"Stress is Detrimental and Moderate Exercise is Beneficial to Lupus Nephritis Pathogenesis: Extra-Medicinal Influences on Chronic Autoimmune Inflammation"
Presented this work as a poster tour presentation at The European League Against Rheumatism (EULAR) Annual European Congress of Rheumatology meeting June 10-13, 2015 in Rome, Italy. Awarded a travel bursary to attend this conference.
Common dermatologic disorders systemic lupus erythematosusDr. Faramarz Didar
SLE or lupus is a systemic autoimmune disease (or autoimmune connective tissue disease) that can affect any part of the body.
The immune system attacks the body's cells and tissue, resulting in inflammation and tissue damage.SLE most often harms the heart, joints, skin, lungs, blood vessels, liver, kidneys, and nervous system.
Characteristic facial rash of SLE is a butterfly rash which spread from one side of nose to other side.
It is very important to diagnose this Rash and SLE in patients who attend a cosmetic Clinic in order to solve their facial disfiguration. SLE butterfly facial rash is resistant to treatment by variety of cosmetic procedures like ablative and non-ablative laser, IPL , chemical peel and PRP. The diagnosis of SLE and systemic treatment od this disease is paramount to cosmetic approach. Cosmetic practitioner should have a broad knowledge of dermatological disorder and relevant approach to them.
Systemic lupus erythematosus is an autoimmune disease where the immune system attacks healthy cells and tissues. It most commonly affects women between 15-40 years old. Symptoms include painful joints, rashes, fatigue, and organ inflammation. The cause is unknown but genetics and environmental factors like sunlight play a role. Treatment focuses on reducing inflammation with medications like NSAIDs, anti-malarials, and corticosteroids. Nursing care centers around managing symptoms, preventing infections and flares, maintaining nutrition, and educating patients on self-management.
This document provides an overview of systemic lupus erythematosus (SLE). It defines SLE as a chronic autoimmune disease where the immune system attacks its own tissues. Common symptoms include issues affecting the skin, joints, kidneys, brain and other organs. It discusses genetic, environmental, immunological and hormonal factors that can contribute to SLE. The document also outlines several autoantibodies associated with SLE, potential pathophysiological mechanisms, common drug treatments including antimalarials, NSAIDs, DMARDS and corticosteroids, and their mechanisms of action. It concludes by discussing hopes for more targeted biologic therapies in the future to better treat SLE.
Sebuah edukasi pasien tentang lupus, meliputi berbagai aspek yang patut diketahui, agar pasien dan keluarganya tidak larut dalam fase denial dan bargaining yang berkepanjangan
This document discusses the immunological mechanism leading to glomerulonephritis, or inflammation of the glomeruli in the kidneys. It first defines glomerulonephritis and explains that it occurs when the glomeruli are damaged and unable to properly filter blood and remove excess fluids. It then describes how Type III hypersensitivity, or immune-complex mediated hypersensitivity, can cause membranous glomerulonephritis. In Type III reactions, antigen-antibody complexes are formed in the blood and deposited in tissues like the kidney glomeruli, activating the complement system and attracting neutrophils that cause tissue injury. Examples of diseases that can lead to glomerulonephritis this way include
The document discusses autoimmune disorders and summarizes key points about Graves' disease. It explains that autoimmune disorders occur when the immune system mistakenly attacks healthy body tissue. Graves' disease is described as an autoimmune disorder where antibodies cause the thyroid gland to produce excess hormones, leading to hyperthyroidism. The symptoms and common treatments are outlined, noting Graves' disease can often be managed after diagnosis.
Common dermatologic disorders systemic lupus erythematosusDr. Faramarz Didar
SLE or lupus is a systemic autoimmune disease (or autoimmune connective tissue disease) that can affect any part of the body.
The immune system attacks the body's cells and tissue, resulting in inflammation and tissue damage.SLE most often harms the heart, joints, skin, lungs, blood vessels, liver, kidneys, and nervous system.
Characteristic facial rash of SLE is a butterfly rash which spread from one side of nose to other side.
It is very important to diagnose this Rash and SLE in patients who attend a cosmetic Clinic in order to solve their facial disfiguration. SLE butterfly facial rash is resistant to treatment by variety of cosmetic procedures like ablative and non-ablative laser, IPL , chemical peel and PRP. The diagnosis of SLE and systemic treatment od this disease is paramount to cosmetic approach. Cosmetic practitioner should have a broad knowledge of dermatological disorder and relevant approach to them.
Systemic lupus erythematosus is an autoimmune disease where the immune system attacks healthy cells and tissues. It most commonly affects women between 15-40 years old. Symptoms include painful joints, rashes, fatigue, and organ inflammation. The cause is unknown but genetics and environmental factors like sunlight play a role. Treatment focuses on reducing inflammation with medications like NSAIDs, anti-malarials, and corticosteroids. Nursing care centers around managing symptoms, preventing infections and flares, maintaining nutrition, and educating patients on self-management.
This document provides an overview of systemic lupus erythematosus (SLE). It defines SLE as a chronic autoimmune disease where the immune system attacks its own tissues. Common symptoms include issues affecting the skin, joints, kidneys, brain and other organs. It discusses genetic, environmental, immunological and hormonal factors that can contribute to SLE. The document also outlines several autoantibodies associated with SLE, potential pathophysiological mechanisms, common drug treatments including antimalarials, NSAIDs, DMARDS and corticosteroids, and their mechanisms of action. It concludes by discussing hopes for more targeted biologic therapies in the future to better treat SLE.
