Thoughts on the past, present and future of digital therapeutics and digital medicines. Presentation for NRC Live Zorgtech Conference in Amsterdam, September 2018.
Overcoming Barriers to Scale in Digital TherapeuticsChris Hogg
Presentation at Clinically Validated DTx Conference in Boston (November 2019). What paths have DTx products taken toward commercialization, what are the barriers, what is changing?
> Digital health explosion
> What is ‘Digital Therapeutics’ (DTx)?
> History of DTx
> Digital Therapeutics Alliance (DTA)
> How does DTx work?
> Disease Mx via DTx
> Barriers in the adoption of DTx
> DTx market
> DTx in the post-COVID era
> DTx market boom in post-COVID era
> Future of DTx
> Regulatory aspects of DTx - USFDA
> DTx incorporation guidance by other regulators
> Conclusion
Digital Health Market has exploded in the last few years. Will that continue? What are the main areas of growth in digital days and what the future will bring us.
Overcoming Barriers to Scale in Digital TherapeuticsChris Hogg
Presentation at Clinically Validated DTx Conference in Boston (November 2019). What paths have DTx products taken toward commercialization, what are the barriers, what is changing?
> Digital health explosion
> What is ‘Digital Therapeutics’ (DTx)?
> History of DTx
> Digital Therapeutics Alliance (DTA)
> How does DTx work?
> Disease Mx via DTx
> Barriers in the adoption of DTx
> DTx market
> DTx in the post-COVID era
> DTx market boom in post-COVID era
> Future of DTx
> Regulatory aspects of DTx - USFDA
> DTx incorporation guidance by other regulators
> Conclusion
Digital Health Market has exploded in the last few years. Will that continue? What are the main areas of growth in digital days and what the future will bring us.
Big data, RWE and AI in Clinical Trials made simpleHadas Jacoby
Technology is slowly but surely penetrating the healthcare industry in general and the clinical trials sector in particular. New and advanced solutions offer a variety of possibilities aimed to both improving existing processes and creating new and more efficient ones. And on top of all stands the desire to make clinical trials more patient centric.
In all of this, even though some of the technologies have yet to mature enough to meet the high quality standards necessary, it is important to know them and begin imagining the promise they hold for clinical trials.
The global patient engagement solutions market size stood at around USD 11.8 billion in 2019 and is projected to reach USD xx billion by 2028, exhibiting a CAGR of xx% during the forecast period.
The market for patient engagement solutions is mainly driven by the increasing utilization of electronic health records for patient-centric care and the adoption of mobile health devices. According to a survey conducted by the NHS in 2019, approximately 92.0% of patients feel assured in self-managing treatment.
Market Drivers
Factors such as the growing burden of chronic diseases and a rise in the geriatric population have led to the adoption of patient engagement solutions worldwide. For instance, in 2017, according to CDC statistics, 1.3 million new cases of diabetes were recorded in the US alone. In response to the growing number of diabetic patients, companies are focusing on the development of patient-centric engagement solutions. For example, in June 2019, Allina Health launched a patient-centric engagement solution platform for improving the Diabetes Self-Management Education (DSME) program. This enables diabetic self-care clinical services, particularly for those located in remote locations. Moreover, programs such as these help in cost evaluation, operational effectiveness, and clinical outcomes.
Government support is expected to drive the adoption of patient engagement solutions in the coming years. For instance, in 2018, the FDA established the Patient and Caregiver Connection program. The program was aimed to foster engagement with patients, patient advocates, and caregivers throughout the evaluation and surveillance of medical devices.
Visit https://insights10.com/ for more healthcare industry insights.
Connect with us @ info@insights10.com
The role of real world data and evidence in building a sustainable & efficien...Office of Health Economics
This presentation defines RWD and RWE in the context of digital health, and looks at potential uses for RWD and RWE. It briefly sets out the current landscape in Malaysia and looks at the challenges in using RWE. In particular, the issues of access, governance and ensuring good quality are considered.
