g e | 7
Emergency 2018
Kareem Alnakeeb
II. Potential Circulatory failure
(Cardiovascular signs, Effects of cardiovascular inadequacy)
 Cardiovascular signs
- Adequate cardiovascular function and tissue perfusion
- Effective circulating fluid volume
- Normal core body temperature
- Compare strength and quality of central and peripheral pulses
- Central pulse:
► Infant → Brachial or femoral
► Older child → carotid artery

1. Heart rate:
-  HR with age
- In cardiac arrest  Early: ↑HR, Late: HR
- Normal HR in presence of other signs of circulatory insufficiency is a Bad prognostic sign.
2. Capillary refill time (CRT):
 Normal refill time: < 2 seconds
 Slow refill time (> 2 seconds) indicates poor peripheral perfusion.
- CRT is useful in the warm child & in presence of other signs of shock.
 Delayed refill time (3-5 seconds) indicates:
(poor perfusion, Exposure to cool ambient temperatures).
 Markedly delayed refill time (>5 seconds) indicates Shock.
Age (years) Heart Rate
< 1 110-160
1-2 100-150
2-5 95-140
5-12 80-120
>12 60-100
Goals:
Assessment:
Cardiovascular signs:
The critically ill child
P a g e | 8
Emergency 2018
Kareem Alnakeeb
3. Pulse volume
Grade Description
+4 Full, bounding; not obliterated with pressure
+3 Normal - easily palpated; not easily obliterated with pressure
+2 Difficult to palpate, obliterated with pressure
+1 Thready and weak, Difficult to palpate
0 Absent
4. Blood pressure
- ↑ BP with age
- >2 years: Minimum SBP = 70+(2x age in years)
- Note: Hypotension is a late & pre-terminal sign
- Absence of hypotension does NOT exclude shock, so shock can occur in normal BP.
5. Skin
- Skin color: Pink, pale, blue (cyanotic) or mottled.
- Skin temperature
- Skin moisture
- Skin turgor
• Oxygen
• Position
• Chest compression
• Bleeding control
• Defibrillation
Age (years) SBP (mmHg)
< 1 70-90
1-2 80-95
2-5 80-100
5-12 90-110
>12 100-120
Interventions:
The critically ill child
P a g e | 9
Emergency 2018
Kareem Alnakeeb
 Effects of cardiovascular inadequacy 
1. Heart rate
2. Respiratory rate:
► Early → ↑ without recessions “Quiet tachypnea”
► Late → 
3. Urine output:  (In infants: < 1 ml/kg/h, In children: < 0.5 ml/kg/h)
4. Skin color: Cyanosis is a pre-terminal sign
5. Mental status:
► Early → irritable
► Late → unresponsive
There is a clear overlap between respiratory & circulatory failure.
- The following signs are more in favor of a circulatory condition:
1) Cyanosis despite supplied O2
2) Quiet tachypnea (tachypnea without recessions)
3) Marked tachycardia out of proportion to respiratory distress
4) Gallop rhythm / murmur
5) Raised jugular venous pressure
6) Enlarged liver (beware of posted liver)
7) Absent/ weak femoral pulses
III. Potential Neurological failure
(Neurological function, Effects of neurological failure on other systems)
 Neurological function
1) Conscious level:
 AVPU score: A = Alert
V = Responding to voice
P = Responding to pain
U = Unresponsive to all stimuli
The critically ill child
P a g e | 10
Emergency 2018
Kareem Alnakeeb
 Modified Glasgow Coma Score (GCS):
Child Infant Score
Eye opening (1-4)
Spontaneous Spontaneous 4
To speech To speech 3
To pain To pain 2
No response No response 1
Verbal response (1-5)
Oriented Coos, babbles, fixes, follows 5
Confused Irritable, cries but consolable 4
Inappropriate words Cries to pain, inconsolable 3
Incomprehensible sounds Moans to pain 2
No response No response 1
Motor response (1-6)
Obeys Moves spontaneously 6
Localizes Withdraws to touch 5
Withdraws Withdraws from pain 4
Decorticate to pain Decorticate to pain 3
Decerebrate to pain Decerebrate to pain 2
No response No response 1
 The least score is 3/15; the best is 15/15.