Sebuah edukasi pasien tentang lupus, meliputi berbagai aspek yang patut diketahui, agar pasien dan keluarganya tidak larut dalam fase denial dan bargaining yang berkepanjangan
This document discusses the immunological mechanism leading to glomerulonephritis, or inflammation of the glomeruli in the kidneys. It first defines glomerulonephritis and explains that it occurs when the glomeruli are damaged and unable to properly filter blood and remove excess fluids. It then describes how Type III hypersensitivity, or immune-complex mediated hypersensitivity, can cause membranous glomerulonephritis. In Type III reactions, antigen-antibody complexes are formed in the blood and deposited in tissues like the kidney glomeruli, activating the complement system and attracting neutrophils that cause tissue injury. Examples of diseases that can lead to glomerulonephritis this way include
The document discusses autoimmune disorders and summarizes key points about Graves' disease. It explains that autoimmune disorders occur when the immune system mistakenly attacks healthy body tissue. Graves' disease is described as an autoimmune disorder where antibodies cause the thyroid gland to produce excess hormones, leading to hyperthyroidism. The symptoms and common treatments are outlined, noting Graves' disease can often be managed after diagnosis.
This document provides information on ankylosing spondylitis (AS), including its etiology, pathogenesis, pathology, symptoms, tests, treatment, and physiotherapy management. AS is an inflammatory arthritis that primarily affects the axial skeleton. It has unknown cause but is associated with the genetic marker HLA-B27 in most cases. Symptoms begin with pain in the sacroiliac region and lower back and can progress to fusion of the vertebrae. Treatments include medications like NSAIDs and TNF inhibitors, as well as regular physiotherapy focusing on exercises, hydrotherapy, electrotherapy, and education to maintain mobility and function.
This document summarizes a study on lupus nephritis. It begins by explaining that lupus nephritis is a disease caused by systemic lupus erythematosus (SLE) that results in kidney inflammation. It then discusses the pathogenesis of lupus nephritis, including genetic factors, immune system activation by nuclear particles, and lymphocyte expansion. Symptoms, diagnosis, and treatment options are also outlined, including corticosteroids, immunosuppressive drugs, managing blood pressure, and dialysis or kidney transplantation in severe cases. The conclusion states that lupus nephritis remains a major SLE complication but improved understanding of its causes and management have led to more effective therapies.
critical illness and metabolism ICRC 2012.pptxssuser6aa7a3
This document discusses the stress response pattern seen in critically ill patients. It describes the metabolic changes that occur across multiple organ systems as part of the body's adaptive response to critical illness and injury. These include increases in oxygen demand, protein catabolism, and changes in endocrine and immune function. Recognizing the typical ebb and flow phases of this stress response enables clinicians to better predict patient trajectories, guide diagnostic and therapeutic decisions, and identify unexpected deviations from the expected pattern.
SLE Systemic lupus erythematosus 2022
Basics, updates Prof. Hanan Ali Taha, professor of Internal Medicine and Head of the immunology unit, Faculty of Medicine, Beni-Suef University University
This document provides information on non-narcotic analgesics (NSAIDs) that have analgesic, antipyretic, and anti-inflammatory properties. It discusses the inflammatory process and pain pathway, how NSAIDs work by inhibiting prostaglandin synthesis via inhibition of cyclooxygenase enzymes, and the classification of various NSAIDs including aspirin, ibuprofen, naproxen, indomethacin, and others. It covers the pharmacological actions, pharmacokinetics, uses, and adverse effects of different NSAID classes.
This document discusses inflammation and pain, describing them as physiological processes. It outlines the body's inflammatory response, involving substances like arachidonic acid, prostaglandins, cytokines, and interleukins. Interleukins like IL-1α and IL-1β are identified as primary triggers of inflammation. Conventional anti-inflammatory drugs work by inhibiting enzymes involved in these processes, but often have side effects. Physiological Regulating Medicine provides low-dose formulations of substances like anti-interleukins and β-endorphin that can control inflammation and pain without strong side effects by respecting the body's physiological processes.
Intermittent fasting had a strong anti inflammatory effect beside the many other benefits. Intermittent fasting is an eating pattern and Interventional strategy where in individuals are subjected to varying periods of fasting. It doesn’t specify which foods you should eat but rather when you should eat them. Intermittent fasting (IF) is an eating pattern that cycles between periods of fasting and eating. It’s currently very popular in the health and fitness community. Recently attracted attention because:
1- Its Evidence-Based Health Benefits
2- Its potential for correcting metabolic Abnormalities
3- Better adherence than other methods
This document defines multiple sclerosis and discusses its pathophysiology, risk factors, classification, clinical features, investigations, and management. Multiple sclerosis is an inflammatory disease that damages the myelin sheaths around nerve axons in the brain and spinal cord, leading to demyelination and scarring. It typically affects young adults and is more common in females. While the cause is unknown, it may involve genetic and environmental factors. MRI is the most accurate test for diagnosis, showing lesions in the white matter. Treatment aims to reduce relapses using disease-modifying drugs like interferons or glatiramer acetate.
