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This document discusses relationships and success. It contains 3 key points: 1. Success is achieving your full potential through continuous self-improvement for your own benefit and that of others by pursuing meaningful goals. 2. Relationships are important for success and come in three levels - those ahead of you who can mentor you, those around you as colleagues and friends, and those you can help develop after you. 3. When choosing friends, consider shared values, vision, communication, and focus on inspiring each other through learning rather than associating with negative or gossiping people.
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Physiology of Chemical Sensation of smell.pdf
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Non-respiratory Functions of the Lungs.pdf
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
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Teens
- 1. Welcome Fast Forward 2010
- 2. .
- 4. • Success is being all you can with all you have. • It is the continuous optimization of ones potentials for the benefit of self and others. • It is the progressive realization of worthwhile goals. • Success is when opportunity meets preparation
- 6. i
- 7. Vision Vision is mental picture of a preferred future. Purpose in pictures. It’s more than becoming a doctor, accountant… Your Vision is THE FUTURE.
- 8. WHAT IS YOUR BIGGEST DREAM?
- 10. The Life dimension, Compound laws…
- 11. We are what we think…
- 12. A fish inside water…
- 14. The power of relationships…
- 18. Your Circle Acquaintances (casual friends) ? Semi level Inner Circle
- 19. The Three Levels of What Is Relationship? Relationship
- 20. Ahead – Mentors/Role Models Around –Is Relationship? What Colleagues/Friends After – Protégés/Others
- 21. What to consider before you choose a friend? • Values and Beliefs • Vision – Common purpose • Communication • Learn and Give • Inspire. • Avoid Negative people, gossips and people who lack foresight.
- 22. •How do you Manage Influence in our What Is Relationship? lives?
- 23. Thank YOU…. See YOU at the top
Editor's Notes
- Relationship is connection, association, link …. It is the act of meeting, talking, helping and knowing people whether older, younger and even mates.
- Friendship is companionship, alliance, closeness, acquaintances we have with our peers and others.
- GodParents and SiblingsFriends at school, church, home and others.
- Choosing Friends!
- Choosing Friends!
- Choosing Friends!
- Choosing Friends!
- Choosing Friends!
- Peer pressure is being influenced by what our friends are doing want us to do?
- Peer pressure is being influenced by what our friends are doing want us to do.How do we manage influence in our lives?