As the author of “Big Data in Healthcare Hype and Hope,” Dr. Feldman has interviewed over 180 emerging tech and healthcare companies, always asking, “How can your new approach help patients?” Her research shows that data, as an enabling tool, has the power to give us critical new insights into not only what causes disease, but what comprises normal. Despite this promise, few patients have reaped the benefits of personalized medicine. A panel of leading big data innovators will discuss the evolving health data ecosystem and how big data is being leveraged for research, discovery, clinical trials, genomics, and cancer care. Case studies and real-life examples of what’s working, what’s not working, and how we can help speed up progress to get patients the right care at the right time will be explored and debated.
• Bonnie Feldman, DDS, MBA - Chief Growth Officer, @DrBonnie360
• Colin Hill - CEO, GNS Healthcare
• Jonathan Hirsch - Founder & President, Syapse
• Andrew Kasarskis, PhD - Co-Director, Icahn Institute for Genomics & Multiscale Biology; Associate Professor, Genetics & Genomic Studies, Icaahn School of Medicine at Mt. Sinai
• William King - CEO, Zephyr Health
New York eHealth Collaborative Digital Health Conference
November 18, 2014
Novartis is a global healthcare company based in Switzerland that provides solutions to address the evolving needs of patients worldwide. Our mission is to discover new ways to improve and extend people’s lives. Our vision is to be a trusted leader in changing the practice of medicine.
“Mobile Health(mHealth) is the use of mobile and wireless devices, the technology, to provide Health outcomes, Healthcare services and Health research.”
Precision Medicine: Four Trends Make It PossibleHealth Catalyst
When realized, the promise of precision medicine (to specifically tailor treatment to each individual) stands to transform healthcare for the better by delivering more effective, appropriate care. To date, to achieve precision medicine, health systems have faced financial, data management, and interoperability barriers. Current trends in healthcare, however, will give researchers and clinicians the quality and breadth of health data, biological information, and technical sophistication to overcome the challenges to achieving precision medicine.
Four notable trends in healthcare will bolster to growth of precision medicine in the coming years:
Decision support methods harness the power of the human genome.
Healthcare leverages big data analytics and machine learning.
Reimbursement methods incentivize health systems to keep patients well.
Emerging tools enable more data, more interoperability.
How can one regulatory program simultaneously benefit both blockbuster drugs and rare or neglected diseases? How can your company leverage the opportunities afforded by this program? This presentation walks you through the how’s and why’s of the FDA’s Priority Review Voucher program.
Generic Drugs having low cost. We should know about world drug scenario. In our daily life, we must concern with doctors and take drugs for cure. But we are not aware about drugs.We should know about drugs, not to become a Doctor, but for general awareness or at least to know what we are taking for our helth.
Description of the Brand Booster Program which includes three innovative marketing approaches: the Brand Preference Mix to increase market share - the Behavioral Prescriber Segmentation to increase the efficiency of field forces and the Individual Prescriber Plan to fine tune the marketing mix
APPLICATION OF DATA SCIENCE IN HEALTHCAREAnnaAntony16
About the application of data science in healthcare. Healthcare is an essential field that touches on people's lives in many ways, and it has been revolutionized by data science over the years. Data science has enabled healthcare providers to better understand patients' needs, identify the root causes of diseases, and design effective treatment plans.
Precision Medicine is now a funded NIH initiative and an organic movement in the clinic and at the research institute. Based on work with Genomics England, multiple large pharmaceutical firms, and research hospitals, attendees will learn about the best practices for epidemiology, signal detection, research, and the clinical diagnostics associated with Precision Medicine, including the development of high-scale bio-repositories that link traditional patient data with genomic information. Come hear about how leadership, collaboration, consent, and compute can lead to success or failure in your Precision Medicine initiative, and how to bring your stakeholders together for an aligned mission response.
The Digital Medicine Crystal Ball: Unlocking the Future of Real-Time, Precise...Cris De Luca
The last five years have seen an unprecedented eruption in technological and health advances.
These new technologies and products—many undergoing rigorous clinical validation—will have significant direct impacts on diagnosing, preventing, monitoring or treating a disease, condition or syndrome, which in turn will transform disease management and alter business models across industries.