This document describes a study investigating the relationship between colitis-induced inflammation in the gut and neuroinflammation in the brain. The study found that a mild acute colitis model resulted in a small, non-significant increase in microglia activation in the brain, but a more severe acute colitis model did not. In a chronic colitis model, some animals showed increased microglia activation in the brain while others did not, indicating variable responses. The results provide preliminary evidence that gut inflammation may be linked to neuroinflammation, but the relationship requires further investigation.
This document discusses diabetic neuropathy, its types, risk factors, pathogenesis, and treatment. Diabetic neuropathies are chronic complications of diabetes that manifest in diverse clinical ways. The most common types are distal symmetric polyneuropathy and diabetic autonomic neuropathies. Tight control of blood sugar levels is the primary treatment approach, though additional therapies show some benefits for neuropathic pain relief and prevention of progression. Overall management of this condition remains challenging as existing nerve damage is largely irreversible.
The document discusses nonsteroidal anti-inflammatory drugs (NSAIDs). It describes how NSAIDs work by inhibiting cyclooxygenase (COX) enzymes and thereby reducing the production of prostaglandins involved in inflammation, pain, and fever. NSAIDs are commonly used to treat inflammation and pain conditions like arthritis as well as fever. Common NSAIDs include aspirin, ibuprofen, and naproxen. The document outlines their mechanisms of action, therapeutic uses, and potential adverse effects like gastrointestinal irritation and hypersensitivity reactions.
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that can affect multiple organs systems. It is more common in young women. The cause is unknown but involves genetic and environmental factors. Symptoms vary depending on the organs involved but can include rashes, joint pain, fatigue, and organ inflammation. Diagnosis involves evaluating symptoms, blood tests, and tissue biopsies. Treatment aims to reduce inflammation and prevent organ damage using medications like anti-inflammatories, antimalarials, steroids, and immunosuppressants. Managing SLE requires lifestyle modifications and monitoring for flare-ups.
Arthritis (Rheumatoid Arthritis, Osteoarthritis, Gout)
PPT contains content for UG healthcare students.
Elaborated topics referred from Nursing books, Orthopedics books, and some live cases from the department.
This randomized controlled trial compared early initiation of low-dose hydrocortisone therapy versus standard therapy for septic shock in geriatric patients. 120 patients were randomly assigned to receive early hydrocortisone upon initiation of vasopressors or standard therapy where hydrocortisone was given after fluids and vasopressors failed. The primary outcome of 28-day mortality did not significantly differ between groups. Secondary outcomes of ICU stay duration, vasopressor requirement, and mechanical ventilation need also showed no significant differences. While reversal of shock was higher in the early group, more adverse effects like hyperglycemia occurred. The study concluded that early steroids provided limited benefit for outcomes in elderly patients with septic shock.
Systemic lupus erythematosus (SLE) is a complex autoimmune disease where the immune system attacks the body's own cells and tissues, causing inflammation and damage. It most often affects the heart, joints, skin, lungs, blood vessels, liver, and kidneys. SLE prevalence is highest in women aged 15-65 years old. While the cause is unknown, genetic and environmental factors like UV light, infections, and smoking may play a role. Symptoms include rashes, fatigue, joint pain, and organ involvement. Treatment focuses on controlling symptoms with drugs like NSAIDs, antimalarials, corticosteroids, and immunosuppressants to minimize long-term damage. With effective treatment
This document summarizes the clinical management of diabetic neuropathy. It discusses the types and classification of diabetic neuropathy, signs and symptoms, diagnosis, incidence and risk factors. It also reviews the evidence for preventing neuropathy through tight glycemic control from studies like the DCCT trial. Finally, it discusses medications used to treat painful diabetic neuropathy, including tricyclic antidepressants, gabapentin, and SSRIs based on clinical trials.
Low-Dose Naltrexone in Diseases’ Treatment: Global Reviewresearchinventy
Naltrexone is a non-selective opioid antagonist, which shows effects on delta, mu and kappa receptors. Its therapeutic use is designed for drug addicts’ treatment, reducing withdrawal side effects. However, several researchers have used low-dose Naltrexone (LDN) for therapeutic purposes in diseases associated to immune system deficiency and inflammatory and tumor processes. Consequently, enhance evidences that LDN use hypothesis promotes, through a compensation mechanism, an increase of endorphins and enkephalins, in addition to opioid receptors up-regulation mechanism, in Central Nervous System (CNS), becoming it a potentially effective clinical practice in these pathologies. Thus, we present a review about LDN use in different pathologies, all they published in literature, and its therapeutic effects, enabling us to conclude that 3.0-4.5mg/day dose use in humans is effective for idiopathic diseases with alterations in immune system, as well as those ones with inflammatory and tumor characteristics.
The document discusses different types of shock including hypovolumic, cardiogenic, septic, anaphylactic, and neurogenic shock. It defines shock as systemic hypoperfusion caused by reduced cardiac output or effective circulatory blood volume. Key signs are hypotension, tissue hypoperfusion, cellular hypoxia, and potential end organ dysfunction. Management involves treating the underlying cause, restoring circulating volume, providing vasoactive drugs and oxygenation support, and monitoring for multiple organ failure in intensive care. Prognosis depends on the shock type and duration, with septic and cardiogenic shock having higher mortality risks.
