This document summarizes a study conducted by the Nuclear Energy Agency (NEA) on the system costs of decarbonizing electricity generation with high shares of nuclear power and renewables. The study models eight scenarios with different technology mixes to achieve a 50g CO2/kWh target by 2050. It finds that a balanced mix of variable renewables, nuclear, and other dispatchable generation results in the lowest system costs. High shares of variable renewables increase costs due to integration challenges, though these costs can be reduced through policies that value reliability and flexibility. The study provides policymakers with insights on cost-effectively achieving deep decarbonization of the electricity sector.