This whitepaper describes the current and future influence of digital medicine on the health ecosystem and highlights how various stakeholders are working to deliver clinically impactful and economically viable solutions in a saturated yet still-emerging business environment.
Topics addressed in the whitepaper include:
How various stakeholders are working to deliver clinically impactful and economically viable solutions in a saturated yet still-emerging business environment
The new roles of traditional healthcare players
How the entrance of new technologies will affect partnership models and business strategies
The future of digital medicine’s regulatory environment
Author: Nicole Fisher
The report, produced by EBD Group in collaboration with Hogan Lovells, and authored by Forbes contributor, Nicole Fisher, features insights from Christine Lemke, Evidation Health, Hogan Lovells, Cris De Luca, J&J Innovation, NIH/PMI, Rachel Sha, Sanofi, StartUp Health, and key opinion leaders such as John Nosta and Unity Stoakes.
Big data, RWE and AI in Clinical Trials made simpleHadas Jacoby
Technology is slowly but surely penetrating the healthcare industry in general and the clinical trials sector in particular. New and advanced solutions offer a variety of possibilities aimed to both improving existing processes and creating new and more efficient ones. And on top of all stands the desire to make clinical trials more patient centric.
In all of this, even though some of the technologies have yet to mature enough to meet the high quality standards necessary, it is important to know them and begin imagining the promise they hold for clinical trials.
The global patient engagement solutions market size stood at around USD 11.8 billion in 2019 and is projected to reach USD xx billion by 2028, exhibiting a CAGR of xx% during the forecast period.
The market for patient engagement solutions is mainly driven by the increasing utilization of electronic health records for patient-centric care and the adoption of mobile health devices. According to a survey conducted by the NHS in 2019, approximately 92.0% of patients feel assured in self-managing treatment.
Market Drivers
Factors such as the growing burden of chronic diseases and a rise in the geriatric population have led to the adoption of patient engagement solutions worldwide. For instance, in 2017, according to CDC statistics, 1.3 million new cases of diabetes were recorded in the US alone. In response to the growing number of diabetic patients, companies are focusing on the development of patient-centric engagement solutions. For example, in June 2019, Allina Health launched a patient-centric engagement solution platform for improving the Diabetes Self-Management Education (DSME) program. This enables diabetic self-care clinical services, particularly for those located in remote locations. Moreover, programs such as these help in cost evaluation, operational effectiveness, and clinical outcomes.
Government support is expected to drive the adoption of patient engagement solutions in the coming years. For instance, in 2018, the FDA established the Patient and Caregiver Connection program. The program was aimed to foster engagement with patients, patient advocates, and caregivers throughout the evaluation and surveillance of medical devices.
Visit https://insights10.com/ for more healthcare industry insights.
Connect with us @ info@insights10.com
The role of real world data and evidence in building a sustainable & efficien...Office of Health Economics
This presentation defines RWD and RWE in the context of digital health, and looks at potential uses for RWD and RWE. It briefly sets out the current landscape in Malaysia and looks at the challenges in using RWE. In particular, the issues of access, governance and ensuring good quality are considered.
As the author of “Big Data in Healthcare Hype and Hope,” Dr. Feldman has interviewed over 180 emerging tech and healthcare companies, always asking, “How can your new approach help patients?” Her research shows that data, as an enabling tool, has the power to give us critical new insights into not only what causes disease, but what comprises normal. Despite this promise, few patients have reaped the benefits of personalized medicine. A panel of leading big data innovators will discuss the evolving health data ecosystem and how big data is being leveraged for research, discovery, clinical trials, genomics, and cancer care. Case studies and real-life examples of what’s working, what’s not working, and how we can help speed up progress to get patients the right care at the right time will be explored and debated.
• Bonnie Feldman, DDS, MBA - Chief Growth Officer, @DrBonnie360
• Colin Hill - CEO, GNS Healthcare
• Jonathan Hirsch - Founder & President, Syapse
• Andrew Kasarskis, PhD - Co-Director, Icahn Institute for Genomics & Multiscale Biology; Associate Professor, Genetics & Genomic Studies, Icaahn School of Medicine at Mt. Sinai
• William King - CEO, Zephyr Health
New York eHealth Collaborative Digital Health Conference
November 18, 2014
Novartis is a global healthcare company based in Switzerland that provides solutions to address the evolving needs of patients worldwide. Our mission is to discover new ways to improve and extend people’s lives. Our vision is to be a trusted leader in changing the practice of medicine.