"Oral administration of nano-emulsion curcumin suppresses LPS-induced NFkB si...Nicholas Young
Sildes from a portion of my talk per invitation of the Physiology research group at aTyr Pharma June 1-3, 2014, San Diego, CA. Subsequently, this project has translated to a human clinical trial of this patented anti-inflammatory drug (nanoemulsified curcumin; patented through my collaboration with the Department of Pharmacology at Ohio State).
More Related Content
Similar to "Stress is Detrimental and Moderate Exercise is Beneficial to Lupus Nephritis Pathogenesis: Extra-Medicinal Influences on Chronic Autoimmune Inflammation"
This document provides information on ankylosing spondylitis (AS), including its etiology, pathogenesis, pathology, symptoms, tests, treatment, and physiotherapy management. AS is an inflammatory arthritis that primarily affects the axial skeleton. It has unknown cause but is associated with the genetic marker HLA-B27 in most cases. Symptoms begin with pain in the sacroiliac region and lower back and can progress to fusion of the vertebrae. Treatments include medications like NSAIDs and TNF inhibitors, as well as regular physiotherapy focusing on exercises, hydrotherapy, electrotherapy, and education to maintain mobility and function.
This document summarizes a study on lupus nephritis. It begins by explaining that lupus nephritis is a disease caused by systemic lupus erythematosus (SLE) that results in kidney inflammation. It then discusses the pathogenesis of lupus nephritis, including genetic factors, immune system activation by nuclear particles, and lymphocyte expansion. Symptoms, diagnosis, and treatment options are also outlined, including corticosteroids, immunosuppressive drugs, managing blood pressure, and dialysis or kidney transplantation in severe cases. The conclusion states that lupus nephritis remains a major SLE complication but improved understanding of its causes and management have led to more effective therapies.
critical illness and metabolism ICRC 2012.pptxssuser6aa7a3
This document discusses the stress response pattern seen in critically ill patients. It describes the metabolic changes that occur across multiple organ systems as part of the body's adaptive response to critical illness and injury. These include increases in oxygen demand, protein catabolism, and changes in endocrine and immune function. Recognizing the typical ebb and flow phases of this stress response enables clinicians to better predict patient trajectories, guide diagnostic and therapeutic decisions, and identify unexpected deviations from the expected pattern.
SLE Systemic lupus erythematosus 2022
Basics, updates Prof. Hanan Ali Taha, professor of Internal Medicine and Head of the immunology unit, Faculty of Medicine, Beni-Suef University University
This document provides information on non-narcotic analgesics (NSAIDs) that have analgesic, antipyretic, and anti-inflammatory properties. It discusses the inflammatory process and pain pathway, how NSAIDs work by inhibiting prostaglandin synthesis via inhibition of cyclooxygenase enzymes, and the classification of various NSAIDs including aspirin, ibuprofen, naproxen, indomethacin, and others. It covers the pharmacological actions, pharmacokinetics, uses, and adverse effects of different NSAID classes.
This document discusses inflammation and pain, describing them as physiological processes. It outlines the body's inflammatory response, involving substances like arachidonic acid, prostaglandins, cytokines, and interleukins. Interleukins like IL-1α and IL-1β are identified as primary triggers of inflammation. Conventional anti-inflammatory drugs work by inhibiting enzymes involved in these processes, but often have side effects. Physiological Regulating Medicine provides low-dose formulations of substances like anti-interleukins and β-endorphin that can control inflammation and pain without strong side effects by respecting the body's physiological processes.
Intermittent fasting had a strong anti inflammatory effect beside the many other benefits. Intermittent fasting is an eating pattern and Interventional strategy where in individuals are subjected to varying periods of fasting. It doesn’t specify which foods you should eat but rather when you should eat them. Intermittent fasting (IF) is an eating pattern that cycles between periods of fasting and eating. It’s currently very popular in the health and fitness community. Recently attracted attention because:
1- Its Evidence-Based Health Benefits
2- Its potential for correcting metabolic Abnormalities
3- Better adherence than other methods
This document defines multiple sclerosis and discusses its pathophysiology, risk factors, classification, clinical features, investigations, and management. Multiple sclerosis is an inflammatory disease that damages the myelin sheaths around nerve axons in the brain and spinal cord, leading to demyelination and scarring. It typically affects young adults and is more common in females. While the cause is unknown, it may involve genetic and environmental factors. MRI is the most accurate test for diagnosis, showing lesions in the white matter. Treatment aims to reduce relapses using disease-modifying drugs like interferons or glatiramer acetate.
This document describes a study investigating the relationship between colitis-induced inflammation in the gut and neuroinflammation in the brain. The study found that a mild acute colitis model resulted in a small, non-significant increase in microglia activation in the brain, but a more severe acute colitis model did not. In a chronic colitis model, some animals showed increased microglia activation in the brain while others did not, indicating variable responses. The results provide preliminary evidence that gut inflammation may be linked to neuroinflammation, but the relationship requires further investigation.
This document discusses diabetic neuropathy, its types, risk factors, pathogenesis, and treatment. Diabetic neuropathies are chronic complications of diabetes that manifest in diverse clinical ways. The most common types are distal symmetric polyneuropathy and diabetic autonomic neuropathies. Tight control of blood sugar levels is the primary treatment approach, though additional therapies show some benefits for neuropathic pain relief and prevention of progression. Overall management of this condition remains challenging as existing nerve damage is largely irreversible.