 If GCS is < 8, airway management should be considered
2) Posture:
- Hypotonia in a previously well is a sign of serious illness
- Stiff posturing: is a sign of serious brain dysfunction
► Decorticate (flexed arms, extended legs)
► Decerebrate (extended arms, extended legs)
- Stiffing dog position: Overextension of the neck
► upper airway obstruction e.g. epiglottitis
- Opisthotonus → meningeal irritation
3) Pupillary signs:
- Unequal pupils is a medical emergency
- Dilated fixed pupils are not always due to brain death
The critically ill child
P a g e | 11
Emergency 2018
Kareem Alnakeeb
4) Other signs: (TICLS)
• Abnormal muscle tone
• Abnormal reflexes
• Motor activity
• Distractibility by parents
• Eye contact (> 2 months of age)
• Speech/Cry
 Effects of neurological failure on other systems
- Abnormal breathing patterns e.g. Cheyne Stokes respirations
- Increased blood pressure with sinus bradycardia (Cushing's response)
o Indicates compression of the medulla oblongata caused by herniation of the cerebellar
tonsils through the foramen magnum.
o So, ↑ ICP → ↑ MAP → To keep CPP Constant
 Late & pre-terminal signs:
- Silent chest
- Cyanosis
- Hypotension
CerebralPerfusionPressure(CPP)=MeanArterialPressure(MAP)-IntracranialPressure(ICP)
 Cushing's triad: a sign of increase intracranial pressure (ICP)
• Hypertension
• Bradycardia
• Respiratory depression
 Cushing's response:
• Hypertension
• Bradycardia

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The critically ill child; Pediatrics 2018

  • 1. The critically ill child P a g e | 1 Emergency 2018 Kareem Alnakeeb The critically ill child (Initial evaluation and management) 1. Why children are different? - Children are NOT young adults. - They are different in: (Weight, Anatomical factors, Physiological factors, Psychological factors). Weight: • Scales • The Broselow Tape → Most accurate it uses the height (or length) of the child to estimate weight • Formulas; - 3-13 months: Weight (kg) = [ Age(months)+ 9] /2 - 1-6 years: Weight (kg) = [ Age(years) x 2 ] + 8 - 7-12 years: Weight (kg) = { [ Age(years) x 7 ] - 5 } /2 Anatomical factors: (Airway) - Large occiput and short neck → neck flexion and airway narrowing - Relatively large tongue (Most common cause of airway obstruction in the unconscious pediatric victim is the tongue) - The floor of the mouth is easily compressible - Infants are obligate nasal breathers (Up to age of 6 months) Physiological factors: - The infant has a relatively greater metabolic rate and oxygen consumption than adults - Hb F → has higher affinity for O2 than HbA1 & HbA2 - Tidal Volume (Air that enters lung with each quiet inspiration) is constant o the only way to ↑ minute ventilation is to ↑ RR o So, Tachypnea is the earliest sign of respiratory distress - The diaphragm is the main respiratory muscle → easily fatigable Psychological factors: - Communication - Fear e.g. white coat hypertension (++ Sympathetic → ↑HR, RR, sweating→ Overlap with the disease) Minutevolume=TidalvolumexRespiratoryrate Recognition of critical illness:
  • 2. The critically ill child P a g e | 2 Emergency 2018 Kareem Alnakeeb 2. What is cardiac arrest? - Absence of palpable central pulse in;  Carotid  in older children & adults  Brachial / Femoral  in young children 3. What are the causes of cardiac arrest? • Respiratory failure (Hypoxemia is the most common cause of cardiac arrest in children) • Circulatory failure • Neurological failure 4. How to recognize serious illness? Respiratory failure: 1. Airway problems 2. Efficacy of breathing 3. Effects of respiratory inadequacy Circulatory failure: 1. Cardiovascular signs 2. Effects of circulatory inadequacy Neurological failure: 1. Neurological function 2. Effects of neurological failure on other systems The assessment of a seriously unwell child involves the following: • Pediatric assessment triangle (PAT) (first impression) • primary survey (ABCDE assessment) • Secondary survey - Vital signs - Focused history - Detailed physical examination • Ongoing assessment. Components of a pediatric initial assessment:
  • 3. The critically ill child P a g e | 3 Emergency 2018 Kareem Alnakeeb A. Pediatric Assessment Triangle (first impression) 1. (Across-the-room) assessment 2. No equipment required 3. 60 seconds or less  PAT purpose: • To classify children into: - Sick/Not sick - Urgency of further investigations  PAT decision  Sick → (Basic Life Support, Advanced Life Support)  Not Sick → (Primary survey, secondary survey, Repeated exam)  PAT components: 1. Appearance 2. Breathing 3. Circulation PAT components Reflect the adequacy of Assessment areas 1. Appearance - Oxygenation - Ventilation - Brain perfusion - CNS function Mnemonic: TICLS - Tone (muscle tone) - Interactivity/mental status - Consolability (ability to calm the child) - Look or gaze - Speech or cry 2. Work of Breathing - Airway - Oxygenation - Ventilation - Posture (e.g. Tripod or Sniffing position) - Respiratory rate - Respiratory effort - Audible sounds 3. Circulation - Cardiac output - Perfusion of vital organs - Skin color e.g. pallor, mottling and cyanosis
