steroids role, importance, uses, side effects

1. Presented by,
S.Nizam Pakkir Maideen,
Clinical Pharmacist.

2. Steroids
 Steroids are Drugs , often hormones, that our
body makes naturally.
 It help our organs, tissues, and cells do their
jobs.
 "Steroids" can also refer to man-made
medicines.
 The two main types are corticosteroids
(Catabolics) and anabolic-androgenic steroids (
anabolics).

3. Where the secretion
of steroid hormones
takes place jn our
body?

4. Secretion
• Steroid hormones are secreted from Adrenal
gland

5. Location Of Adrenal Gland

6. Rate Of Secretion
• Glucorticoids:
10 - 20 mg Daily,
• Mineralocorticoids:
0.125 mg Daily.

7. Functions Of Steroids
Steroids have two principal biological functions:
1.As important components of cell
membranes which alter membrane fluidity,
2.As signaling molecules.

8. Signaling Molecules
• Carbohydrate Regulation (Glucocorticoids),
• Mineral Balance (Mineralocorticoids),
• Reproductive Function (Gonadal Steroids).

9. Mechanism Of Action

10. Binding Site
Receptors for steroid hormones are located inside target cells, in the
cytoplasm or nucleus

11. Basic Structure Of SteroidsBasic Structure Of Steroids

12. CholesterolCholesterol

13. SteroidogenesisSteroidogenesis

14. Types Of Steroids
• Anabolic Streroids,
• Catabolic Steroids,
–Glucocorticoids,
–Mineralocorticoids,
–Cortisol Derivatives

15. Anabolic SteroidsAnabolic Steroids

16. Anabolic SteroidsAnabolic Steroids

17. Anabolic steroids
• Anabolic steroids helps in faster muscle gain,
• It enchances the performance of athletes due
that it was misused,

18. GlucocorticoidsGlucocorticoids

19. GlucocorticoidsGlucocorticoids

20. MineralocorticoidsMineralocorticoids

21. Corticisteroids used to treat
• Rheumatoid arthritis
• Asthma
• Chronic obstructive pulmonary disorder
(COPD)
• Lupus and other autoimmune disorders
• Multiple sclerosis
• Rashes and skin conditions like eczema

22. Metabolism & ExcretionMetabolism & Excretion

23. Anti-Inflammatory Action Of SteroidsAnti-Inflammatory Action Of Steroids

24. Harmful EffectsHarmful Effects

25. Available Dosage Form
• They come in pill form, as inhalers or nasal
sprays, creams and ointments.
• Steroid pills help treat inflammation and pain
in conditions such as arthritis and lupus.
• Inhalers and nasal sprays help treat asthma
and allergies.
• Creams and ointments can help some skin
conditions, such as eczema and contact
dermatitis.

26. Injection
• Solu Medrol ,40/80/125/500/1000 Mg,
• Depo Medrol 80,
• Ivepred 500/1000 mg,

27. Tablet
• Omnacortil 5/10/20/30/40 mg,
• Medrol 4/16 mg,
• Wysolone 5/10 mg,
• Deflazocort 6 mg,
• Fludrocortisone 100 mg,

28. Respules
• Budate Forte,
• Foracort 0.5, 1,

29. Inhalers
• Budesonide 100, 200, 400,
• Momeflo,