The document discusses nonsteroidal anti-inflammatory drugs (NSAIDs). It describes how NSAIDs work by inhibiting cyclooxygenase (COX) enzymes and thereby reducing the production of prostaglandins involved in inflammation, pain, and fever. NSAIDs are commonly used to treat inflammation and pain conditions like arthritis as well as fever. Common NSAIDs include aspirin, ibuprofen, and naproxen. The document outlines their mechanisms of action, therapeutic uses, and potential adverse effects like gastrointestinal irritation and hypersensitivity reactions.
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that can affect multiple organs systems. It is more common in young women. The cause is unknown but involves genetic and environmental factors. Symptoms vary depending on the organs involved but can include rashes, joint pain, fatigue, and organ inflammation. Diagnosis involves evaluating symptoms, blood tests, and tissue biopsies. Treatment aims to reduce inflammation and prevent organ damage using medications like anti-inflammatories, antimalarials, steroids, and immunosuppressants. Managing SLE requires lifestyle modifications and monitoring for flare-ups.
Arthritis (Rheumatoid Arthritis, Osteoarthritis, Gout)
PPT contains content for UG healthcare students.
Elaborated topics referred from Nursing books, Orthopedics books, and some live cases from the department.
This randomized controlled trial compared early initiation of low-dose hydrocortisone therapy versus standard therapy for septic shock in geriatric patients. 120 patients were randomly assigned to receive early hydrocortisone upon initiation of vasopressors or standard therapy where hydrocortisone was given after fluids and vasopressors failed. The primary outcome of 28-day mortality did not significantly differ between groups. Secondary outcomes of ICU stay duration, vasopressor requirement, and mechanical ventilation need also showed no significant differences. While reversal of shock was higher in the early group, more adverse effects like hyperglycemia occurred. The study concluded that early steroids provided limited benefit for outcomes in elderly patients with septic shock.
Systemic lupus erythematosus (SLE) is a complex autoimmune disease where the immune system attacks the body's own cells and tissues, causing inflammation and damage. It most often affects the heart, joints, skin, lungs, blood vessels, liver, and kidneys. SLE prevalence is highest in women aged 15-65 years old. While the cause is unknown, genetic and environmental factors like UV light, infections, and smoking may play a role. Symptoms include rashes, fatigue, joint pain, and organ involvement. Treatment focuses on controlling symptoms with drugs like NSAIDs, antimalarials, corticosteroids, and immunosuppressants to minimize long-term damage. With effective treatment
This document summarizes the clinical management of diabetic neuropathy. It discusses the types and classification of diabetic neuropathy, signs and symptoms, diagnosis, incidence and risk factors. It also reviews the evidence for preventing neuropathy through tight glycemic control from studies like the DCCT trial. Finally, it discusses medications used to treat painful diabetic neuropathy, including tricyclic antidepressants, gabapentin, and SSRIs based on clinical trials.
Low-Dose Naltrexone in Diseases’ Treatment: Global Reviewresearchinventy
Naltrexone is a non-selective opioid antagonist, which shows effects on delta, mu and kappa receptors. Its therapeutic use is designed for drug addicts’ treatment, reducing withdrawal side effects. However, several researchers have used low-dose Naltrexone (LDN) for therapeutic purposes in diseases associated to immune system deficiency and inflammatory and tumor processes. Consequently, enhance evidences that LDN use hypothesis promotes, through a compensation mechanism, an increase of endorphins and enkephalins, in addition to opioid receptors up-regulation mechanism, in Central Nervous System (CNS), becoming it a potentially effective clinical practice in these pathologies. Thus, we present a review about LDN use in different pathologies, all they published in literature, and its therapeutic effects, enabling us to conclude that 3.0-4.5mg/day dose use in humans is effective for idiopathic diseases with alterations in immune system, as well as those ones with inflammatory and tumor characteristics.
The document discusses different types of shock including hypovolumic, cardiogenic, septic, anaphylactic, and neurogenic shock. It defines shock as systemic hypoperfusion caused by reduced cardiac output or effective circulatory blood volume. Key signs are hypotension, tissue hypoperfusion, cellular hypoxia, and potential end organ dysfunction. Management involves treating the underlying cause, restoring circulating volume, providing vasoactive drugs and oxygenation support, and monitoring for multiple organ failure in intensive care. Prognosis depends on the shock type and duration, with septic and cardiogenic shock having higher mortality risks.
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"Oral administration of nano-emulsion curcumin suppresses LPS-induced NFkB si...Nicholas Young
Sildes from a portion of my talk per invitation of the Physiology research group at aTyr Pharma June 1-3, 2014, San Diego, CA. Subsequently, this project has translated to a human clinical trial of this patented anti-inflammatory drug (nanoemulsified curcumin; patented through my collaboration with the Department of Pharmacology at Ohio State).