“Mobile Health(mHealth) is the use of mobile and wireless devices, the technology, to provide Health outcomes, Healthcare services and Health research.”
Precision Medicine: Four Trends Make It PossibleHealth Catalyst
When realized, the promise of precision medicine (to specifically tailor treatment to each individual) stands to transform healthcare for the better by delivering more effective, appropriate care. To date, to achieve precision medicine, health systems have faced financial, data management, and interoperability barriers. Current trends in healthcare, however, will give researchers and clinicians the quality and breadth of health data, biological information, and technical sophistication to overcome the challenges to achieving precision medicine.
Four notable trends in healthcare will bolster to growth of precision medicine in the coming years:
Decision support methods harness the power of the human genome.
Healthcare leverages big data analytics and machine learning.
Reimbursement methods incentivize health systems to keep patients well.
Emerging tools enable more data, more interoperability.
How can one regulatory program simultaneously benefit both blockbuster drugs and rare or neglected diseases? How can your company leverage the opportunities afforded by this program? This presentation walks you through the how’s and why’s of the FDA’s Priority Review Voucher program.
Generic Drugs having low cost. We should know about world drug scenario. In our daily life, we must concern with doctors and take drugs for cure. But we are not aware about drugs.We should know about drugs, not to become a Doctor, but for general awareness or at least to know what we are taking for our helth.
Description of the Brand Booster Program which includes three innovative marketing approaches: the Brand Preference Mix to increase market share - the Behavioral Prescriber Segmentation to increase the efficiency of field forces and the Individual Prescriber Plan to fine tune the marketing mix
APPLICATION OF DATA SCIENCE IN HEALTHCAREAnnaAntony16
About the application of data science in healthcare. Healthcare is an essential field that touches on people's lives in many ways, and it has been revolutionized by data science over the years. Data science has enabled healthcare providers to better understand patients' needs, identify the root causes of diseases, and design effective treatment plans.
Precision Medicine is now a funded NIH initiative and an organic movement in the clinic and at the research institute. Based on work with Genomics England, multiple large pharmaceutical firms, and research hospitals, attendees will learn about the best practices for epidemiology, signal detection, research, and the clinical diagnostics associated with Precision Medicine, including the development of high-scale bio-repositories that link traditional patient data with genomic information. Come hear about how leadership, collaboration, consent, and compute can lead to success or failure in your Precision Medicine initiative, and how to bring your stakeholders together for an aligned mission response.
The Digital Medicine Crystal Ball: Unlocking the Future of Real-Time, Precise...Cris De Luca
The last five years have seen an unprecedented eruption in technological and health advances.
These new technologies and products—many undergoing rigorous clinical validation—will have significant direct impacts on diagnosing, preventing, monitoring or treating a disease, condition or syndrome, which in turn will transform disease management and alter business models across industries.
This whitepaper describes the current and future influence of digital medicine on the health ecosystem and highlights how various stakeholders are working to deliver clinically impactful and economically viable solutions in a saturated yet still-emerging business environment.
Topics addressed in the whitepaper include:
How various stakeholders are working to deliver clinically impactful and economically viable solutions in a saturated yet still-emerging business environment
The new roles of traditional healthcare players
How the entrance of new technologies will affect partnership models and business strategies
The future of digital medicine’s regulatory environment
Author: Nicole Fisher
The report, produced by EBD Group in collaboration with Hogan Lovells, and authored by Forbes contributor, Nicole Fisher, features insights from Christine Lemke, Evidation Health, Hogan Lovells, Cris De Luca, J&J Innovation, NIH/PMI, Rachel Sha, Sanofi, StartUp Health, and key opinion leaders such as John Nosta and Unity Stoakes.
mHealth Israel_ Digital Medicine_Whitepaper_The Digital Medicine Chrystal BallLevi Shapiro
The Digital Medicine Chrystal Ball: Unlocking the Future of Real-Time, Precise, Effective Healthcare. How will new digital technologies impact disease management and healthcare over the next decade? How will new digital technologies impact disease management and healthcare over the next decade?