  • 4. The critically ill child P a g e | 4 Emergency 2018 Kareem Alnakeeb B. Primary survey: (ABCDE assessment) • Hands-on assessment  Purpose: determine if life-threatening conditions exist  Components; - Airway and cervical spine control - Breathing - Circulation - Disability (neurologic status) - Exposure I. Potential respiratory failure: (Airway, Breathing, Effects of respiratory inadequacy)  Airway - Determine if the airway is patent, maintainable, or unmaintainable  Patent: able to be maintained independently  Maintainable: with positioning, suctioning  Unmaintainable: requires assistance  Tracheal intubation  Cricothyrotomy  Foreign body removal  If the airway is open → move on to evaluation of breathing  If the airway is not open → assess for sounds of airway compromise:  Snoring  Stridor  Wheeze  If C-spine injury is suspected → manually stabilize head & neck in a neutral, in-line position - Look in the mouth:  Blood  Broken teeth  Gastric contents  Foreign objects (loose teeth/gum/small toys) Goals:
  • 5. The critically ill child P a g e | 5 Emergency 2018 Kareem Alnakeeb  Spinal stabilization as needed for trauma (by history or physical examination)  Jaw thrust without head tilt  Suction  Reposition  Removal of foreign body  Airway adjuncts  Breathing 1. Adequate gas exchange with no signs of hypoxia 2. Absence of dyspnea, stridor, and signs of increased work of breathing o Evaluation of breathing should take no more than 10 seconds o Confirm child is breathing o Breathing (Effort – Efficacy – Effect on other organs)  If breathing adequate→ assess circulation. A. Respiratory Rate: -  RR with age - In cardiac arrest  Early: ↑RR, Late: RR - Normal RR in presence of other signs of respiratory distress is a Bad sign. B. Alar nasal flare: Dilatation of air passages →  Resistance → effort of breathing C. Recessions: - Indrawing of lower part of thoracic cage - Represent the use of accessory muscles to help in breathing D. Audible Noises i. Stridor: - Inspiratory sound that is usually indicating upper airway obstruction ii. Wheeze: - Expiratory sound that is usually indicating lower airway obstruction iii. Grunting: - Forced expiration against a partially closed glottis to increase the end expiratory pressure to assist gas exchange and prevent alveolar collapse - It indicates alveolar disease. Age Respiratory Rate First 2 months 50 2-12 months 40 1-5 years 25-30 6-12 years 20-25 >12 years 15-20 Interventions: Goals: 1. Efforts of breathing:
  • 6. The critically ill child P a g e | 6 Emergency 2018 Kareem Alnakeeb  Manifestations of increased effort of breathing are Absent in: 1. Central respiratory depression e.g. Morphine 2. Neuromuscular diseases e.g. spinal muscular atrophy or muscular dystrophy 3. Exhausted patients (with imminent respiratory arrest). • Chest expansion • Air entry (Note: Silent chest is a pre-terminal sign) • Pulse oximetry (Note: Hypoxemia is a danger sign) Early Late A. Mental status Irritable “inconsolable” unresponsive B. Heart rate ↑  C. Skin color - Pallor - O2 saturation < 85% in room air is a serious sign - Cyanosis is a late & pre-terminal sign Respiratory distress Respiratory failure • ↑ Respiratory Rate & depth of breathing • Nasal flaring • Inspiratory retractions • Grunting / Stridor • Restlessness • Tachycardia •  Respiratory rate, effort, or chest excursion • Cyanosis • Use of accessory muscles •  breath sounds •  skeletal tone •  conscious level or response to pain • Bradycardia • Suction • Oxygen • Airway adjuncts • Positive-pressure ventilation 2. Efficacy of breathing: 3. Effects of respiratory inadequacy: Signs of Respiratory distress & Respiratory failure: Interventions:
  • 7. The critically ill child P a g e | 7 Emergency 2018 Kareem Alnakeeb II. Potential Circulatory failure (Cardiovascular signs, Effects of cardiovascular inadequacy)  Cardiovascular signs - Adequate cardiovascular function and tissue perfusion - Effective circulating fluid volume - Normal core body temperature - Compare strength and quality of central and peripheral pulses - Central pulse: ► Infant → Brachial or femoral ► Older child → carotid artery  1. Heart rate: -  HR with age - In cardiac arrest  Early: ↑HR, Late: HR - Normal HR in presence of other signs of circulatory insufficiency is a Bad prognostic sign. 2. Capillary refill time (CRT):  Normal refill time: < 2 seconds  Slow refill time (> 2 seconds) indicates poor peripheral perfusion. - CRT is useful in the warm child & in presence of other signs of shock.  Delayed refill time (3-5 seconds) indicates: (poor perfusion, Exposure to cool ambient temperatures).  Markedly delayed refill time (>5 seconds) indicates Shock. Age (years) Heart Rate < 1 110-160 1-2 100-150 2-5 95-140 5-12 80-120 >12 60-100 Goals: Assessment: Cardiovascular signs:
  • 8. The critically ill child P a g e | 8 Emergency 2018 Kareem Alnakeeb 3. Pulse volume Grade Description +4 Full, bounding; not obliterated with pressure +3 Normal - easily palpated; not easily obliterated with pressure +2 Difficult to palpate, obliterated with pressure +1 Thready and weak, Difficult to palpate 0 Absent 4. Blood pressure - ↑ BP with age - >2 years: Minimum SBP = 70+(2x age in years) - Note: Hypotension is a late & pre-terminal sign - Absence of hypotension does NOT exclude shock, so shock can occur in normal BP. 5. Skin - Skin color: Pink, pale, blue (cyanotic) or mottled. - Skin temperature - Skin moisture - Skin turgor • Oxygen • Position • Chest compression • Bleeding control • Defibrillation Age (years) SBP (mmHg) < 1 70-90 1-2 80-95 2-5 80-100 5-12 90-110 >12 100-120 Interventions:
  • 9. The critically ill child P a g e | 9 Emergency 2018 Kareem Alnakeeb  Effects of cardiovascular inadequacy  1. Heart rate 2. Respiratory rate: ► Early → ↑ without recessions “Quiet tachypnea” ► Late →  3. Urine output:  (In infants: < 1 ml/kg/h, In children: < 0.5 ml/kg/h) 4. Skin color: Cyanosis is a pre-terminal sign 5. Mental status: ► Early → irritable ► Late → unresponsive There is a clear overlap between respiratory & circulatory failure. - The following signs are more in favor of a circulatory condition: 1) Cyanosis despite supplied O2 2) Quiet tachypnea (tachypnea without recessions) 3) Marked tachycardia out of proportion to respiratory distress 4) Gallop rhythm / murmur 5) Raised jugular venous pressure 6) Enlarged liver (beware of posted liver) 7) Absent/ weak femoral pulses III. Potential Neurological failure (Neurological function, Effects of neurological failure on other systems)  Neurological function 1) Conscious level:  AVPU score: A = Alert V = Responding to voice P = Responding to pain U = Unresponsive to all stimuli
  • 10. The critically ill child P a g e | 10 Emergency 2018 Kareem Alnakeeb  Modified Glasgow Coma Score (GCS): Child Infant Score Eye opening (1-4) Spontaneous Spontaneous 4 To speech To speech 3 To pain To pain 2 No response No response 1 Verbal response (1-5) Oriented Coos, babbles, fixes, follows 5 Confused Irritable, cries but consolable 4 Inappropriate words Cries to pain, inconsolable 3 Incomprehensible sounds Moans to pain 2 No response No response 1 Motor response (1-6) Obeys Moves spontaneously 6 Localizes Withdraws to touch 5 Withdraws Withdraws from pain 4 Decorticate to pain Decorticate to pain 3 Decerebrate to pain Decerebrate to pain 2 No response No response 1  The least score is 3/15; the best is 15/15.  If GCS is < 8, airway management should be considered 2) Posture: - Hypotonia in a previously well is a sign of serious illness - Stiff posturing: is a sign of serious brain dysfunction ► Decorticate (flexed arms, extended legs) ► Decerebrate (extended arms, extended legs) - Stiffing dog position: Overextension of the neck ► upper airway obstruction e.g. epiglottitis - Opisthotonus → meningeal irritation 3) Pupillary signs: - Unequal pupils is a medical emergency - Dilated fixed pupils are not always due to brain death
  • 11. The critically ill child P a g e | 11 Emergency 2018 Kareem Alnakeeb 4) Other signs: (TICLS) • Abnormal muscle tone • Abnormal reflexes • Motor activity • Distractibility by parents • Eye contact (> 2 months of age) • Speech/Cry  Effects of neurological failure on other systems - Abnormal breathing patterns e.g. Cheyne Stokes respirations - Increased blood pressure with sinus bradycardia (Cushing's response) o Indicates compression of the medulla oblongata caused by herniation of the cerebellar tonsils through the foramen magnum. o So, ↑ ICP → ↑ MAP → To keep CPP Constant  Late & pre-terminal signs: - Silent chest - Cyanosis - Hypotension CerebralPerfusionPressure(CPP)=MeanArterialPressure(MAP)-IntracranialPressure(ICP)  Cushing's triad: a sign of increase intracranial pressure (ICP) • Hypertension • Bradycardia • Respiratory depression  Cushing's response: • Hypertension • Bradycardia