Aberrant muscle antigen exposure in mice is sufficient to cause myositis in a...Nicholas Young
The document summarizes a study investigating the role of regulatory T cells (Tregs) and the protein synaptotagmin 7 (Syt7) in the development of autoimmune myositis. The study found that mice lacking both Tregs and Syt7 (double knockout or DKO mice) developed more severe autoimmune myositis compared to mice with either deficiency alone. Adoptive transfer of immune cells from DKO mice into recipient mice also induced myositis. Additionally, the study identified the muscle protein myosin as a potential self-antigen that can stimulate an inflammatory response. Supplementation of Tregs was able to suppress the myositis induced by DKO immune cells, highlighting the role
“A Chimeric Human-Mouse Model of Sjögren's Syndrome” Nicholas Young
This document describes the development of a novel chimeric mouse model of Sjögren's syndrome (SjS) using human peripheral blood mononuclear cells (PBMCs) engrafted into NOD scid gamma (NSG) mice. The model showed robust CD4+ T-cell infiltration in the salivary and lacrimal glands of mice engrafted with SjS PBMCs compared to healthy controls. SjS mice also exhibited significantly higher levels of pro-inflammatory cytokines associated with SjS and histopathological features that mimic human SjS. This chimeric mouse model provides a tool for studying the molecular mechanisms and evaluating potential therapies for SjS.
"Bioluminescent Imaging of Histidyl-Transfer RNA Synthetase-Induced Myositis ...Nicholas Young
My talk from the American College of Rheumatology Meeting in Boston, MA, November 14-19, 2014: • "Bioluminescent Imaging of Histidyl-Transfer RNA Synthetase-Induced Myositis Reveals Early-Phase Involvement of NF-kB-Mediated Inflammation".
“Manocept, a derivative of FDA-approved 99mTc-Tilmanocept, exhibits diagnosti...Nicholas Young
My talk from The European League Against Rheumatism (EULAR) Annual European Congress of Rheumatology meeting June 10-13, 2015 in Rome, Italy: • “Manocept, a derivative of FDA-approved 99mTc-Tilmanocept, exhibits diagnostic potential by specifically identifying macrophages in rheumatoid arthritis: a novel application of an existing drug”. Awarded a travel bursary to attend this conference.
“Estrogen-mediated TLR8 expression via STAT1 facilitates endogenous miRokine ...Nicholas Young
My talk at The Federation of Clinical Immunology Societies (FOCIS) annual meeting June 24-27, 2015 in San Diego, CA: “Estrogen-mediated TLR8 expression via STAT1 facilitates endogenous miRokine ligand activation by exosomes containing miR-21: a novel innate inflammatory pathway in systemic lupus erythematosus”. Presented during the "Best in Rheumatology 2015" conference session. Recipient of a second consecutive travel award given to selected abstracts to attend this conference.
Nicholas Young, Sphingosine 1-phosphate Receptor Subtype Influence over Gliob...Nicholas Young
My talk presenting my thesis work per invitation of Research and Development Division of Genzyme Corporation to the Lipid Storage Disorders Department. October 5, 2007. Boston, MA: "Sphingosine 1-phosphate Receptor Subtype Influence over Glioblastoma Multiforme Pathology". My PhD was earned through the Integrated Biomedical Sciences, September 2007, The Ohio State University, College of Medicine Columbus, OH. Area of focus for my PhD: Biochemical and Molecular Disease Mechanisms. Dissertation title: Sphingosine 1-phosphate Receptor Subtype Influence Over Glioblastoma Multiforme Malignant Behavior"
Deep Behavioral Phenotyping in Systems Neuroscience for Functional Atlasing a...Ana Luísa Pinho
Functional Magnetic Resonance Imaging (fMRI) provides means to characterize brain activations in response to behavior. However, cognitive neuroscience has been limited to group-level effects referring to the performance of specific tasks. To obtain the functional profile of elementary cognitive mechanisms, the combination of brain responses to many tasks is required. Yet, to date, both structural atlases and parcellation-based activations do not fully account for cognitive function and still present several limitations. Further, they do not adapt overall to individual characteristics. In this talk, I will give an account of deep-behavioral phenotyping strategies, namely data-driven methods in large task-fMRI datasets, to optimize functional brain-data collection and improve inference of effects-of-interest related to mental processes. Key to this approach is the employment of fast multi-functional paradigms rich on features that can be well parametrized and, consequently, facilitate the creation of psycho-physiological constructs to be modelled with imaging data. Particular emphasis will be given to music stimuli when studying high-order cognitive mechanisms, due to their ecological nature and quality to enable complex behavior compounded by discrete entities. I will also discuss how deep-behavioral phenotyping and individualized models applied to neuroimaging data can better account for the subject-specific organization of domain-general cognitive systems in the human brain. Finally, the accumulation of functional brain signatures brings the possibility to clarify relationships among tasks and create a univocal link between brain systems and mental functions through: (1) the development of ontologies proposing an organization of cognitive processes; and (2) brain-network taxonomies describing functional specialization. To this end, tools to improve commensurability in cognitive science are necessary, such as public repositories, ontology-based platforms and automated meta-analysis tools. I will thus discuss some brain-atlasing resources currently under development, and their applicability in cognitive as well as clinical neuroscience.
Remote Sensing and Computational, Evolutionary, Supercomputing, and Intellige...University of Maribor
Slides from talk:
Aleš Zamuda: Remote Sensing and Computational, Evolutionary, Supercomputing, and Intelligent Systems.