Large amount of data is generated in Healthcare.Big data predicts epidemics,cure diseases and thus identifies problems before they even occur.Big data plays vital role in health care sector.
In this report we set out ten provocative statements predicting the world of 2020. Each prediction is articulated and brought to life through a series of portraits which imagine how patients, healthcare professionals and life sciences organizations might behave in this new world. Our predictions lean more towards an optimistic view of the future, although we organized that many in our industry are organized about the constraints and therefore pace of change. We describe the big trends rolled forward to 2020 and some of the constraints that will need to be overcome.
We also provide examples and evidence, based on the here and now, that show that the predictions are perfectly plausible, perhaps inspiring and surprising!
Our industry is changing quickly – requiring a bold response that is often difficult to implement – and yet organizations struggle to understand how to respond effectively and build a sense of urgency. We hope this report creates rich dialogue and enables a move to action.– we have had enormous fun discussing these predictions and sharing our experiences. We hope you have the same experience within your own organizations as you peruse this report and reflect on your current situation and future scenarios.
How Pharma Can Use Digital Health to Drive Value | A Medullan WebinarMedullan
With the shift to value, healthcare payers are insisting that pharmaceutical manufacturers deliver real world evidence of their drug’s efficacy before being allowed on formulary. The cost of new specialty treatments has forced companies to bolster and go beyond clinical trial, proving that their drugs improve health outcomes and reduce the cost of care with real world evidence.
So how do pharmaceutical companies gather these data points and what kind of digital tools should they use?
Real world data is no longer just for those trained in health economics and outcomes research — it can and will touch everyone in the pharma/healthcare space.
CBI asked industry's foremost RWD thought leaders a variety of questions to better understand how bio/pharmaceutical teams can collaborate and capture data in an aggregated form to continue to improve the value of products in development with real world, real-time data.
Real World Data - The New Currency in HealthcareJohn Reites
White paper published in June 2015 by CBI Life Sciences with interview insights from John Reites.
Real World Data (RWD) have become the bio/pharmaceutical industry’s treasure trove for information to inspire stakeholder decision-making. As an industry, professionals have increasingly been looking to RWD to not only assess the bene ts and risks of new medicines in clinical and real world settings, but also as a way to advise healthcare reimbursement decisions worldwide.
Digital healthcare solutions are designed to help save time, combine technologies, and boost the accuracy and efficiency of the healthcare delivery system.
20 tendencias digitales en salud digital_ The Medical FuturistRichard Canabate
Resaltado de las tendencias que darán forma a la atención médica post COVID19.
No se trata de enumerar estas tendencias, sino de dar una valiosa visión de los factores de conducción detrás de ellas mientras que es muy específico. Se trata de mostrar cuáles son las áreas exactas que deben destacarse entre todas las áreas en el tema "IA en la atención médica", por ejemplo.
Data analytics are having a significant impact on the healthcare industry. As the world's population lives longer on average, current treatment options face substantial hurdles in Clinical Data Science.
Successfully Managing Chronic Health Conditions with Human-Centered Digital T...Cognizant
By adopting evidence-based digital therapeutics, healthcare organizations can alleviate the mounting costs of caring for patients with chronic conditions — and enter the fourth wave of digital healthcare.
Next Generation Diabetes Therapy and Drug Delivery Market: Size, Share, and I...Kumar Satyam
The global diabetes epidemic is an escalating public health crisis, affecting millions worldwide. As the prevalence of diabetes continues to rise, so does the demand for innovative and effective therapies and drug delivery methods. The global next generation diabetes therapy and drug delivery market, valued at USD 22.25 billion in 2022, is projected to grow at a compound annual growth rate (CAGR) of 7.25% from 2024 to 2028. This market encompasses advanced technologies and personalized treatments designed to improve diabetes management and patient outcomes. This report, based on the latest insights from TechSci Research, provides an in-depth analysis of market trends, drivers, competitive landscape, and key benefits of next-generation diabetes therapies and drug delivery systems.
