The active site for many enzymes involves A-amino acids that are brought into close proximity by extensive protein folding and may require a conenzyme or cofactor B-ususally depends on only one amino acid C-involves amino acids that are brought into close physical proximity to eachother by extensive protein folding D-contains amino acids that are next to eachother in the polypeptide chain E-may require a coenzyme or cofactor Solution The active site for many enzymes involves A- Amino acids that are brought into close proximity by extensive protein folding and may require aco-enzymeor cofactor.