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Inter-Society Networking Panel GRSS/MTT-S/CIS Panel Session: Promoting Connection and Cooperation
https://www.etran.rs/2024/en/home-english/
hematic appreciation test is a psychological assessment tool used to measure an individual's appreciation and understanding of specific themes or topics. This test helps to evaluate an individual's ability to connect different ideas and concepts within a given theme, as well as their overall comprehension and interpretation skills. The results of the test can provide valuable insights into an individual's cognitive abilities, creativity, and critical thinking skills
Unlocking the mysteries of reproduction: Exploring fecundity and gonadosomati...AbdullaAlAsif1
The pygmy halfbeak Dermogenys colletei, is known for its viviparous nature, this presents an intriguing case of relatively low fecundity, raising questions about potential compensatory reproductive strategies employed by this species. Our study delves into the examination of fecundity and the Gonadosomatic Index (GSI) in the Pygmy Halfbeak, D. colletei (Meisner, 2001), an intriguing viviparous fish indigenous to Sarawak, Borneo. We hypothesize that the Pygmy halfbeak, D. colletei, may exhibit unique reproductive adaptations to offset its low fecundity, thus enhancing its survival and fitness. To address this, we conducted a comprehensive study utilizing 28 mature female specimens of D. colletei, carefully measuring fecundity and GSI to shed light on the reproductive adaptations of this species. Our findings reveal that D. colletei indeed exhibits low fecundity, with a mean of 16.76 ± 2.01, and a mean GSI of 12.83 ± 1.27, providing crucial insights into the reproductive mechanisms at play in this species. These results underscore the existence of unique reproductive strategies in D. colletei, enabling its adaptation and persistence in Borneo's diverse aquatic ecosystems, and call for further ecological research to elucidate these mechanisms. This study lends to a better understanding of viviparous fish in Borneo and contributes to the broader field of aquatic ecology, enhancing our knowledge of species adaptations to unique ecological challenges.
Current Ms word generated power point presentation covers major details about the micronuclei test. It's significance and assays to conduct it. It is used to detect the micronuclei formation inside the cells of nearly every multicellular organism. It's formation takes place during chromosomal sepration at metaphase.
The binding of cosmological structures by massless topological defectsSérgio Sacani
Assuming spherical symmetry and weak field, it is shown that if one solves the Poisson equation or the Einstein field
equations sourced by a topological defect, i.e. a singularity of a very specific form, the result is a localized gravitational
field capable of driving flat rotation (i.e. Keplerian circular orbits at a constant speed for all radii) of test masses on a thin
spherical shell without any underlying mass. Moreover, a large-scale structure which exploits this solution by assembling
concentrically a number of such topological defects can establish a flat stellar or galactic rotation curve, and can also deflect
light in the same manner as an equipotential (isothermal) sphere. Thus, the need for dark matter or modified gravity theory is
mitigated, at least in part.
Or: Beyond linear.
Abstract: Equivariant neural networks are neural networks that incorporate symmetries. The nonlinear activation functions in these networks result in interesting nonlinear equivariant maps between simple representations, and motivate the key player of this talk: piecewise linear representation theory.
Disclaimer: No one is perfect, so please mind that there might be mistakes and typos.
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Phenomics assisted breeding in crop improvementIshaGoswami9
As the population is increasing and will reach about 9 billion upto 2050. Also due to climate change, it is difficult to meet the food requirement of such a large population. Facing the challenges presented by resource shortages, climate
change, and increasing global population, crop yield and quality need to be improved in a sustainable way over the coming decades. Genetic improvement by breeding is the best way to increase crop productivity. With the rapid progression of functional
genomics, an increasing number of crop genomes have been sequenced and dozens of genes influencing key agronomic traits have been identified. However, current genome sequence information has not been adequately exploited for understanding
the complex characteristics of multiple gene, owing to a lack of crop phenotypic data. Efficient, automatic, and accurate technologies and platforms that can capture phenotypic data that can
be linked to genomics information for crop improvement at all growth stages have become as important as genotyping. Thus,
high-throughput phenotyping has become the major bottleneck restricting crop breeding. Plant phenomics has been defined as the high-throughput, accurate acquisition and analysis of multi-dimensional phenotypes
during crop growing stages at the organism level, including the cell, tissue, organ, individual plant, plot, and field levels. With the rapid development of novel sensors, imaging technology,
and analysis methods, numerous infrastructure platforms have been developed for phenotyping.
BREEDING METHODS FOR DISEASE RESISTANCE.pptxRASHMI M G
Plant breeding for disease resistance is a strategy to reduce crop losses caused by disease. Plants have an innate immune system that allows them to recognize pathogens and provide resistance. However, breeding for long-lasting resistance often involves combining multiple resistance genes
ANAMOLOUS SECONDARY GROWTH IN DICOT ROOTS.pptxRASHMI M G
Abnormal or anomalous secondary growth in plants. It defines secondary growth as an increase in plant girth due to vascular cambium or cork cambium. Anomalous secondary growth does not follow the normal pattern of a single vascular cambium producing xylem internally and phloem externally.
Nucleophilic Addition of carbonyl compounds.pptxSSR02
Nucleophilic addition is the most important reaction of carbonyls. Not just aldehydes and ketones, but also carboxylic acid derivatives in general.
Carbonyls undergo addition reactions with a large range of nucleophiles.
Comparing the relative basicity of the nucleophile and the product is extremely helpful in determining how reversible the addition reaction is. Reactions with Grignards and hydrides are irreversible. Reactions with weak bases like halides and carboxylates generally don’t happen.
Electronic effects (inductive effects, electron donation) have a large impact on reactivity.