Similar to The coming era of digital therapeutics nrc live - sept 2018 (20)
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
5. People now expect solutions that just work.
They want solutions that solve their problems
and fit into their daily lives.
6. We are just beginning to see the
digitization of healthcare
Physicians: Office Visit → Telemedicine or Virtual Primary Care
7. We are just beginning to see the
digitization of healthcare
Pharmacist: In Pharmacy → Mobile / Home Delivery
8. We are just beginning to see the
digitization of healthcare
Pharmaceuticals: Traditional medicines → Digital therapeutics
9. ...represent the next generation of healthcare
...use software and technology to improve
clinically-meaningful endpoints
...are clinically-validated in rigorous clinical trials
...can be used alone or in combination with
existing treatments
Digital therapeutics...
What is a digital therapeutic?
10. Digital therapeutics represent the next
era of development in medicine
Small molecule
medicines
Large molecule
biologic medicines
Technology, data,
behavior, content
11. Digital therapeutics typically have
two core mechanisms of action
Individual Care Team
Goal:
Mechanisms:
Improve individual’s clinical status
● Behavior change
● Improved adherence
● Personalized content and
coaching
● Data driven user experiences
● New data + data science
Identify patients most in need of added
attention, services or treatment changes
● Data on non-adherence
● Data on clinical status
● Data on progress or worsening
● Prediction of exacerbation or
hospitalization
12. Just like traditional medicines, digital therapeutics are
clinically validated, regulated and prescribed by physicians
13. Just like traditional medicines, digital therapeutics will be
used alone and in combination with existing medicines
14. Similar to pharma and biotech development, digital
therapeutics developers are mostly disease specific
15. A look at 5 leading digital therapeutics companies
16. WellDoc
FDA-cleared in 2013
Target indication:
Type 2 diabetes
1 Quinn CC, et al. Diabetes Technol Ther. 2008;10(3):160-168. Quinn CC, et al.
Diabetes Care. 2011:34(9):1934-1942.. Richard Katz, MD; George Washington
University Medical Center; Journal of Health Communication, December 2011.
Quinn, CC, et al. Glycemic Control: Impact on Physician Prescribing Behavior,
Presentation ADA 72nd Scientific Sessions, 2012. Tang PY, et al. eHealth-Assisted
Lay Health Coaching for Diabetes Self-Management Support American Diabetes
Association 76th Scientific Sessions Poster Presentation 2016.
17. Propeller
FDA-cleared in 2012
Reduced Acute Care Utilization 1
(150%)
Hospitalizations
(100%)
(50%)
0%
50%
100%
150%
(77%)
10%
(86%)
1%
(70%)
(17%)
53%
(1%)
Hosp.
Days
ED Visits Clinic
Visits
Asthma Non-Asthma
Improved Adherence 2
0
2
0
4
0
6
0
Control Intervention
Medicationadherence%
+58%
1 Merchant et al (under review). “Impact of a Digital Health Intervention on Asthma Resource Utilization”
2 Van Sickle D, Humblet O, Barrett M, Henderson K, and Hogg C. 2016. Randomized, controlled study of the impact of a mobile health tool on asthma SABA use, control
and adherence. European Respiratory Journal:48: PA1018. http://erj.ersjournals.com/content/48/suppl_60/PA1018
Target indications:
Asthma and COPD
18. Akili Interactive
FDA-clearance - submitted
Children with Sensory Processing Dysfunction (SPD)
Anguera JA, et al., (2017) A pilot study to determine the feasibility of enhancing cognitive
abilities in children with sensory processing dysfunction. PLoS ONE 12(4): e0172616.
