Because the autism spectrum is so broad and complex, no universal approach to care is going to fit the needs of each child affected by this challenge. Many different elements enter into the bigger picture, so recognizing and diagnosing what makes each particular case unique is critical to remediating the associated conditions.

1. Supporting Systems
In The Body That
Impact Autism
By Dr. Roger Kendall

2. A B O U T T H E A U T H O R
Dr. Roger V. Kendall, Ph.D., is considered to be the
leading expert in the biochemistry and health benefits of
DMG. He has spent over 30 years conducting research
on this vital nutrient and has established DMG's
therapeutic role as an immune modulator, antioxidant
and metabolic enhancer in human and animal health.
Dr. Kendall has lectured widely, and has authored
numerous articles in both peer reviewed journals and leading
nutritional magazines.
Dr. Kendall holds a Ph.D. in organic biochemistry from
Penn State University, and has held teaching positions
at University of Bridgeport and Ambassador University.
He presently holds seven U.S. Patents and two European
Patents, six of them on DMG.
Dr. Kendall has compiled his research and clinical experience
with DMG in his well-received book entitled "Building
Wellness with DMG."

3. The autism spectrum includes a wide range
of behavioral characteristics, neurological
impairments, and digestive disorders.
It’s a complex developmental disorder with impaired
communication and social skills being hallmarks of the
condition. It affects behavioral and neurological functions in
both the body and the brain, as well as how an individual
receives and absorbs messages.
There are so many factors that contribute to the challenges
of autism, trying to mitigate the symptoms
of the condition becomes uniquely difficult.
I N T R O

4. PA R T O N E
No Universal
Approach to Care

5. N O U N I V E R S A L A P P R O A C H T O C A R E
Because the autism spectrum is so broad and complex,
no universal approach to care is going to fit the needs of
each child affected by this challenge.
Many different elements enter into the bigger picture, so recognizing
and diagnosing what makes each particular case unique is critical
to remediating the associated conditions.
There are genetic disorders, neurological, immunological, and even
gastrointestinal factors. So as a practitioner, and even as a parent,
you have to approach treatment of the symptoms with a wide brush
until you can develop a refined program that works for that
individual child. Providing additional methylation, immune system,
GI tract support is often a step in the right direction.

6. PA R T T W O
How DMG
Supports
The Body

7. Dimethylglycine (DMG) is an amino
acid that is an essential part of the
metabolic pathway. It’s important
because DMG is a one-carbon-
donator that directly affects the
methylation pathways, the immune
system, and detoxification pathways.
H O W D M G S U P P O R T S T H E B O D Y

8. Methylation
The importance of methylation can’t be understated. Methylation plays a role in the
reversal of many degenerative conditions, and it impacts a wide range of factors that
help to establish what functional medical practitioners consider good health and well-
being. In short, DMG supports methylation.
Immune Systems
Many autistic children suffer from immunological imbalances. Their bodies often have
trouble dealing with viruses and bacteria that other (non-autistic) children would more
easily handle. Children with autism seem to have an impaired ability to develop a
robust immune system.
A number of published studies have shown DMG to enhance and improve impaired
immune systems. The beauty of it is that it has been shown to enhance antibody
production (B Cells) as well as T Cells, which produce specific protein molecules that
help keep the immune system strong and defend the body from outside invaders.
Detoxification and Glutathione Production
One of the most well-known factors that lead to autism is exposure to environmental
toxins. Heavy metals, pesticides, and chlorinated hydrocarbons are linked to major
cognitive and neurological disorders along with inflammation and immune system
issues.
H O W D M G S U P P O R T S T H E B O D Y

9. Dimethylglycine helps isolate free radicals. On top of that, DMG is one of
the principal building blocks for the production of glutathione. The liver
produces glutathione as one of the body’s primary detoxifying agents and
antioxidants. DMG also helps increase oxygenation and reduces levels of
lactic acid. These are all factors that contribute to a variety of disorders
and can cause aberrations in autistic children.
Dimethylglycine is a biomedical intervention, but sometimes the body just
isn’t producing enough of it. Under these circumstances, providing DMG as
a supplement can help the patient reap the benefits and biomedical
enhancements that adequate levels of this particular amino acid impart.
A great example of DMG’s impact on the immune response is when
Dimethylglycine is given to an individual along with the Pneumovax
vaccine, the patient receiving the DMG has a fourfold increase in antibody
response to pneumococcal vaccine. Other studies have shown even
greater extents of improvements, so DMG is extremely effective at
improving methylation, the immune system, and detoxification.
H O W D M G S U P P O R T S T H E B O D Y

10. PA R T T H R E E
DMG and
the GI Tract

11. Gut issues and GI tract impairment are affected by diet and antibiotics. Heavy
metals are also factors, and they’re a constant issue for the body, found in a
number of sources, including vaccines.
By the age of two, some children get between 30-40 vaccines all of which may
contain thimerosal, a preservative that contains mercury. Many also include
adjuvants with aluminum or other heavy metals.
Because gut dysfunction is often a result of a partially blocked methylation
process, DMG can help balance the GI tract. Additionally, the detoxification
and glutathione support can help the body reduce its levels of heavy metals
and environmental chemicals.
DMG doesn’t work alone though. It is a precursor to SAM-e, and there are
some enzymes, vitamins, and cofactors such as vitamin B12 and folic acid
which help transfer the methyl groups to SAM-e. So, if the patient is deficient
in any of these lateral areas, supplementing with DMG could cause
Dimethylglycine to build up and result in other imbalances.
D M G A N D T H E G I T R A C T

12. PA R T F O U R
Factoring It
All Together

13. DMG can help support systems in
the body in a number of ways:
And it doesn’t take a long time for patients to see positive
results. DMG begins working in days, not weeks.
There are a number of DMG supplements available on the market,
but some are better than others. The best DMG supplements for
targeting systems that influence behavior combine many of the
essential cofactors and are created based upon research on the
optimization of methylation pathways.
FA C T O R I N G I T A L L T O G E T H E R
• Improved speech communication
• Improved social skills
• Improved eye contact
• Improved quality sleep
• Reduced hyperactivity
• Reduced, in some cases, repetitive habits

14. DMG supplementation isn’t going to help every
patient. But it is something practitioners can
test. If it doesn’t work, they can still utilize this
information to create a plan that works for that
specific child—the problem causing the
symptoms may not be related to the
methylation pathways. However, if the problem
does have to do with methylation, DMG and
adjacent supplementation may provide
significant benefits to the patient.
FA C T O R I N G I T A L L T O G E T H E R

15. L E A R N M O R E A B O U T S U P P O R T I N G O P T I M A L H E A LT H I N C H I L D R E N
SEE THE GUIDE
We all know good health depends on a nutritious diet and
plenty of exercise, but sometimes growing bodies need
extra support for key metabolic processes.
In partnership with top pediatric specialists, our researchers have
been busy developing supports for proper focus and brain
development, a good night's sleep, immune health, and improving
challenges with behavior and focus.
In our guide, "Health Alternatives For Your Children," Drs. Adam
Killpartrick and Matthew Hand will explain how these protocols work,
and what parents need to know about nutrients that will offer kids the
support they need.