Large groups adjacent to the carbonyl will slow the rate of reaction.
Neutral nucleophiles can also add to carbonyls, although their additions are generally slower and more reversible. Acid catalysis is sometimes employed to increase the rate of addition.
This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
Sharlene Leurig - Enabling Onsite Water Use with Net Zero Water
"Stress is Detrimental and Moderate Exercise is Beneficial to Lupus Nephritis Pathogenesis: Extra-Medicinal Influences on Chronic Autoimmune Inflammation"
1. Stress is Detrimental and
Moderate Exercise is Beneficial to
Lupus Nephritis Pathogenesis:
Extra-Medicinal Influences on
Chronic Autoimmune Inflammation
1
2. Chronic inflammation contributes to the pathogenesis of many
diseases
2
Chronic
inflammation
CVD
Atherosclerosis
Cardiomyopathy
Heart failure
Stroke
Autoimmunity
Rheumatoid arthritis
Lupus
Sjogren’s syndrome
Diabetes
IBD
Psoriasis
Cancer
Lung
Colon
Pancteatic
lymphoma
Neurological
Disorders
Alzheimer’s
Parkinson’s
ALS
Metabolic Disorder
Complications
Fatty liver disease
Heart disease
Bone, musculoskeletal
disease
Osteoporosis
Osteoarthritis
Muscular dystrophy
3. Background
The effect of exercise over inflammatory diseases
remains unclear
Model displaying the systemic effects of exercise is
lacking
Hypothesis: exercise can suppress inflammation
systemically, but its effects are lost over time
3
4. Background
Exercise could be a very potent therapeutic intervention to control
inflammatory disease
Underutilized in clinical practice
Exercise is a robust systemic biological response modifier
regulating inflammatory responses
Effects of exercise are transient
Lost after 36-48 hours
Suggests greatest benefits achieved with daily exercise
4
5. BUN Levels Increase and Weight Decreases in
NZM Mice with Disease Progression
5
NZM 2410 Mouse
(develops lupus
nephritis from 22-
40 weeks of age)
-0.5
0.5
1.5
2.5
3.5
4.5
5.5
6.5
23 25 27 29 31 33
BUNandWeight
RelativetoBaseline
Age (Weeks)
Weight
BUN
Removal Criteria
Mice that lost 20% or
more of their body weight
and found to have BUN
levels over 50 mg/dL
were sacrificed.
6. Effects of exercise on lupus nephritis
6
Exercise =
45 min 9
M/min daily
Submandibular bleeds,
biweekly, 100µL of
blood collected, serum
isolated. Mice were
weighed weekly.
Blood Urea
Nitrogen tests
were completed
biweekly using
Bioo Scientific
BUN Enzymatic
Kit
7. 7
Effects of Exercise in Lupus Nephritis
0
2
4
6
8
10
12
14
16
BUNLevelRelativetoBaseline
Blood Urea Nitrogen
Levels at 32 Weeks
Exercise
Non-Exercise
*
11. Effects of social stress on lupus nephritis
Aggressor mouse
introduced into
cage of NZM 2410
males for 2 hours
everyday for 6
days.
Submandibular bleeds,
weekly, 100µL of blood
collected, serum
isolated. Mice were
weighed weekly.
Blood Urea
Nitrogen tests
were completed
biweekly using
Bioo Scientific
BUN Ezymatic Kit
14. • Chronic levels of inflammation lead to
autoimmune disease pathogenesis
• exercise and stress reduction could be a very
potent therapeutic intervention to control the
inflammation
• therapeutic to control disease activity
• Use in conjunction with clinical treatments
could offer greater success in the
management of chronic inflammation in LN
14
CONCLUSIONS
15. Future studies
• IL-6 ELISA analysis
• Expand these cohorts and repeat/validate data
• IRB study to investigate the effects of yoga
• , known to be both moderate exercise and stress
reduction
• Arthritis Foundation
• therapeutic effects of exercise in animal models of
rheumatoid arthritis, osteoarthritis, and lupus
• AstraZeneca
• effects of exercise in an animal model of gout
15
Editor's Notes
It is well-known that chronic levels of inflammation (both low and high levels) are present and contributing factors leading to the pathogenesis of many diseases. These disorders cover a broad spectrum and include cardiovascular disease (CVD), autoimmune disorders, neurological disorders, bone and musculoskeletal diseases, complications associated with metabolic disorders, and even cancer. Furthermore, many studies have shown the positive effects of exercise in the management and clinical outcome of many of these same diseases.
Despite this strong correlation between inflammation and exercise, the exact explanation of how exercise is effecting these diseases still remains unclear. Additionally, an animal model to study the systemic effects of exercise over inflammation is currently lacking. Thus, we set out to explore the following hypothesis in this study: that exercise can regulate inflammation by systemic suppression and that this effect would eventually be lost over time.
In conclusion, we suggest that moderate exercise could therefore be a very potent therapeutic intervention to be used to control the inflammation associated with a variety of different diseases, but is unfortunately a tremendously underutilized therapeutic modality in clinical practice today. Also, we have demonstrated that exercise is a robust and systemic biological response modifier that can subsequently serve to regulate inflammation. Lastly, we have shown that the effects of exercise in modulating these responses are completely lost after 36-48 hours, which suggests that the greatest benefits may be achieved with a daily exercise routine.