https://doi.org/10.1371/journal.pone.0172616
Target indications:
ADHD, Autism Spectrum Disorder, Major
Depressive Disorder, Parkinson’s
19. Pear Therapeutics
FDA-cleared in 2017
1. Campbell et al. Am J Psychiatry. 2014.
2. Hubbard et al. Psychol Addict Behav. 1997.
3. Simpson. Am J Psychiatry. 1979.
4. Zhang et al. Addiction. 2003
Target indications:
Substance abuse disorders, PTSD, major
depression, schizophrenia, multiple sclerosis
20. Proteus Digital Health
FDA-cleared in 2012
FDA-approved drug combination in 2017
Frias J, et al., “Effectiveness of Digital Medicines to Improve Clinical
Outcomes in Patients with Uncontrolled Hypertension and Type 2 Diabetes:
Prospective, Open-Label, Cluster-Randomized Pilot Clinical Trial”; J Med
Internet Res 2017;19(7):e246
Target indications:
Schizophrenia, high blood pressure, high
cholesterol, orphan diseases
23. We will see a proliferation new digital therapeutics
companies, with increased development of digital
therapeutics across all therapeutic areas
24. We will see increasing partnerships between digital
therapeutics companies and big pharma, who see DTx as a
new source of innovation they can commercialize
.
Biopharma Digital News
Novartis Pear Therapeutics 2/28/18: Announce collaboration to develop digital therapeutics for Schizophrenia and
Multiple Sclerosis
Otsuka Proteus 11/15/17: Received FDA approval (NDA) of digital medicine (pill with embedded sensor)
Novo Nordisk Glooko 7/17/17: Announce partnership to develop and market app for diabetes management
Roche MySugr 6/30/17: Roche acquires MySugr (popular app for diabetes self management)
Bayer BetaConnect
5/30/17: Beyer gets FDA approval (sBLA) for BetaConnect (connected betaseron pen
injector for MS)
Sonofi Verily 9/12/16: Jointly create OnDuo joint venture with $500M investment
Teva CareTRx 9/27/15: Teva acquires Gecko Health for its respiratory CareTRx platform and apps
AZ Adherium 8/19/15: AstraZeneca invests $3M in Adherium and signs commercial agreement
GSK / BI / Novartis Propeller
Development and commercial deals signed in 2014 (Boehringer Ingelheim), 2016 (GSK)
and 2017 (Novartis)
25. Alternative:
Connected medium-
dose ICS+LABA
Alternative:
Connected high- dose
ICS+LABA
Use connected
high-dose ICS+LABA
+ SABA to determine
appropriateness of
omazlizumab
Alternative:
Connected high- dose
ICS+LABA
Use connected
high-dose ICS+LABA
+ SABA to determine
appropriateness of
omazlizumab
We will see digital therapeutics find their place in
treatment algorithms and guidelines
26. Patient journey with digital therapeutics
A patient meets with her doctor,
who evaluates her.
Her doctor selects the appropriate therapy,
and she leaves with a prescription.
27. Patient journey with digital therapeutics
The patient goes to the pharmacy
and picks up her Rx.
Her doctor selected a digital therapeutic, so
her connected medicine comes with an app.
28. Patient journey with digital therapeutics
As she goes about her normal life, she
uses her medicines as she normally does.
She also receives a software-based
intervention, and starts to improve.
29. Patient journey with digital therapeutics
Meanwhile….
Many patients have been prescribed digital therapeutics that are delivering
data back to physicians and hospital systems
30. Patient journey with digital therapeutics
Healthcare providers and care managers use the data from digital therapeutics
to risk stratify patients and prioritize outreach.
31. Patient journey with digital therapeutics
Patient returns to her doctor and they
review data on adherence and disease
status from her digital therapeutic.
Her physician uses the data from her digital
therapeutic to get her to the right therapy regimen.
Disease severity and
level of control
32. Digital therapeutics present new opportunities
for patients, healthcare providers and payers
Patients will have more therapy options, will get to the best
therapy regimen faster, and have better control of their health.
Care teams will have better data on how patients are doing,
and be able to offer better solutions to their patients.
Payers and hospitals will lower utilization and costs, and have data
on which therapies are most useful in which patient groups.
33. With digital therapeutics, we will finally be
able to deliver on the main promise
of digital health
The ability to deliver...
...the right intervention
...to the right patient
...at the right time.