Bogota-Region has been working on two productive development agendas: implementing Colombia's Smart Specialization Strategy (RIS3) and developing clusters. Bogota has the most ambitious cluster development agenda in Colombia. The Regional Competitiveness Commission of Bogota-Region has made RIS3 and cluster initiatives its central focus to increase productivity. Remaining challenges include determining the role of clusters in RIS3 implementation, prioritizing RIS3 projects, addressing sectors without clusters, and aligning agendas and resources across levels of government.